Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system

Journal of Biological Chemistry

Volumn 280, Issue 36, 2005, Pages 31405-31412

  Högestätt, Edward D ^a   Jönsson, Bo A G ^a   Ermund, Anna ^a   Andersson, David A ^a   Björk, Henrik ^a   Alexander, Jessica P ^b   Cravatt, Benjamin F ^b   Basbaum, Allan I ^c   Zygmunt, Peter M ^a  

^a LUND UNIVERSITY   (Sweden)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; BRAIN; DRUG PRODUCTS; ENZYMES; LIVING SYSTEMS STUDIES; NEUROLOGY; ORGANIC ACIDS;

ANTI-INFLAMMATORY DRUGS; ANTIPYRETIC AGENT; ENZYME FATTY ACID AMIDE HYDROLASE; THERMOREGULATORY PATHWAYS;

FATTY ACIDS;

ACETYLSALICYLIC ACID; ANANDAMIDE; ARACHIDONIC ACID; CANNABINOID; CAPSAICIN; CAPSAZEPINE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; FATTY ACID AMIDASE; INDOMETACIN; LIPOPOLYSACCHARIDE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N (4 HYDROXYPHENYL)ARACHIDONAMIDE; N ACYLPHENOLAMINE; PARACETAMOL; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIPYRETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DEACETYLATION; DRUG METABOLISM; DRUG POTENCY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PURIFICATION; FEMALE; NERVOUS SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RAT;

ACETAMINOPHEN; AMIDOHYDROLASES; AMINOPHENOLS; ANIMALS; ARACHIDONIC ACID; ARACHIDONIC ACIDS; BRAIN; CELL LINE; CENTRAL NERVOUS SYSTEM; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DINOPROSTONE; FEMALE; GANGLIA, SPINAL; MACROPHAGES; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, WISTAR;

EID: 24744469860     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501489200     Document Type: Article

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