P2X7 Receptor signaling pathway as a therapeutic target for neurodegenerative diseases

Archivum Immunologiae et Therapiae Experimentalis

Volumn 58, Issue 2, 2010, Pages 91-96

  Takenouchi, Takato ^a,b   Sekiyama, Kazunari ^a   Sekigawa, Akio ^a   Fujita, Masayo ^a   Waragai, Masaaki ^a   Sugama, Shuei ^a   Iwamaru, Yoshifumi ^c   Kitani, Hiroshi ^b   Hashimoto, Makoto ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

^c NATIONAL INSTITUTE OF ANIMAL HEALTH   (Japan)

Author keywords

Microglia; Neurodegenerative disease; Neuroinflammation; P2X7 receptor

Indexed keywords

BRILLIANT BLUE; INTERLEUKIN 1BETA; PURINERGIC P2X7 RECEPTOR; ANTIINFLAMMATORY AGENT; AUTACOID; NEUROPROTECTIVE AGENT; PURINERGIC P2 RECEPTOR;

ALZHEIMER DISEASE; ASTROCYTE; BLOOD BRAIN BARRIER; CELL ACTIVATION; CELL DEATH; CELL PROLIFERATION; CYTOKINE RELEASE; DEGENERATIVE DISEASE; DRUG EFFICACY; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENE LOCATION; GENE TARGETING; HUMAN; HUNTINGTON CHOREA; MICROGLIA; MULTIPLE SCLEROSIS; NERVE CELL; NERVE DEGENERATION; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; PARKINSONISM; PHARMACOLOGICAL BLOCKING; PRION DISEASE; REGULATORY MECHANISM; REVIEW; SPINAL CORD DISEASE; UPREGULATION; ANIMAL; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; ENCEPHALITIS; IMMUNOLOGY; METABOLISM; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTROCYTES; DISEASE MODELS, ANIMAL; ENCEPHALITIS; HUMANS; INFLAMMATION MEDIATORS; MICROGLIA; NEURODEGENERATIVE DISEASES; NEURONS; NEUROPROTECTIVE AGENTS; RECEPTORS, PURINERGIC P2; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 77952746529     PISSN: 0004069X     EISSN: 16614917     Source Type: Journal    
DOI: 10.1007/s00005-010-0069-y     Document Type: Review

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