Naloxone-reversible antinociception by paracetamol in the rat

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 2, 1997, Pages 934-940

  Pini, L A ^a,b   Vitale, G ^a   Ottani, A ^a   Sandrini, M ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b Clinical Pharmacology Unit   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FORMALDEHYDE; MORPHINE SULFATE; NALOXONE; PARACETAMOL; SEROTONIN; SEROTONIN 2 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; HOT PLATE TEST; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOTOR ACTIVITY; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SEROTONIN BRAIN LEVEL; SUBCUTANEOUS DRUG ADMINISTRATION;

ACETAMINOPHEN; ANIMALS; CEREBRAL CORTEX; FORMALDEHYDE; HEAT; KETANSERIN; KINETICS; MALE; MORPHINE; MOTOR ACTIVITY; NALOXONE; PAIN; PONS; RATS; RATS, WISTAR; RECEPTORS, SEROTONIN; SEROTONIN; STEREOTYPED BEHAVIOR;

EID: 0030898943     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. ABDEL-ALIM, M. S., SJØQVIST, B. AND ANGGARD, E.: Inhibition of prostaglandin synthesis in rat brain. Acta Pharmacol. Toxicol. 43: 266-272, 1978.
2. BARALDI, M., POGGIOLI, R., SANTI, M., VERGONI, A. V. AND BERTOLINI A.: Antidepressants and opiates interactions: pharmacological and biochemical evidences. Pharmacol. Res. Commun. 15: 843-857, 1983.
3. BENSEMANA, D. AND GASCON, A. L.: Relationship between analgesia and turn- over of brain biogenic amines. Can. J. Physiol. Pharmacol. 56: 721-730, 1978.
4. BENTLEY, K. C. AND HEAD T. W.: The additive analgesic efficacy of acetaminophen, 1000 mg, and codeine, 60 mg, in dental pain. Clin. Pharmacol. Ther. 42: 634-640, 1987.
5. BHARGAVA, H. A., LARSEN, A. K., RAHMANI, N. H. AND VILLAR, V. M.: Naltrexone-induced alterations of the distribution of morphine in brain regions and spinal cord of the rat. Brain Res. 607: 1-8, 1993.
6. BINEAU-THUROTTES, M., GODEFROY, F., WEIL-FUGAZZA, J. AND BESSON, J. M.: The effect of morphine on the potassium evoked release of tritiated 5-HT from spinal cord slices in the rat. Brain Res. 291: 293-299, 1984.
7. BJØRKLUND, A., DUNNETT, S. B., STENEVI, U., LEWIS, M. E. AND IVERSEN, S. D.: Reinnervation of the denerved striatum by substantia nigra transplants: Function consequences as revealed by pharmacological and sensomotor testing. Brain Res. 199: 307-333, 1980.
8. BJÖRKMAN, R.: Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Acta Anaesthesiol. Scand. 39: suppl. 103, 7-43, 1995.
9. BJÖRKMAN R., HEDNER, J., HEDNER, T. AND HENNING, M.: Central, naloxone reversible antinociception by diclofenac in the rat. Naunyn-Schmiedeberger's Arch. Pharmacol. 342: 171-176, 1990.
10. BODNAR, R. J., KORDOWER, J. H., WALLACE, M. M. AND TAMIR, H.: Stress and morphine analgesia: alterations following p-chlorophenylalanine. Pharmacol. Biochem. Behav. 14: 645-651, 1981.
11. CARLSSON, K. H., MONZEL, W. AND JURNA, I.: Depression by morphine and the non-opioid analgesic agents metamizol (Dipyrone), lysine acetylate and paracetamol, of activity in rat thalamus neurones evoked by electrical stimulation of nociceptive afferents. Pain 32: 313-326, 1988.
12. CHEN, A. C. N. AND CHAPMAN, C. R.: Aspirin analgesia evaluated by event-related potentials in man: possible central action in brain. Exp. Brain Res. 39: 359-364, 1980.
13. CLISSOLD, S. P.: Paracetamol and Phenacetin. Drugs 32: suppl. 4, 46-59, 1986.
14. DARMANI, N. A., MARTIN, B. R. AND GLENNON, R. A.: Behavioral evidence for differential adaptiatin of the serotonergic system after acute and chronic treatment with (±)-1-(2,5-dimetoxy-4-iodophenyl)-2-aminopropane (DOI) or ketanserin. J. Pharmacol. Exp. Ther. 262: 692-698, 1992.
