-
1
-
-
0019465748
-
Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt1+2-T lymphocytes
-
Pettinelli C.B., McFarlin D.E. Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt1+2-T lymphocytes. J. Immunol. 1981, 127:1420-1423.
-
(1981)
J. Immunol.
, vol.127
, pp. 1420-1423
-
-
Pettinelli, C.B.1
McFarlin, D.E.2
-
2
-
-
0023856205
-
Antigen-specific inhibition of immune interferon production by suppressor cells of autoimmune encephalomyelitis
-
McDonald A.H., Swanborg R.H. Antigen-specific inhibition of immune interferon production by suppressor cells of autoimmune encephalomyelitis. J. Immunol. 1988, 140:1132-1138.
-
(1988)
J. Immunol.
, vol.140
, pp. 1132-1138
-
-
McDonald, A.H.1
Swanborg, R.H.2
-
3
-
-
0024368359
-
Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype
-
Ando D.G., Clayton J., Kono D., Urban J.L., Sercarz E.E. Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell. Immunol. 1989, 124:132-143.
-
(1989)
Cell. Immunol.
, vol.124
, pp. 132-143
-
-
Ando, D.G.1
Clayton, J.2
Kono, D.3
Urban, J.L.4
Sercarz, E.E.5
-
4
-
-
0030039962
-
Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Preferential expansion of interferon-gamma-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms
-
Waldburger K.E., Hastings R.C., Schaub R.G., Goldman S.L., Leonard J.P. Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Preferential expansion of interferon-gamma-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms. Am. J. Pathol. 1996, 148:375-382.
-
(1996)
Am. J. Pathol.
, vol.148
, pp. 375-382
-
-
Waldburger, K.E.1
Hastings, R.C.2
Schaub, R.G.3
Goldman, S.L.4
Leonard, J.P.5
-
5
-
-
0035421324
-
Role of MOG-stimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE)
-
Yura M., Takahashi I., Serada M., Koshio T., Nakagami K., Yuki Y., Kiyono H. Role of MOG-stimulated Th1 type "light up" (GFP+) CD4+ T cells for the development of experimental autoimmune encephalomyelitis (EAE). J. Autoimmun. 2001, 17:17-25.
-
(2001)
J. Autoimmun.
, vol.17
, pp. 17-25
-
-
Yura, M.1
Takahashi, I.2
Serada, M.3
Koshio, T.4
Nakagami, K.5
Yuki, Y.6
Kiyono, H.7
-
6
-
-
8444226727
-
Silencing T-bet defines critical role in the differentiation of autoreactive T lymphocytes
-
Lovett-Racke A.E., Rocchini A.E., Choy J., Northrop S.C., Hussain R.Z., Ratts R.B., Sikder D., Racke M.K. Silencing T-bet defines critical role in the differentiation of autoreactive T lymphocytes. Immunity 2004, 21:719-731.
-
(2004)
Immunity
, vol.21
, pp. 719-731
-
-
Lovett-Racke, A.E.1
Rocchini, A.E.2
Choy, J.3
Northrop, S.C.4
Hussain, R.Z.5
Ratts, R.B.6
Sikder, D.7
Racke, M.K.8
-
7
-
-
33846514266
-
T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity
-
Gocke A.R., Cravens P.D., Ben L., Hussain R.Z., Northrop S.C., Racke M.K., Lovett-Racke A.E. T-bet regulates the fate of Th1 and Th17 lymphocytes in autoimmunity. J. Immunol. 2007, 178:1341-1348.
-
(2007)
J. Immunol.
, vol.178
, pp. 1341-1348
-
-
Gocke, A.R.1
Cravens, P.D.2
Ben, L.3
Hussain, R.Z.4
Northrop, S.C.5
Racke, M.K.6
Lovett-Racke, A.E.7
-
8
-
-
0028116618
-
Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease
-
Racke M.K., Bonomo A., Scott D.E., Cannella B., Levine A., Raine C.S., Shevach E.M., Rocken M. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J. Exp. Med. 1994, 180:1961-1966.
-
(1994)
J. Exp. Med.
, vol.180
, pp. 1961-1966
-
-
Racke, M.K.1
Bonomo, A.2
Scott, D.E.3
Cannella, B.4
Levine, A.5
Raine, C.S.6
Shevach, E.M.7
Rocken, M.8
-
9
-
-
0028876611
-
Retinoid treatment of experimental allergic encephalomyelitis. IL-4 production correlates with improved disease course
-
Racke M.K., Burnett D., Pak S.H., Albert P.S., Cannella B., Raine C.S., McFarlin D.E., Scott D.E. Retinoid treatment of experimental allergic encephalomyelitis. IL-4 production correlates with improved disease course. J. Immunol. 1995, 154:450-458.
