Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: A crucial role of P2X7 receptor-mediated IL-1β release

Journal of Neurochemistry

Volumn 106, Issue 1, 2008, Pages 271-280

  Bernardino, Liliana ^a,b   Balosso, Silvia ^a   Ravizza, Teresa ^a   Marchi, Nicola ^a   Ku, George ^c   Randle, John C ^c   Malva, João O ^b   Vezzani, Annamaria ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c VERTEX PHARMACEUTICALS   (United States)

Author keywords

Apoptosis; Cytokines; Excitotoxicity; Lipopolysaccharide; Organotypic slice cultures; P2X7 receptors

Indexed keywords

2'3' O (4 BENZOYL BENZOYL) ADENOSINE 5' TRIPHOSPHATE TRIETHYLAMMONIUM; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CD11B ANTIGEN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; PURINERGIC P2X7 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN SLICE; BRAIN TISSUE; CELL CULTURE; CELL DEATH; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; EXCITOTOXICITY; HIPPOCAMPUS; INCUBATION TIME; INFLAMMATION; MICROGLIA; MOUSE; NERVE CELL; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; DRUG SYNERGISM; ENCEPHALITIS; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICROGLIA; NERVE DEGENERATION; NEUROTOXINS; ORGAN CULTURE TECHNIQUES; PYRAMIDAL CELLS; RECEPTORS, INTERLEUKIN-1; RECEPTORS, PURINERGIC P2;

MUS;

EID: 45249094554     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05387.x     Document Type: Article

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