-
1
-
-
0024955886
-
Approaching the asymptote? Evolution and revolution in immunology
-
Janeway, C. A. Jr. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 54, 1-13 (1989).
-
(1989)
Cold Spring Harb. Symp. Quant. Biol.
, vol.54
, pp. 1-13
-
-
Janeway Jr., C.A.1
-
2
-
-
0025777448
-
Interleukin-1 and interleukin-1 antagonism
-
Dinarello, C. A. Interleukin-1 and interleukin-1 antagonism. Blood 77, 1627-1652 (1991).
-
(1991)
Blood
, vol.77
, pp. 1627-1652
-
-
Dinarello, C.A.1
-
3
-
-
0023683844
-
CDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily
-
Sims, J. E. et al. cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science 241, 585-589 (1988).
-
(1988)
Science
, vol.241
, pp. 585-589
-
-
Sims, J.E.1
-
4
-
-
0025774776
-
Drosophila Toll and IL-1 receptor
-
Gay, N. J. & Keith, F. J. Drosophila Toll and IL-1 receptor. Nature 351, 355-356 (1991).
-
(1991)
Nature
, vol.351
, pp. 355-356
-
-
Gay, N.J.1
Keith, F.J.2
-
5
-
-
0022230197
-
Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product
-
Anderson, K. V., Jurgens, G. & Nusslein-Volhard, C. Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product. Cell 42, 779-789 (1985).
-
(1985)
Cell
, vol.42
, pp. 779-789
-
-
Anderson, K.V.1
Jurgens, G.2
Nusslein-Volhard, C.3
-
6
-
-
0023619362
-
Dorsal, an embryonic polarity gene in Drosophila, is homologous to the vertebrate proto-oncogene, c-rel
-
Steward, R. Dorsal, an embryonic polarity gene in Drosophila, is homologous to the vertebrate proto-oncogene, c-rel. Science 238, 692-694 (1987).
-
(1987)
Science
, vol.238
, pp. 692-694
-
-
Steward, R.1
-
7
-
-
0022930702
-
Inducibility of κ immunoglobulin enhancer-binding protein Nf-κB by a posttranslational mechanism
-
Sen, R. & Baltimore, D. Inducibility of κ immunoglobulin enhancer-binding protein Nf-κB by a posttranslational mechanism. Cell 47, 921-928 (1986).
-
(1986)
Cell
, vol.47
, pp. 921-928
-
-
Sen, R.1
Baltimore, D.2
-
8
-
-
0028174061
-
Function and activation of NF-κB in the immune system
-
Baeuerle, P. A. & Henkel, T. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12, 141-179 (1994).
-
(1994)
Annu. Rev. Immunol.
, vol.12
, pp. 141-179
-
-
Baeuerle, P.A.1
Henkel, T.2
-
9
-
-
0026786698
-
Amino acids conserved in interleukin-1 receptors (IL-1Rs) and the Drosophila toll protein are essential for IL-1R signal transduction
-
Heguy, A., Baldari, C. T., Macchia, G., Telford, J. L. & Melli, M. Amino acids conserved in interleukin-1 receptors (IL-1Rs) and the Drosophila toll protein are essential for IL-1R signal transduction. J. Biol. Chem. 267, 2605-2609 (1992).
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 2605-2609
-
-
Heguy, A.1
Baldari, C.T.2
MacChia, G.3
Telford, J.L.4
Melli, M.5
-
10
-
-
0027931646
-
The product of the tobacco mosaic virus resistance gene N: Similarity to toll and the interleukin-1 receptor
-
Whitham, S. et al. The product of the tobacco mosaic virus resistance gene N: similarity to toll and the interleukin-1 receptor. Cell 78, 1101-1115 (1994).
-
(1994)
Cell
, vol.78
, pp. 1101-1115
-
-
Whitham, S.1
-
11
-
-
0027443688
-
Dif, a dorsal-related gene that mediates an immune response in Drosophila
-
Ip, Y. T. et al. Dif, a dorsal-related gene that mediates an immune response in Drosophila. Cell 75, 753-763 (1993).
-
(1993)
Cell
, vol.75
, pp. 753-763
-
-
Ip, Y.T.1
-
12
-
-
0019386682
-
Sequence and specificity of two antibacterial proteins involved in insect immunity
-
Steiner, H., Hultmark, D., Engstrom, A., Bennich, H. & Boman, H. G. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 292, 246-248 (1981).
-
(1981)
Nature
, vol.292
, pp. 246-248
-
-
Steiner, H.1
Hultmark, D.2
Engstrom, A.3
Bennich, H.4
Boman, H.G.5
-
14
-
-
0030595339
-
The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
-
Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J. M. & Hoffmann, J. A. The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86, 973-983 (1996).