-
(1995)
J. Immunol.
, vol.154
, pp. 450-458
-
-
Racke, M.K.1
Burnett, D.2
Pak, S.H.3
Albert, P.S.4
Cannella, B.5
Raine, C.S.6
McFarlin, D.E.7
Scott, D.E.8
-
10
-
-
0034789247
-
Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis
-
Chitnis T., Najafian N., Benou C., Salama A.D., Grusby M.J., Sayegh M.H., Khoury S.J. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J. Clin. Invest. 2001, 108:739-747.
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 739-747
-
-
Chitnis, T.1
Najafian, N.2
Benou, C.3
Salama, A.D.4
Grusby, M.J.5
Sayegh, M.H.6
Khoury, S.J.7
-
11
-
-
3142724732
-
Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis
-
Bettelli E., Sullivan B., Szabo S.J., Sobel R.A., Glimcher L.H., Kuchroo V.K. Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J. Exp. Med. 2004, 200:79-87.
-
(2004)
J. Exp. Med.
, vol.200
, pp. 79-87
-
-
Bettelli, E.1
Sullivan, B.2
Szabo, S.J.3
Sobel, R.A.4
Glimcher, L.H.5
Kuchroo, V.K.6
-
12
-
-
33745188887
-
T-bet is essential for the progression of experimental autoimmune encephalomyelitis
-
Nath N., Prasad R., Giri S., Singh A.K., Singh I. T-bet is essential for the progression of experimental autoimmune encephalomyelitis. Immunology 2006, 118:384-391.
-
(2006)
Immunology
, vol.118
, pp. 384-391
-
-
Nath, N.1
Prasad, R.2
Giri, S.3
Singh, A.K.4
Singh, I.5
-
13
-
-
0029671318
-
Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE)
-
Ferber I.A., Brock S., Taylor-Edwards C., Ridgway W., Dinisco C., Steinman L., Dalton D., Fathman C.G. Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 1996, 156:5-7.
-
(1996)
J. Immunol.
, vol.156
, pp. 5-7
-
-
Ferber, I.A.1
Brock, S.2
Taylor-Edwards, C.3
Ridgway, W.4
Dinisco, C.5
Steinman, L.6
Dalton, D.7
Fathman, C.G.8
-
14
-
-
0030587910
-
IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
-
Willenborg D.O., Fordham S., Bernard C.C., Cowden W.B., Ramshaw I.A. IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J. Immunol. 1996, 157:3223-3227.
-
(1996)
J. Immunol.
, vol.157
, pp. 3223-3227
-
-
Willenborg, D.O.1
Fordham, S.2
Bernard, C.C.3
Cowden, W.B.4
Ramshaw, I.A.5
-
15
-
-
0027889130
-
Monoclonal anti-gamma interferon antibodies enhance experimental allergic encephalomyelitis
-
Lublin F.D., Knobler R.L., Kalman B., Goldhaber M., Marini J., Perrault M., D'Imperio C., Joseph J., Alkan S.S., Korngold R. Monoclonal anti-gamma interferon antibodies enhance experimental allergic encephalomyelitis. Autoimmunity 1993, 16:267-274.
-
(1993)
Autoimmunity
, vol.16
, pp. 267-274
-
-
Lublin, F.D.1
Knobler, R.L.2
Kalman, B.3
Goldhaber, M.4
Marini, J.5
Perrault, M.6
D'Imperio, C.7
Joseph, J.8
Alkan, S.S.9
Korngold, R.10
-
16
-
-
0029829385
-
Chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice: enhancement by monoclonal antibodies against interferon-gamma
-
Heremans H., Dillen C., Groenen M., Martens E., Billiau A. Chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice: enhancement by monoclonal antibodies against interferon-gamma. Eur. J. Immunol. 1996, 26:2393-2398.
-
(1996)
Eur. J. Immunol.
, vol.26
, pp. 2393-2398
-
-
Heremans, H.1
Dillen, C.2
Groenen, M.3
Martens, E.4
Billiau, A.5
-
17
-
-
0034601012
-
Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis
-
Chu C.Q., Wittmer S., Dalton D.K. Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis. J. Exp. Med. 2000, 192:123-128.
-
(2000)
J. Exp. Med.
, vol.192
, pp. 123-128
-
-
Chu, C.Q.1
Wittmer, S.2
Dalton, D.K.3
-
18
-
-
0036677420
-
Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12
-
Becher B., Durell B.G., Noelle R.J. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J. Clin. Invest. 2002, 110:493-497.
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 493-497
-
-
Becher, B.1
Durell, B.G.2
Noelle, R.J.3
-
19
-
-
0037114150
-
IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
-
Gran B., Zhang G.X., Yu S., Li J., Chen X.H., Ventura E.S., Kamoun M., Rostami A. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J. Immunol. 2002, 169:7104-7110.
