Does paracetamol (acetaminophen) reduce the pain of osteoarthritis?: A meta-analysis of randomised controlled trials

Annals of the Rheumatic Diseases

Volumn 63, Issue 8, 2004, Pages 901-907

  Zhang, W ^a   Jones, A ^b   Doherty, M ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b NOTTINGHAM CITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL;

ABDOMINAL PAIN; ANALGESIA; ARTHRALGIA; CLINICAL TRIAL; DIARRHEA; DRUG EFFECT; DRUG EFFICACY; DRUG RESPONSE; DYSPEPSIA; GASTROINTESTINAL SYMPTOM; HIP OSTEOARTHRITIS; HUMAN; KNEE OSTEOARTHRITIS; META ANALYSIS; NAUSEA; OSTEOARTHRITIS; PAIN ASSESSMENT; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; VISUAL ANALOG SCALE; VOMITING;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; HUMANS; OSTEOARTHRITIS; PATIENT SATISFACTION; RANDOMIZED CONTROLLED TRIALS; TREATMENT OUTCOME;

EID: 3242685960     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2003.018531     Document Type: Review

References (54)

1. Raffa RB, Stone DJ, Tallarida RJ. Unexpected and pronounced antinociceptive synergy between spinal acetaminophen (paracetamol) and phentolamine. Eur J Pharmacol 2001;412:R1-2.
2. Peat G, McCarney R, Croft P. Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care. Ann Rheum Dis 2001;60:91-7.
3. Guccione AA, Felson DT, Anderson JJ, Anthony JM, Zhang Y, Wilson PW, et al. The effects of specific medical conditions on the functional limitations of elders in the Framingham study. Am J Public Health 1994;84:351-8.
4. Pendleton A, Arden N, Dougados M, Doherty M, Bannwarth B, Bijlsma JWJ, et al. EULAR recommendations for the management of knee osteoarthritis: report of a task force of the Standing Committee for International Clinical Studies Including Therapeutics Trials (ESCISIT). Ann Rheum Dis 2000;59:936-44.
5. Jordan K, Arden N, Doherty M, Bannworth B, Bijlsma JWJ, Dieppe P, et al. EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis. Ann Rheum Dis 2003;62:1145-55.
6. Amadio P Jr, Cummings DM. Evaluation of acetaminophen in the management of osteoarthritis of the knee. Curr Ther Res 1983;34:59-66.
7. Towheed TE, Judd MJ, Hochberg MC, Wells G. Acetaminophen for osteoarthritis (Cochrane Review). In: The Cochrane Library, Issue 2. Oxford: Update Software, 2003.
8. March L, Irwig L, Schwarz J, Simpson J, Chock C, Brooks P. n of 1 trials comparing a non-steroidal anti-inflammatory drug with paracetamol in osteoorthritis. BMJ 1994;309:1041-5, discussion 1045-6.
9. Williams HJ, Ward JR, Egger MJ, Neuner R, Brooks RH, Clegg DO, et al. Comparison of naproxen and acetaminophen in a two-year study of treatment of osteoarthritis of the knee.[comment]. Arthritis Rheum 1993;36:1196-206.
10. Bradley JD, Brandt KD, Katz BP, Kalasinski LA, Ryan Sl. Comparison of an antiinflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. N Engl J Med 1991;325:87-91.
11. Bradley JD, Brandt KD, Katz BP, Kalasinski LA, Ryan SI. Treatment of knee osteoarthritis: relationship of clinical features of joint inflammation to the response to a nonsteroidal antiinflammatory drug or pure analgesic. J Rheumatol 1992;19:1950-4.
12. Bradley JD, Katz BP, Brandt KD. Severity of knee pain does not predict a better response to an antiinflammatory dose of ibuprofen than to analgesic therapy in patients with osteoarthritis.[comment]. J Rheumatol 2001;28:1073-6.
13. Case JP, Baliunas AJ, Block JA. Lack of efficacy of acetaminophen in treating symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled comparison trial with diclofenac sodium. Arch Intern Med 2003;163:169-78.
14. Abramson SA. Et tu acetaminophen? Arthritis Rheum 2002;46:2831-5.
15. Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, et al. Assessing the quality of randomised clinical trials: is blinding necessary: Control Clin Trials 1996;17:1-12.
