Inhibition of phosphorylated STAT3 by cucurbitacin I enhances chemoradiosensitivity in medulloblastoma-derived cancer stem cells

Child's Nervous System

Volumn 28, Issue 3, 2012, Pages 363-373

  Chang, Charn Jung ^a   Chiang, Chih Hung ^c,d   Song, Wen Shin ^b,c   Tsai, Shen Kou ^b,c   Woung, Lin Chung ^c,e   Chang, Chin Hong ^f   Jeng, Shaw Yeu ^c,d   Tsai, Ching Yao ^c,e   Hsu, Chuan Chih ^f   Lee, Hung Fu ^b,c   Huang, Chi Shuan ^b,c   Yung, Ming Chi ^c,g   Liu, Jorn Hon ^b,c   Lu, Kai Hsi ^b,c  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b CHENG HSIN GENERAL HOSPITAL   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^e TAIPEI CITY HOSPITAL   (Taiwan)

^f CHI MEI MEDICAL CENTER   (Taiwan)

^g TAIWAN ADVENTIST HOSPITAL   (Taiwan)

Author keywords

Cancer stem cells; CD133; Cucurbitacin I; Medulloblastoma; Radioresistance; STAT3

Indexed keywords

ANTINEOPLASTIC AGENT; CUCURBITACIN I; STAT3 PROTEIN; UNCLASSIFIED DRUG; CD133 ANTIGEN; GLYCOPROTEIN; LEUKOCYTE ANTIGEN; PEPTIDE; TRITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BIOINFORMATICS; CANCER STEM CELL; CARCINOGENICITY; CELL ISOLATION; CHEMORADIOTHERAPY; CONTROLLED STUDY; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; MEDULLOBLASTOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; RADIOSENSITIVITY; ANIMAL; BIOLOGY; CELL DIFFERENTIATION; CELL MOTION; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; HUMAN; METABOLISM; MICROARRAY ANALYSIS; PATHOLOGY; PHOSPHORYLATION; RADIATION EXPOSURE; RADIATION RESPONSE; SIGNAL TRANSDUCTION; TUMOR CELL LINE; ULTRAVIOLET RADIATION;

ANIMALS; ANTIGENS, CD; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; COMPUTATIONAL BIOLOGY; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; GLYCOPROTEINS; HUMANS; MEDULLOBLASTOMA; MICE; MICROARRAY ANALYSIS; NEOPLASTIC STEM CELLS; PEPTIDES; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRITERPENES; ULTRAVIOLET RAYS;

EID: 84860855712     PISSN: 02567040     EISSN: 14330350     Source Type: Journal    
DOI: 10.1007/s00381-011-1672-x     Document Type: Article

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