Cucurbitacin e Induces G 2/M Phase Arrest through STAT3/p53/p21 Signaling and Provokes Apoptosis via Fas/CD95 and Mitochondria-Dependent Pathways in Human Bladder Cancer T24 Cells

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Huang, Wen Wen ^a   Yang, Jai Sing ^a   Lin, Meng Wei ^a   Chen, Po Yuan ^a   Chiou, Shang Ming ^b   Chueh, Fu Shin ^c   Lan, Yu Hsuan ^a   Pai, Shu Jen ^a   Tsuzuki, Minoru ^a,d   Ho, Wai Jane ^e   Chung, Jing Gung ^a,c  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c ASIA UNIVERSITY   (Taiwan)

^d NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

^e DA YEH UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 8; CASPASE 9; CELL DNA; CUCURBITACIN E; CYCLIN B; CYCLIN DEPENDENT KINASE 1; CYTOCHROME C; FAS ANTIGEN; LIPOCORTIN 5; PROTEIN P21; PROTEIN P53; STAT3 PROTEIN; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLADDER CANCER; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL GROWTH; CELL STRUCTURE; CONTROLLED STUDY; CUCURBITACEAE; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME RELEASE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MITOCHONDRIAL MEMBRANE POTENTIAL; PHASE CONTRAST MICROSCOPE; PRIORITY JOURNAL; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84863057259     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/952762     Document Type: Article

References (54)

1. Kumar B., Koul S., Petersen J., Khandrika L., Hwa J. S., Meacham R. B., Wilson S., Koul H. K., p38 Mitogen-activated protein kinase-driven MAPKAPK2 regulates invasion of bladder cancer by modulation of MMP-2 and MMP-9 activity Cancer Research 2010 70 2 832 841
2. Zapatero A., Martin de Vidales C., Arellano R., Bocardo G., Pérez M., Ros P., Updated results of bladder-sparing trimodality approach for invasive bladder cancer Urologic Oncology 2010 28 4 368 374
3. Matés J. M., Segura J. A., Alonso F. J., Mrquez J., Anticancer antioxidant regulatory functions of phytochemicals Current Medicinal Chemistry 2011 18 15 2315 2338
4. Neto C. C., Amoroso J. W., Liberty A. M., Anticancer activities of cranberry phytochemicals: an update Molecular Nutrition and Food Research 2008 52 1 S18 S27
5. Newman D. J., Cragg G. M., Holbeck S., Sausville E. A., Natural products and derivatives as leads to cell cycle pathway targets in cancer chemotherapy Current Cancer Drug Targets 2002 2 4 279 308 (Pubitemid 35303466)
6. Attard E., Brincat M. P., Cuschieri A., Immunomodulatory activity of cucurbitacin E isolated from Ecballium elaterium Fitoterapia 2005 76 5 439 441 (Pubitemid 40922604)
7. Gilbert J. N., Mathieson D. W., The functional groupings of cucurbitacin E (alpha-elaterin) The Journal of Pharmacy and Pharmacology 1958 10 supplement 252T 255T
8. Momma K., Masuzawa Y., Nakai N., Chujo M., Murakami A., Kioka N., Kiyama Y., Akita T., Nagao M., Direct interaction of Cucurbitacin E isolated from Alsomitra macrocarpa to actin filament Cytotechnology 2008 56 1 33 39
9. Dong Y., Lu B., Zhang X., Zhang J., Lai L., Li D., Wu Y., Song Y., Luo J., Pang X., Yi Z., Liu M., Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway Carcinogenesis 2010 31 12 2097 2104
10. Tannin-Spitz T., Bergman M., Grossman S., Cucurbitacin glucosides: antioxidant and free-radical scavenging activities Biochemical and Biophysical Research Communications 2007 364 1 181 186 (Pubitemid 47599438)