-
(2002)
J. Immunol.
, vol.169
, pp. 7104-7110
-
-
Gran, B.1
Zhang, G.X.2
Yu, S.3
Li, J.4
Chen, X.H.5
Ventura, E.S.6
Kamoun, M.7
Rostami, A.8
-
20
-
-
0037434789
-
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
-
Cua D.J., Sherlock J., Chen Y., Murphy C.A., Joyce B., Seymour B., Lucian L., To W., Kwan S., Churakova T., Zurawski S., Wiekowski M., Lira S.A., Gorman D., Kastelein R.A., Sedgwick J.D. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003, 421:744-748.
-
(2003)
Nature
, vol.421
, pp. 744-748
-
-
Cua, D.J.1
Sherlock, J.2
Chen, Y.3
Murphy, C.A.4
Joyce, B.5
Seymour, B.6
Lucian, L.7
To, W.8
Kwan, S.9
Churakova, T.10
Zurawski, S.11
Wiekowski, M.12
Lira, S.A.13
Gorman, D.14
Kastelein, R.A.15
Sedgwick, J.D.16
-
21
-
-
13244283212
-
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
-
Langrish C.L., Chen Y., Blumenschein M., Mattson J., Basham B., Sedgwick J.D., McClanahan T., Kastelein R.A., Cua D.J. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 2005, 201:233-240.
-
(2005)
J. Exp. Med.
, vol.201
, pp. 233-240
-
-
Langrish, C.L.1
Chen, Y.2
Blumenschein, M.3
Mattson, J.4
Basham, B.5
Sedgwick, J.D.6
McClanahan, T.7
Kastelein, R.A.8
Cua, D.J.9
-
22
-
-
33745321276
-
IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis
-
Komiyama Y., Nakae S., Matsuki T., Nambu A., Kakuta H.S., Suko K., Iwakura Y. IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J. Immunol. 2006, 177:566-573.
-
(2006)
J. Immunol.
, vol.177
, pp. 566-573
-
-
Komiyama, Y.1
Nakae, S.2
Matsuki, T.3
Nambu, A.4
Kakuta, H.S.5
Suko, K.6
Iwakura, Y.7
-
23
-
-
61749093508
-
IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice
-
Haak S., Croxford A.L., Dreymborg K., Heppner F.L., Pouly S., Becher B., Waisman A. IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J. Clin. Invest. 2009, 119:61-69.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 61-69
-
-
Haak, S.1
Croxford, A.L.2
Dreymborg, K.3
Heppner, F.L.4
Pouly, S.5
Becher, B.6
Waisman, A.7
-
24
-
-
32244442562
-
TGFbeta in the context of an inflammatory cytokine nilieu supports de novo differentiation of IL-17-producing T cells
-
Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., Stockinger B. TGFbeta in the context of an inflammatory cytokine nilieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006, 24:179-189.
-
(2006)
Immunity
, vol.24
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
Locksley, R.M.4
Stockinger, B.5
-
25
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli E., Carrier Y., Gao W., Kom T., Strom T.B., Oukka M., Weiner H.L., Kuchroo V.J. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441:235-238.
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
Kom, T.4
Strom, T.B.5
Oukka, M.6
Weiner, H.L.7
Kuchroo, V.J.8
-
26
-
-
33646560950
-
Transforming growth factor-β induces development of the Th17 lineage
-
Mangan P.R., Harrington L.E., O'Quinn D.B., Helms W.S., Bullard D.C., Elson C.O., Hatton R.D., Wahl S.M., Schoeb T.R., Weaver C.T. Transforming growth factor-β induces development of the Th17 lineage. Nature 2006, 441:231-234.
-
(2006)
Nature
, vol.441
, pp. 231-234
-
-
Mangan, P.R.1
Harrington, L.E.2
O'Quinn, D.B.3
Helms, W.S.4
Bullard, D.C.5
Elson, C.O.6
Hatton, R.D.7
Wahl, S.M.8
Schoeb, T.R.9
Weaver, C.T.10
-
27
-
-
67650433931
-
T-bet is essential for encephalitogenicity of both Th1 and Th17 cells
-
Yang Y., Weiner J., Liu Y., Smith A.J., Huss D.J., Winger R., Peng H., Cravens P.D., Racke M.K., Lovett-Racke A.E. T-bet is essential for encephalitogenicity of both Th1 and Th17 cells. J. Exp. Med. 2009, 206:1549-1564.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1549-1564
-
-
Yang, Y.1
Weiner, J.2
Liu, Y.3
Smith, A.J.4
Huss, D.J.5
Winger, R.6
Peng, H.7
Cravens, P.D.8
Racke, M.K.9
Lovett-Racke, A.E.10
-
28
-
-
70449711235
-
Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation
-
Das J., Ren G., Zhang L., Roberts A.I., Zhao X., Bothwell A.L., Van Kaer L., Shi Y., Das G. Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. J. Exp. Med. 2009, 206:2407-2416.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 2407-2416
-
-
Das, J.1
Ren, G.2
Zhang, L.3
Roberts, A.I.4
Zhao, X.5
Bothwell, A.L.6
Van Kaer, L.7
Shi, Y.8
Das, G.9
-
29
-
-
33748588423
-
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
-
Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., Cua D.J., Littman D.R. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006, 126:1121-1133.
