메뉴 건너뛰기




Volumn 139, Issue 3, 2013, Pages 313-326

Microglia during development and aging

Author keywords

Aging; Development; Microglia P2X receptors; Synapse stripping

Indexed keywords

ANGIOTENSIN II; APOLIPOPROTEIN E; AQUAPORIN; BRADYKININ; CALCITONIN GENE RELATED PEPTIDE; CANNABINOID; CHAPERONIN 60; CHEMOKINE RECEPTOR CX3CR1; CHEMOKINE RECEPTOR CXCR3; CHITINASE; COLONY STIMULATING FACTOR 1; COMPLEMENT FACTOR; ENDOTHELIN; GLUCOCORTICOID; GLUTAMATE RECEPTOR; HISTAMINE; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; MINERALOCORTICOID; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUROTRANSMITTER; NEUROTRANSMITTER RECEPTOR; NEUROTROPHIC FACTOR; NITRIC OXIDE; OPIATE; PATTERN RECOGNITION RECEPTOR; PROTEIN TYROSINE PHOSPHATASE; PURINERGIC P2X RECEPTOR; REACTIVE OXYGEN METABOLITE;

EID: 84881251933     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2013.04.013     Document Type: Review
Times cited : (383)

References (286)
  • 2
    • 0034049694 scopus 로고    scopus 로고
    • Interaction between neurone and microglia mediated by platelet- activating factor
    • DOI 10.1046/j.1365-2443.2000.00333.x
    • M. Aihara, S. Ishii, K. Kume, and T. Shimizu Interaction between neurone and microglia mediated by platelet-activating factor Genes Cells 5 2000 397 406 (Pubitemid 30409095)
    • (2000) Genes to Cells , vol.5 , Issue.5 , pp. 397-406
    • Aihara, M.1    Ishii, S.2    Kume, K.3    Shimizu, T.4
  • 3
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • DOI 10.1038/nn2014, PII NN2014
    • B. Ajami, J.L. Bennett, C. Krieger, W. Tetzlaff, and F.M. Rossi Local self-renewal can sustain CNS microglia maintenance and function throughout adult life Nat Neurosci 10 2007 1538 1543 (Pubitemid 350175883)
    • (2007) Nature Neuroscience , vol.10 , Issue.12 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.V.5
  • 4
    • 80052246111 scopus 로고    scopus 로고
    • Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
    • B. Ajami, J.L. Bennett, C. Krieger, K.M. McNagny, and F.M. Rossi Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool Nat Neurosci 14 2011 1142 1149
    • (2011) Nat Neurosci , vol.14 , pp. 1142-1149
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    McNagny, K.M.4    Rossi, F.M.5
  • 5
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • DOI 10.1016/j.cell.2006.02.015, PII S0092867406001905
    • S. Akira, S. Uematsu, and O. Takeuchi Pathogen recognition and innate immunity Cell 124 2006 783 801 (Pubitemid 43261452)
    • (2006) Cell , vol.124 , Issue.4 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 6
    • 0032737272 scopus 로고    scopus 로고
    • Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain
    • DOI 10.1016/S0165-3806(99)00113-3, PII S0165380699001133
    • F. Alliot, I. Godin, and B. Pessac Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain Brain Res Dev Brain Res 117 1999 145 152 (Pubitemid 29531505)
    • (1999) Developmental Brain Research , vol.117 , Issue.2 , pp. 145-152
    • Alliot, F.1    Godin, I.2    Pessac, B.3
  • 7
    • 0032517803 scopus 로고    scopus 로고
    • Macrophages/microglial cells in human central nervous system during development: An immunohistochemical study
    • DOI 10.1016/S0006-8993(98)00830-0, PII S0006899398008300
    • A.V. Andjelkovic, B. Nikolic, J.S. Pachter, and N. Zecevic Macrophages/microglial cells in human central nervous system during development: an immunohistochemical study Brain Res 814 1998 13 25 (Pubitemid 29023407)
    • (1998) Brain Research , vol.814 , Issue.1-2 , pp. 13-25
    • Andjelkovic, A.V.1    Nikolic, B.2    Pachter, J.S.3    Zecevic, N.4
  • 8
    • 78751689107 scopus 로고    scopus 로고
    • Endogenous microglia regulate development of embryonic cortical precursor cells
    • J.M. Antony, A. Paquin, S.L. Nutt, D.R. Kaplan, and F.D. Miller Endogenous microglia regulate development of embryonic cortical precursor cells J Neurosci Res 89 2011 286 298
    • (2011) J Neurosci Res , vol.89 , pp. 286-298
    • Antony, J.M.1    Paquin, A.2    Nutt, S.L.3    Kaplan, D.R.4    Miller, F.D.5
  • 9
    • 35649003133 scopus 로고    scopus 로고
    • Toll-like receptors in defense and damage of the central nervous system
    • R.N. Aravalli, P.K. Peterson, and J.R. Lokensgard Toll-like receptors in defense and damage of the central nervous system J Neuroimmune Pharmacol 2007 2 2007 297 312
    • (2007) J Neuroimmune Pharmacol , vol.2007 , Issue.2 , pp. 297-312
    • Aravalli, R.N.1    Peterson, P.K.2    Lokensgard, J.R.3
  • 12
  • 13
    • 0036606950 scopus 로고    scopus 로고
    • CD200 and membrane protein interactions in the control of myeloid cells
    • DOI 10.1016/S1471-4906(02)02223-8, PII S1471490602022238
    • A.N. Barclay, G.J. Wright, G. Brooke, and M.H. Brown CD200 and membrane protein interactions in the control of myeloid cells Trends Immunol 23 2002 285 290 (Pubitemid 34628770)
    • (2002) Trends in Immunology , vol.23 , Issue.6 , pp. 285-290
    • Barclay, A.N.1    Wright, G.J.2    Brooke, G.3    Brown, M.H.4
  • 14
    • 0033104019 scopus 로고    scopus 로고
    • Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor
    • P.E. Batchelor, G.T. Liberatore, J.Y. Wong, M.J. Porritt, F. Frerichs, and G.A. Donnan Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor J Neurosci 19 1999 1708 1716 (Pubitemid 29094189)
    • (1999) Journal of Neuroscience , vol.19 , Issue.5 , pp. 1708-1716
    • Batchelor, P.E.1    Liberatore, G.T.2    Wong, J.Y.F.3    Porritt, M.J.4    Frerichs, F.5    Donnan, G.A.6    Howells, D.W.7
  • 16
    • 0035318421 scopus 로고    scopus 로고
    • Presence of B7-2 (CD86) and lack of B7-1 (CD80) on myelin phagocytosing MHC-II-positive rat microglia is associated with nondestructive immunity in vivo
    • I. Bechmann, S. Peter, M. Beyer, U. Gimsa, and R. Nitsch Presence of B7-2 (CD86) and lack of B7-1 (CD80) on myelin phagocytosing MHC-II-positive rat microglia is associated with nondestructive immunity in vivo FASEB J 15 2001 1086 1088
    • (2001) FASEB J , vol.15 , pp. 1086-1088
    • Bechmann, I.1    Peter, S.2    Beyer, M.3    Gimsa, U.4    Nitsch, R.5
  • 18
    • 33846887598 scopus 로고    scopus 로고
    • Microglial control of neuronal death and synaptic properties
    • DOI 10.1002/glia.20459
    • A. Bessis, C. Bechade, D. Bernard, and A. Roumier Microglial control of neuronal death and synaptic properties Glia 55 2007 233 238 (Pubitemid 46225955)
    • (2007) GLIA , vol.55 , Issue.3 , pp. 233-238
    • Bessis, A.1    Bechade, C.2    Bernard, D.3    Roumier, A.4
  • 19
    • 35748939409 scopus 로고    scopus 로고
    • Neuronal 'On' and 'Off' signals control microglia
    • DOI 10.1016/j.tins.2007.08.007, PII S0166223607002482
    • K. Biber, H. Neumann, K. Inoue, and H.W. Boddeke Neuronal 'on' and 'off' signals control microglia Trends Neurosci 30 2007 596 602 (Pubitemid 350051426)
    • (2007) Trends in Neurosciences , vol.30 , Issue.11 , pp. 596-602
    • Biber, K.1    Neumann, H.2    Inoue, K.3    Boddeke, H.W.G.M.4
  • 20
    • 79955623602 scopus 로고    scopus 로고
    • Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development
    • K. Biber, M. Tsuda, H. Tozaki-Saitoh, K. Tsukamoto, E. Toyomitsu, and T. Masuda Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development EMBO J 30 2011 1864 1873
    • (2011) EMBO J , vol.30 , pp. 1864-1873
    • Biber, K.1    Tsuda, M.2    Tozaki-Saitoh, H.3    Tsukamoto, K.4    Toyomitsu, E.5    Masuda, T.6
  • 21
    • 0038053021 scopus 로고    scopus 로고
    • Purinergic receptors on microglial cells: Functional expression in acute brain slices and modulation of microglial activation in vitro
    • DOI 10.1046/j.1460-9568.2003.02663.x
    • C. Boucsein, R. Zacharias, K. Farber, S. Pavlovic, U.K. Hanisch, and H. Kettenmann Purinergic receptors on microglial cells: functional expression in acute brain slices and modulation of microglial activation in vitro Eur J Neurosci 17 2003 2267 2276 (Pubitemid 36793736)
    • (2003) European Journal of Neuroscience , vol.17 , Issue.11 , pp. 2267-2276
    • Boucsein, C.1    Zacharias, R.2    Farber, K.3    Pavlovic, S.4    Hanisch, U.-K.5    Kettenmann, H.6
  • 22
    • 0033215009 scopus 로고    scopus 로고
    • Microglial-neuronal interactions in synaptic damage and recovery
    • DOI 10.1002/(SICI)1097-4547(19991001)58:1<191::AID-JNR17>3.0.CO;2-E
    • A.J. Bruce-Keller Microglial-neuronal interactions in synaptic damage and recovery J Neurosci Res 58 1999 191 201 (Pubitemid 29463703)
    • (1999) Journal of Neuroscience Research , vol.58 , Issue.1 , pp. 191-201
    • Bruce-Keller, A.J.1
  • 23
    • 46249110091 scopus 로고    scopus 로고
    • Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice
    • J.B. Buchanan, N.L. Sparkman, J. Chen, and R.W. Johnson Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice Psychoneuroendocrinology 33 2008 755 765
    • (2008) Psychoneuroendocrinology , vol.33 , pp. 755-765
    • Buchanan, J.B.1    Sparkman, N.L.2    Chen, J.3    Johnson, R.W.4
  • 25
    • 0001619989 scopus 로고
    • Contribucion al conocimiento de la meuroglia del cerebro humano
    • R. Cajal Contribucion al conocimiento de la meuroglia del cerebro humano Trab Lab Invest Biol 11 1913
    • (1913) Trab Lab Invest Biol , vol.11
    • Cajal, R.1
  • 27
    • 33845217688 scopus 로고    scopus 로고
    • The cellular response in neuroinflammation: The role of leukocytes, microglia and astrocytes in neuronal death and survival
    • DOI 10.1016/j.cnr.2006.09.004, PII S1566277206000429, Immune Mechanisms of Neurodegeneration
    • M.J. Carson, J.C. Thrash, and B. Walter The cellular response in neuroinflammation: the role of leukocytes, microglia and astrocytes in neuronal death and survival Clin Neurosci Res 6 2006 237 245 (Pubitemid 44849175)
    • (2006) Clinical Neuroscience Research , vol.6 , Issue.5 , pp. 237-245
    • Carson, M.J.1    Cameron Thrash, J.2    Walter, B.3
  • 29
    • 0031985336 scopus 로고    scopus 로고
    • Mature microglia resemble immature antigen-presenting cells
    • DOI 10.1002/(SICI)1098-1136(199801)22:1<72::AID-GLIA7>3.0.CO;2-A
    • M.J. Carson, C.R. Reilly, J.G. Sutcliffe, and D. Lo Mature microglia resemble immature antigen-presenting cells Glia 22 1998 72 85 (Pubitemid 28038045)
    • (1998) GLIA , vol.22 , Issue.1 , pp. 72-85
    • Carson, M.J.1    Reilly, C.R.2    Sutcliffe, J.G.3    Lo, D.4
  • 30
    • 34848863163 scopus 로고    scopus 로고
    • A Rose by Any Other Name? The Potential Consequences of Microglial Heterogeneity During CNS Health and Disease
    • DOI 10.1016/j.nurt.2007.07.002, PII S1933721307001377
    • M.J. Carson, T.V. Bilousova, S.S. Puntambekar, B. Melchior, J.M. Doose, and I.M. Ethell A rose by any other name? The potential consequences of microglial heterogeneity during CNS health and disease Neurotherapeutics 4 2007 571 579 (Pubitemid 47499284)
    • (2007) Neurotherapeutics , vol.4 , Issue.4 , pp. 571-579
    • Carson, M.J.1    Bilousova, T.V.2    Puntambekar, S.S.3    Melchior, B.4    Doose, J.M.5    Ethell, I.M.6
  • 31
    • 13444278829 scopus 로고    scopus 로고
    • Chemokine receptors in the central nervous system: Role in brain inflammation and neurodegenerative diseases
    • DOI 10.1016/j.brainresrev.2004.07.021
    • L. Cartier, O. Hartley, M. Dubois-Dauphin, and K.H. Krause Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases Brain Res Rev 48 2005 16 42 (Pubitemid 40215781)
    • (2005) Brain Research Reviews , vol.48 , Issue.1 , pp. 16-42
    • Cartier, L.1    Hartley, O.2    Dubois-Dauphin, M.3    Krause, K.-H.4
  • 32
    • 41149112041 scopus 로고    scopus 로고
    • Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke
    • DOI 10.1161/STROKEAHA.107.498212, PII 0000767020080400000041
    • J.R. Caso, J.M. Pradillo, O. Hurtado, J.C. Leza, M.A. Moro, and I. Lizasoain Toll-like receptor 4 is involved in subacute stress-induced neuroinflammation and in the worsening of experimental stroke Stroke 39 2008 1314 1320 (Pubitemid 351440707)
    • (2008) Stroke , vol.39 , Issue.4 , pp. 1314-1320
    • Caso, J.R.1    Pradillo, J.M.2    Hurtado, O.3    Leza, J.C.4    Moro, M.A.5    Lizasoain, I.6
  • 33
    • 0025833766 scopus 로고