15. DOMER, F.: Characterization of the analgesic activity of ketorolac in mice. Eur. J. Pharmacol. 61: 17-24, 1990.
16. DRISSEN, B. AND REIMAN, W.: Interaction of the central analgesic tramadol with the uptake and release of 5-hydroxytryptamine in vitro. Br. J. Pharmacol. 105: 147-151, 1992.
17. 2 receptors in spinal cord in the control of nociceptive responsiveness. Neuropharmacology 30: 727-731, 1991.
18. GLAZER, E. J., STEINBUSH, H., VERHOFSTAD, A. AND BASBAUM, A.: Serotonin neurons in nucleus raphe dorsalis and paragigantocellularis of the cat contains enkephalin. J. Physiol. 77: 241-245, 1981.
19. GRANADOS-SOTO, V., FLORES-MURRIETA, F., CASTANETA-HERN ANDEZ, G., SALAZAR, L. A., VILLAREAL, J. E. AND FLORES-MURRIETA, F. L.: Characterization of analgesic effects of paracetamol and caffeine combinations in the pain-induced functional impairment model in the rat. J. Pharm. Pharmacol. 47: 514-517, 1995.
20. GRAUER, S. N., TAG, R. AND AUERBACH, S. B.: Morphine induces an increase in extracellular serotoninin the rat diencephalon. Brain Res. 599: 277-282, 1992.
21. HEAPY, C. G., JAMIESON, A. AND RUSSEL, N. J. W.: Afferent C-fiber and A-delta activity in models of inflammation. Br. J. Pharmacol. 90: 164P, 1987.
22. HOLE, K. AND TJØLSEN, A.: The tail-flick and formalin tests in rodents: changes in skin temperature as a confounding factor. Pain 53: 247-251, 1993.
23. HUNSKAAR, S., FASMER, O. B. AND HOLE, K.: Formalin test in mice: A useful technique for evaluating mild analgesics. J. Neurosci. Methods 14: 69-76, 1985.
24. 3H]ligand for serotonin receptor binding sites. Mol. Pharmacol. 21: 301-314, 1982.
25. 2 receptors, roles and regulations. Ann. NY Acad. Sci. 600: 183-193, 1990.
26. LIN, M. T., CHI, M. L., CHANDRA, A. AND TSAY, B. L.: Serotonergic mechanism of beta-endorphin and clonidine-induced analgesia in rats. Pharmacology 20: 323-328, 1980.
27. MALMBERG, A. B. AND YAKSH, T. L.: Antinociceptive actions of spinal anti-inflammatory agents on the formalin test in the rat. J. Pharmacol. Exp. Ther. 263: 136-146, 1992.
28. MALMBERG, A. B. AND YAKSH, T. L.: Pharmacology of spinal action of Ketorolac, Morphine, ST-91, U50488, and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction. Anesthesiology 79: 270-281, 1993.
29. MALMBERG, A. B. AND YAKSH, T. L.: Antinociception produced by spinal delivery of the S and R enantiomers of flurbiprofen in the formalin test. Eur. J. Pharmacol. 256: 205-209, 1994.
30. MALMGREX, R.: The central serotonergic system. Cephalalgia 10: 199-204, 1990.
31. MANZ, B., KOSFELE, H., BELOVSKY, O., GRILL, H. J. AND POLLOW, K.: Direckte radioimmunologische Bestimmung des Serotonin in normalen und patologlschen Seren. Arztl. Lab. 32: 135-139, 1986.
32. MAVES, T. J., PECHMAN, P. S., MELLER, S. T. AND GEBHART, G. F.: Ketorolac potentiates morphine antinociception during visceral nociception. Anesthesiology 80: 1094-1101, 1994.
33. 1A receptors and the tail-flick response. II. High efficacy 5-HT1A agonists attenuate morphine induced antinociception in mice in a competitive-like manner. J. Pharmacol. Exp. Ther. 256: 983-993, 1991.
34. OCHS, H. R., GREENBLATT, D. J., ABERNETHY, D. R., ERENDT, R. M., GERLOFF, J., EICHELKRAUT, W. AND HAHN N.: Cerebrospinal fluid uptake and peripheral distribution of centrally acting drugs: Relation to lipid solubility. J. Pharm Pharmacol. 37: 428-431, 1985.
35. 3 receptors. NeuroReport 6: 1546-1548, 1995.
36. PILETTA, P., PORCHET, H. C. AND BAYER, P.: Central analgesic effect of acetaminophen but not of aspirin. Clin. Pharmacol. Ther. 49: 350-354, 1991.
