Microglia in the developing brain: From immunity to behaviour

Current Opinion in Neurobiology

Volumn 21, Issue 1, 2011, Pages 5-10

  Schlegelmilch, Timm ^a   Henke, Katrin ^a,b   Peri, Francesca ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BEHAVIOR; BRAIN DEVELOPMENT; CELL ACTIVITY; CELL INVASION; COMPLEMENT FACTOR; COMPULSION; CYTOKINE RELEASE; EMBRYO PATTERN FORMATION; HUMAN; IMMUNITY; INTERNALIZATION; LONG TERM DEPRESSION; LONG TERM POTENTIATION; MACROPHAGE; MICROGLIA; NERVE CELL NECROSIS; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; REVIEW;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; HUMANS; MICROGLIA; NEURONS;

EID: 79952068402     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.conb.2010.08.004     Document Type: Review

References (48)

1. Wake H., Moorhouse A.J., Jinno S., Kohsaka S., Nabekura J. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J Neurosci 2009, 29:3974-3980.
2. Ribes S., Ebert S., Czesnik D., Regen T., Zeug A., Bukowski S., Mildner A., Eiffert H., Hanisch U.-K., Hammerschmidt S., et al. Toll-like receptor prestimulation increases phagocytosis of Escherichia coli DH5alpha and Escherichia coli K1 strains by murine microglial cells. Infect Immun 2009, 77:557-564.
3. Ribes S., Ebert S., Regen T., Agarwal A., Tauber S.C., Czesnik D., Spreer A., Bunkowski S., Eiffert H., Hanisch U.-K., et al. Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia. Infect Immun 2010, 78:865-871.
4. Magnus T., Chan A., Grauer O., Toyka K.V., Gold R. Microglial phagocytosis of apoptotic inflammatory T cells leads to down-regulation of microglial immune activation. J Immunol 2001, 167:5004-5010.
5. Peri F., Nüsslein-Volhard C. Live imaging of neuronal degradation by microglia reveals a role for v0-ATPase a1 in phagosomal fusion in vivo. Cell 2008, 133:916-927.
6. Perry V.H., Nicoll J.A.R., Holmes C. Microglia in neurodegenerative disease. Nat Rev Neurol 2010, 6:193-201.
7. Nimmerjahn A., Kirchhoff F., Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 2005, 308:1314-1318.
8. Liu Y., Luo S., Lv Z., Huang H. A neural network structure evolution algorithm based on e, m projections and model selection criterion. Advances in Neural Networks-ISNN 2006 2006, 732-738. Springer.
9. Pakkenberg B., Pelvig D., Marner L., Bundgaard M.J., Gundersen H.J., Nyengaard J.R., Regeur L. Aging and the human neocortex. Exp Gerontol 2003, 38:95-99.
10. de la Rosa E.J., de Pablo F. Cell death in early neural development: beyond the neurotrophic theory. Trends Neurosci 2000, 23:454-458.
11. Marín-Teva J.L., Dusart I., Colin C., Gervais A., van Rooijen N., Mallat M. Microglia promote the death of developing Purkinje cells. Neuron 2004, 41:535-547.
12. Herbomel P., Thisse B., Thisse C. Zebrafish early macrophages colonize cephalic mesenchyme and developing brain, retina, and epidermis through a M-CSF receptor-dependent invasive process. Dev Biol 2001, 238:274-288.
13. Rhodes J., Hagen A., Hsu K., Deng M., Liu T.X., Look A.T., Kanki J.P. Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish. Dev Cell 2005, 8:97-108.
14. McKercher S.R., Torbett B.E., Anderson K.L., Henkel G.W., Vestal D.J., Baribault H., Klemsz M., Feeney A.J., Wu G.E., Paige C.J., et al. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J 1996, 15:5647-5658.
15. Beers D.R., Henkel J.S., Xiao Q., Zhao W., Wang J., Yen A.A., Siklos L., McKercher S.R., Appel S.H. Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis. Proc Natl Acad Sci USA 2006, 103:16021-16026.
16. Pollard J.W. Trophic macrophages in development and disease. Nat Rev Immunol 2009, 9:259-270.
17. Kondo Y., Lemere C.A., Seabrook T.J. Osteopetrotic (op/op) mice have reduced microglia, no Abeta deposition, and no changes in dopaminergic neurons. J Neuroinflamm 2007, 4:31.
18. Wegiel J, Wiśniewski H.M., Dziewiatkowski J., Tarnawski M., Kozielski R., Trenkner E., Wiktor-Jedrzejczak W. Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice. Brain Res 1998, 804:135-139.
19. Alliot F., Godin I., Pessac B. Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain. Brain Res Dev Brain Res 1999, 117:145-152.
20. Chen S.-K., Tvrdik P., Peden E., Cho S., Wu S., Spangrude G., Capecchi M.R. Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Cell 2010, 141:775-785.
21. Hanisch U.-K., Kettenmann H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 2007, 10:1387-1394.
22. Liang K.J., Lee J.E., Wang Y.D., Ma W., Fontainhas A.M., Fariss R.N., Wong W.T. Regulation of dynamic behavior of retinal microglia by CX3CR1 signaling. Invest Ophthalmol Vis Sci 2009, 50:4444-4451.