    • Fibronectin and laminin regulate the in vitro differentiation of microglial cells
    • B. Chamak, and M. Mallat Fibronectin and laminin regulate the in vitro differentiation of microglial cells Neuroscience 45 1991 513 527
    • (1991) Neuroscience , vol.45 , pp. 513-527
    • Chamak, B.1    Mallat, M.2
  • 34
    • 0028342433 scopus 로고
    • Brain macrophages stimulate neurite growth and regeneration by secreting thrombospondin
    • DOI 10.1002/jnr.490380213
    • B. Chamak, V. Morandi, and M. Mallat Brain macrophages stimulate neurite growth and regeneration by secreting thrombospondin J Neurosci Res 38 1994 221 233 (Pubitemid 24155739)
    • (1994) Journal of Neuroscience Research , vol.38 , Issue.2 , pp. 221-233
    • Chamak, B.1    Morandi, V.2    Mallat, M.3
  • 36
    • 79961159284 scopus 로고    scopus 로고
    • Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice
    • 10.1371/journal.pone.0022818
    • M. Chen, J.V. Forrester, and H. Xu Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice PLoS One 6 8 2011 e22818 10.1371/journal.pone.0022818
    • (2011) PLoS One , vol.6 , Issue.8 , pp. 22818
    • Chen, M.1    Forrester, J.V.2    Xu, H.3
  • 37
    • 0019414892 scopus 로고
    • Hematogenous cells in the central nervous system of developing human embryos and fetuses
    • DOI 10.1002/cne.901960412
    • B.H. Choi Hematogenous cells in the central nervous system of developing human embryos and fetuses J Comp Neurol 196 1981 683 694 (Pubitemid 11099050)
    • (1981) Journal of Comparative Neurology , vol.196 , Issue.4 , pp. 683-694
    • Choi, B.H.1
  • 38
    • 34247868178 scopus 로고    scopus 로고
    • 7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain
    • DOI 10.1523/JNEUROSCI.5417-06.2007
    • H.B. Choi, J.K. Ryu, S.U. Kim, and J.G. McLarnon Modulation of the purinergic P2X7 receptor attenuates lipopolysaccharide-mediated microglial activation and neuronal damage in inflamed brain J Neurosci 27 2007 4957 4968 (Pubitemid 46699068)
    • (2007) Journal of Neuroscience , vol.27 , Issue.18 , pp. 4957-4968
    • Choi, H.B.1    Ryu, J.K.2    Kim, S.U.3    McLarnon, J.G.4
  • 40
    • 44649201117 scopus 로고    scopus 로고
    • Activity-Dependent Regulation of Synaptic AMPA Receptor Composition and Abundance by β3 Integrins
    • DOI 10.1016/j.neuron.2008.04.011, PII S0896627308003371
    • L.A. Cingolani, A. Thalhammer, L.M. Yu, M. Catalano, T. Ramos, and M.A. Colicos Activity-dependent regulation of synaptic AMPA receptor composition and abundance by beta3 integrins Neuron 58 2008 749 762 (Pubitemid 351778467)
    • (2008) Neuron , vol.58 , Issue.5 , pp. 749-762
    • Cingolani, L.A.1    Thalhammer, A.2    Yu, L.M.Y.3    Catalano, M.4    Ramos, T.5    Colicos, M.A.6    Goda, Y.7
  • 43
    • 81755165476 scopus 로고    scopus 로고
    • Dissecting the immune component of neurologic disorders: A grand challenge for the 21st century
    • P.K. Coyle Dissecting the immune component of neurologic disorders: a grand challenge for the 21st century Front Neurol 2 2011 37
    • (2011) Front Neurol , vol.2 , pp. 37
    • Coyle, P.K.1
  • 44
    • 0031690332 scopus 로고    scopus 로고
    • The origin and differentiation of microglial cells during development
    • DOI 10.1016/S0301-0082(98)00035-5, PII S0301008298000355
    • M.A. Cuadros, and J. Navascues The origin and differentiation of microglial cells during development Prog Neurobiol 56 1998 173 189 (Pubitemid 28432564)
    • (1998) Progress in Neurobiology , vol.56 , Issue.2 , pp. 173-189
    • Cuadros, M.A.1    Navascues, J.2
  • 45
    • 0032585044 scopus 로고    scopus 로고
    • Expression of purine metabolism-related enzymes by microglial cells in the developing rat brain
    • DOI 10.1002/(SICI)1096-9861(19980831)398:3<333::AID-CNE3>3.0.CO;2-0
    • I. Dalmau, J.M. Vela, B. Gonzalez, and B. Castellano Expression of purine metabolism-related enzymes by microglial cells in the developing rat brain J Comp Neurol 398 1998 333 346 (Pubitemid 28360038)
    • (1998) Journal of Comparative Neurology , vol.398 , Issue.3 , pp. 333-346
    • Dalmau, I.1    Vela, J.M.2    Gonzalez, B.3    Castellano, B.4
  • 48
    • 34548498175 scopus 로고    scopus 로고
    • Modulation of glial cell functions by adenosine receptors
    • DOI 10.1016/j.physbeh.2007.05.031, PII S0031938407002259
    • E. Dare, G. Schulte, O. Karovic, C. Hammarberg, and B.B. Fredholm Modulation of glial cell functions by adenosine receptors Physiol Behav 92 2007 15 20 (Pubitemid 47374251)
    • (2007) Physiology and Behavior , vol.92 , Issue.1-2 , pp. 15-20
    • Dare, E.1    Schulte, G.2    Karovic, O.3    Hammarberg, C.4    Fredholm, B.B.5
  • 51
    • 23844452985 scopus 로고    scopus 로고
    • Vesicle-mediated transport and release of CCL21 in endangered neurons: A possible explanation for microglia activation remote from a primary lesion
    • DOI 10.1523/JNEUROSCI.1019-05.2005
    • E.K. de Jong, I.M. Dijkstra, M. Hensens, N. Brouwer, M. van Amerongen, and R.S. Liem Vesicle mediated transport and release of CCL21 in endangered neurons: a possible explanation for microglia acti-vation remote from a primary lesion J Neurosci 25 2005 7548 7557 (Pubitemid 41170612)
    • (2005) Journal of Neuroscience , vol.25 , Issue.33 , pp. 7548-7557
    • De Jong, E.K.1    Dijkstra, I.M.2    Hensens, M.3    Brouwer, N.4    Van Amerongen, M.5    Liem, R.S.B.6    Boddeke, H.W.G.M.7    Biber, K.8
  • 53
    • 1342303483 scopus 로고    scopus 로고
    • Cutting Edge: Activity of Human Adult Microglia in Response to CC Chemokine Ligand 21
    • I.M. Dijkstra, S. Hulshof, P. van der Valk, H.W.G.M. Boddeke, and K. Biber Cutting edge: activity of human adult microglia in response to CC chemokine ligand 21 J Immunol 172 2004 2744 2747 (Pubitemid 38263656)
    • (2004) Journal of Immunology , vol.172 , Issue.5 , pp. 2744-2747
    • Dijkstra, I.M.1    Hulshof, S.2    Van Der Valk, P.3    Boddeke, H.W.G.M.4    Biber, K.5
  • 54
    • 54249124166 scopus 로고    scopus 로고
    • Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system
    • R.N. Dilger, and R.W. Johnson Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system J Leukoc Biol 84 2008 932 939
    • (2008) J Leukoc Biol , vol.84 , pp. 932-939
    • Dilger, R.N.1    Johnson, R.W.2
  • 55
    • 0033008209 scopus 로고    scopus 로고
    • Induction of potassium channels in mouse brain microglia: Cells acquire responsiveness to pneumococcal cell wall components during late development
    • DOI 10.1016/S0306-4522(98)00407-2, PII S0306452298004072
    • H.J. Draheim, M. Prinz, J.R. Weber, T. Weiser, H. Kettenmann, and U.K. Hanisch Induction of potassium channels in mouse brain microglia: cells acquire responsiveness to pneumococcal cell wall components during late development Neuroscience 89 1999 1379 1390 (Pubitemid 29074653)
    • (1999) Neuroscience , vol.89 , Issue.4 , pp. 1379-1390
    • Draheim, H.J.1    Prinz, M.2    Weber, J.R.3    Weiser, T.4    Kettenmann, H.5    Hanisch, U.-K.6
  • 56
    • 0041357082 scopus 로고    scopus 로고
    • Age-related dendritic and spine changes in corticocortically projecting neurons in macaque monkeys
    • DOI 10.1093/cercor/13.9.950
    • H. Duan, S.L. Wearne, A.B. Rocher, A. Macedo, J.H. Morrison, and P.R. Hof Age-related dendritic and spine changes in corticocortically projecting neurons in macaque monkeys Cereb Cortex 13 2003 950 961 (Pubitemid 37064832)
    • (2003) Cerebral Cortex , vol.13 , Issue.9 , pp. 950-961
    • Duan, H.1    Wearne, S.L.2    Rocher, A.B.3    Macedo, A.4    Morrison, J.H.5    Hof, P.R.6
  • 57
    • 84858072878 scopus 로고    scopus 로고
    • Comparison of polarization properties of human adult microglia and blood-derived macrophages
    • B.A. Durafourt, C.S. Moore, D.A. Zammit, T.A. Johnson, F. Zaguia, and M.C. Guiot Comparison of polarization properties of human adult microglia and blood-derived macrophages Glia 60 2012 717 727
    • (2012) Glia , vol.60 , pp. 717-727
    • Durafourt, B.A.1    Moore, C.S.2    Zammit, D.A.3    Johnson, T.A.4    Zaguia, F.5    Guiot, M.C.6
  • 59
    • 80055051144 scopus 로고    scopus 로고
    • Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits
    • B. Erblich, L. Zhu, A.M. Etgen, K. Dobrenis, and J.W. Pollard Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits PLoS One 6 2011 e26317
    • (2011) PLoS One , vol.6 , pp. 26317
    • Erblich, B.1    Zhu, L.2    Etgen, A.M.3    Dobrenis, K.4    Pollard, J.W.5
  • 60
    • 0026022020 scopus 로고
    • Macrophages, microglial cells, and HLA-DR antigens in fetal and infant brain
    • M.M. Esiri, M.S. al Izzi, and M.C. Reading Macrophages, microglial cells, and HLA-DR antigens in fetal and infant brain J Clin Pathol 44 1991 102 106
    • (1991) J Clin Pathol , vol.44 , pp. 102-106
    • Esiri, M.M.1    Al Izzi, M.S.2    Reading, M.C.3
  • 61
    • 18144381188 scopus 로고    scopus 로고
    • Dopamine and noradrenaline control distinct functions in rodent microglial cells
    • DOI 10.1016/j.mcn.2005.01.003
    • K. Farber, U. Pannasch, and H. Kettenmann Dopamine and noradrenaline control distinct functions in rodent microglial cells Mol Cell Neurosci 29 2005 128 138 (Pubitemid 40613058)
    • (2005) Molecular and Cellular Neuroscience , vol.29 , Issue.1 , pp. 128-138
    • Farber, K.1    Pannasch, U.2    Kettenmann, H.3
  • 62
    • 12344297883 scopus 로고    scopus 로고
    • Preferential expression and function of Toll-like receptor 3 in human astrocytes
    • DOI 10.1016/j.jneuroim.2004.09.009, PII S0165572804003261
    • C. Farina, M. Krumbholz, T. Giese, G. Hartmann, F. Aloisi, and E. Meinl Preferential expression and function of toll-like receptor 3 in human astrocytes J Neuroimmunol 159 2005 12 19 (Pubitemid 40126172)
    • (2005) Journal of Neuroimmunology , vol.159 , Issue.1-2 , pp. 12-19
    • Farina, C.1    Krumbholz, M.2    Giese, T.3    Hartmann, G.4    Aloisi, F.5    Meinl, E.6
  • 63
    • 84861989218 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice
    • A.M. Fenn, C.J. Henry, Y. Huang, A. Dugan, and J.P. Godbout Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice Brain Behav Immun 26 2012 766 777
    • (2012) Brain Behav Immun , vol.26 , pp. 766-777
    • Fenn, A.M.1    Henry, C.J.2    Huang, Y.3    Dugan, A.4    Godbout, J.P.5
  • 64
    • 0031054641 scopus 로고    scopus 로고
    • Purinergic modulation of interleukin-1β release from microglial cells stimulated with bacterial endotoxin
    • DOI 10.1084/jem.185.3.579
    • D. Ferrari, P. Chiozzi, S. Falzoni, S. Hanau, and F. Di Virgilio Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin J Exp Med 185 1997 579 582 (Pubitemid 27078376)
    • (1997) Journal of Experimental Medicine , vol.185 , Issue.3 , pp. 579-582
    • Ferrari, D.1    Chiozzi, P.2    Falzoni, S.3    Hanau, S.4    Di Virgilio, F.5
  • 67
    • 0034094052 scopus 로고    scopus 로고
    • Microglial activation in the developing rat olfactory bulb
    • DOI 10.1016/S0306-4522(99)00601-6, PII S0306452299006016
    • B.K. Fiske, and P.C. Brunjes Microglial activation in the developing rat olfactory bulb Neuroscience 96 2000 807 815 (Pubitemid 30155744)
    • (2000) Neuroscience , vol.96 , Issue.4 , pp. 807-815
    • Fiske, B.K.1    Brunjes, P.C.2
  • 68
    • 33947397925 scopus 로고    scopus 로고
    • Evidence that aging and amyloid promote microglial cell senescence
    • DOI 10.1089/rej.2006.9096
    • B.E. Flanary, N.W. Sammons, C. Nguyen, D. Walker, and W.J. Streit Evidence that aging and amyloid promote microglial cell senescence Rejuvenation Res 10 2007 61 74 (Pubitemid 46449433)
    • (2007) Rejuvenation Research , vol.10 , Issue.1 , pp. 61-74
    • Flanary, B.E.1    Sammons, N.W.2    Nguyen, C.3    Walker, D.4    Streit, W.J.5
  • 69
    • 0347285467 scopus 로고    scopus 로고
    • Progressive Telomere Shortening Occurs in Cultured Rat Microglia, but Not Astrocytes
    • DOI 10.1002/glia.10301
    • B.E. Flanary, and W.J. Streit Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes Glia 45 2004 75 88 (Pubitemid 38076230)
    • (2004) GLIA , vol.45 , Issue.1 , pp. 75-88
    • Flanary, B.E.1    Streit, W.J.2
  • 70
    • 79960744467 scopus 로고    scopus 로고
    • Microglia demonstrate age-dependent interaction with amyloid-beta fibrils