11. Shan X.-L., Zhou X.-Y., Yang J., Wang Y.-L., Deng Y.-H., Zhang M.-X., Inhibitory effect and mechanism of cucurbitacin E on the proliferation of ovarian cancer cells Chinese Journal of Cancer 2010 29 1 20 23
12. Sadzuka Y., Hatakeyama H., Sonobe T., Enhancement of doxorubicin concentration in the M5076 ovarian sarcoma cells by cucurbitacin E co-treatment International Journal of Pharmaceutics 2010 383 1-2 186 191
13. Nakashima S., Matsuda H., Kurume A., Oda Y., Nakamura S., Yamashita M., Yoshikawa M., Cucurbitacin E as a new inhibitor of cofilin phosphorylation in human leukemia U937 cells Bioorganic and Medicinal Chemistry Letters 2010 20 9 2994 2997
14. Li Y., Wang R., Ma E., Deng Y., Wang X., Xiao J., Jing Y., The induction of G 2 /M cell-cycle arrest and apoptosis by cucurbitacin e is associated with increased phosphorylation of eIF2 in leukemia cells Anti-Cancer Drugs 2010 21 4 389 400
15. Sun C., Zhang M., Shan X., Zhou X., Yang J., Wang Y., Li-Ling J., Deng Y., Inhibitory effect of cucurbitacin e on pancreatic cancer cells growth via STAT3 signaling Journal of Cancer Research and Clinical Oncology 2010 136 4 603 610
16. Kidd V. J., Proteolytic activities that mediate apoptosis Annual Review of Physiology 1998 60 533 573 (Pubitemid 28157886)
17. Kaufmann S. H., Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note Cancer Research 1989 49 21 5870 5878 (Pubitemid 19274139)
18. Friesen C., Herr I., Krammer P. H., Debatin K. M., Involvement of the CD95 (APO-1/Fas) receptor/ligand system in drug-induced apoptosis in leukemia cells Nature Medicine 1996 2 5 574 577 (Pubitemid 26150685)
19. Fulda S., Debatin K. M., Death receptor signaling in cancer therapy Current Medicinal Chemistry 2003 3 4 253 262 (Pubitemid 36758300)
20. Ramnath N., Khushalani N., Toth K., Litwin A. M., Intengan M. E., Slocum H. K., Pendyala L., Smith P. F., Stewart C. C., Hoffman J. L., Javle M. M., Berdzik J., Creaven P. J., Rustum Y. M., S-phase modulation by irinotecan: pilot studies in advanced solid tumors Cancer Chemotherapy and Pharmacology 2005 56 5 447 454 (Pubitemid 41549145)
21. Orren D. K., Petersen L. N., Bohr V. A., Persistent DNA damage inhibits S-phase and G2 progression, and results in apoptosis Molecular Biology of the Cell 1997 8 6 1129 1142 (Pubitemid 27276331)
22. Fujimoto K., Hosotani R., Doi R., Wada M., Lee J. U., Koshiba T., Miyamoto Y., Tsuji S., Nakajima S., Imamura M., Induction of cell-cycle arrest and apoptosis by a novel retinobenzoic- acid derivative, TAC-101, in human pancreatic-cancer cells International Journal of Cancer 1999 81 4 637 644 (Pubitemid 29203064)
23. Gamet-Payrastre L., Li P., Lumeau S., Cassar G., Dupont M. A., Chevolleau S., Gasc N., Tulliez J., Tercé F., Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells Cancer Research 2000 60 5 1426 1433 (Pubitemid 30152017)
24. Lin J. G., Chen G. W., Li T. M., Chouh S. T., Tan T. W., Chung J. G., Aloe-Emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway Journal of Urology 2006 175 1 343 347
25. Wu P.-P., Liu K.-C., Huang W.-W., Ma C.-Y., Lin H., Yang J.-S., Chung J.-G., Triptolide induces apoptosis in human adrenal cancer NCI-H295 cells through a mitochondrial-dependent pathway Oncology Reports 2011 25 2 551 557