-
(1996)
Cell
, vol.86
, pp. 973-983
-
-
Lemaitre, B.1
Nicolas, E.2
Michaut, L.3
Reichhart, J.M.4
Hoffmann, J.A.5
-
15
-
-
0033711445
-
The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila
-
Rutschmann, S. et al. The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila. Immunity 12, 569-580 (2000).
-
(2000)
Immunity
, vol.12
, pp. 569-580
-
-
Rutschmann, S.1
-
17
-
-
0030831210
-
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
-
Medzhitov, R., Preston-Hurlburt, P. & Janeway, C. A. Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388, 394-397 (1997).
-
(1997)
Nature
, vol.388
, pp. 394-397
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Janeway Jr., C.A.3
-
18
-
-
0031905311
-
A family of human receptors structurally related to Drosophila Toll
-
Rock, F. L., Hardiman, G., Timans, J. C., Kastelein, R. A. & Bazan, J. F. A family of human receptors structurally related to Drosophila Toll. Proc. Natl Acad. Sci. USA 95, 588-593 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 588-593
-
-
Rock, F.L.1
Hardiman, G.2
Timans, J.C.3
Kastelein, R.A.4
Bazan, J.F.5
-
19
-
-
0001575306
-
Chemische erforschung von lipopolysacchariden gram-negativer bakterien
-
Westphal, O. & Luderitz, O. Chemische erforschung von lipopolysacchariden gram-negativer bakterien. Angew. Chemie 66, 407-417 (1954).
-
(1954)
Angew. Chemie
, vol.66
, pp. 407-417
-
-
Westphal, O.1
Luderitz, O.2
-
20
-
-
0020622348
-
Characterization of lipopolysaccharide from a heptoseless mutant of Escherichia coli by carbon 13 nuclear magnetic resonance
-
Strain, S. M., Fesik, S. W. & Armitage, I. M. Characterization of lipopolysaccharide from a heptoseless mutant of Escherichia coli by carbon 13 nuclear magnetic resonance. J. Biol. Chem. 258, 2906-2910 (1983).
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 2906-2910
-
-
Strain, S.M.1
Fesik, S.W.2
Armitage, I.M.3
-
21
-
-
0022462376
-
Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum
-
Tobias, P. S., Soldau, K. & Ulevitch, R. J. Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum. J. Exp. Med. 164, 777-793 (1986).
-
(1986)
J. Exp. Med.
, vol.164
, pp. 777-793
-
-
Tobias, P.S.1
Soldau, K.2
Ulevitch, R.J.3
-
22
-
-
0027424403
-
Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14
-
Han, J., Lee, J. D., Tobias, P. S. & Ulevitch, R. J. Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14. J. Biol. Chem. 268, 25009-25014 (1993).
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 25009-25014
-
-
Han, J.1
Lee, J.D.2
Tobias, P.S.3
Ulevitch, R.J.4
-
23
-
-
0025874032
-
Recognition and plasma clearance of endotoxin by scavenger receptors
-
Hampton, R. Y., Golenbock, D. T., Penman, M., Krieger, M. & Raetz, C. R. Recognition and plasma clearance of endotoxin by scavenger receptors. Nature 352, 342-344 (1991).
-
(1991)
Nature
, vol.352
, pp. 342-344
-
-
Hampton, R.Y.1
Golenbock, D.T.2
Penman, M.3
Krieger, M.4
Raetz, C.R.5
-
24
-
-
0025298591
-
Identification of lipopolysaccharide-binding proteins in 70Z/3 cells by photoaffinity cross-linking
-
Kirkland, T. N. et al. Identification of lipopolysaccharide-binding proteins in 70Z/3 cells by photoaffinity cross-linking. J. Biol. Chem. 265, 9520-9525 (1990).
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 9520-9525
-
-
Kirkland, T.N.1
-
25
-
-
0025166114
-
CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
-
Wright, S. D., Ramos, R. A., Tobias, P. S., Ulevitch, R. J. & Mathison, J. C. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249, 1431-1433 (1990).
-
(1990)
Science
, vol.249
, pp. 1431-1433
-
-
Wright, S.D.1
Ramos, R.A.2
Tobias, P.S.3
Ulevitch, R.J.4
Mathison, J.C.5
-
26
-
-
0025107568
-
Structure and function of lipopolysaccharide binding protein
-
Schumann, R. R. et al. Structure and function of lipopolysaccharide binding protein. Science 249, 1429-1431 (1990).