    • A.M. Floden, and C.K. Combs Microglia demonstrate age-dependent interaction with amyloid-beta fibrils J Alzheimers Dis 25 2011 279 293
    • (2011) J Alzheimers Dis , vol.25 , pp. 279-293
    • Floden, A.M.1    Combs, C.K.2
  • 71
    • 79551570269 scopus 로고    scopus 로고
    • Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission
    • 10.1371/journal.pone.0015973 (Jan 25)
    • A.M. Fontainhas, M. Wang, K.J. Liang, S. Chen, P. Mettu, and M. Damani Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission PLoS One 6 1 2011 e15973 10.1371/journal.pone.0015973 (Jan 25)
    • (2011) PLoS One , vol.6 , Issue.1 , pp. 15973
    • Fontainhas, A.M.1    Wang, M.2    Liang, K.J.3    Chen, S.4    Mettu, P.5    Damani, M.6
  • 73
    • 0035209620 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors
    • B.B. Fredholm, I.J. AP, K.A. Jacobson, K.N. Klotz, and J. Linden International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors Pharmacol Rev 53 2001 527 552 (Pubitemid 33136237)
    • (2001) Pharmacological Reviews , vol.53 , Issue.4 , pp. 527-552
    • Fredholm, B.B.1    Ijzerman, A.P.2    Jacobson, K.A.3    Klotz, K.-N.4    Linden, J.5
  • 74
    • 34250703015 scopus 로고    scopus 로고
    • 2A signaling
    • DOI 10.1016/j.pneurobio.2007.07.005, PII S0301008207001311, Targeting Adenosine A2A Receptors in Parkinson's Disease and other CNS Disorders
    • B.B. Fredholm, Y. Chern, R. Franco, and M. Sitkovsky Aspects of the general biology of adenosine A2A signaling Prog Neurobiol 83 2007 263 276 (Pubitemid 350102746)
    • (2007) Progress in Neurobiology , vol.83 , Issue.5 , pp. 263-276
    • Fredholm, B.B.1    Chern, Y.2    Franco, R.3    Sitkovsky, M.4
  • 75
    • 78649673357 scopus 로고    scopus 로고
    • HMGB1 inhibits macrophage activity in efferocytosis through binding to the αvβ3-integrin
    • A. Friggeri, Y. Yang, S. Banerjee, Y.J. Park, G. Liu, and E. Abraham HMGB1 inhibits macrophage activity in efferocytosis through binding to the αvβ3-integrin Am J Physiol 299 2010 C1267 C1276
    • (2010) Am J Physiol , vol.299
    • Friggeri, A.1    Yang, Y.2    Banerjee, S.3    Park, Y.J.4    Liu, G.5    Abraham, E.6
  • 76
    • 79958032955 scopus 로고    scopus 로고
    • Participation of the receptor for advanced glycation end products in efferocytosis
    • A. Friggeri, S. Banerjee, S. Biswas, A. de Freitas, G. Liu, and A. Bierhaus Participation of the receptor for advanced glycation end products in efferocytosis J Immunol 186 2011 6191 6198
    • (2011) J Immunol , vol.186 , pp. 6191-6198
    • Friggeri, A.1    Banerjee, S.2    Biswas, S.3    De Freitas, A.4    Liu, G.5    Bierhaus, A.6
  • 77
    • 0024437592 scopus 로고
    • Histochemical study of the differentiation of microglial cells in the developing human cerebral hemispheres
    • E. Fujimoto, A. Miki, and H. Mizoguti Histochemical study of the differentiation of microglial cells in the developing human cerebral hemispheres J Anat 166 1989 253 264 (Pubitemid 19262863)
    • (1989) Journal of Anatomy , vol.166 , pp. 253-264
    • Fujimoto, E.1    Miki, A.2    Mizoguti, H.3
  • 78
    • 0030459070 scopus 로고    scopus 로고
    • Effects of GM-CSF and ordinary supplements on the ramification of microglia in culture: A morphometrical study
    • DOI 10.1002/(SICI)1098-1136(199612)18:4<269::AID-GLIA2>3.0.CO;2-T
    • H. Fujita, J. Tanaka, K. Toku, N. Tateishi, Y. Suzuki, and S. Matsuda Effects of GM-CSF and ordinary supplements on the ramification of microglia in culture: a morphometrical study Glia 18 1996 269 281 (Pubitemid 27028293)
    • (1996) GLIA , vol.18 , Issue.4 , pp. 269-281
    • Fujita, H.1    Tanaka, J.2    Toku, K.3    Tateishi, N.4    Suzuki, Y.5    Matsuda, S.6    Sakanaka, M.7    Maeda, N.8
  • 79
    • 33747463996 scopus 로고    scopus 로고
    • Microglia biology in health and disease
    • DOI 10.1007/s11481-006-9015-5
    • G.A. Garden, and T. Moller Microglia biology in health and disease J Neuroimmune Pharmacol 1 2006 127 137 (Pubitemid 44257488)
    • (2006) Journal of Neuroimmune Pharmacology , vol.1 , Issue.2 , pp. 127-137
    • Garden, G.A.1    Moller, T.2
  • 80
    • 0036182751 scopus 로고    scopus 로고
    • Roles of the complement system in human neurodegenerative disorders: Pro-inflammatory and tissue remodeling activities
    • P. Gasque, J.W. Neal, S.K. Singhrao, E.P. McGreal, Y.D. Dean, and B.J. Van Roles of the complement system in human neurodegenerative disorders: pro-inflammatory and tissue remodeling activities Mol Neurobiol 25 2002 1 17 (Pubitemid 34165501)
    • (2002) Molecular Neurobiology , vol.25 , Issue.1 , pp. 1-17
    • Gasque, P.1    Neal, J.W.2    Singhrao, S.K.3    McGreal, E.P.4    Dean, Y.D.5    Van Beek, J.6    Morgan, B.P.7
  • 82
    • 78149360132 scopus 로고    scopus 로고
    • Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    • F. Ginhoux, M. Greter, M. Leboeuf, S. Nandi, P. See, and S. Gokhan Fate mapping analysis reveals that adult microglia derive from primitive macrophages Science 330 2010 841 845
    • (2010) Science , vol.330 , pp. 841-845
    • Ginhoux, F.1    Greter, M.2    Leboeuf, M.3    Nandi, S.4    See, P.5    Gokhan, S.6
  • 83
    • 0028881820 scopus 로고
    • Cell surface morphology identifies microglia as a distinct class of mononuclear phagocyte
    • D. Giulian, J. Li, S. Bartel, J. Broker, X. Li, and J.B. Kirkpatrick Cell surface morphology identifies microglia as a distinct class of mononuclear phagocyte J Neurosci 15 1995 7712 7726
    • (1995) J Neurosci , vol.15 , pp. 7712-7726
    • Giulian, D.1    Li, J.2    Bartel, S.3    Broker, J.4    Li, X.5    Kirkpatrick, J.B.6
  • 84
    • 33646251131 scopus 로고    scopus 로고
    • Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries
    • DOI 10.1096/fj.05-5234fje
    • I. Glezer, A. Lapointe, and S. Rivest Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries FASEB J 20 2006 750 752 (Pubitemid 46671203)
    • (2006) FASEB Journal , vol.20 , Issue.6 , pp. 750-752
    • Glezer, I.1    Lapointe, A.2    Rivest, S.3
  • 85
    • 34547127632 scopus 로고    scopus 로고
    • Neuroprotective role of the innate immune system by microglia
    • DOI 10.1016/j.neuroscience.2007.02.055, PII S0306452207002588
    • I. Glezer, A.R. Simard, and S. Rivest Neuroprotective role of the innate immune system by microglia Neuroscience 147 2007 867 883 (Pubitemid 47102534)
    • (2007) Neuroscience , vol.147 , Issue.4 , pp. 867-883
    • Glezer, I.1    Simard, A.R.2    Rivest, S.3
  • 87
    • 77953268611 scopus 로고    scopus 로고
    • Alternative activation of macrophages: Mechanism and functions
    • S. Gordon, and F.O. Martinez Alternative activation of macrophages: mechanism and functions Immunity 32 2010 593 604
    • (2010) Immunity , vol.32 , pp. 593-604
    • Gordon, S.1    Martinez, F.O.2
  • 88
    • 78149322599 scopus 로고    scopus 로고
    • Changing face of microglia
    • M.B. Graeber Changing face of microglia Science 330 2010 783 788
    • (2010) Science , vol.330 , pp. 783-788
    • Graeber, M.B.1
  • 90
    • 0036510168 scopus 로고    scopus 로고
    • Justavascular microglia migrate along brain microvessels following activation during early postnatal development
    • R. Grossmann, N. Stence, J. Carr, L. Fuller, M. Waite, and M.E. Dailey Justavascular microglia migrate along brain microvessels following activation during early postnatal development Glia 37 2002 229 240
    • (2002) Glia , vol.37 , pp. 229-240
    • Grossmann, R.1    Stence, N.2    Carr, J.3    Fuller, L.4    Waite, M.5    Dailey, M.E.6
  • 91
    • 1542373666 scopus 로고    scopus 로고
    • Microglia, macrophages, perivascular macrophages, and pericytes: A review of function and identification
    • DOI 10.1189/jlb.0303114
    • G.J. Guillemin, and B.J. Brew Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification J Leukoc Biol 75 2004 388 397 (Pubitemid 38316367)
    • (2004) Journal of Leukocyte Biology , vol.75 , Issue.3 , pp. 388-397
    • Guillemin, G.J.1    Brew, B.J.2
  • 92
    • 0042731679 scopus 로고    scopus 로고
    • 3 receptors in microglia cells
    • DOI 10.1046/j.1471-4159.2003.01919.x
    • C. Hammarberg, G. Schulte, and B.B. Fredholm Evidence for functional adenosine A3 receptors in microglia cells J Neurochem 86 2003 1051 1054 (Pubitemid 36988815)
    • (2003) Journal of Neurochemistry , vol.86 , Issue.4 , pp. 1051-1054
    • Hammarberg, C.1    Schulte, G.2    Fredholm, B.B.3
  • 93
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
    • DOI 10.1038/nn1997, PII NN1997
    • U.K. Hanisch, and H. Kettenmann Microglia: active sensor and versatile effector cells in the normal and pathologic brain Nat Neurosci 10 2007 1387 1394 (Pubitemid 350014685)
    • (2007) Nature Neuroscience , vol.10 , Issue.11 , pp. 1387-1394
    • Hanisch, U.-K.1    Kettenmann, H.2
  • 94
    • 84857008054 scopus 로고    scopus 로고
    • Microglia in the developing brain: A potential target with lifetime effects
    • G.J. Harry, and A.D. Kraft Microglia in the developing brain: a potential target with lifetime effects Neurotoxicology 33 2012 191 206
    • (2012) Neurotoxicology , vol.33 , pp. 191-206
    • Harry, G.J.1    Kraft, A.D.2
  • 95
    • 0034527782 scopus 로고    scopus 로고
    • Age-dependent cytokine responses: Trimethyltin hippocampal injury in wild-type, APOE knockout, and APOE4 mice
    • DOI 10.1006/brbi.2000.0606
    • G.J. Harry, C. Lefebvre d'Hellencourt, A. Bruccoleri, and D. Schmechel Age-dependent cytokine responses: trimethyltin hippocampal injury in wild-type, APOE knockout, and APOE4 mice Brain Behav Immun 14 2000 288 304 (Pubitemid 32060520)
    • (2000) Brain, Behavior, and Immunity , vol.14 , Issue.4 , pp. 288-304
    • Harry, G.J.1    Lefebvre D'Hellencourt, C.2    Bruccoleri, A.3    Schmechel, D.4
  • 97
    • 0031594241 scopus 로고    scopus 로고
    • NF-κB modulates lipopolysaccharide-induced microglial nerve growth factor expression
    • DOI 10.1002/(SICI)1098-1136(199804)22:4<401::AID-GLIA9>3.0.CO;2-5
    • K. Heese, B.L. Fiebich, J. Bauer, and U. Otten NF-kappaB modulates lipopolysaccharide-induced microglial nerve growth factor expression Glia 22 1998 401 407 (Pubitemid 28129717)
    • (1998) GLIA , vol.22 , Issue.4 , pp. 401-407
    • Heese, K.1    Fiebich, B.L.2    Bauer, J.3    Otten, U.4
  • 98
    • 61349193143 scopus 로고    scopus 로고
    • Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines
    • C.J. Henry, Y. Huang, A.M. Wynne, and J.P. Godbout Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1beta and anti-inflammatory IL-10 cytokines Brain Behav Immun 23 2009 309 317
    • (2009) Brain Behav Immun , vol.23 , pp. 309-317
    • Henry, C.J.1    Huang, Y.2    Wynne, A.M.3    Godbout, J.P.4
  • 99
  • 101
    • 4544322402 scopus 로고    scopus 로고
    • The aging brain: Morphomolecular senescence of cortical circuits
    • DOI 10.1016/j.tins.2004.07.013, PII S0166223604002413
    • P.R. Hof, and J.H. Morrison The aging brain: morphomolecular senescence of cortical circuits Trends Neurosci 27 2004 607 613 (Pubitemid 39221397)
    • (2004) Trends in Neurosciences , vol.27 , Issue.10 , pp. 607-613
    • Hof, P.R.1    Morrison, J.H.2
  • 102
    • 84856739147 scopus 로고    scopus 로고
    • Microglia are required for astroglial toll-like receptor 4 response and for optimal TLR2 and TLR3 response
    • T.H. Holm, S. Draeby, and T. Owens Microglia are required for astroglial toll-like receptor 4 response and for optimal TLR2 and TLR3 response Glia 60 2012 630 638
    • (2012) Glia , vol.60 , pp. 630-638
    • Holm, T.H.1    Draeby, S.2    Owens, T.3
  • 103
    • 73349117449 scopus 로고    scopus 로고
    • Activation and deactivation of periventricular white matter phagocytes during postnatal mouse development
    • M. Hristova, D. Cuthill, V. Zbarsky, A. Acosta-Saltos, A. Wallace, and K. Blight Activation and deactivation of periventricular white matter phagocytes during postnatal mouse development Glia 58 2010 11 28
    • (2010) Glia , vol.58 , pp. 11-28
    • Hristova, M.1    Cuthill, D.2    Zbarsky, V.3    Acosta-Saltos, A.4    Wallace, A.5    Blight, K.6
  • 104
    • 84868209611 scopus 로고    scopus 로고
    • Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia
