Molecular genetic analysis of an endotoxin nonresponder mutant cell line: A point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling

Journal of Experimental Medicine

Volumn 194, Issue 1, 2001, Pages 79-88

  Schromm, Andra B ^a,b   Lien, Egil ^c   Henneke, Philipp ^a   Chow, Jesse C ^d   Yoshimura, Atsutoshi ^e   Heine, Holger ^b   Latz, Eicke ^a   Monks, Brian G ^a   Schwartz, David A ^f   Miyake, Kensuke ^g   Golenbock, Douglas T ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RESEARCH CENTER BORSTEL   (Germany)

^c NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^d EISAI RESEARCH INSTITUTE   (United States)

^e NAGASAKI UNIVERSITY   (Japan)

^f DUKE UNIVERSITY MEDICAL CENTER   (United States)

^g SAGA UNIVERSITY   (Japan)

Author keywords

Gram negative bacteria; Lipopolysaccharide; Sepsis; Signal transduction; Toll like receptors

Indexed keywords

CELL SURFACE PROTEIN; ENDOTOXIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL LINE; CELL MUTANT; CONFORMATIONAL TRANSITION; GENETIC COMPLEMENTATION; GENETIC TRANSFECTION; GRAM NEGATIVE BACTERIUM; MOLECULAR CLONING; MOLECULAR GENETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; RECEPTOR AFFINITY; SEPSIS; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD14; ANTIGENS, SURFACE; CELL LINE; CHO CELLS; CLONE CELLS; CLONING, MOLECULAR; CRICETINAE; DNA MUTATIONAL ANALYSIS; DROSOPHILA PROTEINS; ENDOTOXINS; GENETIC COMPLEMENTATION TEST; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; MEMBRANE GLYCOPROTEINS; MUTATION; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035796406     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.1.79     Document Type: Article

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