IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation

Journal of Immunology

Volumn 184, Issue 6, 2010, Pages 3186-3190

  Sehra, Sarita ^a   Yao, Yongxue ^a   Howell, Michael D ^c   Nguyen, Evelyn T ^a   Kansas, Geoffrey S ^d   Leung, Donald Y M ^c   Travers, Jeffrey B ^a,b   Kaplan, Mark H ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c DEPARTMENT OF MEDICINE   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 4; STAT6 PROTEIN; AUTACOID; STAT6 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; EPIDERMIS; FEMALE; GENE EXPRESSION; HOMEOSTASIS; MOUSE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN ALLERGY; ANIMAL; ATOPIC DERMATITIS; BIOSYNTHESIS; C57BL MOUSE; CELL DIFFERENTIATION; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; MOUSE MUTANT; PATHOLOGY; PERMEABILITY; PHYSIOLOGY; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; CELL DIFFERENTIATION; DERMATITIS, ATOPIC; EPIDERMIS; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HOMEOSTASIS; HUMANS; IMMUNITY, INNATE; INFLAMMATION MEDIATORS; INTERLEUKIN-4; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; PERMEABILITY; STAT6 TRANSCRIPTION FACTOR; UP-REGULATION;

EID: 77951890216     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901860     Document Type: Article

References (26)