    • X. Hu, P. Li, Y. Guo, H. Wang, R.K. Leak, and S. Chen Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia Stroke 43 2012 3063 3070
    • (2012) Stroke , vol.43 , pp. 3063-3070
    • Hu, X.1    Li, P.2    Guo, Y.3    Wang, H.4    Leak, R.K.5    Chen, S.6
  • 106
    • 71749083143 scopus 로고    scopus 로고
    • Activation of microglia by neuronal activity: Results from a new in vitro paradigm based on neuronal-silicon interfacing technology
    • J. Hung, M. Chansard, S.S. Ousman, M.D. Nguyen, and M.A. Colicos Activation of microglia by neuronal activity: results from a new in vitro paradigm based on neuronal-silicon interfacing technology Brain Behav Immun 24 2010 31 40
    • (2010) Brain Behav Immun , vol.24 , pp. 31-40
    • Hung, J.1    Chansard, M.2    Ousman, S.S.3    Nguyen, M.D.4    Colicos, M.A.5
  • 107
    • 0029555385 scopus 로고
    • Griffonia simplicifolia II lectin labels a population of radial glial cells in the embryonic rat brain
    • S.D. Hurley, and W.J. Streit Griffonia simplicifolia II lectin labels a population of radial glial cells in the embryonic rat brain Dev Neurosci 17 1995 324 334 (Pubitemid 26093787)
    • (1995) Developmental Neuroscience , vol.17 , Issue.5-6 , pp. 324-334
    • Hurley, S.D.1    Streit, W.J.2
  • 108
    • 0025335694 scopus 로고
    • Localization of morphologically distinct microglial populations in the developing human fetal brain: Implicatons for ontogeny
    • DOI 10.1016/0165-3806(90)90109-C
    • K.D. Hutchins, D.W. Dickson, W.K. Rashbaum, and W.D. Lyman Localization of morphologically distinct microglial populations in the developing human fetal brain: implications for ontogeny Brain Res Dev Brain Res 55 1990 95 102 (Pubitemid 20241307)
    • (1990) Developmental Brain Research , vol.55 , Issue.1 , pp. 95-102
    • Hutchins, K.D.1    Dickson, D.W.2    Rashbaum, W.K.3    Lyman, W.D.4
  • 110
    • 0018096010 scopus 로고
    • Radioautographic investigation of gliogenesis in the corpus callosum of young rats. II. Origin of microglial cells
    • K. Imamoto, and C.P. Leblond Radioautographic investigation of gliogenesis in the corpus callosum of young rats. II. Origin of microglial cells J Comp Neurol 180 1978 139 163
    • (1978) J Comp Neurol , vol.180 , pp. 139-163
    • Imamoto, K.1    Leblond, C.P.2
  • 112
    • 43149123118 scopus 로고    scopus 로고
    • Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia
    • DOI 10.1002/jnr.21610
    • Y. Irino, Y. Nakamura, K. Inoue, S. Kohsaka, and K. Ohsawa Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia J Neurosci Res 86 2008 1511 1519 (Pubitemid 351642444)
    • (2008) Journal of Neuroscience Research , vol.86 , Issue.7 , pp. 1511-1519
    • Irino, Y.1    Nakamura, Y.2    Inoue, K.3    Kohsaka, S.4    Ohsawa, K.5
  • 114
    • 0030759136 scopus 로고    scopus 로고
    • Life-span dendritic and spine changes in areas 10 and 18 of human cortex: A quantitative golgi study
    • DOI 10.1002/(SICI)1096-9861(19971006)386:4<661::AID-CNE11>3.0.CO;2- N
    • B. Jacobs, L. Driscoll, and M. Schall Life-span dendritic and spine changes in areas 10 and 18 of human cortex: a quantitative Golgi study J Comp Neurol 386 1997 661 680 (Pubitemid 27415497)
    • (1997) Journal of Comparative Neurology , vol.386 , Issue.4 , pp. 661-680
    • Jacobs, B.1    Driscoll, L.2    Schall, M.3
  • 115
    • 0034105793 scopus 로고    scopus 로고
    • Macrophage cell-conditioned medium promotes cholinergic differentiation of undifferentiated progenitors and synergizes with nerve growth factor action in the developing basal forebrain
    • DOI 10.1006/exnr.1999.7255
    • G.M. Jonakait, Y. Wen, Y. Wan, and L. Ni Macrophage cell-conditioned medium promotes cholinergic differentiation of undifferentiated progenitors and synergizes with nerve growth factor action in the developing basal forebrain Exp Neurol 161 2000 285 296 (Pubitemid 30136550)
    • (2000) Experimental Neurology , vol.161 , Issue.1 , pp. 285-296
    • Jonakait, G.M.1    Wen, Y.2    Wan, Y.3    Ni, L.4
  • 116
    • 79955732851 scopus 로고    scopus 로고
    • Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisomes proliferator-activated receptor-γ agonists
    • C.J. Kane, K.D. Phelan, L. Han, R.R. Smith, J. Xie, and J.C. Douglas Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisomes proliferator-activated receptor-γ agonists Brain Behav Immun 25 2011 S137 S145
    • (2011) Brain Behav Immun , vol.25
    • Kane, C.J.1    Phelan, K.D.2    Han, L.3    Smith, R.R.4    Xie, J.5    Douglas, J.C.6
  • 117
    • 0026331351 scopus 로고
    • Study of the transformation of amoeboid microglial cells into microglia labelled with the isolectin Griffonia simplicifolia in postnatal rats
    • C. Kaur, and E.A. Ling Study of the transformation of amoeboid microglial cells into microglia labelled with the isolectin Griffonia simplicifolia in postnatal rats Acta Anat (Basel) 142 1991 118 125
    • (1991) Acta Anat (Basel) , vol.142 , pp. 118-125
    • Kaur, C.1    Ling, E.A.2
  • 118
    • 0027343512 scopus 로고
    • Electrophysiological behavior of microglia
    • H. Kettenmann, R. Banati, and W. Walz Electrophysiological behavior of microglia Glia 7 1993 93 101
    • (1993) Glia , vol.7 , pp. 93-101
    • Kettenmann, H.1    Banati, R.2    Walz, W.3
  • 120
    • 84875892857 scopus 로고    scopus 로고
    • Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
    • K. Kierdorf, E. Erny, T. Goldmann, V. Sander, C. Schulz, and E.G. Perdiguero Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways Nat Neurosci 16 2013 273 279
    • (2013) Nat Neurosci , vol.16 , pp. 273-279
    • Kierdorf, K.1    Erny, E.2    Goldmann, T.3    Sander, V.4    Schulz, C.5    Perdiguero, E.G.6
  • 121
    • 70350558453 scopus 로고    scopus 로고
    • Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord
    • K.A. Kigerl, J.C. Gensel, D.P. Ankeny, J.K. Alexander, D.J. Donnelly, and P.G. Popovich Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord J Neurosci 29 2009 13435 13444
    • (2009) J Neurosci , vol.29 , pp. 13435-13444
    • Kigerl, K.A.1    Gensel, J.C.2    Ankeny, D.P.3    Alexander, J.K.4    Donnelly, D.J.5    Popovich, P.G.6
  • 122
    • 45049087782 scopus 로고    scopus 로고
    • TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration
    • U. Kilic, E. Kilic, C.M. Matter, C.L. Bassetti, and D.M. Hermann TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration Neurobiol Dis 31 2008 33 40
    • (2008) Neurobiol Dis , vol.31 , pp. 33-40
    • Kilic, U.1    Kilic, E.2    Matter, C.M.3    Bassetti, C.L.4    Hermann, D.M.5
  • 123
  • 124
    • 2442698974 scopus 로고    scopus 로고
    • Type 2 monocyte and microglia differentiation mediated by glatiramer acetate therapy in patients with multiple sclerosis
    • H.J. Kim, I. Ifergan, J.P. Antel, R. Seguin, M. Duddy, and Y. Lapierre Type 2 monocyte and microglia differentiation mediated by glatiramer acetate therapy in patients with multiple sclerosis J Immunol 172 2004 7144 7153 (Pubitemid 38669158)
    • (2004) Journal of Immunology , vol.172 , Issue.11 , pp. 7144-7153
    • Kim, H.J.1    Ifergan, I.2    Antel, J.P.3    Seguin, R.4    Duddy, M.5    Lapierre, Y.6    Jalili, F.7    Bar-Or, A.8
  • 125
    • 0036570325 scopus 로고    scopus 로고
    • Correlation between the sequential ingrowth of afferents and transient patterns of cortical lamination in preterm infants
    • DOI 10.1002/ar.10069
    • I. Kostovic, and M. Judas Correlation between the sequential ingrowth of afferents and transient patterns of cortical lamination in preterm infants Anat Rec 267 2002 1 6 (Pubitemid 34465292)
    • (2002) Anatomical Record , vol.267 , Issue.1 , pp. 1-6
    • Kostovi, I.1    Judas, M.2
  • 126
    • 84857194922 scopus 로고    scopus 로고
    • Activation of serotonin receptors promotes microglial injury-induced motility but attenuates phagocytic activity
    • G. Krabbe, V. Matyash, U. Pannasch, L. Mamer, H.W. Boddeke, and H. Kettenmann Activation of serotonin receptors promotes microglial injury-induced motility but attenuates phagocytic activity Brain Behav Immun 26 2012 419 428
    • (2012) Brain Behav Immun , vol.26 , pp. 419-428
    • Krabbe, G.1    Matyash, V.2    Pannasch, U.3    Mamer, L.4    Boddeke, H.W.5    Kettenmann, H.6
  • 127
    • 84877102781 scopus 로고    scopus 로고
    • Beyond pattern recognition: NOD-like receptors in dendritic cells
    • 10.1016/j.it.2012.12.003
    • J.K. Krishnaswamy, T. Chu, and S.C. Eisenbarth Beyond pattern recognition: NOD-like receptors in dendritic cells Trends Immunol 2013 10.1016/j.it.2012.12.003
    • (2013) Trends Immunol
    • Krishnaswamy, J.K.1    Chu, T.2    Eisenbarth, S.C.3
  • 130
    • 0026073369 scopus 로고
    • Microglial cells are a component of the perivascular glia limitans
    • H. Lassmann, F. Zimprich, K. Vass, and W.F. Hickey Microglial cells are a component of the perivascular glia limitans J Neurosci Res 28 1991 236 243
    • (1991) J Neurosci Res , vol.28 , pp. 236-243
    • Lassmann, H.1    Zimprich, F.2    Vass, K.3    Hickey, W.F.4
  • 131
    • 0025220976 scopus 로고
    • Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
    • L.J. Lawson, V.H. Perry, P. Dri, and S. Gordon Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain Neuroscience 39 1990 151 170
    • (1990) Neuroscience , vol.39 , pp. 151-170
    • Lawson, L.J.1    Perry, V.H.2    Dri, P.3    Gordon, S.4
  • 132
    • 0026552605 scopus 로고
    • Turnover of resident microglia in the normal adult mouse brain
    • L.J. Lawson, V.H. Perry, and S. Gordon Turnover of resident microglia in the normal adult mouse brain Neuroscience 48 1992 405 415
    • (1992) Neuroscience , vol.48 , pp. 405-415
    • Lawson, L.J.1    Perry, V.H.2    Gordon, S.3
  • 133
    • 77957316313 scopus 로고    scopus 로고
    • CX3CR1 deficiency alters microglial activation and reduces β-amyloid deposition in two Alzheimer's disease mouse models
    • S. Lee, N.H. Varvel, M.E. Konerth, G. Zu, A.E. Cardona, and R.M. Ransohoff CX3CR1 deficiency alters microglial activation and reduces β-amyloid deposition in two Alzheimer's disease mouse models Am J Pathol 177 2010 2549 2562
    • (2010) Am J Pathol , vol.177 , pp. 2549-2562
    • Lee, S.1    Varvel, N.H.2    Konerth, M.E.3    Zu, G.4    Cardona, A.E.5    Ransohoff, R.M.6
  • 134
    • 75849151435 scopus 로고    scopus 로고
    • Innate immunity and neuroinflammation in the CNS: The role of microglia in toll-like receptor-mediated neuronal injury
    • S. Lehnardt Innate immunity and neuroinflammation in the CNS: the role of microglia in toll-like receptor-mediated neuronal injury Glia 2010 58 2010 253 263
    • (2010) Glia , vol.2010 , Issue.58 , pp. 253-263
    • Lehnardt, S.1
  • 137
    • 40449097556 scopus 로고    scopus 로고
    • A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS
    • DOI 10.1523/JNEUROSCI.4760-07.2008
    • S. Lehnardt, E. Schott, T. Trimbuch, D. Laubisch, C. Krueger, and G. Wulczyn A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS J Neurosci 28 2008 2320 2331 (Pubitemid 351348178)
    • (2008) Journal of Neuroscience , vol.28 , Issue.10 , pp. 2320-2331
    • Lehnardt, S.1    Schott, E.2    Trimbuch, T.3    Laubisch, D.4    Krueger, C.5    Wulczyn, G.6    Nitsch, R.7    Weber, J.R.8
  • 138
    • 84873693906 scopus 로고    scopus 로고
    • Microglia are essential to masculinization of brain and behavior
    • K.M. Lenz, B.M. Nugent, R. Haliyur, and M.M. McCarthy Microglia are essential to masculinization of brain and behavior J Neurosci 33 2013 2761 2772
    • (2013) J Neurosci , vol.33 , pp. 2761-2772
    • Lenz, K.M.1    Nugent, B.M.2    Haliyur, R.3    McCarthy, M.M.4
  • 143
    • 51349095669 scopus 로고    scopus 로고
    • Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity
    • K.O. Lopes, D.L. Sparks, and W.J. Streit Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity Glia 56 2008 1048 1060
    • (2008) Glia , vol.56 , pp. 1048-1060
    • Lopes, K.O.1    Sparks, D.L.2    Streit, W.J.3
  • 144
    • 77950826971 scopus 로고    scopus 로고
    • Microglia in the aging brain: Relevance to neurodegeneration
    • X.G. Luo, J.Q. Ding, and S.D. Chen Microglia in the aging brain: relevance to neurodegeneration Mol Neurodegener 5 2010 12