37. PINI, L. A., SANDRINI, M. AND VITALE, G.: The antinociceptive action of paracetamol is associated with changes in the serotonergic system in the rat brain. Eur. J. Pharmacol. 308: 31-40, 1996.
38. PIRCIO, A. W., BUYNISKI, J. P. AND ROEBEL, L. E.: Pharmacological effects of a combination of butorphanol and acetaminophen. Arch. Int. Pharmacodyn. 235: 116-123, 1978.
39. POGGIOLI, R., CASTELLI, M., GENEDANI, S. AND BERTOLINI A.: Influence of prostag-landin-synthetase inhibitors on the analgesic effect of morphine in the rat. Riv. Farmacol. Terap. XI: 11-14, 1980.
40. RICHARDSON, B. P.: Serotonin and nociception. Ann. NY Acad. Sci. 600: 511-520, 1990.
41. RIVOT, J. P., POINTIS, D. AND BESSON, J. M.: Morphine increases 5-HT metabolism in the nucleus raphe magnus: an in vivo study in freely moving rats using 5-Hydroxyindole electrochemical detection. Brain Res. 446: 333-342, 1988.
42. ROSENTHAL, H.: A graphic method for the determination and presentation of binding parameter in a complex system. Anal. Biochem. 20: 520-532, 1967.
43. SACERDOTE, P., MOZA, G., MANTEGAZZA, P., PANERAI, A. E.: Diclofenac and pirprofen modify pituitary and hypothalamic beta-endorphin concentrations. Pharmacol. Res. Commun. 17: 679-684, 1983.
44. SANDRINI, M., VITALE, G., DONDI, M. AND PINI, L. A.: Effects of acetylsalicylic acid on serotonin brain receptor subtypes. Gen. Pharmacol. 26: 737-741, 1995.
45. SNEDECOR, G. W. AND COCHRAN, W. J.: Statistical Methods, pp. 298-307. Iowa State University Press, Ames, 1980.
46. TAO, R. AND AUERBACH, S. B.: Increased extracellular serotonin in rat brain after systemic or intra-raphe administration of morphine. J. Neurochem. 63: 517-524, 1994.
47. TAO, R. AND AUERBACH, S. B.: Involvement of the dorsal raphe but not median raphe nucleus in morphine-induced increases in serotonin release in the rat forebrain. Neuroscience 68: 553-561, 1995.
48. TJØLSEN, A., LUND, A. AND HOLE, K.: Antinociceptive effect of paracetamol in rats is partly dependent on spinal serotonergic systems. Eur. J. Pharmacol. 193: 193-201, 1991.
49. TÖRK, I.: Anatomy of the serotonergic system. Ann. NY Acad. Sci. 600: 9-26, 1990.
50. UPHOUSE, L. A., WELCH, S. P., WARD, C. R., ELLIS, E. F. AND EMBREY, J. P.: Antinociceptive activity of intrathecal ketorolac is blocked by the κ-opioid receptor antagonist nor-binaltorphimine. Eur. J. Pharmacol. 242: 53-58, 1993.
51. VANE, J. R. AND BOTTING, R. M.: New insights into the mode of action of anti-inflammatory drugs. Inflammation Res. 44: 1-10, 1995.
52. VITALE, G., SANDRINI, M. AND PINI, L. A.: Involvement of brain serotonergic system in the analgesic action of paracetamol. Pharmacol. Res. 31: suppl., 160, 1995.
53. WARNER, R., HUDSON-HOWARD, L., JOHNSTON, C. AND SKOLNIK, M.: Serotonin involvement in analgesia induced by transcranial electrostimulation. Life Sci. 48: 1131-1138, 1990.
54. WHEELER-ACETO, H., PORRECA, F. AND COWAN, A.: The rat paw formalin test: Comparison of noxious agents. Pain 40: 229-238, 1990.
55. WINDH, R. T., LITTLE, P. G. AND KUHN, C. M.: The ontogeny of μ opiate tolerance and dependence in the rat: antinociceptive and biochemical studies. J. Pharmacol. Exp. Ther. 273: 1361-1374, 1995.
56. YANG, S. W., ZHANG, Z. H., WANG, R., XIE, Y-F., QIAO, J-T. AND DAFNY, N.: Norepinephrine and serotonin iduced antinociception are blocked by naloxone with different dosages. Brain Res. Bull. 35: 113-117, 1994.