NMR and HPLC-NMR spectroscopic studies of futile deacetylation in paracetamol metabolites in rat and man

Journal of Pharmaceutical and Biomedical Analysis

Volumn 15, Issue 7, 1997, Pages 901-910

  Nicholls, Andrew W ^a   Farrant, R Duncan ^b   Shockcor, John P ^c   Unger, Steve E ^c   Wilson, Ian D ^d   Lindon, John C ^a   Nicholson, Jeremy K ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c GLAXOSMITHKLINE   (United States)

^d ASTRAZENECA   (United Kingdom)

Author keywords

4 acetamidophenol; 13C labeling; 2H labeling; Futile deacetylation; HPLC NMR; Human; Metabolites; Paracetamol; Rat

Indexed keywords

DRUG METABOLITE; PARACETAMOL; PARACETAMOL GLUCURONIDE;

ARTICLE; DEACETYLATION; DRUG DETERMINATION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NONHUMAN; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SOLID PHASE EXTRACTION; URINALYSIS;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; RATS; SPECIES SPECIFICITY;

EID: 0030952767     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(96)01950-4     Document Type: Article

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