    • (2010) Mol Neurodegener , vol.5 , pp. 12
    • Luo, X.G.1    Ding, J.Q.2    Chen, S.D.3
  • 145
    • 34547680192 scopus 로고    scopus 로고
    • CD200 ligand-receptor interaction modulates microglial activation in vivo and in vitro: A role for IL-4
    • DOI 10.1523/JNEUROSCI.1781-07.2007
    • A. Lyons, E.J. Downer, S. Crotty, Y.M. Nolan, K.H. Mills, and M.A. Lynch CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4 J Neurosci 27 2007 8309 8313 (Pubitemid 47219605)
    • (2007) Journal of Neuroscience , vol.27 , Issue.31 , pp. 8309-8313
    • Lyons, A.1    Downer, E.J.2    Crotty, S.3    Nolan, Y.M.4    Mills, K.H.G.5    Lynch, M.A.6
  • 146
    • 84863400997 scopus 로고    scopus 로고
    • Microglia in the outer retina and their relevance to pathogenesis of age-related macular degeneration
    • W. Ma, L. Zhao, and W.T. Wong Microglia in the outer retina and their relevance to pathogenesis of age-related macular degeneration Adv Exp Med Biol 723 2012 37 42
    • (2012) Adv Exp Med Biol , vol.723 , pp. 37-42
    • Ma, W.1    Zhao, L.2    Wong, W.T.3
  • 147
    • 84870515243 scopus 로고    scopus 로고
    • A2E accumulation influences retinal microglial activation and complement regulation
    • W. Ma, S. Coon, L. Zhao, R.N. Fariss, and W.T. Wong A2E accumulation influences retinal microglial activation and complement regulation Neurobiol Aging 34 2013 943 960
    • (2013) Neurobiol Aging , vol.34 , pp. 943-960
    • Ma, W.1    Coon, S.2    Zhao, L.3    Fariss, R.N.4    Wong, W.T.5
  • 148
    • 13844275290 scopus 로고    scopus 로고
    • Phagocytosis in the developing CNS: More than clearing the corpses
    • DOI 10.1016/j.conb.2005.01.006
    • M. Mallat, J.L. Marin-Teva, and C. Cheret Phagocytosis in the developing CNS: more than clearing the corpses Curr Opin Neurobiol 15 2005 101 107 (Pubitemid 40249968)
    • (2005) Current Opinion in Neurobiology , vol.15 , Issue.1 , pp. 101-107
    • Mallat, M.1    Marin-Teva, J.L.2    Cheret, C.3
  • 149
    • 0022347657 scopus 로고
    • Early vascularization of the embryonic cerebral cortex: Golgi and electron microscopic studies
    • DOI 10.1002/cne.902410210
    • M. Marin-Padilla Early vascularization of the embryonic cerebral cortex: Golgi and electron microscopic studies J Comp Neurol 241 1985 237 249 (Pubitemid 16202815)
    • (1985) Journal of Comparative Neurology , vol.241 , Issue.2 , pp. 237-249
    • Marin-Padilla, M.1
  • 150
    • 1942447829 scopus 로고    scopus 로고
    • Microglia Promote the Death of Developing Purkinje Cells
    • DOI 10.1016/S0896-6273(04)00069-8
    • J.L. Marin-Teva, I. Dusart, C. Colin, A. Gervais, N. van Rooijen, and M. Mallat Microglia promote the death of developing Purkinje cells Neuron 41 2004 535 547 (Pubitemid 38253066)
    • (2004) Neuron , vol.41 , Issue.4 , pp. 535-547
    • Marin-Teva, J.L.1    Dusart, I.2    Colin, C.3    Gervais, A.4    Van Rooijen, N.5    Mallat, M.6
  • 151
    • 62149113356 scopus 로고    scopus 로고
    • Subventricular zone microglia possess a unique capacity for massive in vitro expansion
    • G.P. Marshall 2nd, M. Demir, D.A. Steindler, and E.D. Laywell Subventricular zone microglia possess a unique capacity for massive in vitro expansion Glia 56 2008 1799 1808
    • (2008) Glia , vol.56 , pp. 1799-1808
    • Marshall II, G.P.1    Demir, M.2    Steindler, D.A.3    Laywell, E.D.4
  • 152
    • 19344364684 scopus 로고    scopus 로고
    • Hematopoietic cells maintain hematopoietic fates upon entering the brain
    • DOI 10.1084/jem.20050030
    • M. Massengale, A.J. Wagers, H. Vogel, and I.L. Weissman Hematopoietic cells maintain hematopoietic fates upon entering the brain J Exp Med 201 2005 1579 1589 (Pubitemid 40721003)
    • (2005) Journal of Experimental Medicine , vol.201 , Issue.10 , pp. 1579-1589
    • Massengale, M.1    Wagers, A.J.2    Vogel, H.3    Weissman, I.L.4
  • 153
    • 80052791226 scopus 로고    scopus 로고
    • Capillary blood flow around microglial somata determines dynamics of microglial processes in ischemic conditions
    • T. Masuda, D. Croom, H. Hida, and S.A. Kirov Capillary blood flow around microglial somata determines dynamics of microglial processes in ischemic conditions Glia 59 2011 1744 1753
    • (2011) Glia , vol.59 , pp. 1744-1753
    • Masuda, T.1    Croom, D.2    Hida, H.3    Kirov, S.A.4
  • 154
    • 0345999337 scopus 로고
    • Absence of donor-type major histocompatibility complex class I antigen-bearing microglia in the rat central nervous system of radiation bone marrow chimeras
    • DOI 10.1016/0165-5728(87)90032-4
    • Y. Matsumoto, and M. Fujiwara Absence of donor-type major histocompatibility complex class I antigen-bearing microglia in the rat central nervous system of radiation bone marrow chimeras J Neuroimmunol 17 1987 71 82 (Pubitemid 18017111)
    • (1987) Journal of Neuroimmunology , vol.17 , Issue.1 , pp. 71-82
    • Matsumoto, Y.1    Fujiwara, M.2
  • 155
    • 0029610011 scopus 로고
    • The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
    • DOI 10.1016/0165-0173(95)00011-9
    • P.L. McGeer, and E.G. McGeer The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases Brain Res Brain Res Rev 21 1995 195 218 (Pubitemid 26061873)
    • (1995) Brain Research Reviews , vol.21 , Issue.2 , pp. 195-218
    • McGeer, P.L.1    McGeer, E.G.2
  • 156
    • 0034210449 scopus 로고    scopus 로고
    • How does the immune system distinguish self from nonself?
    • DOI 10.1006/smim.2000.0230
    • R. Medzhitov, and C.A. Janeway Jr. How does the immune system distinguish self from nonself? Semin Immunol 12 2000 185 188 (Pubitemid 30479437)
    • (2000) Seminars in Immunology , vol.12 , Issue.3 , pp. 185-188
    • Medzhitov, R.1    Janeway Jr., C.A.2
  • 158
    • 33750601018 scopus 로고    scopus 로고
    • Upregulated expression of purinergic P2X7 receptor in Alzheimer disease and amyloid-β peptide-treated microglia and in peptide-injected rat hippocampus
    • DOI 10.1097/01.jnen.0000240470.97295.d3, PII 0000507220061100000008
    • J.G. McLarnon, J.K. Ryu, D.G. Walker, and H.B. Choi Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus J Neuropathol Exp Neurol 65 2006 1090 1097 (Pubitemid 44684667)
    • (2006) Journal of Neuropathology and Experimental Neurology , vol.65 , Issue.11 , pp. 1090-1097
    • McLarnon, J.G.1    Ryu, J.K.2    Walker, D.G.3    Choi, H.B.4
  • 159
    • 84866696413 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors inhibit microglial glutamate release
    • 10.1042/AN20120044 (art:e00094)
    • S.M. McMullan, B. Phanavanh, G.G. Li, and S.W. Barger Metabotropic glutamate receptors inhibit microglial glutamate release ASN Neuro 4 5 2012 10.1042/AN20120044 (art:e00094)
    • (2012) ASN Neuro , vol.4 , Issue.5
    • McMullan, S.M.1    Phanavanh, B.2    Li, G.G.3    Barger, S.W.4
  • 160
    • 79957901900 scopus 로고    scopus 로고
    • Interleukin (IL)-1 and IL-6 regulation of neural progenitor cell proliferation with hippocampal injury: Differential regulatory pathways in the subgranular zone (SGZ) of the adolescent and mature mouse brain
    • C.A. McPherson, M. Aoyama, and G.J. Harry Interleukin (IL)-1 and IL-6 regulation of neural progenitor cell proliferation with hippocampal injury: differential regulatory pathways in the subgranular zone (SGZ) of the adolescent and mature mouse brain Brain Behav Immun 25 2011 850 862
    • (2011) Brain Behav Immun , vol.25 , pp. 850-862
    • McPherson, C.A.1    Aoyama, M.2    Harry, G.J.3
  • 161
    • 79751537734 scopus 로고    scopus 로고
    • Injury-induced neurogenesis: Consideration of resident microglia as supportive of neural progenitor cells
    • C.A. McPherson, A.D. Kraft, and G.J. Harry Injury-induced neurogenesis: consideration of resident microglia as supportive of neural progenitor cells Neurotox Res 19 2011 341 352
    • (2011) Neurotox Res , vol.19 , pp. 341-352
    • McPherson, C.A.1    Kraft, A.D.2    Harry, G.J.3
  • 164
    • 67349251479 scopus 로고    scopus 로고
    • Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta
    • A. Michelucci, T. Heurtaux, L. Grandbarbe, E. Morga, and P. Heuschling Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: effects of oligomeric and fibrillar amyloid-beta J Neuroimmunol 210 2009 3 12
    • (2009) J Neuroimmunol , vol.210 , pp. 3-12
    • Michelucci, A.1    Heurtaux, T.2    Grandbarbe, L.3    Morga, E.4    Heuschling, P.5
  • 165
    • 78650996588 scopus 로고    scopus 로고
    • Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration
    • J. Mikita, N. Dubourdieu-Cassagno, M.S. Deloire, A. Vekris, M. Biran, and G. Raffard Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration Mult Scler 17 2011 2 15
    • (2011) Mult Scler , vol.17 , pp. 2-15
    • Mikita, J.1    Dubourdieu-Cassagno, N.2    Deloire, M.S.3    Vekris, A.4    Biran, M.5    Raffard, G.6
  • 166
    • 42649097901 scopus 로고    scopus 로고
    • The effects of aging, injury and disease on microglial function: A case for cellular senescence
    • DOI 10.1017/S1740925X08000136, PII S1740925X08000136
    • K.R. Miller, and W.J. Streit The effects of aging, injury and disease on microglial function: a case for cellular senescence Neuron Glia Biol 3 2007 245 253 (Pubitemid 351594233)
    • (2007) Neuron Glia Biology , vol.3 , Issue.3 , pp. 245-253
    • Miller, K.R.1    Streit, W.J.2
  • 167
    • 37449011204 scopus 로고    scopus 로고
    • In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brain
    • R. Mingam, V. De Smedt, T. Amedee, R.M. Bluthe, K.W. Kelley, and R. Dantzer In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1 beta in the murine brain Brain Behav Immun 22 2008 234 244
    • (2008) Brain Behav Immun , vol.22 , pp. 234-244
    • Mingam, R.1    De Smedt, V.2    Amedee, T.3    Bluthe, R.M.4    Kelley, K.W.5    Dantzer, R.6
  • 168
    • 0035105538 scopus 로고    scopus 로고
    • Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude
    • M. Mittelbronn, K. Dietz, H.J. Schluesener, and R. Meyermann Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude Acta Neuropathol 101 2001 249 255 (Pubitemid 32219759)
    • (2001) Acta Neuropathologica , vol.101 , Issue.3 , pp. 249-255
    • Mittelbronn, M.1    Dietz, K.2    Schluesener, H.J.3    Meyermann, R.4
  • 170
    • 33750213032 scopus 로고    scopus 로고
    • Distribution and differentiation of microglia in the human encephalon during the first two trimesters of gestation
    • DOI 10.1002/cne.21123
    • A. Monier, P. Evrard, P. Gressens, and C. Verney Distribution and differentiation of microglia in the human encephalon during the first two trimesters of gestation J Comp Neurol 499 2006 565 582 (Pubitemid 44606764)
    • (2006) Journal of Comparative Neurology , vol.499 , Issue.4 , pp. 565-582
    • Monier, A.1    Evrard, P.2    Gressens, P.3    Verney, C.4
  • 171
    • 1442299203 scopus 로고    scopus 로고
    • The facial nerve axotomy model
    • DOI 10.1016/j.brainresrev.2003.11.004, PII S0165017303002595
    • L.B. Moran, and M.B. Graeber The facial nerve axotomy model Brain Res Rev 44 2004 154 178 (Pubitemid 38293431)
    • (2004) Brain Research Reviews , vol.44 , Issue.2-3 , pp. 154-178
    • Moran, L.B.1    Graeber, M.B.2
  • 172
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • D.M. Mosser, and J.P. Edwards Exploring the full spectrum of macrophage activation Nat Rev Immunol 8 2008 958 969
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 173
    • 77950619535 scopus 로고    scopus 로고
    • Long-term gliosis and molecular changes in the cervical spinal cord of the rhesus monkey after traumatic brain injury
    • K. Nagamoto-Combs, R.J. Morecraft, W.G. Darling, and C.K. Combs Long-term gliosis and molecular changes in the cervical spinal cord of the rhesus monkey after traumatic brain injury J Neurotrauma 27 2010 565 585
    • (2010) J Neurotrauma , vol.27 , pp. 565-585
    • Nagamoto-Combs, K.1    Morecraft, R.J.2    Darling, W.G.3    Combs, C.K.4
  • 174
    • 0026659883 scopus 로고
    • Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins
    • M. Neeper, A.M. Schmidt, J. Brett, S.D. Yan, F. Wang, and Y.C. Pan Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins J Biol Chem 267 1992 14998 15004
