Acetaminophen, like conventional NSAIDs, may reduce synovitis in osteoarthritic knees

Rheumatology

Volumn 45, Issue 11, 2006, Pages 1389-1394

  Brandt, Kenneth D ^a   Mazzuca, Steven A ^a   Buckwalter, Kenneth A ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELECOXIB; DICLOFENAC; ETODOLAC; GADOLINIUM; IBUPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; ROFECOXIB; SULINDAC;

ADULT; ARTHRALGIA; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; CLINICAL PROTOCOL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HUMAN; IMAGE ANALYSIS; JOINT EFFUSION; KNEE OSTEOARTHRITIS; KNEE PAIN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PAIN ASSESSMENT; PILOT STUDY; PRIORITY JOURNAL; SCORING SYSTEM; SYNOVITIS;

ACETAMINOPHEN; AGED; ANALGESICS, NON-NARCOTIC; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PAIN; PAIN MEASUREMENT; PILOT PROJECTS; SYNOVITIS; TREATMENT OUTCOME;

EID: 33750203697     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/kel100     Document Type: Article

References (39)

1. Bradley JD, Brandt KD, Katz BP, Kalasinski LA, Ryan SI. Comparison of an anti-inflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. N Engl J Med 1991;325:87-91.
2. Cimmino MA, Cutolo M, Samantà E, Accardo S. Short-term treatment of osteoarthritis: A comparison of sodium meclofenamate and ibuprofen. J Int Med Res 1982;10:46-52.
3. Moxley TE, Royer GL, Hearron MS, Donovan JF, Levi L. Ibuprofen versus buffered phenylbutazone in the treatment of osteoarthritis: Double blind trial. J Am Geriatr Soc 1975;23:343-9.
4. Doyle DV, Dieppe PA, Scott J, Huskisson EC. An articular index for the assessment of osteoarthritis. Ann Rheum Dis 1981;40:75-8.
5. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. Arthritis Rheum 2000;43:1905-15.
6. American Geriatrics Society Panel on Chronic Pain in Older Persons. The management of chronic pain in older persons: AGS panel on chronic pain in older persons. American Geriatrics Society. J Am Geriatr Soc 1998;46:635-51.
7. Pendleton A, Arden N, Dougados M et al. EULAR recommendations for the management of knee osteoarthritis: Report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 2000;59:936-44.
8. Graham D. FDA: Review of epidemiologic studies and cardiovascular risk with selected NSAIDs. Presentation at the Joint Meeting of the Arthritis Advisory Committee and the Drug Safety and Risk Management Advisory Committee, Food and Drug Administration, Center for Drug Selection and Research, Gaithersburg MD. February 17, 2005.
9. Villalba L. Vioxx Cardiovascular Safety. Presentation at the Joint Meeting of the Arthritis Advisory Committee and the Drug Safety and Risk Management Advisory Committee, Food and Drug Administration, Center for Drug Selection and Research, Gaithersburg MD. February 16, 2005.
10. Kellgren JH, Lawrence JS. Radiographic assessment of osteoarthritis. Ann Rheum Dis 1957;16:494-502.
11. Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: A health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 1988;15:1833-40.
12. Bellamy N, Campbell J, Hill J, Band P. A comparative study of telephone versus onsite completion of the WOMAC 3.0 osteoarthritis index. J Rheumatol 2002;29:783-6.
13. Øtergaard M, Stoltenberg M, Henriksen O, Lorenzen I. The accuracy of MRI-determined synovial membrane and joint effusion volumes in arthritis: A comparison of pre- and post-aspiration volumes. Scan J Rheumatol 1995;24:305-11.
14. Øtergaard M, Stoltenberg M, Gideon P, Sorensen K, Henriksen O, Lorenzen I. Changes in synovial membrane and joint effusion volumes following intraarticular methylprednisolone: Quantitative assessment of inflammatory and destructive changes in rheumatoid arthritis by MRI. J Rheumatol 1996;23:1151-61.
15. Flower RJ, Vane JR. Inhibition of prostaglandin synthetase in brain explains the anti-pyretic activity of paracetamol (4-acetamidophenol). Nature 1972;240:410-1.
16. Simmons DL, Botting RM, Robertson PM, Madsen ML, Vane JR. Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci USA 1999;96:3275-80.
