Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice

Investigational New Drugs

Volumn 30, Issue 3, 2012, Pages 916-926

  Onimoe, Grace Ifeyinwa ^a,e   Liu, Aiguo ^a,b   Lin, Li ^a,b   Wei, Chang Ching ^c   Schwartz, Eric B ^d   Bhasin, Deepak ^d   Li, Chenglong ^d   Fuchs, James R ^d   Li, Pui Kai ^d   Houghton, Peter ^a,e   Termuhlen, Amanda ^e   Gross, Thomas ^e   Lin, Jiayuh ^a,e,f  

^a NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d OHIO STATE UNIVERSITY   (United States)

^e THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^f THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

Author keywords

Osteosarcoma; Small molecule inhibitors; STAT3

Indexed keywords

ANTINEOPLASTIC AGENT; FLLL 32; LLL 12; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; COLONY FORMATION; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MIGRATION INHIBITION; MITOSIS INHIBITION; MOUSE; NONHUMAN; OSTEOSARCOMA; OSTEOSARCOMA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

ANIMALS; ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BONE NEOPLASMS; CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CURCUMIN; FEMALE; HUMANS; INTERLEUKIN-6; MICE; MICE, NUDE; OSTEOSARCOMA; PHOSPHORYLATION; STAT3 TRANSCRIPTION FACTOR; SULFONAMIDES; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84864350035     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-011-9645-1     Document Type: Article

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