Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation

Science

Volumn 334, Issue 6057, 2011, Pages 809-813

  Nomura, Daniel K ^a,b   Morrison, Bradley E ^a   Blankman, Jacqueline L ^a   Long, Jonathan Z ^a   Kinsey, Steven G ^c   Marcondes, Maria Cecilia G ^a   Ward, Anna M ^a   Hahn, Yun Kyung ^d   Lichtman, Aron H ^d   Conti, Bruno ^a   Cravatt, Benjamin F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WEST VIRGINIA UNIVERSITY   (United States)

^d VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; ACYLGLYCEROL LIPASE; ANANDAMIDE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; CYTOKINE; DOPAMINE; ENDOCANNABINOID; ENZYME INHIBITOR; FATTY ACID; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; JZL 184; MONOACYLGLYCEROL LIPASE INHIBITOR; PHOSPHOLIPASE A2; PROSTAGLANDIN D2; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN SYNTHASE; RIMONABANT; THROMBOXANE B2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

BRAIN; ENZYME ACTIVITY; HYDROLYSIS; INHIBITION; INHIBITOR; NEUROLOGY; PHYSIOLOGICAL RESPONSE; SIGNALING;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; BRAIN; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEGENERATIVE DISEASE; DOPAMINERGIC NERVE CELL; DRUG TARGETING; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; INFLAMMATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLOMICS; MOUSE; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; SUBSTANTIA NIGRA;

ANIMALIA; PARKINSONIA;

EID: 81055156684     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1209200     Document Type: Article

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