Intrathecally applied flurbiprofen produces an endocannabinoid-dependent antinociception in the rat formalin test

European Journal of Neuroscience

Volumn 17, Issue 3, 2003, Pages 597-604

  Ates, Mehmet ^a   Hamza, May ^a,c   Seidel, Kay ^a   Kotalla, Carolin E ^a   Ledent, Catherine ^b   Gühring, Hans ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^c Ain Shams University   (Egypt)

Author keywords

CB1 gene deficient mice; Prostaglandin E2; Spinal nociception; Vas deferens twitch response

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; ANANDAMIDE; ARACHIDONIC ACID; BENZYLSULFONYL FLUORIDE; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; FATTY ACID AMIDASE; FLURBIPROFEN; FORMALDEHYDE; KETONE DERIVATIVE; METHANANDAMIDE; METHYLARACHIDONYLFLUOROPHOSPHONATE; N (PIPERIDIN 1 YL) 5 (4 IODOPHENYL) 1 (2,4 CHLOROPHENYL) 4 METHYL 1 H PYRAZOLE 3 CARBOXAMIDE; PALMITOYLTRIFLUOROMETHYLKETONE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PHOSPHONIC ACID DERIVATIVE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PYRAZOLE DERIVATIVE; THIOMERSAL; UNCLASSIFIED DRUG;

ACYLATION; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ELECTROSTIMULATION; ENZYME INHIBITION; EVOKED RESPONSE; KNOCKOUT MOUSE; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; VAS DEFERENS;

EID: 0037330445     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2003.02470.x     Document Type: Article

References (44)

