Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations

Biochemical Pharmacology

Volumn 79, Issue 8, 2010, Pages 1156-1164

  Koelsch, Maud ^a,b   Mallak, Roger ^a,b   Graham, Garry G ^b   Kajer, Tracey ^a,d   Milligan, Marian K ^b   Nguyen, Ly Q ^b   Newsham, Dawn W ^b   Keh, Jeremy S ^b   Kettle, Anthony J ^c   Scott, Kieran F ^b   Ziegler, John B ^b   Pattison, David I ^a   Fu, Shanlin ^d   Hawkins, Clare L ^a   Rees, Martin D ^a   Davies, Michael J ^a,e  

^a HEART RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF OTAGO   (New Zealand)

^d UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^e University of Sydney   (Australia)

Author keywords

Acetaminophen; Myeloperoxidase; Neutrophil; Oxidation; Paracetamol

Indexed keywords

HALIDE; HEPARAN SULFATE; HYDROBROMIC ACID; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; LUCIGENIN; MYELOPEROXIDASE; PARACETAMOL; PEROXIDASE; TAURINE; THIOCYANATE;

ANALGESIA; ANTIPYRETIC ACTIVITY; ARTICLE; ASTHMA; ATHEROSCLEROSIS; CHEMOLUMINESCENCE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYSTIC FIBROSIS; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME RELEASE; ENZYME SUBSTRATE; EXTRACELLULAR MATRIX; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; INHIBITION KINETICS; LEUKOCYTE ACTIVATION; MALIGNANT NEOPLASTIC DISEASE; MASS SPECTROMETRY; MONOCYTE; NORMAL HUMAN; OXIDATION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; TISSUE INJURY;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; BROMATES; CATALYSIS; HUMANS; HYPOCHLOROUS ACID; NEUTROPHILS; OXIDANTS; PEROXIDASE; SUPEROXIDES;

EID: 77249152615     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2009.11.024     Document Type: Article

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