A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/ paracetamol in community-derived people with knee pain

Annals of the Rheumatic Diseases

Volumn 70, Issue 9, 2011, Pages 1534-1541

  Doherty, Michael ^a   Hawkey, Chris ^b   Goulder, Michael ^c   Gibb, Iain ^d   Hill, Nicola ^e   Aspley, Sue ^f   Reader, Sandie ^g  

^a NOTTINGHAM CITY HOSPITAL   (United Kingdom)

^b QUEEN S MEDICAL CENTRE   (United Kingdom)

^c Worldwide Clinical Trials   (United Kingdom)

^d Creative Clinical   (United Kingdom)

^e Hill Pharma Consulting Ltd   (United Kingdom)

^f RECKITT BENCKISER   (United Kingdom)

^g Clearcut Clinical Consulting   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; IBUPROFEN; IBUPROFEN PLUS PARACETAMOL; PARACETAMOL; UNCLASSIFIED DRUG;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANALGESIA; ANGINA PECTORIS; ARTICLE; BLOOD PRESSURE; CHRONIC PAIN; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FATALITY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSPEPSIA; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GASTROINTESTINAL HEMORRHAGE; HEMOGLOBIN BLOOD LEVEL; HUMAN; KIDNEY DYSFUNCTION; KNEE OSTEOARTHRITIS; KNEE PAIN; KNEE RADIOGRAPHY; LIVER FUNCTION TEST; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MULTICENTER STUDY; NAUSEA; PARALLEL DESIGN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SHORT COURSE THERAPY; SIDE EFFECT;

ACETAMINOPHEN; ADULT; AGED; AGED, 80 AND OVER; ANALGESICS, NON-NARCOTIC; CHRONIC DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; FEMALE; HEMOGLOBINS; HUMANS; IBUPROFEN; KNEE JOINT; MALE; MIDDLE AGED; NONPRESCRIPTION DRUGS; OSTEOARTHRITIS, KNEE; PAIN; PAIN MEASUREMENT; TREATMENT OUTCOME;

EID: 79961218698     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2011.154047     Document Type: Article

References (38)

