The modern pharmacology of paracetamol: Therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings

Inflammopharmacology

Volumn 21, Issue 3, 2013, Pages 201-232

  Graham, Garry G ^a   Davies, Michael J ^b,c   Day, Richard O ^a   Mohamudally, Anthoulla ^d   Scott, Kieran F ^e  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b University of Sydney   (Australia)

^c HEART RESEARCH INSTITUTE   (Australia)

^d ROYAL DARWIN HOSPITAL   (Australia)

^e UNIVERSITY OF WESTERN SYDNEY   (Australia)

Author keywords

Acetaminophen; Analgesia; Atherosclerosis; COX 2; COX 3; Cyclooxygenase, COX 1; Diabetes, rhabdomyolysis; Inflammation; MIF; Myeloperoxidase; Pain; Paracetamol; Peroxidase; Prostacyclin; Prostaglandin; Resveratrol; Thromboxane

Indexed keywords

CAFFEINE; CELECOXIB; CODEINE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 3; ENDOCANNABINOID; ETORICOXIB; GLUTAMIC ACID; IBUPROFEN; INDOMETACIN; KETOPROFEN; MACROPHAGE MIGRATION INHIBITION FACTOR; MYELOPEROXIDASE; N (4 HYDROXYPHENYL)ARACHIDONAMIDE; NAPROXEN; NARCOTIC ANALGESIC AGENT; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PHENOL DERIVATIVE; PROSTAGLANDIN; PROTEIN FOS; RESVERATROL; SEROTONIN; SUBSTANCE P; WARFARIN;

ALCOHOL ABUSE; ANALGESIC ACTIVITY; ANTICOAGULATION; ANTIDIABETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIPYRETIC ACTIVITY; ASTHMA; BRONCHOSPASM; CANCER PAIN; CARDIOVASCULAR DISEASE; CENTRAL NERVOUS SYSTEM; CHOLINERGIC SYSTEM; CHRONIC PAIN; COLON CANCER; COST BENEFIT ANALYSIS; DIABETES MELLITUS; DOSE RESPONSE; DRUG ABSORPTION; DRUG COST; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG POTENTIATION; DRUG SAFETY; DRUG STRUCTURE; ENDOMETRIUM CANCER; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME ISOLATION; GASTROINTESTINAL SYMPTOM; GASTROINTESTINAL TOXICITY; GENE INTERACTION; HIGH RISK PATIENT; HUMAN; HYPERTENSION; LIVER TOXICITY; LOW BACK PAIN; MALNUTRITION; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; NORADRENERGIC SYSTEM; OSTEOARTHRITIS; OVARY CANCER; PAIN; PERIPHERAL NERVOUS SYSTEM; PHYSICAL CHEMISTRY; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; PROSTATE CANCER; REPERFUSION INJURY; REVIEW; RHABDOMYOLYSIS; RHEUMATOID ARTHRITIS; RISK ASSESSMENT; SEROTONINERGIC SYSTEM; SINGLE DRUG DOSE; UNSPECIFIED SIDE EFFECT;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; HUMANS; INFLAMMATION;

EID: 84878990070     PISSN: 09254692     EISSN: 15685608     Source Type: Journal    
DOI: 10.1007/s10787-013-0172-x     Document Type: Review

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