Unexpected and pronounced antinociceptive synergy between spinal acetaminophen (paracetamol) and phentolamine

European Journal of Pharmacology

Volumn 412, Issue 2, 2001, Pages

  Raffa, Robert B ^a,b   Stone Jr , Dennis J ^a   Tallarida, Ronald J ^a  

^a TEMPLE UNIVERSITY SCHOOL OF PHARMACY   (United States)

^b TEMPLE UNIVERSITY   (United States)

Author keywords

Acetaminophen; Antinociception; Synergy

Indexed keywords

ADRENERGIC RECEPTOR; ION CHANNEL; NITRIC OXIDE SYNTHASE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PHENTOLAMINE; PROSTAGLANDIN SYNTHASE; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; LIGAND BINDING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD;

ACETAMINOPHEN; ADRENERGIC ALPHA-AGONISTS; ANALGESICS; ANALGESICS, NON-NARCOTIC; ANIMALS; DRUG SYNERGISM; INJECTIONS, SPINAL; MALE; MICE; MICE, INBRED ICR; PAIN MEASUREMENT; PHENTOLAMINE;

EID: 0035951628     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)00722-1     Document Type: Article

References (8)

1. Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol
2. The abdominal constriction response and its suppression by analgesic drugs in the mouse
3. Blocking effects of phentolamine on L-type calcium current and ATP-sensitive potassium current in guinea pig ventricular myocytes
4. 3 receptors: In vivo and in vitro evidence
5. Lack of binding of acetaminophen to 5-HT receptor or uptake sites (or eleven other binding/uptake assays)
6. Discovery of "self-synergistic" spinal/supraspinal antinociception produced by acetaminophen (paracetamol)
7. NSAID: An update on their analgesic effects