-
(1990)
Science
, vol.249
, pp. 1429-1431
-
-
Schumann, R.R.1
-
27
-
-
0026463120
-
Soluble CD14 participates in the response of cells to lipopolysaccharide
-
Frey, E. A. et al. Soluble CD14 participates in the response of cells to lipopolysaccharide. J. Exp. Med. 176, 1665-1671 (1992).
-
(1992)
J. Exp. Med.
, vol.176
, pp. 1665-1671
-
-
Frey, E.A.1
-
28
-
-
0027378381
-
Glycosyl-phosphatidylinositol-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin
-
Lee, J. D. et al. Glycosyl-phosphatidylinositol-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin. Proc. Natl Acad. Sci. USA 90, 9930-9934 (1993).
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 9930-9934
-
-
Lee, J.D.1
-
29
-
-
0032541661
-
Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
-
Yang, R. B. et al. Toll-like receptor-2 mediates lipopolysaccharide- induced cellular signalling. Nature 395, 284-288 (1998).
-
(1998)
Nature
, vol.395
, pp. 284-288
-
-
Yang, R.B.1
-
30
-
-
0034662239
-
Cutting edge: Repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2
-
Hirschfeld, M., Ma, Y., Weis, J. H., Vogel, S. N. & Weis, J. J. Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. J. Immunol. 165, 618-622 (2000).
-
(2000)
J. Immunol.
, vol.165
, pp. 618-622
-
-
Hirschfeld, M.1
Ma, Y.2
Weis, J.H.3
Vogel, S.N.4
Weis, J.J.5
-
31
-
-
0032541638
-
Bacterial infection. for whom the bell tolls
-
Gerard, C. Bacterial infection. For whom the bell tolls. Nature 395, 217-219 (1998).
-
(1998)
Nature
, vol.395
, pp. 217-219
-
-
Gerard, C.1
-
32
-
-
0032509295
-
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
-
Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085-2088 (1998).
-
(1998)
Science
, vol.282
, pp. 2085-2088
-
-
Poltorak, A.1
-
33
-
-
0345561540
-
Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
-
Qureshi, S. T. et al. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J. Exp. Med. 189, 615-625 (1999).
-
(1999)
J. Exp. Med.
, vol.189
, pp. 615-625
-
-
Qureshi, S.T.1
-
34
-
-
0033120081
-
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
-
Hoshino, K. et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162, 3749-3752 (1999).
-
(1999)
J. Immunol.
, vol.162
, pp. 3749-3752
-
-
Hoshino, K.1
-
35
-
-
0033532629
-
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
-
Shimazu, R. et al. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189, 1777-1782 (1999).
-
(1999)
J. Exp. Med.
, vol.189
, pp. 1777-1782
-
-
Shimazu, R.1
-
36
-
-
0035796406
-
Molecular genetic analysis of an endotoxin nonresponder mutant cell line: A point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling
-
Schromm, A. B. et al. Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling. J. Exp. Med. 194, 79-88 (2001).
-
(2001)
J. Exp. Med.
, vol.194
, pp. 79-88
-
-
Schromm, A.B.1
-
37
-
-
67349182481
-
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
-
Park, B. S. et al. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 458, 1191-1195 (2009).
-
(2009)
Nature
, vol.458
, pp. 1191-1195
-
-
Park, B.S.1
-
38
-
-
84860832650
-
Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
-
Ohto, U., Fukase, K., Miyake, K. & Shimizu, T. Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2. Proc. Natl Acad. Sci. USA 109, 7421-7426 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 7421-7426
-
-
Ohto, U.1
Fukase, K.2
Miyake, K.3
Shimizu, T.4
-
39
-
-
63649108380
-
The roles of TLRs, RLRs and NLRs in pathogen recognition
-
Kawai, T. & Akira, S. The roles of TLRs, RLRs and NLRs in pathogen recognition. Int. Immunol. 21, 317-337 (2009).
-
(2009)
Int. Immunol.
, vol.21
, pp. 317-337
-
-
Kawai, T.1
Akira, S.2
-
40
-
-
0034922923
-
Discrimination of bacterial lipoproteins by Toll-like receptor 6
-
Takeuchi, O. et al. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int. Immunol. 13, 933-940 (2001).
-
(2001)
Int. Immunol.
, vol.13
, pp. 933-940
-
-
Takeuchi, O.1
-
41
-
-
0036644042
-
Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
-
Takeuchi, O. et al. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 169, 10-14 (2002).
-
(2002)
J. Immunol.
, vol.169
, pp. 10-14
-
-
Takeuchi, O.1
-
42
-
-
34548608447
-
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
-
Jin, M. S. et al. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130, 1071-1082 (2007).
