Acetaminophen (paracetamol) improves pain and well-being in people with advanced cancer already receiving a strong opioid regimen: A randomized, double-blind, placebo-controlled cross-over trial

Journal of Clinical Oncology

Volumn 22, Issue 16, 2004, Pages 3389-3394

  Stockler, Martin ^a   Vardy, Janette ^a   Pillai, Avinesh ^a   Warr, David ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; HYDROMORPHONE; MORPHINE; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PARACETAMOL; PLACEBO; ANALGESIC AGENT; NARCOTIC ANALGESIC AGENT;

ADVANCED CANCER; ARTICLE; CANCER PAIN; CLINICAL ARTICLE; CLINICAL TRIAL; COLD; CONFIDENCE INTERVAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG DETERMINATION; DRUG DOSE REGIMEN; DRUG SAFETY; GENERAL CONDITION IMPROVEMENT; HUMAN; NAUSEA AND VOMITING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SIDE EFFECT; SWEAT; TREATMENT FAILURE; VERBAL BEHAVIOR; VISUAL ANALOG SCALE; WELLBEING; AGED; MIDDLE AGED; MULTICENTER STUDY; NEOPLASM; PAIN; QUALITY OF LIFE;

ACETAMINOPHEN; AGED; AGED, 80 AND OVER; ANALGESICS, NON-NARCOTIC; ANALGESICS, OPIOID; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; HUMANS; HYDROMORPHONE; MIDDLE AGED; MORPHINE; NEOPLASMS; PAIN; PLACEBOS; QUALITY OF LIFE;

EID: 4344619215     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2004.09.122     Document Type: Article

References (24)

1. Foley KM: The treatment of cancer pain. N Engl J Med 313:84-95, 1985
2. Cleeland CS, Gonin R, Hatfield AK, et al: Pain and its treatment in outpatients with metastatic cancer. N Engl J Med 330:592-596, 1994
3. Weiss S, Emanuel L, Fairclough D, et al: Understanding the experience of pain in terminally ill patients. Lancet 357:1311-1315, 2001
4. World Health Organisation. Cancer Pain Relief. Geneva, Switzerland, World Health Organisation, 1986
5. St Jerhsward J: WHO cancer pain relief programme. Cancer Surv 7:195-208, 1988
6. World Health Organisation. Palliative Cancer Care: Pain Relief and Management of Other Symptoms. Geneva, Switzerland, World Health Organisation Publications Centre, 1992
7. Twycross RG, Lack SA: Symptom Control in Terminal Cancer (ed 2). Edinburgh, Scotland, Churchill Livingstone, 1990
8. Bradley JD, Brandt KD, Katz BP, et al: Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. N Engl J Med 325:87-91, 1991
9. Doyle D, Hanks GWC, MacDonald N Oxford Textbook of Palliative Medicine. Oxford, United Kingdom, Oxford University Press, 1993
10. Benson GD: Evaluation of the safety of acetaminophen in chronic liver disease. Clin Pharmacol Ther 33:95-101, 1983
11. De Craen A, Di Giulio G, Lampe-Schoenmaeckers A, et al: Analgesic efficacy and safety of paracetamol-codeine combinations versus paracetamol alone: A systematic review. BMJ 313:321-325, 1996
12. Curatolo M, Sveticic G: Drug combinations in pain treatment: A review of the published evidence and a method for finding the optimal combination. Best Pract Res Clin Anaesthesiol 16:507-519, 2002
13. Camu F, Venlersberghe C: Pharmacology of systemic analgesics. Best Pract Res Clin Anaesthesiol 16:475-488, 2002
14. Hills M, Armitage P: The two-period crossover trial. Br J Clin Pharmacol 8:7-20, 1979
15. Jaeschke R, Singer J, Guyatt GH: Measurement of health status: Ascertaining the minimal clinically important difference. Control Clin Trials 10:407-415, 1989
16. Wells GA, Tugwell P, Kraag GR, et al: Minimum important difference between patients with rheumatoid arthritis: The patient's perspective. J Rheumatol 20:557-560, 1993
17. Bentley K, Head T: The additive analgesic efficacy of acetaminophen 1000mg, and codeine 60mg in dental pain. Clin Pharmacol Ther 42:634-640, 1987
18. Quiding H, Oikarinen V, Sane J, et al: Analgesic efficacy after single and repeated doses of codeine and acetaminophen. J Clin Pharmacol 24:27-34, 1984
19. Schug S, Sidebotham D, McGuinnety M, et al: Acetaminophen as an adjunct to morphine by patient-controlled analgesia in the management of acute postoperative pain. Anesth Analg 87:368-372, 1998
20. Cobby TG, Crighton IM, Kyriakides K, et al: Rectal paracetamol has a significant morphine-sparing effect after hysterectomy. Br J Anaesth 83:253-256, 1999
21. Korpela R, Korvenoja P, Meretoja OA: Morphine-sparing effect of acetaminophen in pediatric day-case surgery. Anesthesiology 91:442-447, 1999
22. Delbos A, Boccard E: The morphine-sparing effect of propacetamol in orthopedic postoperative pain. J Pain Symptom Manage 10:279-285, 1995
23. Hernandez-Palazon J, Tortosa J, Martinez-Lage J. et al: Intravenous administration of propacetamol reduces morphine consumption after spinal fusion surgery. Anesth Analg 92:1473-1476, 2001
24. Peduto VA, Ballabio M, Stafanini S: Efficacy of propacetamol in the treatment of postoperative pain: Morphine-sparing effect in orthopedic surgery. Acta Anaesthesiol Scand 1998:42:293-293