26. Huang W.-W., Ko S.-W., Tsai H.-Y., Chung J.-G., Chiang J.-H., Chen K.-T., Chen Y.-C., Chen H.-Y., Chen Y.-F., Yang J.-S., Cantharidin induces G 2 /M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways International Journal of Oncology 2011 38 4 1067 1073
27. Wu S. H., Hang L. W., Yang J. S., Chen H. Y., Lin H. Y., Chiang J. H., Lu C. C., Yang J. L., Lai T. Y., Ko Y. C., Chung J. G., Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways Anticancer Research 2010 30 6 2125 2133
28. Yang J. S., Hour M. J., Huang W. W., Lin K. L., Kuo S. C., Chung J. G., MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells Journal of Pharmacology and Experimental Therapeutics 2010 334 2 477 488
29. Lu C. C., Yang J. S., Huang A. C., Hsia T. C., Chou S. T., Kuo C. L., Lu H. F., Lee T. H., Wood W. G., Chung J. G., Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells Molecular Nutrition and Food Research 2010 54 7 967 976
30. Chou L. C., Yang J. S., Huang L. J., Wu H. C., Lu C. C., Chiang J. H., Chen K. T., Kuo S. C., Chung J. G., The synthesized 2-(2-fluorophenyl)-6,7- methylenedioxyquinolin-4-one (CHM-1) promoted G 2 /M arrest through inhibition of CDK1 and induced apoptosis through the mitochondrial-dependent pathway in CT-26 murine colorectal adenocarcinoma cells Journal of Gastroenterology 2009 44 10 1055 1063
31. Lin C. C., Yang J. S., Chen J. T., Fan S., Yu F. S., Yang J. L., Lu C. C., Kao M. C., Huang A. C., Lu H. F., Chung J. G., Berberine induces apoptosis in human HSC-3 oral cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway Anticancer Research 2007 27 5 A 3371 3378 (Pubitemid 47607564)
32. Chiang J.-H., Yang J.-S., Ma C.-Y., Yang M.-D., Huang H.-Y., Hsia T.-C., Kuo H.-M., Wu P.-P., Lee T.-H., Chung J.-G., Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways Chemical Research in Toxicology 2011 24 1 20 29
33. Liu K.-C., Huang A.-C., Wu P.-P., Lin H.-Y., Chueh F.-S., Yang J.-S., Lu C.-C., Chiang J.-H., Meng M., Chung J.-G., Gallic acid suppresses the migration and invasion of PC-3 human prostate cancer cells via inhibition of matrix metalloproteinase-2 and -9 signaling pathways Oncology Reports 2011 26 1 177 184
34. Lan Y. U.-H., Wu Y.-C., Wu K.-W., Chung J.-G., Lu C.-C., Chen Y.-L., Wu T.-S., Yang J.-S., Death receptor 5-mediated TNFR family signaling pathways modulate -humulene-induced apoptosis in human colorectal cancer HT29 cells Oncology Reports 2011 25 2 419 424
35. Lai W. W., Yang J. S., Lai K. C., Kuo C. L., Hsu C. K., Wang C. K., Chang C. Y., Lin J. J., Tang N. Y., Chen P. Y., Huang W. W., Chung J. G., Rhein induced apoptosis through the endoplasmic reticulum stress, caspase- and mitochondria-dependent pathways in SCC-4 human tongue squamous cancer cells In Vivo 2009 23 2 309 316
36. Huang W. W., Chiu Y. J., Fan M. J., Lu H. F., Yeh H. F., Li K. H., Chen P. Y., Chung J. G., Yang J. S., Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells Molecular Nutrition and Food Research 2010 54 11 1585 1595
37. Antonsson B., Mitochondria and the Bcl-2 proteins in apoptosis signaling pathways Molecular and Cellular Biochemistry 2004 256-257 1-2 141 155 (Pubitemid 38181242)
38. Kuwana T., Newmeyer D. D., Bcl-2-family proteins and the role of mitochondria in apoptosis Current Opinion in Cell Biology 2003 15 6 691 699 (Pubitemid 37487962)