-
(2007)
Cell
, vol.130
, pp. 1071-1082
-
-
Jin, M.S.1
-
43
-
-
71749118913
-
Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer
-
Kang, J. Y. et al. Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. Immunity 31, 873-884 (2009).
-
(2009)
Immunity
, vol.31
, pp. 873-884
-
-
Kang, J.Y.1
-
44
-
-
0034610291
-
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
-
Ozinsky, A. et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc. Natl Acad. Sci. USA 97, 13766-13771 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 13766-13771
-
-
Ozinsky, A.1
-
45
-
-
0035953543
-
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
-
Hayashi, F. et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410, 1099-1103 (2001).
-
(2001)
Nature
, vol.410
, pp. 1099-1103
-
-
Hayashi, F.1
-
46
-
-
33746161021
-
+ lamina propria cells
-
+ lamina propria cells. Nature Immunol. 7, 868-874 (2006).
-
(2006)
Nature Immunol.
, vol.7
, pp. 868-874
-
-
Uematsu, S.1
-
47
-
-
45549099429
-
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5
-
Uematsu, S. et al. Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nature Immunol. 9, 769-776 (2008).
-
(2008)
Nature Immunol.
, vol.9
, pp. 769-776
-
-
Uematsu, S.1
-
48
-
-
1542377424
-
A toll-like receptor that prevents infection by uropathogenic bacteria
-
Zhang, D. et al. A toll-like receptor that prevents infection by uropathogenic bacteria. Science 303, 1522-1526 (2004).
-
(2004)
Science
, vol.303
, pp. 1522-1526
-
-
Zhang, D.1
-
49
-
-
20644433342
-
TLR11 activation of dendritic cells by a protozoan profilin-like protein
-
Yarovinsky, F. et al. TLR11 activation of dendritic cells by a protozoan profilin-like protein. Science 308, 1626-1629 (2005).
-
(2005)
Science
, vol.308
, pp. 1626-1629
-
-
Yarovinsky, F.1
-
50
-
-
84872596639
-
Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice
-
Andrade, W. A. et al. Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice. Cell Host Microbe 13, 42-53 (2013).
-
(2013)
Cell Host Microbe
, vol.13
, pp. 42-53
-
-
Andrade, W.A.1
-
51
-
-
84872761427
-
Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii
-
Koblansky, A. A. et al. Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii. Immunity 38, 119-130 (2013).
-
(2013)
Immunity
, vol.38
, pp. 119-130
-
-
Koblansky, A.A.1
-
52
-
-
84865571191
-
TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification
-
Oldenburg, M. et al. TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification. Science 337, 1111-1115 (2012).
-
(2012)
Science
, vol.337
, pp. 1111-1115
-
-
Oldenburg, M.1
-
53
-
-
84877579519
-
Sequence specific detection of bacterial 23S ribosomal RNA by TLR13
-
Li, X. D. & Chen, Z. J. Sequence specific detection of bacterial 23S ribosomal RNA by TLR13. eLife 1, e00102 (2012).
-
(2012)
ELife
, vol.1
-
-
Li, X.D.1
Chen, Z.J.2
-
54
-
-
84866159316
-
Cutting edge: TLR13 is a receptor for bacterial RNA
-
Hidmark, A., von Saint Paul, A. & Dalpke, A. H. Cutting edge: TLR13 is a receptor for bacterial RNA. J. Immunol. 189, 2717-2721 (2012).
-
(2012)
J. Immunol.
, vol.189
, pp. 2717-2721
-
-
Hidmark, A.1
Von Saint Paul, A.2
Dalpke, A.H.3
-
55
-
-
0034730146
-
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling
-
Bowie, A. et al. A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling. Proc. Natl Acad. Sci. USA 97, 10162-10167 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 10162-10167
-
-
Bowie, A.1
-
56
-
-
5944261457
-
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
-
Kurt-Jones, E. A. et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nature Immunol. 1, 398-401 (2000).
-
(2000)
Nature Immunol.
, vol.1
, pp. 398-401
-
-
Kurt-Jones, E.A.1
-
57
-
-
0035909372
-
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
-
Alexopoulou, L., Holt, A. C., Medzhitov, R. & Flavell, R. A. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413, 732-738 (2001).
-
(2001)
Nature
, vol.413
, pp. 732-738
-
-
Alexopoulou, L.1
Holt, A.C.2
Medzhitov, R.3
Flavell, R.A.4
-
58
-
-
42349090335
-
Structural basis of toll-like receptor 3 signaling with double-stranded RNA
-
Liu, L. et al. Structural basis of toll-like receptor 3 signaling with double-stranded RNA. Science 320, 379-381 (2008).
