The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1

Journal of Neuroscience

Volumn 21, Issue 16, 2001, Pages 5847-5853

  Yaksh, Tony L ^a   Dirig, David M ^a   Conway, Charles M ^a   Svensson, Camilla ^a   Luo, Z David ^a   Isakson, Peter C ^b  

^a University of California   (United States)

^b PFIZER INC   (United States)

Author keywords

Cyclooxygenase inhibitor; Ibuprofen; Intrathecal injection; NK 1; NMDA; SC 560; SC 58125; Substance P; Thermal hyperalgesia

Indexed keywords

4 (4 FLUOROPHENYL) 3 [(4 METHYLSULFONYL)PHENYL] 1 (2 PROPENYL) 5 (TRIFLUOROMETHYL) 1H PYRAZOLE; 4 (4 FLUOROPHENYL) 5 [(4 METHYLSULFONYL)PHENYL] 1 (2 PROPENYL) 3 (TRIFLUOROMETHYL) 1H PYRAZOLE; 4 [5 (4 CHLOROPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; 5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; CARRAGEENAN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; IBUPROFEN; ISOENZYME; N METHYL DEXTRO ASPARTIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2; SC 384; SC 385; SUBSTANCE P; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; GENE EXPRESSION; HYPERALGESIA; MALE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; RAT; SPINAL CORD DORSAL HORN; SPINAL CORD VENTRAL HORN; SPINAL GANGLION; STEREOSPECIFICITY; WESTERN BLOTTING;

EID: 0035882262     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-16-05847.2001     Document Type: Article

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