1. Bieber, T. 2008. Atopic dermatitis. N. Engl. J. Med. 358: 1483-1494.
2. Leung, D. Y., M. Boguniewicz, M. D. Howell, I. Nomura, and Q. A. Hamid. 2004. New insights into atopic dermatitis. J. Clin. Invest. 113: 651-657.
3. Sehra, S., F. M. Tuana, M. Holbreich, N. Mousdicas, R. S. Tepper, C. H. Chang, J. B. Travers, and M. H. Kaplan. 2008. Scratching the surface: towards understanding the pathogenesis of atopic dermatitis. Crit. Rev. Immunol. 28: 15-43.
4. Howell, M. D., R. L. Gallo, M. Boguniewicz, J. F. Jones, C. Wong, J. E. Streib, and D. Y. Leung. 2006. Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. Immunity 24: 341-348.
5. Howell, M. D., B. E. Kim, P. Gao, A. V. Grant, M. Boguniewicz, A. Debenedetto, L. Schneider, L. A. Beck, K. C. Barnes, and D. Y. Leung. 2007. Cytokine modulation of atopic dermatitis filaggrin skin expression. J. Allergy Clin. Immunol. 120: 150-155.
6. Kim, B. E., D. Y. Leung, M. Boguniewicz, and M. D. Howell. 2008. Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6. Clin. Immunol. 126: 332-337.
7. Chan, L. S., N. Robinson, and L. Xu. 2001. Expression of interleukin-4 in the epidermis of transgenic mice results in a pruritic inflammatory skin disease: an experimental animal model to study atopic dermatitis. J. Invest. Dermatol. 117: 977-983.
8. Elbe-Bürger, A., A. Egyed, S. Olt, R. Klubal, U. Mann, K. Rappersberger, A. Rot, and G. Stingl. 2002. Overexpression of IL-4 alters the homeostasis in the skin. J. Invest. Dermatol. 118: 767-778.
9. Lee, G. R., and R. A. Flavell. 2004. Transgenic mice which overproduce Th2 cytokines develop spontaneous atopic dermatitis and asthma. Int. Immunol. 16: 1155-1160.
10. Bruns, H. A., U. Schindler, and M. H. Kaplan. 2003. Expression of a constitutively active Stat6 in vivo alters lymphocyte homeostasis with distinct effects in T and B cells. J. Immunol. 170: 3478-3487.
11. White, S. J., G. H. Underhill, M. H. Kaplan, and G. S. Kansas. 2001. Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells. J. Immunol. 167: 628-631.
12. Chang, H. C., S. Zhang, V. T. Thieu, R. B. Slee, H. A. Bruns, R. N. Laribee, M. J. Klemsz, and M. H. Kaplan. 2005. PU.1 expression delineates heterogeneity in primary Th2 cells. Immunity 22: 693-703.
13. Roberts, J. M., J. Yang, and F. Ronchese. 2004. IL-4 deficiency does not impair the ability of dendritic cells to initiate CD4+ and CD8+ T cell responses in vivo. Int. Immunol. 16: 1451-1458.
14. Sehra, S., H. A. Bruns, A. N. Ahyi, E. T. Nguyen, N. W. Schmidt, E. G. Michels, G. U. von Bülow, and M. H. Kaplan. 2008. IL-4 is a critical determinant in the generation of allergic inflammation initiated by a constitutively active Stat6. J. Immunol. 180: 3551-3559.
15. Guo, L., J. Hu-Li, J. Zhu, C. Pannetier, C. Watson, G. J. McKenzie, A. N. McKenzie, and W. E. Paul. 2001. Disrupting Il13 impairs production of IL-4 specified by the linked allele. Nat. Immunol. 2: 461-466.
16. Cookson, W. 2004. The immunogenetics of asthma and eczema: a new focus on the epithelium. Nat. Rev. Immunol. 4: 978-988.
17. Baurecht, H., A. D. Irvine, N. Novak, T. Illig, B. Bühler, J. Ring, S. Wagenpfeil, and S. Weidinger. 2007. Toward a major risk factor for atopic eczema: metaanalysis of filaggrin polymorphism data. J. Allergy Clin. Immunol. 120: 1406-1412.
18. Palmer, C. N., A. D. Irvine, A. Terron-Kwiatkowski, Y. Zhao, H. Liao, S. P. Lee, D. R. Goudie, A. Sandilands, L. E. Campbell, F. J. Smith, et al. 2006. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat. Genet. 38: 441-446.
19. Zheng, Y., D. M. Danilenko, P. Valdez, I. Kasman, J. Eastham-Anderson, J. Wu, and W. Ouyang. 2007. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445: 648-651. (Pubitemid 46232884)
20. Tepper, R. I., D. A. Levinson, B. Z. Stanger, J. Campos-Torres, A. K. Abbas, and P. Leder. 1990. IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell 62: 457-467. (Pubitemid 20263216)
21. Gupta, J., E. Grube, M. B. Ericksen, M. D. Stevenson, A. W. Lucky, A. P. Sheth, A. H. Assa'ad, and G. K. Khurana Hershey. 2008. Intrinsically defective skin barrier function in children with atopic dermatitis correlates with disease severity. J. Allergy Clin. Immunol. 121: 725-730.e2.
22. Nemoto-Hasebe, I., M. Akiyama, T. Nomura, A. Sandilands, W. H. McLean, and H. Shimizu. 2009. Clinical severity correlates with impaired barrier in filaggrinrelated eczema. J. Invest. Dermatol. 129: 682-689.
23. Sakurai, K., H. Sugiura, M. Matsumoto, and M. Uehara. 2002. Occurrence of patchy parakeratosis in normal-appearing skin in patients with active atopic dermatitis and in patients with healed atopic dermatitis: a cause of impaired barrier function of the atopic skin. J. Dermatol. Sci. 30: 37-42.
24. Werner, Y., and M. Lindberg. 1985. Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis. Acta Derm. Venereol. 65: 102-105.
25. Rhodes, H. L., R. Sporik, P. Thomas, S. T. Holgate, and J. J. Cogswell. 2001. Early life risk factors for adult asthma: a birth cohort study of subjects at risk. J. Allergy Clin. Immunol. 108: 720-725.
26. Zeiger, R. S., and S. Heller. 1995. The development and prediction of atopy in high-risk children: follow-up at age seven years in a prospective randomized study of combined maternal and infant food allergen avoidance. J. Allergy Clin. Immunol. 95: 1179-1190.