-
(2008)
Science
, vol.320
, pp. 379-381
-
-
Liu, L.1
-
59
-
-
48749128643
-
Structures of the toll-like receptor family and its ligand complexes
-
Jin, M. S. & Lee, J. O. Structures of the toll-like receptor family and its ligand complexes. Immunity 29, 182-191 (2008).
-
(2008)
Immunity
, vol.29
, pp. 182-191
-
-
Jin, M.S.1
Lee, J.O.2
-
60
-
-
84857335818
-
Structural basis of TLR5-flagellin recognition and signaling
-
Yoon, S. I. et al. Structural basis of TLR5-flagellin recognition and signaling. Science 335, 859-864 (2012).
-
(2012)
Science
, vol.335
, pp. 859-864
-
-
Yoon, S.I.1
-
61
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
Hemmi, H. et al. A Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745 (2000).
-
(2000)
Nature
, vol.408
, pp. 740-745
-
-
Hemmi, H.1
-
62
-
-
0042123694
-
Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
-
Lund, J., Sato, A., Akira, S., Medzhitov, R. & Iwasaki, A. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198, 513-520 (2003).
-
(2003)
J. Exp. Med.
, vol.198
, pp. 513-520
-
-
Lund, J.1
Sato, A.2
Akira, S.3
Medzhitov, R.4
Iwasaki, A.5
-
63
-
-
3142683548
-
TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function
-
Krug, A. et al. TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity 21, 107-119 (2004).
-
(2004)
Immunity
, vol.21
, pp. 107-119
-
-
Krug, A.1
-
64
-
-
0842328805
-
Herpes simplex virus type 1 activates murine natural interferon-producing cells through tolllike receptor 9
-
Krug, A. et al. Herpes simplex virus type 1 activates murine natural interferon-producing cells through tolllike receptor 9. Blood 103, 1433-1437 (2004).
-
(2004)
Blood
, vol.103
, pp. 1433-1437
-
-
Krug, A.1
-
65
-
-
0036008014
-
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
-
Hemmi, H. et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nature Immunol. 3, 196-200 (2002).
-
(2002)
Nature Immunol.
, vol.3
, pp. 196-200
-
-
Hemmi, H.1
-
66
-
-
1542317578
-
Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8
-
Heil, F. et al. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 303, 1526-1529 (2004).
-
(2004)
Science
, vol.303
, pp. 1526-1529
-
-
Heil, F.1
-
67
-
-
1542317550
-
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
-
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S. & Reis e Sousa, C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303, 1529-1531 (2004).
-
(2004)
Science
, vol.303
, pp. 1529-1531
-
-
Diebold, S.S.1
Kaisho, T.2
Hemmi, H.3
Akira, S.4
Reis Sousae, C.5
-
68
-
-
1842631428
-
Recognition of single-stranded RNA viruses by Toll-like receptor 7
-
Lund, J. M. et al. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc. Natl Acad. Sci. USA 101, 5598-5603 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 5598-5603
-
-
Lund, J.M.1
-
69
-
-
0037061453
-
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
-
Leadbetter, E. A. et al. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416, 603-607 (2002).
-
(2002)
Nature
, vol.416
, pp. 603-607
-
-
Leadbetter, E.A.1
-
70
-
-
85047693371
-
Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9
-
Means, T. K. et al. Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J. Clin. Invest. 115, 407-417 (2005).
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 407-417
-
-
Means, T.K.1
-
71
-
-
28544449709
-
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
-
Vollmer, J. et al. Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J. Exp. Med. 202, 1575-1585 (2005).
-
(2005)
J. Exp. Med.
, vol.202
, pp. 1575-1585
-
-
Vollmer, J.1
-
72
-
-
27744444832
-
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
-
Lau, C. M. et al. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J. Exp. Med. 202, 1171-1177 (2005).
-
(2005)
J. Exp. Med.
, vol.202
, pp. 1171-1177
-
-
Lau, C.M.1
-
73
-
-
0031423761
-
MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
-
Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S. & Cao, Z. MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 7, 837-847 (1997).
-
(1997)
Immunity
, vol.7
, pp. 837-847
-
-
Wesche, H.1
Henzel, W.J.2
Shillinglaw, W.3
Li, S.4
Cao, Z.5
-
74
-
-
0030694108
-
IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
-
Muzio, M., Ni, J., Feng, P. & Dixit, V. M. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 278, 1612-1615 (1997).