17. Chandrasekharan NV, Dai H, Roos KL et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression. Proc Natl Acad Sci USA 2002;99:13926-31.
18. Vane JR, Botting RM. Overview-mechanisms of action of anti-inflammatory drugs. pp.1-27. In: Improved Non-steroid Anti-inflammatory Drugs. COX-2 Enzyme Inhibitors. J Vane, J Botting, R Botting, eds. Kluwer Academic Publishers, Lancaster UK 1996; pp 1-248.
19. Catella-Lawson F, Reilly MP, Kapoor SC et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med 2001;345:1809-17.
20. Bjørnsson GA, Haanæs HR, Skoglund LA. A randomized, double-blind crossover trial of paracetamol 1000 mg four times daily vs ibuprofen 600 mg: Effect on swelling and other postoperative events after third molar surgery. Br J Clin Pharmacol 2003;55:405-12.
21. Voigt W. Die antiphlogistische therapie mit ibuprofen im vergleigh mit paracetamol in der oralchirugie. ZWR 1992;101:430-5.
22. Skjelbred P, Løkken P. Paracetamol versus placebo. Effects on postoperative course. Eur J Clin Pharmacol 1979;15:27-33.
23. Skjelbred P, Løkken P, Skoglund LA. Postoperative administration of acetaminophen to reduce swelling and other inflammatory events. Cur Ther Res 1984;35:377-85.
24. Lewis SC, Langman MJ, Laporte JR, Matthews JN. Rawlins MD, Wiholm BE. Dose-response relationships between individual nonaspirin nonsteroidal anti-inflammatory drugs (NANSAIDs) and serious upper gastrointestinal bleeding: A meta-analysis based on individual patient data. Br J Clin Pharmacol 2002;54:320-6.
25. Blot WJ, McLaughlin JK. Over the counter non-steroidal anti-inflammatory drugs and risk of gastrointestinal bleeding. J Epidemiol Biostat 2000;5:137-42.
26. Laporte JR, Carné X, Vidal X, Moreno V, Juan J. Upper gastrointestinal bleeding in relation to previous use of analgesics and non-steroidal anti-inflammatory drugs. Lancet 1991;337:85-9.
27. Holvoet J, Terriere L, Van Hee W, Verbist L, Fierens E, Haulekeete ML. Relation of upper gastrointestinal bleeding to non-steroidal anti-inflammatory drugs and aspirin: A case-control study. Gut 1991;32:730-4.
28. Nobili A, Mosconi P, Franzosi MG, Tongnoni G. Non-steroidal anti-inflammatory drugs and upper gastrointestinal bleeding: A postmarketing surveillance case-control study. Pharmacoepidemiol Drug Saf 1992;1:65-72.
29. Savage RT, Moller PW, Ballantyne CL, Wells JE. Variation in the risk of peptic ulcer complications with nonsteroidal anti-inflammatory drug therapy. Arthritis Rheum 1993;36:84-90.
30. Langman MJ, Weil J, Wainwright P et al. Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs. Lancet 1994;343:1075-8.
31. García Rodríquez LA, Hernández-Díaz S. Relative risk of upper gastrointestinal complications among users of acetaminophen and nonsteroidal anti-inflammatory drugs. Epidemiology 2001;12:570-6.
32. Rahme E, Pettitt D, LeLorier J. Determinants and sequelae associated with utilization of acetaminophen versus traditional nonsteroidal antiinflammatory drugs in an elderly population. Arthritis Rheum 2002;46:3046-54.
33. Cryer B, Feldman M. Comparison of effects of celecoxib, rofecoxib naproxen and acetaminophen on gastric COX inhibition (abstract). Am J Gastroenterol 2002;97(suppl 9): S57.
34. Högestätt ED, Jönsson BAG, Ermund A et al. Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. J. Biol Chem 2005;280:31405-12.
35. Dieppe P, Cushnaghan J, Jasani MK, McCrae F, Watt I. A two-year, placebo controlled trial of nonsteroidal anti-inflammatory therapy in osteoarthritis of the knee. Br J Rheumatol 1993: 32: 595-600.
36. Levine JD, Moskowitz MA, Basbaum AI. The contribution of neurogenic inflammation in experimental arthritis. J Immunol 1995; 135:843s-7s.
37. Bjorkman R, Hallman KM, Hedner J, Hedner T, Henning M. Acetaminophen blocks spinal hyperalgesia induced by NMDA and substance P. Pain 1994;259-64.
38. Bjorkman R. Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat. Acta Anesthesiol Scand 1995;103(suppl):1-44.
39. Pelletier JP, Jovanovic D, Fernandes JC et al. Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase. Arthritis Rheum 1998;41:1275-86.