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
McKenzie, B.S.2
Zhou, L.3
Tadokoro, C.E.4
Lepelley, A.5
Lafaille, J.J.6
Cua, D.J.7
Littman, D.R.8
-
30
-
-
0034733039
-
Requirement for RORgamma in thymocyte survival and lymphoid organ development
-
Sun Z., Unutmaz D., Zou Y.R., Sunshine M.J., Pierani A., Brenner-Morton S., Mebius R.E., Littman D.R. Requirement for RORgamma in thymocyte survival and lymphoid organ development. Science 2000, 288:2369-2373.
-
(2000)
Science
, vol.288
, pp. 2369-2373
-
-
Sun, Z.1
Unutmaz, D.2
Zou, Y.R.3
Sunshine, M.J.4
Pierani, A.5
Brenner-Morton, S.6
Mebius, R.E.7
Littman, D.R.8
-
31
-
-
28044463563
-
T-bet-dependent expression of osteopontin contributes to T cell polarization
-
Shinohara M.L., Jansson M., Hwang E.S., Werneck M.B., Glimcher L.H., Cantor H. T-bet-dependent expression of osteopontin contributes to T cell polarization. Proc. Natl. Acad. Sci. USA 2005, 102:17101-17106.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 17101-17106
-
-
Shinohara, M.L.1
Jansson, M.2
Hwang, E.S.3
Werneck, M.B.4
Glimcher, L.H.5
Cantor, H.6
-
32
-
-
0035941106
-
The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease
-
Chabas D., Baranzini S.E., Mitchell D., Bernard C.C., Rittling S.R., Denhardt D.T., Sobel R.A., Lock C., Karpuj M., Pedotti R., Heller R., Oksenberg J.R., Steinman L. The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science 2001, 294:1731-1735.
-
(2001)
Science
, vol.294
, pp. 1731-1735
-
-
Chabas, D.1
Baranzini, S.E.2
Mitchell, D.3
Bernard, C.C.4
Rittling, S.R.5
Denhardt, D.T.6
Sobel, R.A.7
Lock, C.8
Karpuj, M.9
Pedotti, R.10
Heller, R.11
Oksenberg, J.R.12
Steinman, L.13
-
33
-
-
0036499086
-
Attenuated experimental autoimmune encephalomyelitis in eta-1/osteopontin-deficient mice
-
Jansson M., Panoutsakopoulou V., Baker J., Klein L., Cantor H. Attenuated experimental autoimmune encephalomyelitis in eta-1/osteopontin-deficient mice. J. Immunol. 2002, 168:2096-2099.
-
(2002)
J. Immunol.
, vol.168
, pp. 2096-2099
-
-
Jansson, M.1
Panoutsakopoulou, V.2
Baker, J.3
Klein, L.4
Cantor, H.5
-
34
-
-
40449089827
-
Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells
-
Stromnes I.M., Cerretti L.M., Liggitt D., Harris R.A., Goverman J.M. Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells. Nat. Med. 2008, 14:337-342.
-
(2008)
Nat. Med.
, vol.14
, pp. 337-342
-
-
Stromnes, I.M.1
Cerretti, L.M.2
Liggitt, D.3
Harris, R.A.4
Goverman, J.M.5
-
35
-
-
0026506799
-
Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin
-
Yednock T.A., Cannon C., Fritz L.C., Sanchez-Madrid F., Steinman L., Karin N. Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature 1992, 356:63-66.
-
(1992)
Nature
, vol.356
, pp. 63-66
-
-
Yednock, T.A.1
Cannon, C.2
Fritz, L.C.3
Sanchez-Madrid, F.4
Steinman, L.5
Karin, N.6
-
36
-
-
0027529932
-
Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma
-
Baron J.L., Madri J.A., Ruddle N.H., Hashim G., Janeway C.A. Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J. Exp. Med. 1993, 177:57-68.
-
(1993)
J. Exp. Med.
, vol.177
, pp. 57-68
-
-
Baron, J.L.1
Madri, J.A.2
Ruddle, N.H.3
Hashim, G.4
Janeway, C.A.5
-
37
-
-
22844445230
-
Progressive multifocal leukoencephalopathy in a patient treated with natalizumab
-
Langer-Gould A., Atlas S.W., Green A.J., Bollen A.W., Pelletier D. Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N Engl J. Med. 2005, 353:375-381.
-
(2005)
N Engl J. Med.