1. Jinks C, Jordan K, Ong BN, et al. A brief screening tool for knee pain in primary care (KNEST). 2. Results from a survey in the general population aged 50 and over. Rheumatology (Oxford) 2004;43:55-61. (Pubitemid 38088369)
2. McAlindon TE, Cooper C, Kirwan JR, et al. Knee pain and disability in the community. Br J Rheumatol 1992;31:189-92.
3. O'Reilly SC, Muir KR, Doherty M. Knee pain and disability in the Nottingham community: association with poor health status and psychological distress. Br J Rheumatol 1998;37:870-3.
4. Linsell L, Dawson J, Zondervan K, et al. Population survey comparing older adults with hip versus knee pain in primary care. Br J Gen Pract 2005;55:192-8. (Pubitemid 40372074)
5. Mäntyselkä P, Kumpusalo E, Ahonen R, et al. Pain as a reason to visit the doctor: a study in Finnish primary health care. Pain 2001;89:175-80. (Pubitemid 32146396)
6. Peat G, McCarney R, Croft P. Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care. Ann Rheum Dis 2001;60:91-7. (Pubitemid 32102197)
7. Thorstensson CA, Andersson ML, Jönsson H, et al. Natural course of knee osteoarthritis in middle-aged subjects with knee pain: 12-year follow-up using clinical and radiographic criteria. Ann Rheum Dis 2009;68:1890-3.
8. Peat G, Thomas E, Handy J, et al. The Knee Clinical Assessment Study-CAS(K). A prospective study of knee pain and knee osteoarthritis in the general population. BMC Musculoskelet Disord 2004;5:4.
9. Dieppe P, Basler HD, Chard J, et al. Knee replacement surgery for osteoarthritis: effectiveness, practice variations, indications and possible determinants of utilization. Rheumatology (Oxford) 1999;38:73-83. (Pubitemid 29509660)
10. American College of Rheumatology. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis Rheum 2000;43:1905-15.
11. Jordan KM, Arden NK, Doherty M, et al. EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis 2003;62:1145-55. (Pubitemid 37500619)
12. National Collaborating Centre for Chronic Conditions. Osteoarthritis: the care and management of osteoarthritis in adults. London: NICE, 2008. http://www.nice.org.uk/nicemedia/pdf/CG59NICEguideline.pdf (accessed 30th May 2011).
13. Zhang W, Moskowitz RW, Nuki G, et al. OARSI recommendations for the management of hip and knee osteoarthritis. Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthr Cartil 2008;16:137-62. (Pubitemid 351222155)
14. Towheed T, Maxwell L, Judd M, et al. Acetaminophen for osteoarthritis. Cochrane Database Syst Rev 2006; 1:CD004257.
15. Wegman A, van der Windt D, van Tulder M, et al. Nonsteroidal antiinflammatory drugs or acetaminophen for osteoarthritis of the hip or knee? A systematic review of evidence and guidelines. J Rheumatol 2004;31:344-54. (Pubitemid 38160758)
16. Raffa RB. Pharmacology of oral combination analgesics: rational therapy for pain. J Clin Pharm Ther 2001;26:257-64. (Pubitemid 34205775)
17. Vane JR, Botting RM. Mechanism of action of anti-inflammatory drugs. Scand J Rheumatol Suppl 1996;102:9-21. (Pubitemid 26134842)
18. Bonnefont J, Courade JP, Alloui A, et al. [Antinociceptive mechanism of action of paracetamol]. Drugs 2003;63:1-4.
19. Hinz B, Cheremina O, Brune K. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J 2008;22:383-90. (Pubitemid 351225574)
20. Catella-Lawson F, Reilly MP, Kapoor SC, et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med 2001;345:1809-17.
21. Arendt-Nielsen L, Nielsen JC, Bjerring P. Double-blind, placebo controlled comparison of paracetamol and paracetamol plus codeine-a quantitative evaluation by laser induced pain. Eur J Clin Pharmacol 1991;40:241-7.
22. Barkin RL. Acetaminophen, aspirin, or Ibuprofen in combination analgesic products. Am J Ther 2001;8:433-42. (Pubitemid 33753139)
23. Beaver WT. Combination analgesics. Am J Med 1984;77:38-53. (Pubitemid 14014252)
24. Gertzbein SD, Tile M, McMurty RY, et al. Analysis of the analgesic efficacy of acetaminophen 1000 mg, codeine phosphate 60 mg, and the combination of acetaminophen 1000 mg and codeine phosphate 60 mg in the relief of postoperative pain. Pharmacotherapy 1986;6:104-7. (Pubitemid 16003474)
25. Skoglund LA, Skjelbred P, Fyllingen G. Analgesic efficacy of acetaminophen 1000 mg, acetaminophen 2000 mg, and the combination of acetaminophen 1000 mg and codeine phosphate 60 mg versus placebo in acute postoperative pain. Pharmacotherapy 1991;11:364-9.
26. Sindrup SH, Brøsen K. The pharmacogenetics of codeine hypoalgesia. Pharmacogenetics 1995;5:335-46. (Pubitemid 26011440)
27. Hochberg MC, Chang RW, Dwosh I, et al. The American College of Rheumatology 1991 revised criteria for the classification of global functional status in rheumatoid arthritis. Arthritis Rheum 1992;35:498-502.
28. Wilkinson CE, Carr AJ, Doherty M. Does increasing the grades of the knee osteoarthritis line drawing atlas alter its clinimetric properties? Ann Rheum Dis 2005;64:1467-73. (Pubitemid 41623859)
29. Bohannon RW. Sit-to-stand test for measuring performance of lower extremity muscles. Percept Mot Skills 1995;80:163-6.
30. Dougados M, Leclaire P, van der Heijde D, et al. Response criteria for clinical trials on osteoarthritis of the knee and hip: a report of the Osteoarthritis Research Society International Standing Committee for Clinical Trials response criteria initiative. Osteoarthr Cartil 2000;8:395-403. (Pubitemid 32000962)
31. Miceli-Richard C, Le Bars M, Schmidely N, et al. Paracetamol in osteoarthritis of the knee. Ann Rheum Dis 2004;63:923-30. (Pubitemid 38961916)
32. Todd KH, Funk KG, Funk JP, et al. Clinical significance of reported changes in pain severity. Ann Emerg Med 1996;27:485-9. (Pubitemid 26103814)
33. Kelly AM. The minimum clinically significant difference in visual analogue scale pain score does not differ with severity of pain. Emerg Med J 2001;18:205-7.
34. Brune K, Hinz B, Otterness I. Aspirin and acetaminophen: should they be available over the counter? Curr Rheumatol Rep 2009;11:36-40.
35. Rodriguez LAG, Hernámdez-Diaz S. The risk of upper gastrointestinal complications associated with nonsteroidal anti-inflammatory drugs, glucocorticoids, acetaminophen, and combinations of these agents. Arthritis Research 2001; 3:98-101.
36. Rahme E, Barkun A, Nedjar H, et al. Hospitalizations for upper and lower GI events associated with traditional NSAIDs and acetaminophen among the elderly in Quebec, Canada. Am J Gastroenterol 2008;103:872-82. (Pubitemid 351501121)
37. de Vries F, Setakis E, van Staa TP. Concomitant use of ibuprofen and paracetamol and the risk of major clinical safety outcomes. Br J Clin Pharmacol 2010;70:429-38.
38. Lanas A. A review of the gastrointestinal safety data-a gastroenterologist's perspective. Rheumatology 2010; 49:ii3-10.