(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2

Nature Chemical Biology

Volumn 7, Issue 11, 2011, Pages 803-809

  Duggan, Kelsey C ^a   Hermanson, Daniel J ^b   Musee, Joel ^a   Prusakiewicz, Jeffery J ^a   Scheib, Jami L ^a   Carter, Bruce D ^a   Banerjee, Surajit ^c,e   Oates, J A ^a   Marnett, Lawrence J ^a,b,d  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c Department of Obstetrics Gynecology   (United States)

^d VANDERBILT INGRAM CANCER CENTER   (United States)

^e ARGONNE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; ARGININE; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; ENDOCANNABINOID; FLURBIPROFEN; IBUPROFEN; LIPOPOLYSACCHARIDE; LUMIRACOXIB; MEFENAMIC ACID; NAPROXEN; ROFECOXIB;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; ENANTIOMER; ENZYME ACTIVE SITE; MOUSE; NEUROPATHIC PAIN; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; RAT; SITE DIRECTED MUTAGENESIS; SPINAL GANGLION; STRUCTURE ACTIVITY RELATION;

EID: 80054953106     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.663     Document Type: Article

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