, vol.353
, pp. 375-381
-
-
Langer-Gould, A.1
Atlas, S.W.2
Green, A.J.3
Bollen, A.W.4
Pelletier, D.5
-
38
-
-
0037413467
-
A controlled trial of natalizumab for relapsing multiple sclerosis
-
International Natalizumab Multiple Sclerosis Trial Group
-
Miller D.H., Khan O.A., Sheremata W.A., Blumhardt L.D., Rice G.P., Libonati M.A., Willmer-Hulme A.J., Dalton C.M., Miszkiel K.A., O'Connor P.W. A controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J. Med. 2003, 348:15-23. International Natalizumab Multiple Sclerosis Trial Group.
-
(2003)
N Engl J. Med.
, vol.348
, pp. 15-23
-
-
Miller, D.H.1
Khan, O.A.2
Sheremata, W.A.3
Blumhardt, L.D.4
Rice, G.P.5
Libonati, M.A.6
Willmer-Hulme, A.J.7
Dalton, C.M.8
Miszkiel, K.A.9
O'Connor, P.W.10
-
39
-
-
72649089874
-
Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis
-
Brucklacher-Waldert V., Sturner K., Kolster M., Wolthausen J., Tolosa E. Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis. Brain 2009, 132:3329-3341.
-
(2009)
Brain
, vol.132
, pp. 3329-3341
-
-
Brucklacher-Waldert, V.1
Sturner, K.2
Kolster, M.3
Wolthausen, J.4
Tolosa, E.5
-
40
-
-
46949104323
-
IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition
-
Kroenke M.A., Carlson T.J., Andjelkovic A.V., Segal B.M. IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition. J. Exp. Med. 2008, 205:1535-1541.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1535-1541
-
-
Kroenke, M.A.1
Carlson, T.J.2
Andjelkovic, A.V.3
Segal, B.M.4
-
41
-
-
69249134656
-
IL-23-driven encephalo-tropism and Th17 polarization during CNS-inflammation in vivo
-
Gyulveszi G., Haak S., Becher B. IL-23-driven encephalo-tropism and Th17 polarization during CNS-inflammation in vivo. Eur. J. Immunol. 2009, 39:1864-1869.
-
(2009)
Eur. J. Immunol.
, vol.39
, pp. 1864-1869
-
-
Gyulveszi, G.1
Haak, S.2
Becher, B.3
-
42
-
-
34547734621
-
Phenotypic and functional features of human Th17 cells
-
Annunziato F., Cosmi L., Santarlasci V., Maggi L., Liotta F., Mazzinghi B., Parente E., Fili L., Ferri S., Frosali F., Giudici F., Romagnani P., Parronchi P., Tonelli F., Maggi E., Romagnani S. Phenotypic and functional features of human Th17 cells. J. Exp. Med. 2007, 204:1849-1861.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1849-1861
-
-
Annunziato, F.1
Cosmi, L.2
Santarlasci, V.3
Maggi, L.4
Liotta, F.5
Mazzinghi, B.6
Parente, E.7
Fili, L.8
Ferri, S.9
Frosali, F.10
Giudici, F.11
Romagnani, P.12
Parronchi, P.13
Tonelli, F.14
Maggi, E.15
Romagnani, S.16
-
43
-
-
64849093508
-
Inhibition of CCR6 function reduces the severity of experimental autoimmune encephalomyelitis via effects on the priming phase of the immune response
-
Liston A., Kohler R.E., Townley S., Haylock-Jacobs S., Comerford I., Caon A.C., Webster J., Harrison J.M., Swann J., Clark-Lewis I., Korner H., McColl S.R. Inhibition of CCR6 function reduces the severity of experimental autoimmune encephalomyelitis via effects on the priming phase of the immune response. J. Immunol. 2009, 182:3121-3130.
-
(2009)
J. Immunol.
, vol.182
, pp. 3121-3130
-
-
Liston, A.1
Kohler, R.E.2
Townley, S.3
Haylock-Jacobs, S.4
Comerford, I.5
Caon, A.C.6
Webster, J.7
Harrison, J.M.8
Swann, J.9
Clark-Lewis, I.10
Korner, H.11
McColl, S.R.12
-
44
-
-
65249175159
-
C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choriod plexus is required for the initiation of EAE
-
Reboldi A., Coisne C., Baumjohann D., Benvenuto F., Bottinelli D., Lira S., Uccelli A., Lanzavecchia A. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choriod plexus is required for the initiation of EAE. Nat. Immunol. 2009, 10:514-523.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 514-523
-
-
Reboldi, A.1
Coisne, C.2
Baumjohann, D.3
Benvenuto, F.4
Bottinelli, D.5
Lira, S.6
Uccelli, A.7
Lanzavecchia, A.8
-
45
-
-
67649525179
-
CCR6 regulates EAE pathogenesis by controlling regulatory CD4+ T-cell recruitment to target tissues
-
Villares R., Cadenas V., Lozano M., Almonacid L., Zaballos A., Martinez C., Varona R. CCR6 regulates EAE pathogenesis by controlling regulatory CD4+ T-cell recruitment to target tissues. Eur. J. Immunol. 2009, 39:1671-1681.
