Pharmacokinetic parameters and killing rates in serum of volunteers receiving amoxicillin, cefadroxil or cefixime alone or associated with niflumic acid or paracetamol

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 23, Issue 3, 1998, Pages 357-366

  Carsenti Etesse, H ^a,c   Farinotti, R ^b   Durant, J ^a   Roger, P M ^a   De Salvador, F ^a   Bernard, E ^a   Rouveix, B ^b   Dellamonica, P ^a  

^a UNIVERSITY HOSPITAL OF NICE   (France)

^b INSERM   (France)

^c CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

Author keywords

Bactericidal activities; Niflumic acid; Non steroidal anti inflammatory drugs; Pharmacokinetic interactions; lactam

Indexed keywords

AMOXICILLIN; ANALGESIC AGENT; ANTIBIOTIC AGENT; CEFADROXIL; CEFIXIME; NIFLUMIC ACID; PARACETAMOL;

ADULT; AREA UNDER THE CURVE; ARTICLE; BACTERICIDAL ACTIVITY; BIOASSAY; BRONCHITIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; EAR NOSE THROAT DISEASE; FEMALE; HAEMOPHILUS INFLUENZAE TYPE A; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; OTITIS MEDIA; RANDOMIZED CONTROLLED TRIAL; SINUSITIS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

EID: 0031796035     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03192294     Document Type: Article

References (16)

1. Manach Y., Ditisheim A. (1990) : Double-blind, placebo-controlled multicentre trial of the efficacy and tolerance of morniflumate suppositories in the treatment of tonsillitis in children. J. Int. Med. Res., 18, 30-36.
2. Bobin S., Ditisheim A., Le Pajolec C., Harboun E., David N. (1989) : A double-blind placebo-controlled trial of niflumic acid in the treatment of acute sinusitis. Curr. Ther. Res., 46, 1119-1128.
3. Carbon C. (1990). Antibiotiques et anti-inflammatoires. Pathol. Biol., 38, 255-260.
4. Dellamonica P., Garraffo R., Carsenti-Etesse H., Bernard E., Mondain V. (1993) : Pharmacokinetic and bacteriological study of cefadroxil-salicylate and josamycin-salicylate drug regimens. Int. J. Clin. Pharmacol. Res., 13, 11-19.
5. Jehl F., Gallion C., Monteil H. (1990) : High performance liquid chromatography of antibiotics. J. Chromatogr., 531, 509-548.
6. Duverne C., Bouten A., Deslandes J.F. et al. (1992) : Modification of cefixime bioavailability by nifedipine in humans: involvement of the dipeptide carrier system. Antimicrob. Agents Chemother., 36, 2462-2467.
7. Joly V., Pangon B., Brion N., Vallois J.M., Carbon C. (1988) : Enhancement of the therapeutic effect of cephalosporins in experimental endocarditis by altering their pharmacokinetics with diclofenac. J. Pharmacol. Exp. Ther., 246, 695-700.
8. Sordelli D.O., Cerquetti M.C., Fontan P.A., Meiss R.P. (1989) : Piroxicam treatment protects mice from lethal pulmonary challenge with Pseudomonas aeruginosa. J. Infect. Dis., 155, 232-236.
9. Tuomanen E., Hengstler B., Rich R., Bray M.A., Zak O., Tomasz A. (1987) : Nonsteroidal anti-inflammatory agents in the therapy for experimental pneumococcal meningitis. J. Infect. Dis., 155, 985-989.
10. Khurana C.M., Deddish P.A. (1986) : Treatment of osteomyelitis caused by oxacillin tolerant Staphylococcus aureus in rabbits. In: Proceedings of the 26th Interscience Conference of Antimicrobial Agents Chemotherapy, Abstract 544.
11. Rosner J.L. (1985) : Noninheritable resistance to chlor- amphenicol and the other antibiotics induced by salicylates and other chemotactic repellents in Escherichia coli K-12. Proc. Natl. Acad. Sci. USA, 82, 8771-8774.
12. Domenico P., Leary R.O., Cunha B.A. (1992) : Differential effects of bismuth and salicylate salts on the antibiotic susceptibility of Pseudomonas aeruginosa. Eur. J. Clin. Microbiol. Infect. Dis., 11, 170-175.
13. Aumercier M., Murray D.M., Rosner J.L. (1990) : Potentiation of susceptibility to aminoglycosides by salicylate in Escherichia coli. Antimicrob. Agents Chemother., 34, 786-791.
14. Rosner J.L., Chai T.J., Foulds J. (1991) : Regulation of ompF porin expression by salicylate in Escherichia coli. J. Bacteriol., 173, 5631-5638.
15. Burns J.L., Clark K. (1992) : Salicylate-inducible antibiotic resistance in Pseudomonas cepacia associated with absence of a pore-forming outer membrane protein. Antimicrob. Agents Chemother., 36, 2280-2285.
16. Sumita Y., Fukasawa M. (1993) : Transient carbapenem resistance induced by salicylate in Pseudomonas aeruginosa associated with suppression of outer membrane protein D2 synthesis. Antimicrob. Agents Chemother., 37, 2743-2746.