    • (1992) J Biol Chem , vol.267 , pp. 14998-15004
    • Neeper, M.1    Schmidt, A.M.2    Brett, J.3    Yan, S.D.4    Wang, F.5    Pan, Y.C.6
  • 175
    • 0035149257 scopus 로고    scopus 로고
    • Control of glial immune function by neurons
    • DOI 10.1002/glia.1108
    • H. Neumann Control of glial immune function by neurons Glia 36 2001 191 199 (Pubitemid 33055907)
    • (2001) GLIA , vol.36 , Issue.2 , pp. 191-199
    • Neumann, H.1
  • 176
    • 33847004767 scopus 로고    scopus 로고
    • Toll-like receptor ligands and CD154 stimulate microglia to produce a factor(s) that promotes excess cholinergic differentiation in the developing rat basal forebrain: Implications for neurodevelopmental disorders
    • DOI 10.1203/01.pdr.0000249981.70618.18, PII 0000645020070100000005
    • L. Ni, G. Acevedo, B. Muralidharan, N. Padala, J. To, and G.M. Jonakait Toll-like receptor ligands and CD154 stimulate microglia to produce a factor(s) that promotes excess cholinergic differentiation in the developing rat basal forebrain: implications for neurodevelopmental disorders Pediatr Res 61 2007 15 20 (Pubitemid 46352309)
    • (2007) Pediatric Research , vol.61 , Issue.1 , pp. 15-20
    • Ni, L.1    Acevedo, G.2    Muralidharan, B.3    Padala, N.4    To, J.5    Jonakait, G.M.6
  • 177
    • 19744380563 scopus 로고    scopus 로고
    • Neuroscience: Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • DOI 10.1126/science.1110647
    • A. Nimmerjahn, F. Kirchhoff, and F. Helmchen Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo Science 308 2005 1314 1318 (Pubitemid 40746128)
    • (2005) Science , vol.308 , Issue.5726 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 179
    • 0034001914 scopus 로고    scopus 로고
    • AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia
    • M. Noda, H. Nakanishi, J. Nabekura, and N. Akaike AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia J Neurosci 20 2000 251 258 (Pubitemid 30220512)
    • (2000) Journal of Neuroscience , vol.20 , Issue.1 , pp. 251-258
    • Noda, M.1    Nakanishi, H.2    Nabekura, J.3    Akaike, N.4
  • 180
    • 84872733391 scopus 로고    scopus 로고
    • Microglia of the aged brain: Primed to be activated and resistant to regulation
    • D.M. Norden, and J.P. Godbout Microglia of the aged brain: primed to be activated and resistant to regulation Neuropathol Appl Neurobiol 39 2012 19 34
    • (2012) Neuropathol Appl Neurobiol , vol.39 , pp. 19-34
    • Norden, D.M.1    Godbout, J.P.2
  • 181
    • 0036788971 scopus 로고    scopus 로고
    • Molecular physiology of P2X receptors
    • R.A. North Molecular physiology of P2X receptors Physiol Rev 82 2002 1013 1067
    • (2002) Physiol Rev , vol.82 , pp. 1013-1067
    • North, R.A.1
  • 182
    • 0141686970 scopus 로고    scopus 로고
    • 2y receptors
    • DOI 10.1016/S0006-8993(03)03028-2
    • T. Ogata, M. Chuai, T. Morino, H. Yamamoto, Y. Nakamura, and P. Schubert Adenosine triphosphate inhibits cytokine release from lipopolysaccharide- activated microglia via P2y receptors Brain Res 981 2003 174 183 (Pubitemid 37281233)
    • (2003) Brain Research , vol.981 , Issue.1-2 , pp. 174-183
    • Ogata, T.1    Chuai, M.2    Morino, T.3    Yamamoto, H.4    Nakamura, Y.5    Schubert, P.6
  • 183
    • 0028309624 scopus 로고
    • Effects of ageing on microglia in the normal rat brain: Immunohistochemical observations
    • K. Ogura, M. Ogawa, and M. Yoshida Effects of ageing on microglia in the normal rat brain: immunohistochemical observations Neuroreport 5 1994 1224 1226 (Pubitemid 24199801)
    • (1994) NeuroReport , vol.5 , Issue.10 , pp. 1224-1226
    • Ogura, K.-I.1    Ogawa, M.2    Yoshida, M.3
  • 184
    • 33947540584 scopus 로고    scopus 로고
    • 12 receptors in ATP-induced microglial chemotaxis
    • DOI 10.1002/glia.20489
    • K. Ohsawa, Y. Irino, Y. Nakamura, C. Akazawa, K. Inoue, and S. Kohsaka Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis Glia 55 2007 604 616 (Pubitemid 46474302)
    • (2007) GLIA , vol.55 , Issue.6 , pp. 604-616
    • Ohsawa, K.1    Irino, Y.2    Nakamura, Y.3    Akazawa, C.4    Inoue, K.5    Kohsaka, S.6
  • 185
    • 77952573195 scopus 로고    scopus 로고
    • P2Y12 receptor-mediated integrin-beta1 activation regulates microglial process extension induced by ATP
    • K. Ohsawa, Y. Irino, T. Sanagi, Y. Nakamura, E. Suzuki, and K. Inoue P2Y12 receptor-mediated integrin-beta1 activation regulates microglial process extension induced by ATP Glia 58 2010 790 801
    • (2010) Glia , vol.58 , pp. 790-801
    • Ohsawa, K.1    Irino, Y.2    Sanagi, T.3    Nakamura, Y.4    Suzuki, E.5    Inoue, K.6
  • 187
    • 83055184202 scopus 로고    scopus 로고
    • Identification of a microglia phenotype supportive of remyelination
    • M. Olah, S. Amor, N. Brouwer, J. Vinet, B. Eggen, and K. Biber Identification of a microglia phenotype supportive of remyelination Glia 60 2012 306 321
    • (2012) Glia , vol.60 , pp. 306-321
    • Olah, M.1    Amor, S.2    Brouwer, N.3    Vinet, J.4    Eggen, B.5    Biber, K.6
  • 188
    • 4644232615 scopus 로고    scopus 로고
    • Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs
    • J.K. Olson, and S.D. Miller Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs J Immunol 173 2004 3916 3924 (Pubitemid 39280755)
    • (2004) Journal of Immunology , vol.173 , Issue.6 , pp. 3916-3924
    • Olson, J.K.1    Miller, S.D.2
  • 191
    • 0038143359 scopus 로고    scopus 로고
    • 7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease
    • DOI 10.1074/jbc.M209478200
    • L.K. Parvathenani, S. Tertyshnikova, C.R. Greco, S.B. Roberts, B. Robertson, and R. Posmantur P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease J Biol Chem 278 2003 13309 13317 (Pubitemid 36800102)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.15 , pp. 13309-13317
    • Parvathenani, L.K.1    Tertyshnikova, S.2    Greco, C.R.3    Roberts, S.B.4    Robertson, B.5    Posmantur, R.6
  • 192
    • 83055181916 scopus 로고    scopus 로고
    • Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice
    • C. Perego, S. Fumagalli, and M.G. De Simoni Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice J Neuroinflammation 8 2011 174
    • (2011) J Neuroinflammation , vol.8 , pp. 174
    • Perego, C.1    Fumagalli, S.2    De Simoni, M.G.3
  • 193
    • 0022387412 scopus 로고
    • Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain
    • DOI 10.1016/0306-4522(85)90215-5
    • V.H. Perry, D.A. Hume, and S. Gordon Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain Neuroscience 15 1985 313 326 (Pubitemid 16197076)
    • (1985) Neuroscience , vol.15 , Issue.2 , pp. 313-326
    • Perry, V.H.1    Hume, D.A.2    Gordon, S.3
  • 194
    • 0027352040 scopus 로고
    • Altered antigen expression of microglia in the aged rodent CNS
    • V.H. Perry, M.K. Matyszak, and S. Fearn Altered antigen expression of microglia in the aged rodent CNS Glia 7 1993 60 67
    • (1993) Glia , vol.7 , pp. 60-67
    • Perry, V.H.1    Matyszak, M.K.2    Fearn, S.3
  • 195
    • 78650063641 scopus 로고    scopus 로고
    • The role of microglia in synaptic stripping and synaptic degeneration: A revised perspective
    • V.H. Perry, and V. O'Connor The role of microglia in synaptic stripping and synaptic degeneration: a revised perspective ASN Neuro 2 2010 e00047
    • (2010) ASN Neuro , vol.2 , pp. 00047
    • Perry, V.H.1    O'Connor, V.2
  • 196
    • 34848843543 scopus 로고    scopus 로고
    • Neurotransmitter receptors on microglia
    • DOI 10.1016/j.tins.2007.07.007, PII S0166223607002111
    • J.M. Pocock, and H. Kettenmann Neurotransmitter receptors on microglia Trends Neurosci 30 2007 527 535 (Pubitemid 47513237)
    • (2007) Trends in Neurosciences , vol.30 , Issue.10 , pp. 527-535
    • Pocock, J.M.1    Kettenmann, H.2
  • 198
    • 0029451822 scopus 로고
    • Calcitonin gene-related peptide and ATP induce immediate early gene expression in cultured rat microglial cells
    • J. Priller, C.A. Haas, M. Reddington, and G.W. Kreutzberg Calcitonin gene-related peptide and ATP induce immediate early gene expression in cultured rat microglial cells Glia 15 1995 447 457
    • (1995) Glia , vol.15 , pp. 447-457
    • Priller, J.1    Haas, C.A.2    Reddington, M.3    Kreutzberg, G.W.4
  • 200
    • 0033811463 scopus 로고    scopus 로고
    • Programmed cell death in the developing human telencephalon
    • S. Rakic, and N. Zecevic Programmed cell death in the developing human telencephalon Eur J Neurosci 12 2000 2721 2734
    • (2000) Eur J Neurosci , vol.12 , pp. 2721-2734
    • Rakic, S.1    Zecevic, N.2
  • 201
    • 67650966680 scopus 로고    scopus 로고
    • Microglial physiology: Unique stimuli, specialized responses
    • R.M. Ransohoff, and V.H. Perry Microglial physiology: unique stimuli, specialized responses Annu Rev Immunol 27 2009 119 145
    • (2009) Annu Rev Immunol , vol.27 , pp. 119-145
    • Ransohoff, R.M.1    Perry, V.H.2
  • 202
    • 33646786443 scopus 로고    scopus 로고
    • 7 receptor immunoreactive profile confined to resting and activated microglia in the epileptic brain
    • DOI 10.1016/j.brainres.2006.03.040, PII S0006899306006159
    • P.M. Rappold, E. Lynd-Balta, and S.A. Joseph P2X7 receptor immunoreactive profile confined to resting and activated microglia in the epileptic brain Brain Res 1089 2006 171 178 (Pubitemid 43766366)
    • (2006) Brain Research , vol.1089 , Issue.1 , pp. 171-178
    • Rappold, P.M.1    Lynd-Balta, E.2    Joseph, S.A.3
  • 203
    • 0038723231 scopus 로고    scopus 로고
    • "Recruitment signals" from apoptotic cells: Invitation to a quiet meal
    • DOI 10.1016/S0092-8674(03)00471-9
    • K.S. Ravichandran "Recruitment signals" from apoptotic cells: invitation to a quiet meal Cell 113 2003 817 820 (Pubitemid 36792025)
    • (2003) Cell , vol.113 , Issue.7 , pp. 817-820
    • Ravichandran, K.S.1
  • 204
    • 70349323417 scopus 로고    scopus 로고
    • CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation
    • E.G. Reed-Geaghan, J.C. Savage, A.G. Hise, and G.E. Landreth CD14 and toll-like receptors 2 and 4 are required for fibrillar A{beta}-stimulated microglial activation J Neurosci 29 2009 11982 11992
    • (2009) J Neurosci , vol.29 , pp. 11982-11992
    • Reed-Geaghan, E.G.1    Savage, J.C.2    Hise, A.G.3    Landreth, G.E.4
  • 205
    • 20544449468 scopus 로고    scopus 로고
    • Microglia in the cerebral wall of the human telencephalon at second trimester
    • DOI 10.1093/cercor/bhh194
    • P. Rezaie, A. Dean, D. Male, and N. Ulfig Microglia in the cerebral wall of the human telencephalon at second trimester Cereb Cortex 15 2005 938 949 (Pubitemid 40848063)
    • (2005) Cerebral Cortex , vol.15 , Issue.7 , pp. 938-949
    • Rezaie, P.1    Dean, A.2    Male, D.3    Ulfig, N.4
  • 206
    • 0033564675 scopus 로고    scopus 로고
    • Colonisation of the developing human brain and spinal cord by microglia: A review
    • DOI 10.1002/(SICI)1097-0029(19990615)45:6<359::AID-JEMT4>3.0.CO;2-D
    • P. Rezaie, and D. Male Colonisation of the developing human brain and spinal cord by microglia: a review Microsc Res Tech 45 1999 359 382 (Pubitemid 29321051)
    • (1999) Microscopy Research and Technique , vol.45 , Issue.6 , pp. 359-382
    • Rezaie, P.1    Male, D.2
  • 207
    • 79851482960 scopus 로고    scopus 로고
    • Pattern of invasion of the embryonic mouse spinal cord by microglial cells at the time of the onset of functional neuronal networks
    • C. Rigato, R. Buckinx, H. Le-Corronc, J.M. Rigo, and P. Legendre Pattern of invasion of the embryonic mouse spinal cord by microglial cells at the time of the onset of functional neuronal networks Glia 59 2011 675 695
    • (2011) Glia , vol.59 , pp. 675-695
    • Rigato, C.1    Buckinx, R.2    Le-Corronc, H.3    Rigo, J.M.4    Legendre, P.5
  • 208
    • 0036556325 scopus 로고    scopus 로고
    • Microglia and astrocytes may participate in the shaping of visual callosal projections during postnatal development
    • DOI 10.1016/S0928-4257(02)00005-0, PII S0928425702000050
    • N. Rochefort, N. Quenech'du, L. Watroba, M. Mallat, C. Giaume, and C. Milleret Microglia and astrocytes may participate in the shaping of visual callosal projections during postnatal development J Physiol Paris 96 2002 183 192 (Pubitemid 36090354)
