The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila

Immunity

Volumn 12, Issue 5, 2000, Pages 569-580

  Rutschmann, Sophie ^a   Jung, Alain C ^a   Hetru, Charles ^a   Reichhart, Jean Marc ^a   Hoffmann, Jules A ^a   Ferrandon, Dominique ^a  

^a INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ATTACIN; DEFENSIN; DIPTERICIN; DROSOCIN; DROSOMYCIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METCHNIKOWIN; PEPTIDE; PROTEIN P50; TRANSCRIPTION FACTOR REL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ARTICLE; BACTERIAL MUTATION; CHEMICAL COMPOSITION; CONTROLLED STUDY; DROSOPHILA; GRAM POSITIVE BACTERIUM; HOST RESISTANCE; IMMUNE RESPONSE; IMMUNOPHENOTYPING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS;

EID: 0033711445     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80208-3     Document Type: Article

References (45)

1. Antimicrobial peptides in insects; structure and function
2. A firm hand on NFkappaB: Structures of the IkappaBalpha-NFkappaB complex
3. Structure of the specificity domain of the Dorsal homologue Gambif1 bound to DNA
4. Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality
5. Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila
6. Drosophila cecropin as an antifungal agent
7. KappaB-like motifs regulate the induction of immune genes in Drosophila
8. The instructive role of innate immunity in the acquired immune response
9. A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway
10. Genetic approaches in mice to understand Rel/NF-κB and I-κB function: Transgenics and knockouts
11. NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses
12. Control of development and immunity by Rel transcription factors in Drosophila
13. Interaction and specificity of Rel-related proteins in regulating Drosophila immunity gene expression
14. Relish, a central factor in the control of humoral but not cellular immunity in Drosophila
15. Drosophila immunity
16. Phylogenetic perspectives in innate immunity
17. Signaling mechanisms in the antimicrobial host defense of Drosophila
18. Dif, a dorsal-related gene that mediates an immune-response in Drosophila
19. Evolution and revolution in immunology
20. Insect immunity. Two 17-bp repeats nesting a kappaB-related sequence confer inducibility to the diptericin gene and bind a polypeptide in bacteria-challenged Drosophila
21. Interactions of a Rel protein with its inhibitor
22. A recessive mutation, immune deficiency(imd), defines two distinct control pathways in the Drosophila host defence
23. Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila
24. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
25. Drosophila host defense: Differential display of antimicrobial peptide genes after infection by various classes of microorganisms
26. Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties
27. Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin
28. Constitutive activation of Toll-mediated antifungal defense in serpin-deficient Drosophila
29. Antimicrobial activity spectrum, cDNA cloning, and mRNA expression of a newly isolated member of the cecropin family from the mosquito vector Aedes aegypti
30. A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF
31. Innate immune recognition and control of adaptive immune responses
32. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
33. Toll receptor-mediated Drosophila immune response requires Dif, an NF- kappaB factor
34. A dorso-ventral shift of embryonic primordia in a new maternal-effect mutant of Drosophila
35. Activators and target genes of Rel/NF-κB transcription factors
36. Serpent regulates Drosophila immunity genes in the larval fat body through an essential GATA motif
37. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
38. A family of human receptors structurally related to Drosophila Toll
39. A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo
40. Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses
41. The Dorsal-related immunity factor (Dif) can define the dorsal-ventral axis of polarity in the Drosophila embryo
42. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
43. Specificity of Rel-inhibitor interactions in Drosophila embryos
44. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
45. Regulated nuclear import of Rel proteins in the Drosophila immune response