16. Bellamy N, Buchanan WW, Goldsmith CH, Combell J, Stitt L. Validation of WOMAC. J Orthop Rheum 1988;1:95-108.
17. Hedges LV. Fitting continues models to effect size dato. J Edu Stat 1982;7:245-70.
18. Zhang WY, Li Wan Po A, Analgesic efficacy of paracetamol and of its combination with codeine and caffeine in surgical pain - a meta-analysis. J Clin Pharmacy Ther 1996;21:261-82.
19. Rothman KJ. Modern epidemiology. Boston: Little, Brown, and Company, 1986:177-233.
20. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-88.
21. Cook RJ, Sackett DL. The number needed to treat: a clinically useful measure of treatment effect. BMJ 1995;320:452-4.
22. Whitehead A, Whitehead J. A general parametric approach to the meta-analysis of randomised clinical trials. Stat Med 1991;10:1665-77.
23. Geba GP, Weaver AL, Polis AB, Dixon ME, Schnitzer TJ, Vioxx ACT (VACT) Group. Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial. JAMA 2002;287:64-71.
24. Pincus T, Koch GG, Sokka T, Lefkowith J, Wolfe F, Jordan JM, et al. A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee[comment]. Arthritis Rheum 2001;44:1587-98.
25. Pincus T, Fort JF, Mongol B, Koch G, Wolfe F, Moskowitz R, et al. Patients preference for placebo, acetaminophen (paracetamol), or celecoxib effectiveness study (PACES-1): a double-blinded, randomised, cross-over clinical trial in patients with osteoorthritis of the hip or knee [abstract]. Ann Rheum Dis 2003;62(suppl 1):73.
26. Shen H, Sprott H, Aeschlimann A, Gay R, Uebelhart D, Michel BA, et al. Primary analgesic action of acetaminophen and rofecoxib in osteoorthritis [abstract]. Ann Rheum Dis 2003;62(suppl 1):258.
27. Zoppi M, Peretti G, Boccard E. Placebo-controlled study of the analgesic efficacy of an effervescent formulation of 500 mg paracetamol in arthritis of the knee or the hip. European Journal of Pain 1995;16:42-8.
28. Amor B, Benarrosh C. A method for comparing analgesics: glafenine and paracetamol. Multicenter cross-over approach. Clin Rheumatol 1988;7:492-7.
29. Bacon TH, Hole JG, North M, Burnett I. Analgesic efficacy of sustained release paracetamol in patients with osteoarthritis of the knee. Br J Clin Pharmacol 2002;53:629-36.
30. Decousus H, Laporte S, Perpoint B, Mismetti P, Hocquart JL, et al. Comparison in 141 outpatients with osteoarthritis of 2 combinations of paracetamol with a narcotic analgesic - a controlled clinical-trial. European Journal of Pharmacology 1990;183:1044.
31. Erturk H, Celiker R, Aydin M, Ugur O. Comparison of efficacy and tolerability of acemetacin and acelaminopnen in the treatment of knee osteoarthritis. Journal of Rheumatology and Medical Rehabilitation 1998;9:157-61.
32. Lequesne M, Fannius J, Reginster JY, Verdickt W, du Laurier MV. Flodafenin versus acetaminophen for pain control in patients with osteoarthritis in the lower limbs. Franco-Belgian Task Force. Rev Rhum Engl Ed 1997;64:327-33.
33. Boissier C, Perpoint B, Laporte-Simitsidis S, Mismeffi P, Hocquart J, Gayet JL, et al. Acceptability and efficacy of two associations of paracetamol with a central analgesic (dextropropoxyphene or codeine): comparison in osteoarthritis. J Clin Pharmacol 1992;32:990-5.
34. Caldwell JR, Hale ME, Boyd RE, Hague JM, Iwan T, Shi M, et al. Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial. J Rheumatol 1999;26:862-9.
35. Glowinski J, Boccard E. Placebo-controlled study of the analgesic efficacy of a paracetamol 500 mg/codeine 30 mg combination together with low- dose vs high-dose diclofenac in rheumatoid arthritis. Clinical Drug Investigation 1999;18:189-97.