    • (2002) Journal of Physiology Paris , vol.96 , Issue.3-4 , pp. 183-192
    • Rochefort, N.1    Quenech'du, N.2    Watroba, L.3    Mallat, M.4    Giaume, C.5    Milleret, C.6
  • 209
    • 84871597188 scopus 로고    scopus 로고
    • Cytokine control of inflammation and repair in the pathology of multiple sclerosis
    • J.M. Rodgers, and S.D. Miller Cytokine control of inflammation and repair in the pathology of multiple sclerosis Yale J Biol Med 85 2012 447 468
    • (2012) Yale J Biol Med , vol.85 , pp. 447-468
    • Rodgers, J.M.1    Miller, S.D.2
  • 210
    • 49649086873 scopus 로고    scopus 로고
    • Neuroinflammation and cognitive function in aged mice following minor surgery
    • H.A. Rosczyk, N.L. Sparkman, and R.W. Johnson Neuroinflammation and cognitive function in aged mice following minor surgery Exp Gerontol 43 2008 840 846
    • (2008) Exp Gerontol , vol.43 , pp. 840-846
    • Rosczyk, H.A.1    Sparkman, N.L.2    Johnson, R.W.3
  • 211
    • 0019480606 scopus 로고
    • Patterns of vascular sprouting in the postnatal development of the cerebral cortex of the rat
    • DOI 10.1002/aja.1001600303
    • R.A. Rowan, and D.S. Maxwell Patterns of vascular sprouting in the postnatal development of the cerebral cortex of the rat Am J Anat 160 1981 247 255 (Pubitemid 11098482)
    • (1981) American Journal of Anatomy , vol.160 , Issue.3 , pp. 247-255
    • Rowan, R.A.1    Maxwell, D.S.2
  • 212
    • 79251551934 scopus 로고    scopus 로고
    • A two-way communication between microglial cells and angiogenic sprouts regulates angiogenesis in aortic ring cultures
    • S.F. Rymo, H. Gerhardt, F. Wolfhagen Sand, R. Lang, A. Uv, and C. Betsholtz A two-way communication between microglial cells and angiogenic sprouts regulates angiogenesis in aortic ring cultures PLoS One 6 2011 e15846
    • (2011) PLoS One , vol.6 , pp. 15846
    • Rymo, S.F.1    Gerhardt, H.2    Wolfhagen Sand, F.3    Lang, R.4    Uv, A.5    Betsholtz, C.6
  • 213
    • 0017288080 scopus 로고
    • How the human brain responds to aging
    • T. Samorajski How the human brain responds to aging J Am Geriatr Soc 24 1976 4 11
    • (1976) J Am Geriatr Soc , vol.24 , pp. 4-11
    • Samorajski, T.1
  • 214
    • 51549101179 scopus 로고    scopus 로고
    • Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury
    • R. Sandhir, G. Onyszchuk, and N.E. Berman Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury Exp Neurol 213 2008 372 380
    • (2008) Exp Neurol , vol.213 , pp. 372-380
    • Sandhir, R.1    Onyszchuk, G.2    Berman, N.E.3
  • 215
    • 77953271370 scopus 로고    scopus 로고
    • Synapse elimination during development and disease: Immune molecules take centre stage
    • D.P. Schafer, and B. Stevens Synapse elimination during development and disease: immune molecules take centre stage Biochem Soc Trans 38 2010 476 481
    • (2010) Biochem Soc Trans , vol.38 , pp. 476-481
    • Schafer, D.P.1    Stevens, B.2
  • 216
    • 79952068402 scopus 로고    scopus 로고
    • Microglia in the developing brain: From immunity to behaviour
    • T. Schlegelmilch, K. Henke, and F. Peri Microglia in the developing brain: from immunity to behaviour Curr Opin Neurobiol 21 2011 5 10
    • (2011) Curr Opin Neurobiol , vol.21 , pp. 5-10
    • Schlegelmilch, T.1    Henke, K.2    Peri, F.3
  • 217
    • 64349105022 scopus 로고    scopus 로고
    • Differential gene expression in LPS/IFNgamma activated microglia and macrophages: In vitro versus in vivo
    • C.D. Schmid, B. Melchior, K. Masek, S.S. Puntambekar, P.E. Danielson, and D.D. Lo Differential gene expression in LPS/IFNgamma activated microglia and macrophages: in vitro versus in vivo J Neurochem 109 Suppl. 1 2009 117 125
    • (2009) J Neurochem , vol.109 , Issue.SUPPL. 1 , pp. 117-125
    • Schmid, C.D.1    Melchior, B.2    Masek, K.3    Puntambekar, S.S.4    Danielson, P.E.5    Lo, D.D.6
  • 219
    • 0026650438 scopus 로고
    • Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface
    • A.M. Schmidt, M. Vianna, M. Gerlach, J. Brett, J. Ryan, and J. Kao Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface J Biol Chem 267 1992 14987 14997
    • (1992) J Biol Chem , vol.267 , pp. 14987-14997
    • Schmidt, A.M.1    Vianna, M.2    Gerlach, M.3    Brett, J.4    Ryan, J.5    Kao, J.6
  • 222
    • 0025900245 scopus 로고
    • Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system
    • J.D. Sedgwick, S. Schwender, H. Imrich, R. Dorries, G.W. Butcher, and W. Meulen Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system Proc Natl Acad Sci U S A 88 1991 I7438 I7442
    • (1991) Proc Natl Acad Sci U S A , vol.88
    • Sedgwick, J.D.1    Schwender, S.2    Imrich, H.3    Dorries, R.4    Butcher, G.W.5    Meulen, W.6
  • 223
    • 40449083110 scopus 로고    scopus 로고
    • Cross talk between P2 purinergic receptors modulates extracellular ATP-mediated interleukin-10 production in rat microglial cells
    • D.R. Seo, S.Y. Kim, K.Y. Kim, H.G. Lee, J.H. Moon, and J.S. Lee Cross talk between P2 purinergic receptors modulates extracellular ATP-mediated interleukin-10 production in rat microglial cells Exp Mol Med 40 2008 19 26
    • (2008) Exp Mol Med , vol.40 , pp. 19-26
    • Seo, D.R.1    Kim, S.Y.2    Kim, K.Y.3    Lee, H.G.4    Moon, J.H.5    Lee, J.S.6
  • 224
    • 84881227255 scopus 로고    scopus 로고
    • Distribution of microglia in the postnatal murine nigrostraital system
    • A. Sharaf, K. Kriegistein, and B. Spittau Distribution of microglia in the postnatal murine nigrostraital system Cell Tissue Res 351 2010 373 382
    • (2010) Cell Tissue Res , vol.351 , pp. 373-382
    • Sharaf, A.1    Kriegistein, K.2    Spittau, B.3
  • 225
    • 0031960498 scopus 로고    scopus 로고
    • Microglial expression of MHC class II increases in normal aging of nonhuman primates
    • DOI 10.1016/S0197-4580(97)00168-1, PII S0197458097001681
    • L.G. Sheffield, and N.E. Berman Microglial expression of MHC class II increases in normal aging of nonhuman primates Neurobiol Aging 19 1998 47 55 (Pubitemid 28167795)
    • (1998) Neurobiology of Aging , vol.19 , Issue.1 , pp. 47-55
    • Sheffield, L.G.1    Berman, N.E.J.2
  • 226
    • 0031909973 scopus 로고    scopus 로고
    • Enlarged and phagocytic, but not primed, interleukin-1α- immunoreactive microglia increase with age in normal human brain
    • DOI 10.1007/s004010050792
    • J.G. Sheng, R.E. Mrak, and W.S. Griffin Enlarged and phagocytic, but not primed, interleukin-1 alpha-immunoreactive microglia increase with age in normal human brain Acta Neuropathol 95 1998 229 234 (Pubitemid 28120667)
    • (1998) Acta Neuropathologica , vol.95 , Issue.3 , pp. 229-234
    • Sheng, J.G.1    Mrak, R.E.2    Griffin, W.S.T.3
  • 227
    • 33846980461 scopus 로고    scopus 로고
    • Microglia derived from aging mice exhibit an altered inflammatory profile
    • A. Sierra, A.C. Gottfried-Blackmore, B.S. Mcewen, and K. Bulloch Microglia derived from aging mice exhibit an altered inflammatory profile Glia 55 2007 412 424
    • (2007) Glia , vol.55 , pp. 412-424
    • Sierra, A.1    Gottfried-Blackmore, A.C.2    McEwen, B.S.3    Bulloch, K.4
  • 229
    • 35648943680 scopus 로고    scopus 로고
    • New Insights into Adaptive Immunity in Chronic Neuroinflammation
    • DOI 10.1016/S0065-2776(07)96001-0, PII S0065277607960010
    • V. Siffrin, A.U. Brandt, J. Herz, and F. Zipp New insights into adaptive immunity in chronic neuroinflammation Adv Immunol 96 2007 1 40 (Pubitemid 350027721)
    • (2007) Advances in Immunology , vol.96 , pp. 1-40
    • Siffrin, V.1    Brandt, A.U.2    Herz, J.3    Zipp, F.4
  • 230
    • 32344440522 scopus 로고    scopus 로고
    • Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    • DOI 10.1016/j.neuron.2006.01.022, PII S0896627306000754
    • A.R. Simard, D. Soulet, G. Gowing, J.P. Julien, and S. Rivest Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease Neuron 49 2006 489 502 (Pubitemid 43221886)
    • (2006) Neuron , vol.49 , Issue.4 , pp. 489-502
    • Simard, A.R.1    Soulet, D.2    Gowing, G.3    Julien, J.-P.4    Rivest, S.5
  • 231
    • 0026530346 scopus 로고
    • Macrophage development: II. Early ontogeny of macrophage populations in brain, liver, and lungs of rat embryos as revealed by a lectin marker
    • S.P. Sorokin, R.R. Hoyt Jr., D.G. Blunt, and N.A. McNelly Macrophage development: II. Early ontogeny of macrophage populations in brain, liver, and lungs of rat embryos as revealed by a lectin marker Anat Rec 232 1992 527 550
    • (1992) Anat Rec , vol.232 , pp. 527-550
    • Sorokin, S.P.1    Hoyt, Jr.R.R.2    Blunt, D.G.3    McNelly, N.A.4
  • 232
    • 15744382068 scopus 로고    scopus 로고
    • Effects of intraperitoneal lipopolysaccharide on Morris maze performance in year-old and 2-month-old female C57BL/6J mice
    • DOI 10.1016/j.bbr.2004.10.011
    • N.L. Sparkman, L.A. Martin, W.S. Calvert, and G.W. Boehm Effects of intraperitoneal lipopolysaccharide on Morris maze performance in year-old and 2-month-old female C57BL/6J mice Behav Brain Res 159 2005 145 151 (Pubitemid 40410596)
    • (2005) Behavioural Brain Research , vol.159 , Issue.1 , pp. 145-151
    • Sparkman, N.L.1    Martin, L.A.2    Calvert, W.S.3    Boehm, G.W.4
  • 234
    • 33646199097 scopus 로고    scopus 로고
    • Synaptic scaling mediated by glial TNF-alpha
    • D. Stellwagen, and R.C. Malenka Synaptic scaling mediated by glial TNF-alpha Nature 440 2006 1054 1059
    • (2006) Nature , vol.440 , pp. 1054-1059
    • Stellwagen, D.1    Malenka, R.C.2
  • 236
    • 3042738397 scopus 로고    scopus 로고
    • Neuronal apoptotic bodies: Phagocytosis and degradation by primary microglial cells
    • A. Stolzing, and T. Grune Neuronal apoptotic bodies: phagocytosis and degradation by primary microglial cells The FASEB J 18 2004 743 745
    • (2004) The FASEB J , vol.18 , pp. 743-745
    • Stolzing, A.1    Grune, T.2
  • 237
    • 21244443731 scopus 로고    scopus 로고
    • Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences
    • R.D. Stout, C. Jiang, B. Matta, I. Tietzel, S.K. Watkins, and J. Suttles Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences J Immunol 175 2005 342 349 (Pubitemid 40884337)
    • (2005) Journal of Immunology , vol.175 , Issue.1 , pp. 342-349
    • Stout, R.D.1    Jiang, C.2    Matta, B.3    Tietzel, I.4    Watkins, S.K.5    Suttles, J.6
  • 238
    • 1042291300 scopus 로고    scopus 로고
    • Dystrophic Microglia in the Aging Human Brain
    • DOI 10.1002/glia.10319
    • W.J. Streit, N.W. Sammons, A.J. Kuhns, and D.L. Sparks Dystrophic microglia in the aging human brain Glia 45 2004 208 212 (Pubitemid 38196997)
    • (2004) GLIA , vol.45 , Issue.2 , pp. 208-212
    • Streit, W.J.1    Sammons, N.W.2    Kuhns, A.J.3    Sparks, D.L.4
  • 239
    • 84866159543 scopus 로고    scopus 로고
    • Alzheimer's disease, neuroprotection, and CNS immunosenescence
    • 10.3389/fphar.2012.00138
    • W.J. Streit, and Q.S. Xue Alzheimer's disease, neuroprotection, and CNS immunosenescence Front Pharmacol 3 2012 138 10.3389/fphar.2012.00138
    • (2012) Front Pharmacol , vol.3 , pp. 138
    • Streit, W.J.1    Xue, Q.S.2
  • 240
    • 69949118284 scopus 로고    scopus 로고
    • Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease
    • W.J. Streit, H. Braak, Q.S. Xue, and I. Bechmann Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's disease Acta Neuropathol 118 2009 475 485
    • (2009) Acta Neuropathol , vol.118 , pp. 475-485
    • Streit, W.J.1    Braak, H.2    Xue, Q.S.3    Bechmann, I.4
  • 241
    • 0024340657 scopus 로고
    • Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury
    • DOI 10.1016/0014-4886(89)90111-8
    • W.J. Streit, M.B. Graeber, and G.W. Kreutzberg Expression of Ia antigen on perivascular and microglial cells after sublethal and lethal motor neuron injury Exp Neurol 105 1989 115 126 (Pubitemid 19201505)
    • (1989) Experimental Neurology , vol.105 , Issue.2 , pp. 115-126
    • Streit, W.J.1    Graeber, M.B.2    Kreutzberg, G.W.3
  • 242
    • 42649098547 scopus 로고    scopus 로고
    • Microglial degeneration in the aging brain - Bad news for neurons?
