Use of pharmaco-metabonomics for early prediction of acetaminophen-induced hepatotoxicity in humans

Clinical Pharmacology and Therapeutics

Volumn 88, Issue 1, 2010, Pages 45-51

  Winnike, J H ^a   Li, Z ^b   Wright, F A ^b   MacDonald, J M ^a   O'Connell, T M ^a,c   Watkins, P B ^a,c  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b IL   (United States)

^c Hamner UNC Institute for Drug Safety Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N ACETYL 1,4 BENZOQUINONE IMINE; PARACETAMOL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CLINICAL TRIAL; DRUG RESPONSE; GENETIC SUSCEPTIBILITY; HUMAN; LIVER INJURY; LIVER TOXICITY; METABOLOMICS; NONHUMAN; PREDICTION; PRIORITY JOURNAL; SIDE EFFECT; STATISTICAL ANALYSIS;

ACETAMINOPHEN; ADOLESCENT; ADULT; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; BIOTRANSFORMATION; COHORT STUDIES; DATA INTERPRETATION, STATISTICAL; DRUG-INDUCED LIVER INJURY; FEMALE; HUMANS; LEAST-SQUARES ANALYSIS; LIVER FUNCTION TESTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE OF TESTS; YOUNG ADULT;

EID: 77953811759     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2009.240     Document Type: Article

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