-
(1997)
Science
, vol.278
, pp. 1612-1615
-
-
Muzio, M.1
Ni, J.2
Feng, P.3
Dixit, V.M.4
-
75
-
-
78049431237
-
The interleukin-1 receptor-associated kinases: Critical regulators of innate immune signalling
-
Flannery, S. & Bowie, A. G. The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling. Biochem. Pharmacol. 80, 1981-1991 (2010).
-
(2010)
Biochem. Pharmacol.
, vol.80
, pp. 1981-1991
-
-
Flannery, S.1
Bowie, A.G.2
-
76
-
-
34247566510
-
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
-
O'Neill, L. A. & Bowie, A. G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nature Rev. Immunol. 7, 353-364 (2007).
-
(2007)
Nature Rev. Immunol.
, vol.7
, pp. 353-364
-
-
O'Neill, L.A.1
Bowie, A.G.2
-
77
-
-
0036318851
-
Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
-
Ahmad-Nejad, P. et al. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol. 32, 1958-1968 (2002).
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 1958-1968
-
-
Ahmad-Nejad, P.1
-
78
-
-
2442565738
-
Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors
-
Nishiya, T. & DeFranco, A. L. Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J. Biol. Chem. 279, 19008-19017 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 19008-19017
-
-
Nishiya, T.1
Defranco, A.L.2
-
79
-
-
10744219675
-
TLR9 signals after translocating from the ER to CpG DNA in the lysosome
-
Latz, E. et al. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nature Immunol. 5, 190-198 (2004).
-
(2004)
Nature Immunol.
, vol.5
, pp. 190-198
-
-
Latz, E.1
-
80
-
-
5444274514
-
Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
-
Kawai, T. et al. Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nature Immunol. 5, 1061-1068 (2004).
-
(2004)
Nature Immunol.
, vol.5
, pp. 1061-1068
-
-
Kawai, T.1
-
81
-
-
17844380477
-
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
-
Honda, K. et al. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434, 1035-1040 (2005).
-
(2005)
Nature
, vol.434
, pp. 1035-1040
-
-
Honda, K.1
-
82
-
-
0035817925
-
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction
-
Fitzgerald, K. A. et al. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413, 78-83 (2001).
-
(2001)
Nature
, vol.413
, pp. 78-83
-
-
Fitzgerald, K.A.1
-
83
-
-
0035555301
-
TIRAP: An adapter molecule in the Toll signaling pathway
-
Horng, T., Barton, G. M. & Medzhitov, R. TIRAP: an adapter molecule in the Toll signaling pathway. Nature Immunol. 2, 835-841 (2001).
-
(2001)
Nature Immunol.
, vol.2
, pp. 835-841
-
-
Horng, T.1
Barton, G.M.2
Medzhitov, R.3
-
84
-
-
0033166472
-
Unresponsiveness of MyD88-deficient mice to endotoxin
-
Kawai, T., Adachi, O., Ogawa, T., Takeda, K. & Akira, S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11, 115-122 (1999).
-
(1999)
Immunity
, vol.11
, pp. 115-122
-
-
Kawai, T.1
Adachi, O.2
Ogawa, T.3
Takeda, K.4
Akira, S.5
-
85
-
-
0035889228
-
Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
-
Kawai, T. et al. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J. Immunol. 167, 5887-5894 (2001).
-
(2001)
J. Immunol.
, vol.167
, pp. 5887-5894
-
-
Kawai, T.1
-
86
-
-
0035339861
-
Endotoxin-induced maturation of MyD88-deficient dendritic cells
-
Kaisho, T., Takeuchi, O., Kawai, T., Hoshino, K. & Akira, S. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J. Immunol. 166, 5688-5694 (2001).
-
(2001)
J. Immunol.
, vol.166
, pp. 5688-5694
-
-
Kaisho, T.1
Takeuchi, O.2
Kawai, T.3
Hoshino, K.4
Akira, S.5
-
87
-
-
0037153130
-
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
-
Horng, T., Barton, G. M., Flavell, R. A. & Medzhitov, R. The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature 420, 329-333 (2002).
-
(2002)
Nature
, vol.420
, pp. 329-333
-
-
Horng, T.1
Barton, G.M.2
Flavell, R.A.3
Medzhitov, R.4
-
88
-
-
0037153191
-
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
-
Yamamoto, M. et al. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 420, 324-329 (2002).
-
(2002)
Nature
, vol.420
, pp. 324-329
-
-
Yamamoto, M.1
-
89
-
-
33646908228
-
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling
-
Kagan, J. C. & Medzhitov, R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 125, 943-955 (2006).