    • DOI 10.2741/2937
    • W.J. Streit, K.R. Miller, K.O. Lopes, and E. Njie Microglial degeneration in the aging brain - bad news for neurons? Front Biosci 13 2008 3423 3438 (Pubitemid 351594693)
    • (2008) Frontiers in Bioscience , vol.13 , Issue.9 , pp. 3423-3438
    • Streit, W.J.1    Miller, K.R.2    Lopes, K.O.3    Njie, E.4
  • 243
    • 27444434995 scopus 로고    scopus 로고
    • CX3CL1 (freactalkine) and CX3CR1 expression in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis: Kinetics and cellular origin
    • D. Sunnemark, S. Eltayeb, M. Nilsson, E. Wallstrom, H. Lassmann, and T. Olsson CX3CL1 (freactalkine) and CX3CR1 expression in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis: kinetics and cellular origin J Neuroinflammation 2 2005 17
    • (2005) J Neuroinflammation , vol.2 , pp. 17
    • Sunnemark, D.1    Eltayeb, S.2    Nilsson, M.3    Wallstrom, E.4    Lassmann, H.5    Olsson, T.6
  • 244
    • 67649639047 scopus 로고    scopus 로고
    • Signaling at purinergic P2X receptors
    • A. Surprenant, and R.A. North Signaling at purinergic P2X receptors Annu Rev Physiol 71 2009 333 359
    • (2009) Annu Rev Physiol , vol.71 , pp. 333-359
    • Surprenant, A.1    North, R.A.2
  • 245
    • 0842322759 scopus 로고    scopus 로고
    • 7 Receptor-Activated Microglia
    • DOI 10.1523/JNEUROSCI.3792-03.2004
    • T. Suzuki, I. Hide, K. Ido, S. Kohsaka, K. Inoue, and Y. Nakata Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia J Neurosci 24 2004 1 7 (Pubitemid 38181664)
    • (2004) Journal of Neuroscience , vol.24 , Issue.1 , pp. 1-7
    • Suzuki, T.1    Hide, I.2    Ido, K.3    Kohsaka, S.4    Inoue, K.5    Nakata, Y.6
  • 246
    • 0027474190 scopus 로고
    • Synaptic density of axotomized hypoglossal motorneurons following pharmacological blockade of the microglial cell proliferation
    • DOI 10.1006/exnr.1993.1046
    • M. Svensson, and H. Aldskogius Synaptic density of axotomized hypoglossal motorneurons following pharmacological blockade of the microglial cell proliferation Exp Neurol 120 1993 123 131 (Pubitemid 23114036)
    • (1993) Experimental Neurology , vol.120 , Issue.1 , pp. 123-131
    • Svensson, M.1    Aldskogius, H.2
  • 247
    • 14244268775 scopus 로고    scopus 로고
    • Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
    • DOI 10.1084/jem.20041611
    • K. Takahashi, C.D. Rochford, and H. Neumann Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2 J Exp Med 201 2005 647 657 (Pubitemid 40289554)
    • (2005) Journal of Experimental Medicine , vol.201 , Issue.4 , pp. 647-657
    • Takahashi, K.1    Rochford, C.D.P.2    Neumann, H.3
  • 250
    • 63849192564 scopus 로고    scopus 로고
    • P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation
    • T. Trang, S. Beggs, X. Wan, and M.W. Salter P2X4-receptor-mediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation J Neurosci 29 2009 3518 3528
    • (2009) J Neurosci , vol.29 , pp. 3518-3528
    • Trang, T.1    Beggs, S.2    Wan, X.3    Salter, M.W.4
  • 252
    • 78649976052 scopus 로고    scopus 로고
    • Microglial interactions with synapses are modulated by visual experience
    • M.E. Tremblay, R.L. Lowery, and A.K. Majewska Microglial interactions with synapses are modulated by visual experience PLoS Biol 8 2010 e1000527
    • (2010) PLoS Biol , vol.8 , pp. 1000527
    • Tremblay, M.E.1    Lowery, R.L.2    Majewska, A.K.3
  • 253
    • 84856756074 scopus 로고    scopus 로고
    • Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices
    • M.E. Tremblay, M.L. Zettel, J.R. Ison, P.D. Allen, and A.K. Majewska Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices Glia 60 2012 541 558
    • (2012) Glia , vol.60 , pp. 541-558
    • Tremblay, M.E.1    Zettel, M.L.2    Ison, J.R.3    Allen, P.D.4    Majewska, A.K.5
  • 254
    • 0042968804 scopus 로고    scopus 로고
    • 4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
    • DOI 10.1038/nature01786
    • M. Tsuda, Y. Shigemoto-Mogami, S. Koizumi, A. Mizokoshi, S. Kohsaka, and M.W. Salter P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury Nature 424 2003 778 783 (Pubitemid 37021707)
    • (2003) Nature , vol.424 , Issue.6950 , pp. 778-783
    • Tsuda, M.1    Shigemoto-Mogami, Y.2    Koizumi, S.3    Mizokoshi, A.4    Kohsaka, S.5    Salter, M.W.6    Inoue, K.7
  • 255
    • 77449099299 scopus 로고    scopus 로고
    • Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: Distinct roles of PI3K-Akt and MEK-ERK signalling pathways
    • M. Tsuda, E. Toyomitsu, M. Kometani, H. Tozaki-Saitoh, and K. Inoue Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways J Cell Mol Med 13 2009 3251 3259
    • (2009) J Cell Mol Med , vol.13 , pp. 3251-3259
    • Tsuda, M.1    Toyomitsu, E.2    Kometani, M.3    Tozaki-Saitoh, H.4    Inoue, K.5
  • 256
    • 56149096976 scopus 로고    scopus 로고
    • Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain
    • L. Ulmann, J.P. Hatcher, J.P. Hughes, S. Chaumont, P.J. Green, and F. Conquet Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain J Neurosci 28 2008 11263 11268
    • (2008) J Neurosci , vol.28 , pp. 11263-11268
    • Ulmann, L.1    Hatcher, J.P.2    Hughes, J.P.3    Chaumont, S.4    Green, P.J.5    Conquet, F.6
  • 257
    • 0018649918 scopus 로고
    • Characteristics of human mononuclear phagocytes
    • R. van Furth, J.A. Raeburn, and T.L. van Zwet Characteristics of human mononuclear phagocytes Blood 54 1979 485 500 (Pubitemid 9247717)
    • (1979) Blood , vol.54 , Issue.2 , pp. 485-500
    • Van Furth, R.1    Raeburn, J.A.2    Van Zwet, T.L.3
  • 259
    • 0016261856 scopus 로고
    • Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: An electron microscope study
    • D.W. Vaughan, and A. Peters Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: an electron microscope study J Neurocytol 3 1974 405 429
    • (1974) J Neurocytol , vol.3 , pp. 405-429
    • Vaughan, D.W.1    Peters, A.2
  • 260
    • 0028847057 scopus 로고
    • Morphology and distribution of microglial cells in the young and adult mouse cerebellum
    • J.M. Vela, I. Dalmau, B. González, and B. Castellano Morphology and distribution of microglial cells in the young and adult mouse cerebellum J Comp Neurol 361 1995 602 616
    • (1995) J Comp Neurol , vol.361 , pp. 602-616
    • Vela, J.M.1    Dalmau, I.2    González, B.3    Castellano, B.4
  • 262
    • 50649101095 scopus 로고    scopus 로고
    • Puzzles, promises and a cure for ageing
    • J. Vijg, and J. Campisi Puzzles, promises and a cure for ageing Nature 454 2008 1065 1071
    • (2008) Nature , vol.454 , pp. 1065-1071
    • Vijg, J.1    Campisi, J.2
  • 265
    • 65249157852 scopus 로고    scopus 로고
    • Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals
    • H. Wake, A.J. Moorhouse, S. Jinno, S. Kohsaka, and J. Nabekura Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals J Neurosci 29 2009 3974 3980
    • (2009) J Neurosci , vol.29 , pp. 3974-3980
    • Wake, H.1    Moorhouse, A.J.2    Jinno, S.3    Kohsaka, S.4    Nabekura, J.5
  • 266
    • 51149091666 scopus 로고    scopus 로고
    • Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor
    • S. Wakselman, C. Bechade, A. Roumier, D. Bernard, A. Triller, and A. Bessis Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor J Neurosci 28 2008 8138 8143
    • (2008) J Neurosci , vol.28 , pp. 8138-8143
    • Wakselman, S.1    Bechade, C.2    Roumier, A.3    Bernard, D.4    Triller, A.5    Bessis, A.6
  • 269
    • 0028062835 scopus 로고
    • Immune regulatory and effector properties of human adult microglia studied in vitro and in situ
    • K. Williams, E. Ulvestad, and J. Antel Immune regulatory and effector properties of human adult microglia studies in vitro and in situ Adv Neuroimmunol 4 1994 273 281 (Pubitemid 24325874)
    • (1994) Advances in Neuroimmunology , vol.4 , Issue.3 , pp. 273-281
    • Williams, K.1    Ulvestad, E.2    Antel, J.3
  • 271
    • 34249057095 scopus 로고    scopus 로고
    • ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents
    • DOI 10.1002/glia.20500
    • L.J. Wu, K.I. Vadakkan, and M. Zhuo ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents Glia 55 2007 810 821 (Pubitemid 46787192)
    • (2007) GLIA , vol.55 , Issue.8 , pp. 810-821
    • Wu, L.-J.1    Vadakkan, K.I.2    Zhuo, M.3
  • 272
    • 0027075103 scopus 로고
    • A quantitative and morpho-metric study of the transformation of ameboid microglia into ramified microglia in the developing corpus callosum in rats
    • C.H. Wu, C.Y. Wen, J.Y. Shieh, and E.A. Ling A quantitative and morpho-metric study of the transformation of ameboid microglia into ramified microglia in the developing corpus callosum in rats J Anat 181 1992 4423 4430
    • (1992) J Anat , vol.181 , pp. 4423-4430
    • Wu, C.H.1    Wen, C.Y.2    Shieh, J.Y.3    Ling, E.A.4
  • 273
    • 78650994912 scopus 로고    scopus 로고
    • Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge
    • A.M. Wynne, C.J. Henry, Y. Huang, A. Cleland, and J.P. Godbout Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge Brain Behav Immun 24 2010 1190 1201
    • (2010) Brain Behav Immun , vol.24 , pp. 1190-1201
    • Wynne, A.M.1    Henry, C.J.2    Huang, Y.3    Cleland, A.4    Godbout, J.P.5
  • 274
    • 27844443094 scopus 로고    scopus 로고
    • Expression of P2X receptors on rat microglial cells during early development
    • DOI 10.1002/glia.20227
    • Z. Xiang, and G. Burnstock Expression of P2X receptors on rat microglial cells during early development Glia 52 2005 119 126 (Pubitemid 41652916)
    • (2005) GLIA , vol.52 , Issue.2 , pp. 119-126
    • Xiang, Z.1    Burnstock, G.2
  • 275
  • 276
    • 38349116263 scopus 로고    scopus 로고
    • Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice
    • H. Xu, M. Chen, A. Manivannan, N. Lois, and J.V. Forrester Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice Aging Cell 7 2008 58 68
    • (2008) Aging Cell , vol.7 , pp. 58-68
    • Xu, H.1    Chen, M.2    Manivannan, A.3    Lois, N.4    Forrester, J.V.5
  • 277
    • 33748607463 scopus 로고    scopus 로고
    • Cell cycle-dependent regulation of kainate-induced inward currents in microglia
    • DOI 10.1016/j.bbrc.2006.08.126, PII S0006291X06018869
    • J. Yamada, M. Sawada, and H. Nakanishi Cell cycle-dependent regulation of kainite-induced inward currents in microglia Biochem Biophys Res Commun 349 2006 913 919 (Pubitemid 44380188)
    • (2006) Biochemical and Biophysical Research Communications , vol.349 , Issue.3 , pp. 913-919
    • Yamada, J.1    Sawada, M.2    Nakanishi, H.3
  • 279
    • 0032916578 scopus 로고    scopus 로고
    • Increased interleukin-6 expression by microglia from brain of aged mice
    • DOI 10.1016/S0165-5728(98)00217-3, PII S0165572898002173
    • S.M. Ye, and R.W. Johnson Increased interleukin-6 expression by microglia from brain of aged mice J Neuroimmunol 93 1999 139 148 (Pubitemid 29051559)
    • (1999) Journal of Neuroimmunology , vol.93 , Issue.1-2 , pp. 139-148
    • Ye, S.-M.1    Johnson, R.W.2
  • 280
    • 0035720799 scopus 로고    scopus 로고
    • An age-related decline in interleukin-10 may contribute to the increased expression of interleukin-6 in brain of aged mice
    • DOI 10.1159/000049025
    • S.M. Ye, and R.W. Johnson An age-related decline in interleukin-10 may contribute to the increased expression of interleukin-6 in brain of aged mice Neuroimmunomodulation 9 2001 183 192 (Pubitemid 34195776)
    • (2001) NeuroImmunoModulation , vol.9 , Issue.4 , pp. 183-192
    • Ye, S.-M.1    Johnson, R.W.2
  • 281
    • 33645224970 scopus 로고    scopus 로고
    • COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord
    • Y. Yiangou, P. Facer, P. Durrenberger, I.P. Chessell, A. Naylor, and C. Bountra COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord BMC Neurol 6 2006 12
    • (2006) BMC Neurol , vol.6 , pp. 12
    • Yiangou, Y.1    Facer, P.2    Durrenberger, P.3    Chessell, I.P.4    Naylor, A.5    Bountra, C.6
  • 282
    • 39149105285 scopus 로고    scopus 로고
    • Cellular localization of P2X7 receptor mRNA in the rat brain
    • Y. Yu, S. Ugawa, T. Ueda, Y. Ishida, K. Inoue, and A. Kyaw Nyunt Cellular localization of P2X7 receptor mRNA in the rat brain Brain Res 1194 2008 45 55
    • (2008) Brain Res , vol.1194 , pp. 45-55
    • Yu, Y.1    Ugawa, S.2    Ueda, T.3    Ishida, Y.4    Inoue, K.5    Kyaw Nyunt, A.6
  • 283
    • 77951591750 scopus 로고    scopus 로고
    • Role of mast cell activation in inducing microglial cells to release neurotrophin
    • H. Yuan, X. Zhu, S. Zhou, Q. Chen, X. Ma, and X. He Role of mast cell activation in inducing microglial cells to release neurotrophin J Neurosci Res 88 2010 1348 1354
    • (2010) J Neurosci Res , vol.88 , pp. 1348-1354
    • Yuan, H.1    Zhu, X.2    Zhou, S.3    Chen, Q.4    Ma, X.5    He, X.6
  • 284
    • 36048991728 scopus 로고    scopus 로고
    • Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain
    • DOI 10.1523/JNEUROSCI.3016-07.2007
    • J. Zhang, X.Q. Shi, S. Echeverry, J.S. Mogil, Y. De Koninck, and S. Rivest Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain J Neurosci 27 2007 12396 12406 (Pubitemid 350085465)
    • (2007) Journal of Neuroscience , vol.27 , Issue.45 , pp. 12396-12406
    • Zhang, J.1    Xiang, Q.S.2    Echeverry, S.3    Mogil, J.S.4    De Koninck, Y.5    Rivest, S.6
  • 285
    • 77954217806 scopus 로고    scopus 로고
    • The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia: The role of tumor necrosis factor-alpha
    • Y. Zhong, L.J. Zhou, W.J. Ren, W.J. Xin, Y.Y. Li, and T. Zhang The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia: the role of tumor necrosis factor-alpha Brain Behav Immun 24 2010 874 880
    • (2010) Brain Behav Immun , vol.24 , pp. 874-880
    • Zhong, Y.1    Zhou, L.J.2    Ren, W.J.3    Xin, W.J.4    Li, Y.Y.5    Zhang, T.6
  • 286
    • 84865022665 scopus 로고    scopus 로고
    • Regulation of postnatal forebrain amoeboid microglial cell proliferation and development by the transcription factor Runx1
    • M. Zusso, L. Methot, R. Lo, A.D. Greenhalgh, S. David, and S. Stifani Regulation of postnatal forebrain amoeboid microglial cell proliferation and development by the transcription factor Runx1 J Neurosci 32 2012 11285 11298
    • (2012) J Neurosci , vol.32 , pp. 11285-11298
    • Zusso, M.1    Methot, L.2    Lo, R.3    Greenhalgh, A.D.4    David, S.5    Stifani, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.