CCL2 promotes P2X4 receptor trafficking to the cell surface of microglia

Purinergic Signalling

Volumn 8, Issue 2, 2012, Pages 301-310

  Toyomitsu, Emika ^a   Tsuda, Makoto ^a   Yamashita, Tomohiro ^a   Tozaki Saitoh, Hidetoshi ^a   Tanaka, Yoshitaka ^a   Inoue, Kazuhide ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

CCR2; Cell surface expression; Lysosome; Microglia; P2X4 receptor

Indexed keywords

BETA N ACETYLHEXOSAMINIDASE; CHEMOKINE RECEPTOR CCR2; FIBRONECTIN; GREEN FLUORESCENT PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN KINASE B; PURINERGIC P2X4 RECEPTOR;

ANIMAL CELL; ARTICLE; BIOTINYLATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXOCYTOSIS; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; LYSOSOME; MICROGLIA; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; TIME LAPSE IMAGING; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; CELL MEMBRANE; CELLS, CULTURED; CHEMOKINE CCL2; MICROGLIA; PROTEIN TRANSPORT; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2X4;

EID: 84861009038     PISSN: 15739538     EISSN: 15739546     Source Type: Journal    
DOI: 10.1007/s11302-011-9288-x     Document Type: Article

References (57)

1. Hanisch UK, Kettenmann H (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10: 1387-1394.
2. Streit WJ (2002) Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40: 133-139.
3. Prinz M, Mildner A (2011) Microglia in the CNS: immigrants from another world. Glia 59: 177-187.
4. Inoue K, Koizumi S, Tsuda M (2007) The role of nucleotides in the neuron-glia communication responsible for the brain functions. J Neurochem 102: 1447-1458.
5. Pocock JM, Kettenmann H (2007) Neurotransmitter receptors on microglia. Trends Neurosci 30: 527-535.
6. Tsuda M, Shigemoto-Mogami Y, Koizumi S et al (2003) P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature 424: 778-783.
7. Cavaliere F, Florenzano F, Amadio S et al (2003) Up-regulation of P2X2, P2X4 receptor and ischemic cell death: prevention by P2 antagonists. Neuroscience 120: 85-98.
8. Guo LH, Trautmann K, Schluesener HJ (2004) Expression of P2X4 receptor in rat C6 glioma by tumor-associated macrophages and activated microglia. J Neuroimmunol 152: 67-72.
9. Guo LH, Trautmann K, Schluesener HJ (2005) Expression of P2X4 receptor by lesional activated microglia during formalin-induced inflammatory pain. J Neuroimmunol 163: 120-127.
10. Zhang Z, Zhang Z, Artelt M et al (2007) Dexamethasone attenuates early expression of three molecules associated with microglia/macrophages activation following rat traumatic brain injury. Acta Neuropathol 113: 675-682.
11. Schwab JM, Guo L, Schluesener HJ (2005) Spinal cord injury induces early and persistent lesional P2X4 receptor expression. J Neuroimmunol 163: 185-189.
12. Zhang Z, Zhang ZY, Fauser U et al (2008) Mechanical allodynia and spinal up-regulation of P2X4 receptor in experimental autoimmune neuritis rats. Neuroscience 152: 495-501.
13. Coull JA, Beggs S, Boudreau D et al (2005) BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 438: 1017-1021.
14. Tsuda M, Inoue K, Salter MW (2005) Neuropathic pain and spinal microglia: a big problem from molecules in "small" glia. Trends Neurosci 28: 101-107.
15. Ohsawa K, Irino Y, Nakamura Y et al (2007) Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis. Glia 55: 604-616.
16. Ohsawa K, Irino Y, Sanagi T et al (2010) P2Y12 receptor-mediated integrin-beta1 activation regulates microglial process extension induced by ATP. Glia 58: 790-801.
17. Wu LJ, Vadakkan KI, Zhuo M (2007) ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents. Glia 55: 810-821.
18. Charo IF, Myers SJ, Herman A et al (1994) Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc Natl Acad Sci U S A 91: 2752-2756.
19. Boumechache M, Masin M, Edwardson JM et al (2009) Analysis of assembly and trafficking of native P2X4 and P2X7 receptor complexes in rodent immune cells. J Biol Chem 284: 13446-13454.
20. Tsuda M, Masuda T, Kitano J et al (2009) IFN-gamma receptor signaling mediates spinal microglia activation driving neuropathic pain. Proc Natl Acad Sci U S A 106: 8032-8037.
21. Nasu-Tada K, Koizumi S, Tsuda M et al (2006) Possible involvement of increase in spinal fibronectin following peripheral nerve injury in upregulation of microglial P2X4, a key molecule for mechanical allodynia. Glia 53: 769-775.
22. Tsuda M, Toyomitsu E, Kometani M et al (2009) Mechanisms underlying fibronectin-induced up-regulation of P2X4R expression in microglia: distinct roles of PI3K-Akt and MEK-ERK signalling pathways. J Cell Mol Med 13: 3251-3259.
23. Tsuda M, Toyomitsu E, Komatsu T et al (2008) Fibronectin/integrin system is involved in P2X(4) receptor upregulation in the spinal cord and neuropathic pain after nerve injury. Glia 56: 579-585.
24. Tsuda M, Tozaki-Saitoh H, Masuda T et al (2008) Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury. Glia 56: 50-58.