-
(2006)
Cell
, vol.125
, pp. 943-955
-
-
Kagan, J.C.1
Medzhitov, R.2
-
90
-
-
70349324347
-
MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3
-
Kenny, E. F. et al. MyD88 adaptor-like is not essential for TLR2 signaling and inhibits signaling by TLR3. J. Immunol. 183, 3642-3651 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 3642-3651
-
-
Kenny, E.F.1
-
91
-
-
0037114185
-
Cutting edge: A novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling
-
Yamamoto, M. et al. Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-β promoter in the Toll-like receptor signaling. J. Immunol. 169, 6668-6672 (2002).
-
(2002)
J. Immunol.
, vol.169
, pp. 6668-6672
-
-
Yamamoto, M.1
-
92
-
-
0037320451
-
TICAM-1 an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-β induction
-
Oshiumi, H., Matsumoto, M., Funami, K., Akazawa, T. & Seya, T. TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-β induction. Nature Immunol. 4, 161-167 (2003).
-
(2003)
Nature Immunol.
, vol.4
, pp. 161-167
-
-
Oshiumi, H.1
Matsumoto, M.2
Funami, K.3
Akazawa, T.4
Seya, T.5
-
93
-
-
0042679529
-
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
-
Hoebe, K. et al. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424, 743-748 (2003).
-
(2003)
Nature
, vol.424
, pp. 743-748
-
-
Hoebe, K.1
-
94
-
-
0043176281
-
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
-
Yamamoto, M. et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301, 640-643 (2003).
-
(2003)
Science
, vol.301
, pp. 640-643
-
-
Yamamoto, M.1
-
95
-
-
0141959224
-
LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the toll adapters TRAM and TRIF
-
Fitzgerald, K. A. et al. LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the toll adapters TRAM and TRIF. J. Exp. Med. 198, 1043-1055 (2003).
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1043-1055
-
-
Fitzgerald, K.A.1
-
96
-
-
0242624622
-
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
-
Yamamoto, M. et al. TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nature Immunol. 4, 1144-1150 (2003).
-
(2003)
Nature Immunol.
, vol.4
, pp. 1144-1150
-
-
Yamamoto, M.1
-
97
-
-
0345991221
-
TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-β
-
Oshiumi, H. et al. TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-β. J. Biol. Chem. 278, 49751-49762 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 49751-49762
-
-
Oshiumi, H.1
-
98
-
-
33748871187
-
The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
-
Carty, M. et al. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nature Immunol. 7, 1074-1081 (2006).
-
(2006)
Nature Immunol.
, vol.7
, pp. 1074-1081
-
-
Carty, M.1
-
99
-
-
84864332905
-
DSarm/Sarm1 is required for activation of an injury-induced axon death pathway
-
Osterloh, J. M. et al. dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science 337, 481-484 (2012).
-
(2012)
Science
, vol.337
, pp. 481-484
-
-
Osterloh, J.M.1
-
100
-
-
84856008042
-
Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt
-
Troutman, T. D. et al. Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt. Proc. Natl Acad. Sci. USA 109, 273-278 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 273-278
-
-
Troutman, T.D.1
-
101
-
-
84855992592
-
B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K
-
Ni, M. et al. B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K. Proc. Natl Acad. Sci. USA 109, 267-272 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 267-272
-
-
Ni, M.1
-
102
-
-
67649422321
-
Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer
-
O'Neill, L. A., Bryant, C. E. & Doyle, S. L. Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol. Rev. 61, 177-197 (2009).
-
(2009)
Pharmacol. Rev.
, vol.61
, pp. 177-197
-
-
O'Neill, L.A.1
Bryant, C.E.2
Doyle, S.L.3
-
103
-
-
27844541797
-
Control of B-cell responses by Toll-like receptors
-
Pasare, C. & Medzhitov, R. Control of B-cell responses by Toll-like receptors. Nature 438, 364-368 (2005).
-
(2005)
Nature
, vol.438
, pp. 364-368
-
-
Pasare, C.1
Medzhitov, R.2
-
104
-
-
0036789814
-
Taking toll: Lipid A mimetics as adjuvants and immunomodulators
-
Persing, D. H. et al. Taking toll: lipid A mimetics as adjuvants and immunomodulators. Trends Microbiol. 10, S32-S37 (2002).
-
(2002)
Trends Microbiol.
, vol.10
-
-
Persing, D.H.1
-
105
-
-
0034123135
-
Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: Selective expression of TLR3 in dendritic cells
-
Muzio, M. et al. Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J. Immunol. 164, 5998-6004 (2000).
