Identification of a new series of STAT3 inhibitors by virtual screening

ACS Medicinal Chemistry Letters

Volumn 1, Issue 8, 2010, Pages 371-375

  Matsuno, Kenji ^a   Masuda, Yoshiaki ^a,b   Uehara, Yutaka ^a   Sato, Hiroshi ^a   Muroya, Ayumu ^b   Takahashi, Osamu ^b   Yokotagawa, Takane ^b   Furuya, Toshio ^b   Okawara, Tadashi ^c   Otsuka, Masami ^d   Ogo, Naohisa ^e   Ashizawa, Tadashi ^f   Oshita, Chie ^f   Tai, Sachiko ^f   Ishii, Hidee ^f   Akiyama, Yasuto ^f   Asai, Akira ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b PharmaDesign Inc   (Japan)

^c KUMAMOTO HEALTH SCIENCE UNIVERSITY   (Japan)

^d KUMAMOTO UNIVERSITY   (Japan)

^e SHIZUOKA INSTITUTE OF ENVIRONMENT AND HYGIENE   (Japan)

^f SHIZUOKA CANCER CENTER   (Japan)

Author keywords

antitumor; dimerization; inhibitor; protein protein interaction; STAT3; virtual screening

Indexed keywords

ANTINEOPLASTIC AGENT; LUCIFERASE; ONCOPROTEIN; STAT3 PROTEIN; STX 0119; STX 0872; SURVIVIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CONTROLLED STUDY; DIMERIZATION; DNA BINDING; DRUG IDENTIFICATION; DRUG INHIBITION; DRUG STRUCTURE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; SCREENING; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT; VIRTUAL REALITY;

EID: 78649286584     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml1000273     Document Type: Article

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