36. Innes EH. Osteoarthritis in elderly patients - a comparison of benorylate (Benoral) with an aspirin-paracetamol mixture. Clinical Trials Journal 1982;19:179-83.
37. Kjaersgaard-Andersen P, Nafei A, Skov O, Madsen F, Andersen HM, Kroner K, et al. Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip - a randomized, double-blind, multicenter study. Pain 1990;43:309-18.
38. Kuntz D, Brossel R. Analgesic effect and clinical tolerance of paracetamol 500 mg plus cafeine 50 mg versus paracetamol 400 mg plus dextropropoxyphen 30 mg for bock pain. Presse Med 1996;25:1171-4.
39. Maneksha S. 'Safapryn' and benorylate - a comparative trial of two new preparations of aspirin and paracetamol in the treatment of rheumatoid arthritis and osteoarthritis. Curr Med Res Opin 1973;1:563-8.
40. Matts SG, Boston PF. Paracetamol plus metoclopramide ('Paramax') as an adjunct analgesic in the treatment of arthritis. Curr Med Res Opin 1983;8:547-52.
41. Seideman P, Samuelson P, Neander G, Naproxen and paracetamol compared with naproxen only in coxarthrosis. Increased effect of the combination in 18 patients. Acta Ortho Scand 1993;64:285-8.
42. Silverfield JC, Kamin M, Wu SC, Rosenthal N. CAPSS-105 Study Group. Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study. Clin Ther 2002;24:282-97.
43. Vignon E, Bonnwarth B, Conrozier T, Derobert E, Verdoncq B. Multicenter, double-blind, clinical trial comparing two tablets bid to one tablet qid of the same acetaminophen-dextropropoxyphen-caffeine combination in patients with osteoarthritis. Semaine Des Hopitaux 1999;75:419-25.
44. Vlok GJ, van Vuren JP. Comparison of a standard ibuprofen treatment regimen with a new ibuprofen/paracetamol/codeine combination in chronic osteo-arthritis. S Afr Med J 1987;(suppl 1):4-6.
45. Begg CB, Cho MK, Eastwood S, Horton R, Moher D, Olkin I, et al. Improving the quality of reporting of randomized controlled trials: the CONSORT statement. JAMA 1996;276:637-9.
46. Cohen J. Statistical power analysis for behavioural sciences. New York: Academic Press, 1977.
47. Ofman JJ, MacLean CH, Straus WL, Morton SC, Berger ML, Roth EA, et al. A metaanalysis of severe upper gastrointestinal complications of nonsteroidal antiinflammatory drugs. J Rheumatol 2002;29:804-12.
48. Garcia Rodriquez LA, Hernandez-Diaz S. Relative risk of upper gastrointestinal complications among users of acetaminophen and nonsteroidal anti-inflammatory drugs. Epidemiology 2001;12:570-6.
49. Rahme E, Pettitt D, LeLorier J. Determinants and sequelae associated with utilization of acetaminophen versus traditional nonsteroidal antiinflammatory drugs in an elderly population. Arthritis Rheum 2002;46:3046-54.
50. Lewis SC, Longman MJS, Laporte J, Matthews JNS, Rawlins MD, Wiholm B. Dose-response relationships between individual nonasprin nonsteroidal anti-inflammatory drugs (NSAIDs) and serious upper gastrointestinal bleeding: a meta-analysis based on individual patient data. Br J Clin Pharmacol 2002;54:320-6.
51. Lanza FL, Codispoti JR, Nelson EB. An endoscopic comparison of gastroduodenal injury with over-the-counter doses of ketoprofen and acetaminophen. Am J Gastroenterol 1998;93:1051-4.
52. Muller P, Simon B, Weise D, Dammann HG. Endoscopic studies on the gastric tolerance of paracetamol and acetylsalicylic acid: a placebo-controlled, double-blind study in healthy volunteers. Arzneimittelforschung 2000;40:316-18.
53. Jerussi TP, Caubet JF, McCray JE, Handley DA. Clinical endoscopic evaluation of the gastroduodenal tolerance to (R)-ketpprofen, (R)-flurbiproren, racemic ketoprofen, and paracetamol: a randomised, single-blind, placebo-controlled trials. J Clin Pharmacol 1998;38(suppl):19-24S.
54. Courtney P, Doherty M. Key questions concerning paracetamol and NSAIDs for osteoarthritis. Ann Rheum Dis 2002;61:767-73.