-
(2000)
J. Immunol.
, vol.164
, pp. 5998-6004
-
-
Muzio, M.1
-
106
-
-
0034443265
-
Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: Involvement of toll-like receptors
-
Tsuji, S. et al. Maturation of human dendritic cells by cell wall skeleton of Mycobacterium bovis bacillus Calmette-Guérin: involvement of toll-like receptors. Infect. Immun. 68, 6883-6890 (2000).
-
(2000)
Infect. Immun.
, vol.68
, pp. 6883-6890
-
-
Tsuji, S.1
-
107
-
-
0035865232
-
Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2
-
Hertz, C. J. et al. Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2. J. Immunol. 166, 2444-2450 (2001).
-
(2001)
J. Immunol.
, vol.166
, pp. 2444-2450
-
-
Hertz, C.J.1
-
108
-
-
0347146027
-
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways
-
Hoebe, K. et al. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nature Immunol. 4, 1223-1229 (2003).
-
(2003)
Nature Immunol.
, vol.4
, pp. 1223-1229
-
-
Hoebe, K.1
-
109
-
-
33846456617
-
A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass
-
Bennett-Guerrero, E. et al. A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass. Anesth. Analg. 104, 378-383 (2007).
-
(2007)
Anesth. Analg.
, vol.104
, pp. 378-383
-
-
Bennett-Guerrero, E.1
-
110
-
-
80052968260
-
Influence of severity of illness on the effects of eritoran tetrasodium (E5564) and on other therapies for severe sepsis
-
Kalil, A. C., LaRosa, S. P., Gogate, J., Lynn, M. & Opal, S. M. Influence of severity of illness on the effects of eritoran tetrasodium (E5564) and on other therapies for severe sepsis. Shock 36, 327-331 (2011).
-
(2011)
Shock
, vol.36
, pp. 327-331
-
-
Kalil, A.C.1
Larosa, S.P.2
Gogate, J.3
Lynn, M.4
Opal, S.M.5
-
111
-
-
77953723966
-
TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus
-
Guiducci, C. et al. TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus. Nature 465, 937-941 (2010).
-
(2010)
Nature
, vol.465
, pp. 937-941
-
-
Guiducci, C.1
-
112
-
-
84860789456
-
Treatment with OPN-305, a humanized anti-Toll-Like receptor-2 antibody, reduces myocardial ischemia/reperfusion injury in pigs
-
Arslan, F. et al. Treatment with OPN-305, a humanized anti-Toll-Like receptor-2 antibody, reduces myocardial ischemia/reperfusion injury in pigs. Circ. Cardiovasc. Interv. 5, 279-287 (2012).
-
(2012)
Circ. Cardiovasc. Interv.
, vol.5
, pp. 279-287
-
-
Arslan, F.1
-
113
-
-
84856521251
-
Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia-reperfusion injury
-
Farrar, C. A. et al. Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia-reperfusion injury. FASEB J. 26, 799-807 (2012).
-
(2012)
FASEB J.
, vol.26
, pp. 799-807
-
-
Farrar, C.A.1
-
114
-
-
84862068459
-
Genetic variation in Toll-like receptors and disease susceptibility
-
Netea, M. G., Wijmenga, C. & O'Neill, L. A. Genetic variation in Toll-like receptors and disease susceptibility. Nature Immunol. 13, 535-542 (2012).
-
(2012)
Nature Immunol.
, vol.13
, pp. 535-542
-
-
Netea, M.G.1
Wijmenga, C.2
O'Neill, L.A.3
-
115
-
-
34548699323
-
TLR3 deficiency in patients with herpes simplex encephalitis
-
Zhang, S. Y. et al. TLR3 deficiency in patients with herpes simplex encephalitis. Science 317, 1522-1527 (2007).
-
(2007)
Science
, vol.317
, pp. 1522-1527
-
-
Zhang, S.Y.1
-
116
-
-
48749109290
-
Pyogenic bacterial infections in humans with MyD88 deficiency
-
von Bernuth, H. et al. Pyogenic bacterial infections in humans with MyD88 deficiency. Science 321, 691-696 (2008).
-
(2008)
Science
, vol.321
, pp. 691-696
-
-
Von Bernuth, H.1
-
117
-
-
34948904198
-
Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity
-
Ku, C. L. et al. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J. Exp. Med. 204, 2407-2422 (2007).
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2407-2422
-
-
Ku, C.L.1
-
118
-
-
79551686422
-
Oncogenically active MYD88 mutations in human lymphoma
-
Ngo, V. N. et al. Oncogenically active MYD88 mutations in human lymphoma. Nature 470, 115-119 (2011).
-
(2011)
Nature
, vol.470
, pp. 115-119
-
-
Ngo, V.N.1
|