39. Forster J. A., Paul A. B., Harnden P., Knowles M. A., Expression of NRG1 and its receptors in human bladder cancer British Journal of Cancer 2011 104 7 1135 1143
40. Gopalkrishna V., Srivastava A. N., Hedau S., Sharma J. K., Das B. C., Detection of human papillomavirus DNA sequences in cancer of the urinary bladder by in situ hybridisation and polymerase chain reaction Genitourinary Medicine 1995 71 4 231 233
41. Filion M. C., Lépicier P., Morales A., Phillips N. C., Mycobacterium phlei cell wall complex directly induces apoptosis in human bladder cancer cells British Journal of Cancer 1999 79 2 229 235 (Pubitemid 29002290)
42. Konstantakou E. G., Voutsinas G. E., Karkoulis P. K., Aravantinos G., Margaritis L. H., Stravopodis D. J., Human bladder cancer cells undergo cisplatin-induced apoptosis that is associated with p53-dependent and p53-independent responses International Journal of Oncology 2009 35 2 401 416
43. Li X., Su B., Liu R., Wu D., He D., Tetrandrine induces apoptosis and triggers caspase cascade in human bladder cancer cells Journal of Surgical Research 2011 166 1 e45 e51
44. Shrader M., Pino M. S., Lashinger L., Bar-Eli M., Adam L., Dinney C. P. N., McConkey D. J., Gefitinib reverses TRAIL resistance in human bladder cancer cell lines via inhibition of AKT-mediated X-linked inhibitor of apoptosis protein expression Cancer Research 2007 67 4 1430 1435 (Pubitemid 46383367)
45. Kelly K., The role of targeted agents in adjuvant therapy for non-small cell lung cancer Clinical Cancer Research 2005 11 13 5027s 5029s
46. Gitter S., Gallily R., Shohat B., Lavie D., Studies on the antitumor effect of cucurbitacins Cancer research 1961 21 516 521
47. Niu G., Wright K. L., Ma Y., Wright G. M., Huang M., Irby R., Briggs J., Karras J., Cress W. D., Pardoll D., Jove R., Chen J., Yu H., Role of Stat3 in regulating p53 expression and function Molecular and Cellular Biology 2005 25 17 7432 7440 (Pubitemid 41170107)
48. Hartwell L. H., Weinert T. A., Checkpoints: controls that ensure the order of cell cycle events Science 1989 246 4930 629 634 (Pubitemid 19283354)
49. Molinari M., Cell cycle checkpoints and their inactivation in human cancer Cell Proliferation 2000 33 5 261 274
50. O'Connor P. M., Ferris D. K., Pagano M., Draetta G., Pines J., Hunter T., Longo D. L., Kohn K. W., G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently Journal of Biological Chemistry 1993 268 11 8298 8308 (Pubitemid 23120421)
51. Boykin C., Zhang G., Chen Y.-H., Zhang R.-W., Fan X.-E., Yang W.-M., Lu Q., Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation British Journal of Cancer 2011 104 5 781 789
52. Salvesen G. S., Dixit V. M., Caspases: intracellular signaling by proteolysis Cell 1997 91 4 443 446 (Pubitemid 27508233)
53. Gross A., McDonnell J. M., Korsmeyer S. J., BCL-2 family members and the mitochondria in apoptosis Genes and Development 1999 13 15 1899 1911 (Pubitemid 29407357)
54. Kuo J. H., Chu Y. L., Yang J. S., Lin J. P., Lai K. C., Kuo H. M., Hsia T. C., Chung J. G., Cantharidin induces apoptosis in human bladder cancer TSGH 8301 cells through mitochondria-dependent signal pathways International Journal of Oncology 2010 37 5 1243 1250