STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 2, 2012, Pages 750-758

  Zhou, Li ^a   Kawate, Tomohiko ^a   Liu, Xiaorong ^a   Kim, Young Bae ^a   Zhao, Yajuan ^a   Feng, Guohong ^a   Banerji, Julian ^a   Nash, Huw ^b   Whitehurst, Charles ^b   Jindal, Satish ^b   Siddiqui, Arshad ^b   Seed, Brian ^a   Wolfe, Jia L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Neogenesis   (United States)

Author keywords

Allergic inflammatory disease; Eotaxin 3; Signal transducers and activators of transcription 6; STAT6 binder; STAT6 inhibitor

Indexed keywords

4 (1 METHYL 1H INDOL 2 YL)PYRIDIDNE 2,6 DICARBOXYLIC ACID; 4 (1 METHYL 1H INDOL 2 YL)PYRIDINE 2,6 DICARBOXYLIC ACID DIMETHYL ESTER; 4 (BENZO[B]THIOPHEN 2 YL) 6 (3 METHYL BUTAN 2 YLCARBAMOYL)PICOLINIC ACID; 4 (BENZO[B]THIOPHEN 2 YL) 6 (3 METHYL BUTAN 2 YLCARBAMOYL)PICOLINIC ACID METHYL ESTER; 4 (BENZO[B]THIOPHEN 2 YL) 6 (METHOXYCARBONYL)PICOLINIC ACID; 4 (BENZO[B]THIOPHEN 2 YL)PYRIDINE 2,6 DICARBOXYLIC ACID DIMETHYL ESTER; BORONIC ACID DERIVATIVE; EOTAXIN 3; INTERLEUKIN 13; INTERLEUKIN 4 RECEPTOR ALPHA; INTERLEUKIN 5; JANUS KINASE 2; PROTEIN INHIBITOR; STAT6 PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CELL INFILTRATION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG PROTEIN BINDING; DRUG SYNTHESIS; EOSINOPHIL; EPITHELIUM CELL; EXPRESSION VECTOR; HUMAN; HUMAN CELL; IMMUNOASSAY; IMMUNOPRECIPITATION; LUNG ALVEOLUS EPITHELIUM; MASS SPECTROMETRY; MOLECULAR CLONING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYMERIZATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; SUZUKI REACTION; TRANSCRIPTION INITIATION;

CELL LINE; CHEMOKINES, CC; DIMERIZATION; EPITHELIAL CELLS; HUMANS; INDOLES; INTERLEUKIN-4; PHOSPHORYLATION; PYRIDINES; RECEPTORS, INTERLEUKIN-4; SIGNAL TRANSDUCTION; STAT6 TRANSCRIPTION FACTOR; STEREOISOMERISM;

EID: 84855779362     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.12.006     Document Type: Article

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