1. Almeida, F.R., Schivo, I.R., Lorenzetti, B.B. & Ferreira, S.H. (2000) Chronic intrathecal cannulation enhances nociceptive responses in rats. Braz. J. Med. Biol. Res., 33, 949-956.
2. Bradbury, J. (2001) Small part of cannabis puzzle solved by animal studies. Lancet, 358, 302.
3. Brooks, P. (1998) Use and benefits of nonsteroidal anti-inflammatory drugs. Am. J. Med., 104, 9S-13S;discussion 21S-22S.
4. Brune, K., Beck, W.S., Geisslinger, G., Menzel-Soglowek, S., Peskar, B.M. & Peskar, B.A. (1991) Aspirin-like drugs may block pain independently of prostaglandin synthesis inhibition. Experientia, 47, 257-261.
5. Campbell, W.B. & Halushka, P.V. (1996) Lipid-derived autacoids. Eicosanoids and platelet-activating factor. In Hardman, J.G., Limbird, L.E., Molinoff, P.B., Ruddon, R.W. & Gilman, A.G. (eds), Goodman and Gilman's the Pharmacological Basis of Therapeutics. McGraw-Hill, New York, pp. 601-616.
6. Deutsch, D.G., Omeir, R., Arreaza, G., Salehani, D., Prestwich, G.D., Huang, Z. & Howlett, A. (1997) Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase. Biochem. Pharmacol., 53, 255-260.
7. Devane, W.A., Hanus, L., Breuer, A., Pertwee, R.G., Stevenson, L.A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A. & Mechoulam, R. (1992) Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science, 258, 1946-1949.
8. Di Marzo, V. (1999) Biosynthesis and inactivation of endocannabinoids: relevance to their proposed role as neuromodulators. Life Sci., 65, 645-655.
9. Dubuisson, D. & Dennis, S.G. (1977) The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain, 4, 161-174.
10. Fernando, S.R. & Pertwee, R.G. (1997) Evidence that methyl arachidonyl fluorophosphonate is an irreversible cannabinoid receptor antagonist. Br. J. Pharmacol., 121, 1716-1720.
11. 2 causes sensitization of the primary afferent neuron via the spinal release of glutamate. Inflamm. Res., 45, 499-502.
12. Fowler, C.J., Janson, U., Johnson, R.M., Wahlstrom, G., Stenstrom, A., Norstrom, K. & Tiger, G. (1999) Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen. Arch. Biochem. Biophys., 362, 191-196.
13. 123I-Labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors. Eur. J. Pharmacol., 307, 331-338.
14. Goppelt-Struebe, M., Koerner, C.F., Hausmann, G., Gemsa, D. & Resch, K. (1986) Control of prostanoid synthesis: role of reincorporation of released precursor fatty acids. Prostaglandins, 32, 373-385.
15. Gühring, H., Hamza, M., Sergejeva, M., Ates, M., Kotalla, C.E., Ledent, C. & Brune, K. (2002) A role for endocannabinoids in indomethacin-induced spinal antinociception. Eur. J. Pharmacol., 454, 153-163.
16. Gühring, H., Schuster, J., Hamza, M., Ates, M., Kotalla, C.E. & Brune, K. (2001) HU-210 shows higher efficacy and potency than morphine after intrathecal administration in the mouse formalin test. Eur. J. Pharmacol., 429, 127-134.
17. Howlett, A.C., Barth, F., Bonner, T.I., Cabral, G., Casellas, P., Devane, W.A., Felder, C.C., Herkenham, M., Mackie, K., Martin, B.R., Mechoulam, R. & Pertwee, R.G. (2002) International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol. Rev., 54, 161-202.
18. Irvine, R.F. (1982) How is the level of free arachidonic acid controlled in mammalian cells? Biochem. J., 204, 3-16.
19. Ito, S., Okuda-Ashitaka, E. & Minami, T. (2001) Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin. Neurosci. Res., 41, 299-332.
20. Koutek, B., Prestwich, G.D., Howlett, A.C., Chin, S.A., Salehani, D., Akhavan, N. & Deutsch, D.G. (1994) Inhibitors of arachidonoyl ethanolamide hydrolysis. J. Biol. Chem., 269, 22937-22940.
21. Kuwae, T., Shiota, Y., Schmid, P.C., Krebsbach, R. & Schmid, H.H. (1999) Biosynthesis and turnover of anandamide and other N-acylethanolamines in peritoneal macrophages. FEBS Lett., 459, 123-127.
22. Lay, L., Angus, J.A. & Wright, C.E. (2000) Pharmacological characterisation of cannabinoid CB(1) receptors in the rat and mouse. Eur J. Pharmacol., 391, 151-161.
23. Ledent, C., Valverde, O., Cossu, G., Petitet, F., Aubert, J.F., Beslot, F., Bohme, G.A., Imperato, A., Pedrazzini, T., Roques, B.P., Vassart, G., Fratta, W. & Parmentier, M. (1999) Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science, 283, 401-404.
24. Malmberg, A.B., Rafferty, M.F. & Yaksh, T.L. (1994) Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on the rat. Neurosci. Lett., 173, 193-196.
25. Malmberg, A.B. & Yaksh, T.L. (1992a) Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat. J. Pharmacol. Exp. Ther, 263, 136-146.
26. Malmberg, A.B. & Yaksh, T.L. (1992b) Hyperalgesia mediated by spinal glutamate or substance P receptor blocked by spinal cyclooxygenase inhibition. Science, 257, 1276-1279.
27. Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N.E., Schatz, A.R., Gopher, A., Almog, S., Martin, B.R., Compton, D.R. & et al. (1995) Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol., 50, 83-90.
28. Mestre, C., Pelissier, T., Fialip, J., Wilcox, G. & Eschalier, A. (1994) A method to perform direct transcutaneous intrathecal injection in rats. J. Pharmacol. Toxicol. Methods, 32, 197-200.
29. Minami, T., Nakano, H., Kobayashi, T., Sugimoto, Y., Ushikubi, F., Ichikawa, A., Narumiya, S. & Ito, S. (2001) Characterization of EP receptor subtypes responsible for prostaglandin FLUORO-induced pain responses by use of EP1 and EP3 receptor knockout mice. Br. J. Pharmacol., 133, 438-444.
30. Minami, T., Nishihara, I., Uda, R., Ito, S., Hyodo, M. & Hayaishi, O. (1994) Characterization of EP-receptor subtypes involved in allodynia and hyperalgesia induced by intrathecal administration of prostaglandin FLUORO to mice. Br. J. Pharmacol., 112, 735-740.
31. Pertwee, R.G. (2001) Cannabinoid receptors and pain. Prog. Neurobiol., 63, 569-611.
32. Pertwee, R.G., Stevenson, L.A., Elrick, D.B., Mechoulam, R. & Corbett, A.D. (1992) Inhibitory effects of certain enantiomeric cannabinoids in the mouse vas deferens and the myenteric plexus preparation of guinea-pig small intestine. Br. J. Pharmacol., 105, 980-984.
33. Peskar, B.M., Kluge, S., Peskar, B.A., Soglowek, S.M. & Brune, K. (1991) Effects of pure enantiomers of flurbiprofen in comparison to racemic flurbiprofen on eicosanoid release from various rat organs ex vivo. Prostaglandins, 42, 515-531.
34. Pestonjamasp, V.K. & Burstein, S.H. (1998) Anandamide synthesis is induced by arachidonate mobilizing agonists in cells of the immune system. Biochim. Biophys. Acta, 1394, 249-260.
35. Svensson, C.L., Killremann, K.E., Dennis, E.A. & Yaksh, T.Y. (2001) Effect of spinal administration of phospholipase A2 inhibitors on carrageenan and formalin induced inflammatory hyperalgesia. [In 20th Annual Scientific Meeting, American Pain Society, Abstract 679.] J. Pain, 2, 679.
36. Svensson, C.I. & Yaksh, T.L. (2002) The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing. Annu. Rev. Pharmacol. Toxicol., 42, 553-583.
37. Taiwo, Y.O. & Levine, J.D. (1990) Effects of cyclooxygenase products of arachidonic acid metabolism on cutaneous nociceptive threshold in the rat. Brain Res., 537, 372-374.
38. Tjolsen, A., Berge, O.G., Hunskaar, S., Rosland, J.H. & Hole, K. (1992) The formalin test: an evaluation of the method. Pain, 51, 5-17.
39. Vanegas, H. & Schaible, H.G. (2001) Prostaglandins and cycloxygenases in the spinal cord. Prog. Neurobiol., 64, 327-363.
40. Vogt, W. (1978) Role of phospholipase A2 in prostaglandin formation. Adv. Prostaglandin Thromboxane Res., 3, 89-95.
41. Wilson, D.E. (1991) Role of prostaglandins in gastroduodenal mucosal protection. J. Clin. Gastroenterol., 13, S65-S71.
42. Yaksh, T.L. (1997) Preclinical models of nociception. In Yaksh, T.L., Lynch, C.I., Zapol, W.M., Maze, M., Biebuyck, J.F. & Saidman, L.J. (eds), Anesthesia: Biologic Foundations. Lippincott-Raven, Philadelphia, PA, pp. 685-718.
43. Yaksh, T.L. & Malmberg, A.B. (1994) Central pharmacology of nociceptive transmission. In Wall, P.D. & Melzack, R. (eds), Textbook of Pain. Churchill Livingstone, New York, pp. 165-200.
44. Zimmermann, M. (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain, 16, 109-110.