25. Qureshi OS, Paramasivam A, Yu JC et al (2007) Regulation of P2X4 receptors by lysosomal targeting, glycan protection and exocytosis. J Cell Sci 120: 3838-3849.
26. Schwartz M, Butovsky O, Bruck W et al (2006) Microglial phenotype: is the commitment reversible? Trends Neurosci 29: 68-74.
27. Nakajima K, Shimojo M, Hamanoue M et al (1992) Identification of elastase as a secretory protease from cultured rat microglia. J Neurochem 58: 1401-1408.
28. Kuronita T, Eskelinen EL, Fujita H et al (2002) A role for the lysosomal membrane protein LGP85 in the biogenesis and maintenance of endosomal and lysosomal morphology. J Cell Sci 115: 4117-4131.
29. Mirzadegan T, Diehl F, Ebi B et al (2000) Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem 275: 25562-25571.
30. Nanki T, Nagasaka K, Hayashida K et al (2001) Chemokines regulate IL-6 and IL-8 production by fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Immunol 167: 5381-5385.
31. Jimenez-Sainz MC, Fast B, Mayor F Jr et al (2003) Signaling pathways for monocyte chemoattractant protein 1-mediated extracellular signal-regulated kinase activation. Mol Pharmacol 64: 773-782.
32. Myers SJ, Wong LM, Charo IF (1995) Signal transduction and ligand specificity of the human monocyte chemoattractant protein-1 receptor in transfected embryonic kidney cells. J Biol Chem 270: 5786-5792.
33. Wong LM, Myers SJ, Tsou CL et al (1997) Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking. J Biol Chem 272: 1038-1045.
34. Sarafi MN, Garcia-Zepeda EA, MacLean JA et al (1997) Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. J Exp Med 185: 99-109.
35. Inoue K, Tsuda M (2009) Microglia and neuropathic pain. Glia 57: 1469-1479.
36. Royle SJ, Qureshi OS, Bobanovic LK et al (2005) Non-canonical YXXGPhi endocytic motifs: recognition by AP2 and preferential utilization in P2X4 receptors. J Cell Sci 118: 3073-3080.
37. Bobanovic LK, Royle SJ, Murrell-Lagnado RD (2002) P2X receptor trafficking in neurons is subunit specific. J Neurosci 22: 4814-4824.
38. Eskelinen EL, Tanaka Y, Saftig P (2003) At the acidic edge: emerging functions for lysosomal membrane proteins. Trends Cell Biol 13: 137-145.
39. Ulmann L, Hatcher JP, Hughes JP et al (2008) Up-regulation of P2X4 receptors in spinal microglia after peripheral nerve injury mediates BDNF release and neuropathic pain. J Neurosci 28: 11263-11268.
40. Burnstock G (2008) Purinergic signalling and disorders of the central nervous system. Nat Rev Drug Discov 7: 575-590.
41. Stokes L, Surprenant A (2009) Dynamic regulation of the P2X4 receptor in alveolar macrophages by phagocytosis and classical activation. Eur J Immunol 39: 986-995.
42. Toulme E, Garcia A, Samways D et al (2010) P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin. J Gen Physiol 135: 333-353.
43. van Steenwinckel J, Reaux-Le Goazigo A, Pommier B et al (2011) CCL2 released from neuronal synaptic vesicles in the spinal cord is a major mediator of local inflammation and pain after peripheral nerve injury. J Neurosci 31: 5865-5875.
44. Murrell-Lagnado RD, Qureshi OS (2008) Assembly and trafficking of P2X purinergic receptors (review). Mol Membr Biol 25: 321-331.
45. Colvin RA, Means TK, Diefenbach TJ et al (2010) Synaptotagmin-mediated vesicle fusion regulates cell migration. Nat Immunol 11: 495-502.
46. 2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes. J Cell Biol 174: 997-1007.
47. Wu D, LaRosa GJ, Simon MI (1993) G protein-coupled signal transduction pathways for interleukin-8. Science 261: 101-103.
48. Kuehn HS, Gilfillan AM (2007) G protein-coupled receptors and the modification of FcepsilonRI-mediated mast cell activation. Immunol Lett 113: 59-69.
49. Serrano A, Pare M, McIntosh F et al (2010) Blocking spinal CCR2 with AZ889 reversed hyperalgesia in a model of neuropathic pain. Mol Pain 6: 90.
50. Old EA, Malcangio M (2011) Chemokine mediated neuron-glia communication and aberrant signalling in neuropathic pain states. Curr Opin Pharmacol (in press).
51. Terashima Y, Onai N, Murai M et al (2005) Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis. Nat Immunol 6: 827-835.
52. Schilling M, Strecker JK, Ringelstein EB et al (2009) The role of CC chemokine receptor 2 on microglia activation and blood-borne cell recruitment after transient focal cerebral ischemia in mice. Brain Res 1289: 79-84.
53. Galasso JM, Stegman LD, Blaivas M et al (2000) Experimental gliosarcoma induces chemokine receptor expression in rat brain. Exp Neurol 161: 85-95.
54. Abbadie C, Bhangoo S, De Koninck Y et al (2009) Chemokines and pain mechanisms. Brain Res Rev 60: 125-134.
55. Abbadie C, Lindia JA, Cumiskey AM et al (2003) Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proc Natl Acad Sci U S A 100: 7947-7952.
56. Wixey JA, Reinebrant HE, Carty ML et al (2009) Delayed P2X4R expression after hypoxia-ischemia is associated with microglia in the immature rat brain. J Neuroimmunol 212: 35-43.
57. Zhang J, Shi XQ, Echeverry S et al (2007) Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain. J Neurosci 27: 12396-12406.