Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H2 synthases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 10, 2002, Pages 7130-7135

  Boutaud, Olivier ^b   Aronoff, David M ^a   Richardson, Jacob H ^a   Marnett, Lawrence J ^b   Oates, John A ^a,b  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; INTERLEUKIN 1ALPHA; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PEROXIDE; PROSTAGLANDIN G; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; TERT BUTYL HYDROPEROXIDE;

ANALGESIC ACTIVITY; ANTIPYRETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SPECIFICITY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; INFLAMMATION; PRIORITY JOURNAL; THROMBOCYTE; UMBILICAL VEIN;

6-KETOPROSTAGLANDIN F1 ALPHA; ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ARACHIDONIC ACID; BLOOD PLATELETS; CELLS, CULTURED; CYCLOOXYGENASE 1; CYCLOOXYGENASE INHIBITORS; CYTOCHROME P-450 ENZYME SYSTEM; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HUMANS; HYDROGEN PEROXIDE; INTERLEUKIN-1; INTRAMOLECULAR OXIDOREDUCTASES; ISOENZYMES; LIPID PEROXIDATION; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS G; SUBSTRATE SPECIFICITY; UMBILICAL VEINS;

MURINAE; OVIS;

EID: 0037076347     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.102588199     Document Type: Article

References (61)