-
(2009)
Eur. J. Immunol.
, vol.39
, pp. 1671-1681
-
-
Villares, R.1
Cadenas, V.2
Lozano, M.3
Almonacid, L.4
Zaballos, A.5
Martinez, C.6
Varona, R.7
-
46
-
-
68049115475
-
Mice deficient for CCR6 fail to control chronic experimental autoimmune encephalomyelitis
-
Elhofy A., Depaolo R.W., Lira S.A., Lukacs N.W., Karpus W.J. Mice deficient for CCR6 fail to control chronic experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2009, 213:91-99.
-
(2009)
J. Neuroimmunol.
, vol.213
, pp. 91-99
-
-
Elhofy, A.1
Depaolo, R.W.2
Lira, S.A.3
Lukacs, N.W.4
Karpus, W.J.5
-
47
-
-
0025013169
-
Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma
-
Olsson T., Zhi W.W., Höjeberg B., Kostulas V., Jiang Y.P., Anderson G., Ekre H.P., Link H. Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma. J. Clin. Invest. 1990, 86:981-985.
-
(1990)
J. Clin. Invest.
, vol.86
, pp. 981-985
-
-
Olsson, T.1
Zhi, W.W.2
Höjeberg, B.3
Kostulas, V.4
Jiang, Y.P.5
Anderson, G.6
Ekre, H.P.7
Link, H.8
-
48
-
-
0025909739
-
Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls
-
Sun J.B., Olsson T., Wang W.Z., Xiao B.G., Kostulas V., Fredrikson S., Ekre H.P., Link H. Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls. Eur. J. Immunol. 1991, 21:1461-1468.
-
(1991)
Eur. J. Immunol.
, vol.21
, pp. 1461-1468
-
-
Sun, J.B.1
Olsson, T.2
Wang, W.Z.3
Xiao, B.G.4
Kostulas, V.5
Fredrikson, S.6
Ekre, H.P.7
Link, H.8
-
49
-
-
0027292039
-
T helper 1 (Th1) functional phenotype of human myelin basic protein-specific T lymphocytes
-
Voskuhl R.R., Martin R., Bergman C., Dalal M., Ruddle N.H., McFarland H.F. T helper 1 (Th1) functional phenotype of human myelin basic protein-specific T lymphocytes. Autoimmunity 1993, 15:137-143.
-
(1993)
Autoimmunity
, vol.15
, pp. 137-143
-
-
Voskuhl, R.R.1
Martin, R.2
Bergman, C.3
Dalal, M.4
Ruddle, N.H.5
McFarland, H.F.6
-
50
-
-
0034254825
-
Quantification of self-recognition in multiple sclerosis by single-cell analysis of cytokine production
-
Pelfrey C.M., Rudick R.A., Cotleur A.C., Lee J.C., Tary-Lehmann M., Lehmann P.V. Quantification of self-recognition in multiple sclerosis by single-cell analysis of cytokine production. J. Immunol. 2000, 165:1641-1651.
-
(2000)
J. Immunol.
, vol.165
, pp. 1641-1651
-
-
Pelfrey, C.M.1
Rudick, R.A.2
Cotleur, A.C.3
Lee, J.C.4
Tary-Lehmann, M.5
Lehmann, P.V.6
-
51
-
-
0025138302
-
T cells responsive to myelin basic protein in patients with multiple sclerosis
-
Allegretta M., Nicklas J.A., Sriram S., Albertini R.J. T cells responsive to myelin basic protein in patients with multiple sclerosis. Science 1990, 247:718-721.
-
(1990)
Science
, vol.247
, pp. 718-721
-
-
Allegretta, M.1
Nicklas, J.A.2
Sriram, S.3
Albertini, R.J.4
-
52
-
-
0032519421
-
Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells
-
Lovett-Racke A.E., Trotter J.L., Lauber J., Perrin P.J., June C.H., Racke M.K. Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells. J. Clin. Invest. 1998, 101:725-730.
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 725-730
-
-
Lovett-Racke, A.E.1
Trotter, J.L.2
Lauber, J.3
Perrin, P.J.4
June, C.H.5
Racke, M.K.6
-
53
-
-
0032902375
-
Isolation of myelin basic protein-specific T cells predominantly from the memory T-cell compartment in multiple sclerosis
-
Burns J., Bartholomew B., Lobo S. Isolation of myelin basic protein-specific T cells predominantly from the memory T-cell compartment in multiple sclerosis. Ann. Neurol. 1999, 45:33-39.
-
(1999)
Ann. Neurol.
, vol.45
, pp. 33-39
-
-
Burns, J.1
Bartholomew, B.2
Lobo, S.3
-
54
-
-
0033786776
-
Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand
-
Bielekova B., Goodwin B., Richert N., Cortese I., Kondo T., Afshar G., Gran B., Eaton J., Antel J., Frank J.A., McFarland H.F., Martin R. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat. Med. 2000, 6:1167-1175.