23. Lyons A., Lynch A.M., Downer E.J., Hanley R., O'Sullivan J.B., Smith A., Lynch M.A. Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro. J Neurochem 2009, 110:1547-1556.
24. Bachstetter A.D., Morganti J.M., Jernberg J., Schlunk A., Mitchell S.H., Brewster K.W., Hudson C.E., Cole M.J., Harrison J.K., Bickford P.C., et al. Fractalkine and CX(3)CR1 regulate hippocampal neurogenesis in adult and aged rats. Neurobiol Aging 2009.
25. Cardona A.E., Pioro E.P., Sasse M.E., Kostenko V., Cardona S.M., Dijkstra I.M., Huang D., Kidd G., Dombrowski S., Dutta R., et al. Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci 2006, 9:917-924.
26. Truman L.A., Ford C.A., Pasikowska M., Pound J.D., Wilkinson S.J., Dumitriu I.E., Melville L., Melrose L.A., Ogden C.A., Nibbs R., et al. CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis. Blood 2008, 112:5026-5036.
27. Fuller A.D., Van Eldik L.J. MFG-E8 regulates microglial phagocytosis of apoptotic neurons. J Neuroimmune Pharmacol 2008, 3:246-256.
28. Grommes C., Lee C.Y.D., Wilkinson B.L., Jiang Q., Koenigsknecht-Talboo J.L., Varnum B., Landreth G.E. Regulation of microglial phagocytosis and inflammatory gene expression by Gas6 acting on the Axl/Mer family of tyrosine kinases. J Neuroimmune Pharmacol 2008, 3:130-140.
29. Neumann H., Takahashi K. Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis. J Neuroimmunol 2007, 184:92-99.
30. Takahashi K., Prinz M., Stagi M., Chechneva O., Neumann H. TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis. PLoS Med 2007, 4:e124.
31. Berliocchi L., Bano D., Nicotera P. Ca2+ signals and death programmes in neurons. Philos Trans R Soc Lond B Biol Sci 2005, 360:2255-2258.
32. Tanaka T., Ueno M., Yamashita T. Engulfment of axon debris by microglia requires p38 MAPK activity. J Biol Chem 2009, 284:21626-21636.
33. Nikolaev A., McLaughlin T., O'Leary D.D., Tessier-Lavigne M. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 2009, 457:981-989.
34. Finn J.T., Weil M., Archer F., Siman R., Srinivasan A., Raff M.C. Evidence that Wallerian degeneration and localized axon degeneration induced by local neurotrophin deprivation do not involve caspases. J Neurosci 2000, 20:1333-1341.
35. Kim Y.E., Chen J., Chan J.R., Langen R. Engineering a polarity-sensitive biosensor for time-lapse imaging of apoptotic processes and degeneration. Nat Methods 2010, 7:67-73.
36. Bilbo S.D., Schwarz J.M. Early-life programming of later-life brain and behavior: a critical role for the immune system. Front Behav Neurosci 2009, 3:14.
37. Streit W.J., Mrak R.E., Griffin W.S. Microglia and neuroinflammation: a pathological perspective. J Neuroinflamm 2004, 1:14.
38. Krause D.L., Muller N. Neuroinflammation, microglia and implications for anti-inflammatory treatment in Alzheimer's disease. Int J Alzheimers Dis 2010, 2010:9.
39. Deverman B.E., Patterson P.H. Cytokines and CNS development. Neuron 2009, 64:61-78.
40. Mathieu P., Battista D., Depino A., Roca V., Graciarena M., Pitossi F. The more you have, the less you get: the functional role of inflammation on neuronal differentiation of endogenous and transplanted neural stem cells in the adult brain. J Neurochem 2010, 112:1368-1385.
41. Stevens B., Allen N.J., Vazquez L.E., Howell G.R., Christopherson K.S., Nouri N., Micheva K.D., Mehalow A.K., Huberman A.D., Stafford B., et al. The classical complement cascade mediates CNS synapse elimination. Cell 2007, 131:1164-1178.
42. Martin C.B., Ingersoll S.A., Martin B.K. Transcriptional control of the C3a receptor gene in glial cells: dependence upon AP-1 but not Ets. Mol Immunol 2007, 44:703-712.
43. Hung J., Chansard M., Ousman S.S., Nguyen M.D., Colicos M.A. Activation of microglia by neuronal activity: results from a new in vitro paradigm based on neuronal-silicon interfacing technology. Brain Behav Immun 2010, 24:31-40.
44. Jakubs K., Bonde S., Iosif R.E., Ekdahl C.T., Kokaia Z., Kokaia M., Lindvall O. Inflammation regulates functional integration of neurons born in adult brain. J Neurosci 2008, 28:12477-12488.
45. Zhong Y., Zhou L.-J., Ren W.-J., Xin W.-J., Li Y.-Y., Zhang T., Liu X.-G. The direction of synaptic plasticity mediated by C-fibers in spinal dorsal horn is decided by Src-family kinases in microglia: the role of tumor necrosis factor-alpha. Brain Behav Immun 2010.
46. Greer J.M., Capecchi M.R. Hoxb8 is required for normal grooming behavior in mice. Neuron 2002, 33:23-34.
47. Hyman S.E. A bone to pick with compulsive behavior. Cell 2010, 141:752-754.
48. Streit W.J., Xue Q.-S. Life and death of microglia. J Neuroimmune Pharmacol 2009, 4:371-379.