A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice

American Journal of Respiratory Cell and Molecular Biology

Volumn 41, Issue 5, 2009, Pages 516-524

  Chiba, Yoshihiko ^a   Todoroki, Michiko ^a   Nishida, Yuichi ^a   Tanabe, Miki ^a   Misawa, Miwa ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Airway hyperresponsiveness; AS1517499; Bronchial smooth muscle; RhoA; STAT6

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 (BENZYLAMINO) 2 [[2 (3 CHLORO 4 HYDROXYPHENYL)ETHYL]AMINO]PYRIMIDINE 5 CARBOXAMIDE; ACETYLCHOLINE; ANTIASTHMATIC AGENT; AS 1517499; CALCIUM ION; GUANOSINE TRIPHOSPHATASE; INTERLEUKIN 13; OVALBUMIN; RECOMBINANT INTERLEUKIN 13; RHO KINASE INHIBITOR; SMALL INTERFERING RNA; STAT6 INHIBITOR; STAT6 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; BRONCHUS MUSCLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SMOOTH MUSCLE CONTRACTION; WESTERN BLOTTING;

ANIMALS; ANTI-ASTHMATIC AGENTS; ANTIGENS; ASTHMA; BRONCHI; BRONCHIAL HYPERREACTIVITY; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOCONSTRICTION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IMMUNOGLOBULIN E; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-13; MALE; MICE; MICE, INBRED BALB C; MUSCLE, SMOOTH; OVALBUMIN; PHOSPHORYLATION; PYRIMIDINES; RECOMBINANT PROTEINS; RHO GTP-BINDING PROTEINS; RHOA GTP-BINDING PROTEIN; STAT6 TRANSCRIPTION FACTOR; TIME FACTORS;

MUS;

EID: 70349870911     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2008-0163OC     Document Type: Article

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