-
(2000)
Nat. Med.
, vol.6
, pp. 1167-1175
-
-
Bielekova, B.1
Goodwin, B.2
Richert, N.3
Cortese, I.4
Kondo, T.5
Afshar, G.6
Gran, B.7
Eaton, J.8
Antel, J.9
Frank, J.A.10
McFarland, H.F.11
Martin, R.12
-
55
-
-
0344389016
-
Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis
-
Matusevicius D., Kivisakk P., He B., Kostulas N., Ozenci V., Fredrikson S., Link H. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult. Scler. 1999, 5:101-104.
-
(1999)
Mult. Scler.
, vol.5
, pp. 101-104
-
-
Matusevicius, D.1
Kivisakk, P.2
He, B.3
Kostulas, N.4
Ozenci, V.5
Fredrikson, S.6
Link, H.7
-
56
-
-
0036105484
-
Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
-
Lock C., Hermans G., Pedotti R., Brendolan A., Schadt E., Garren H., Langer-Gould A., Strober S., Cannella B., Allard J., Klonowski P., Austin A., Lad N., Kaminski N., Galli S.J., Oksenberg J.R., Raine C.S., Heller R., Steinman L. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. 2002, 8:500-508.
-
(2002)
Nat. Med.
, vol.8
, pp. 500-508
-
-
Lock, C.1
Hermans, G.2
Pedotti, R.3
Brendolan, A.4
Schadt, E.5
Garren, H.6
Langer-Gould, A.7
Strober, S.8
Cannella, B.9
Allard, J.10
Klonowski, P.11
Austin, A.12
Lad, N.13
Kaminski, N.14
Galli, S.J.15
Oksenberg, J.R.16
Raine, C.S.17
Heller, R.18
Steinman, L.19
-
57
-
-
21044448355
-
Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis
-
Ishizu T., Osoeawa M., Mei F.J., Kikuchi H., Tanaka M., Takakura Y., Minohara M., Murai H., Mihara F., Taniwaki T., Kira J. Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis. Brain 2005, 128:988-1002.
-
(2005)
Brain
, vol.128
, pp. 988-1002
-
-
Ishizu, T.1
Osoeawa, M.2
Mei, F.J.3
Kikuchi, H.4
Tanaka, M.5
Takakura, Y.6
Minohara, M.7
Murai, H.8
Mihara, F.9
Taniwaki, T.10
Kira, J.11
-
58
-
-
70350052626
-
Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis
-
Kebir H., Ifergan I., Alvarez J.I., Bernard M., Poirier J., Arbour N., Duquette P., Prat A. Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis. Ann. Neurol. 2009, 66:390-402.
-
(2009)
Ann. Neurol.
, vol.66
, pp. 390-402
-
-
Kebir, H.1
Ifergan, I.2
Alvarez, J.I.3
Bernard, M.4
Poirier, J.5
Arbour, N.6
Duquette, P.7
Prat, A.8
-
59
-
-
0023126661
-
Exacerbations of multiple sclerosis in patients treated with gamma interferon
-
Panitch H.S., Hirsch R.L., Haley A.S., Johnson K.P. Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet 1987, 1:893-895.
-
(1987)
Lancet
, vol.1
, pp. 893-895
-
-
Panitch, H.S.1
Hirsch, R.L.2
Haley, A.S.3
Johnson, K.P.4
-
60
-
-
0034069944
-
Interferon-gamma modulates human oligodendrocyte susceptibility to Fas-mediated apoptosis
-
Pouly S., Becher B., Blain M., Antel J.P. Interferon-gamma modulates human oligodendrocyte susceptibility to Fas-mediated apoptosis. J. Neuropathol. Exp. Neurol. 2000, 59:280-286.
-
(2000)
J. Neuropathol. Exp. Neurol.
, vol.59
, pp. 280-286
-
-
Pouly, S.1
Becher, B.2
Blain, M.3
Antel, J.P.4
-
61
-
-
0029410743
-
Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis
-
Vartanian T., Li Y., Zhao M., Stefansson K. Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis. Mol. Med. 1995, 1:732-743.
-
(1995)
Mol. Med.
, vol.1
, pp. 732-743
-
-
Vartanian, T.1
Li, Y.2
Zhao, M.3
Stefansson, K.4
-
62
-
-
17944383310
-
Randomized study of antibodies to IFN-gamma and TNF-alpha in secondary progressive multiple sclerosis
-
Skurkovich S., et al. Randomized study of antibodies to IFN-gamma and TNF-alpha in secondary progressive multiple sclerosis. Mult. Scler. 2001, 7:277-284.
-
(2001)
Mult. Scler.
, vol.7
, pp. 277-284
-
-
Skurkovich, S.1
-
63
-
-
48849087125
-
Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomized, dose-ranging study
-
Ustekinumab MS Investigators
-
Segal B.M., Constantinescu C.S., Raychaudhuri A., Kim L., Fidelus-Gort R., Kasper L.H. Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomized, dose-ranging study. Lancet Neurol. 2008, 7:796-804. Ustekinumab MS Investigators.
-
(2008)
Lancet Neurol.
, vol.7
, pp. 796-804
-
-
Segal, B.M.1
Constantinescu, C.S.2
Raychaudhuri, A.3
Kim, L.4
Fidelus-Gort, R.5
Kasper, L.H.6
-
64
-
-
0029420295
-
Antagonism of interferon beta on interferon gamma: inhibition of signal transduction in vitro and reduction of serum levels in multiple sclerosis patients
-
Revel M., Chebath J., Mangelus M., Harroch S., Moviglia G.A. Antagonism of interferon beta on interferon gamma: inhibition of signal transduction in vitro and reduction of serum levels in multiple sclerosis patients. Mult. Scler. 1995, 1(Suppl 1):S5-S11.
-
(1995)
Mult. Scler.
, vol.1
, Issue.SUPPL. 1
-
-
Revel, M.1
Chebath, J.2
Mangelus, M.3
Harroch, S.4
Moviglia, G.A.5
-
65
-
-
67249090787
-
T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-beta
-
Durelli L., Conti L., Clerico M., Boselli D., Contessa G., Ripellina P., Ferrero B., Eid P., Novelli F. T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-beta. Ann. Neurol. 2009, 65:499-509.
-
(2009)
Ann. Neurol.
, vol.65
, pp. 499-509
-
-
Durelli, L.1
Conti, L.2
Clerico, M.3
Boselli, D.4
Contessa, G.5
Ripellina, P.6
Ferrero, B.7
Eid, P.8
Novelli, F.9
-
66
-
-
77950526192
-
IFN-beta inhibits human Th17 cell differentiation
-
Ramgolam V.S., Sha Y., Jin J., Zhang X., Markovic-Plese S. IFN-beta inhibits human Th17 cell differentiation. J. Immunol. 2009, 183:5418-5427.
-
(2009)
J. Immunol.
, vol.183
, pp. 5418-5427
-
-
Ramgolam, V.S.1
Sha, Y.2
Jin, J.3
Zhang, X.4
Markovic-Plese, S.5
-
67
-
-
70349853050
-
Expression of Th1 and Th17 cytokines and transcription factors in multiple sclerosis patients: does baseline T-bet mRNA predict the response to interferon-beta treatment?
-
Drulovic J., Savic E., Pekmezovic T., Mesaros S., Stojsavljevic N., Dujmovic-Basuroski I., Kostic J., Vasic V., Mostarica Stojkovic M., Popadic D. Expression of Th1 and Th17 cytokines and transcription factors in multiple sclerosis patients: does baseline T-bet mRNA predict the response to interferon-beta treatment?. J. Neuroimmunol. 2009, 215:90-95.
-
(2009)
J. Neuroimmunol.
, vol.215
, pp. 90-95
-
-
Drulovic, J.1
Savic, E.2
Pekmezovic, T.3
Mesaros, S.4
Stojsavljevic, N.5
Dujmovic-Basuroski, I.6
Kostic, J.7
Vasic, V.8
Mostarica Stojkovic, M.9
Popadic, D.10
-
68
-
-
33745873727
-
A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
-
Sutton C., Brereton C., Keogh B., Mills K.M., Lavelle E.C. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J. Exp. Med. 2006, 203:1685-1691.
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1685-1691
-
-
Sutton, C.1
Brereton, C.2
Keogh, B.3
Mills, K.M.4
Lavelle, E.C.5
-
69
-
-
0031921636
-
Interleukin-6 functions in autoimmune encephalomyelitis: a study in gene-targeted mice
-
Mendel I., Katz A., Kozak N., Ben-Nun A., Revel M. Interleukin-6 functions in autoimmune encephalomyelitis: a study in gene-targeted mice. Eur. J. Immunol. 1998, 28:1727-1737.
-
(1998)
Eur. J. Immunol.
, vol.28
, pp. 1727-1737
-
-
Mendel, I.1
Katz, A.2
Kozak, N.3
Ben-Nun, A.4
Revel, M.5
-
70
-
-
0031920882
-
IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein
-
Okuda Y., Sakoda S., Bernard C.C., Fujimura H., Saeki Y., Kishimoto T., Yanagihara T. IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein. Int. Immunol. 1998, 10:703-708.
-
(1998)
Int. Immunol.
, vol.10
, pp. 703-708
-
-
Okuda, Y.1
Sakoda, S.2
Bernard, C.C.3
Fujimura, H.4
Saeki, Y.5
Kishimoto, T.6
Yanagihara, T.7
|