Sirtuin deacylases: A molecular link between metabolism and immunity

Journal of Leukocyte Biology

Volumn 93, Issue 5, 2013, Pages 669-680

  Preyat, Nicolas ^a   Leo, Oberdan ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Inflammation; NAD; NAMPT; SIRT1; SIRT6

Indexed keywords

ADENOSINE TRIPHOSPHATE; CAMBINOL; HYDROLASE INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; SIRTUIN; SIRTUIN 1; SIRTUIN 6; SIRTUIN INHIBITOR; UNCLASSIFIED DRUG;

B LYMPHOCYTE DIFFERENTIATION; DEACETYLATION; DIET SUPPLEMENTATION; ENZYME INACTIVATION; FATTY ACID OXIDATION; GENE OVEREXPRESSION; GLYCOLYSIS; IMMUNITY; IMMUNOCOMPETENT CELL; INFLAMMATION; METABOLIC REGULATION; METABOLISM; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ADENOSINE TRIPHOSPHATE; ANIMALS; DIETARY SUPPLEMENTS; HOMEOSTASIS; HUMANS; IMMUNITY; INFLAMMATION; NAD; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; SIRTUIN 1; SIRTUINS;

EID: 84877075626     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.1112557     Document Type: Review

References (154)

1. Houtkooper, R. H., Pirinen, E., Auwerx, J. (2012) Sirtuins as regulators of metabolism and healthspan. Nat. Rev. Mol. Cell. Biol. 13, 225-238.
2. Burnett, C., Valentini, S., Cabreiro, F., Goss, M., Somogyvári, M., Piper, M. D., Hoddinott, M., Sutphin, G. L., Leko, V., McElwee, J. J., Vazquez-Manrique, R. P., Orfila, A. M., Ackerman, D., Au, C., Vinti, G., Riesen, M., Howard, K., Neri, C., Bedalov, A., Kaeberlein, M., Soti, C., Partridge, L., Gems, D., (2011) Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature 477, 482-485.
3. Frye, R. A. (2000) Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem. Biophys. Res. Commun. 273, 793-798.
4. Du, J., Zhou, Y., Su, X., Yu, J. J., Khan, S., Jiang, H., Kim, J., Woo, J., Kim, J. H., Choi, B. H., He, B., Chen, W., Zhang, S., Cerione, R. A., Auwerx, J., Hao, Q., Lin, H., (2011) Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science 334, 806-809.
5. Peng, C., Lu, Z., Xie, Z., Cheng, Z., Chen, Y., Tan, M., Luo, H., Zhang, Y., He, W., Yang, K., Zwaans, B. M., Tishkoff, D., Ho, L., Lombard, D., He, T. C., Dai, J., Verdin, E., Ye, Y., Zhao, Y. (2011) The first identification of lysine malonylation substrates and its regulatory enzyme. Mol. Cell. Proteomics 10, M111.012658.
6. Finkel, T., Deng, C-X., Mostoslavsky, R. (2009) Recent progress in the biology and physiology of sirtuins. Nature 460, 587-591.
7. Dioum, E. M., Chen, R., Alexander, M. S., Zhang, Q., Hogg, R. T., Gerard, R. D., Garcia, J. A. (2009) Regulation of hypoxia-inducible factor 2α signaling by the stress-responsive deacetylase sirtuin 1. Science 324, 1289-1293.
8. Lim, J-H., Lee, Y-M., Chun, Y-S., Chen, J., Kim, J-E., Park, J-W. (2010) Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1α. Mol. Cell 38, 864-878.
9. Bell, E. L., Emerling, B. M., Ricoult, S. J. H., Guarente, L. (2011) SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production. Oncogene 30, 2986-2996.
10. Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., Puigserver, P. (2005) Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1. Nature 434, 113-118.
11. Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., Hu, L. S., Cheng, H. L., Jedrychowski, M. P., Gygi, S. P., Sinclair, D. A., Alt, F. W., Greenberg, M. E. (2004) Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011-2015.
12. Imai, S., Armstrong, C. M., Kaeberlein, M., Guarente, L. (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795-800.
13. Nikiforov, A., Dölle, C., Niere, M., Ziegler, M. (2011) Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation. J. Biol. Chem. 286, 21767-21778.
14. Henderson, L. M., Deodhar, T., Krehl, W. A., Elvehjem, C. A. (1947) Factors affecting the growth of rats receiving niacin-tryptophan-deficient diets J. Biol. Chem. 170, 261-268.
15. Watson, M., Roulston, A., Bélec, L., Billot, X., Marcellus, R., Bédard, D., Bernier, C., Branchaud, S., Chan, H., Dairi, K. (2009) The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. Mol. Cell. Biol. 29, 5872-5888.
16. Rongvaux, A., Andris, F., Van Gool, F., Leo, O. (2003) Reconstructing eukaryotic NAD metabolism. Bioessays 25, 683-690.
17. Schmidt, M. T., Smith, B. C., Jackson, M. D., Denu, J. M. (2004) Coenzyme specificity of Sir2 protein deacetylases: implications for physiological regulation. J. Biol. Chem. 279, 40122-40129.
18. Revollo, J. R., Grimm, A. A., Imai, S. (2004) The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells. J. Biol. Chem. 279, 50754-50763.
19. Bitterman, K. J., Anderson, R. M., Cohen, H. Y., Latorre-Esteves, M., Sinclair, D. A. (2002) Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J. Biol. Chem. 277, 45099-45107.
20. Smith, B. C., Hallows, W. C., Denu, J. M. (2009) A continuous microplate assay for sirtuins and nicotinamide-producing enzymes. Anal. Biochem. 394, 101-109.
21. Simonin, F., Poch, O., Delarue, M., De Murcia, G. (1993) Identification of potential active-site residues in the human poly(ADP-ribose) polymerase. J. Biol. Chem. 268, 8529-8535.
22. Samal, B., Sun, Y., Stearns, G., Xie, C., Suggs, S., McNiece, I. (1994) Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol. Cell. Biol. 14, 1431-1437.
23. Skokowa, J., Lan, D., Thakur, B. K., Wang, F., Gupta, K., Cario, G., Brechlin, A. M., Schambach, A., Hinrichsen, L., Meyer, G., Gaestel, M., Stanulla, M., Tong, Q., Welte, K. (2009) NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway. Nat. Med. 15, 151-158.
24. Rongvaux, A., Shea, R. J., Mulks, M. H., Gigot, D., Urbain, J., Leo, O., Andris, F. (2002) Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis. Eur. J. Immunol. 32, 3225-3234.
25. Revollo, J. R., Körner, A., Mills, K. F., Satoh, A., Wang, T., Garten, A., Dasgupta, B., Sasaki, Y., Wolberger, C., Townsend, R. R., Milbrandt, J., Kiess, W., Imai, S. (2007) Nampt/PBEF/Visfatin regulates insulin secretion in β cells as a systemic NAD biosynthetic enzyme. Cell. Metab. 6, 363-375.
26. Revollo, J. R., Grimm, A. A., Imai, S. (2007) The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals. Curr. Opin. Gastroenterol. 23, 164-170.
27. Sills, J. (2007) Retraction of a paper titled "Visfatin: a protein secreted by visceral fat that mimetics the effects of insulin". Science 318, 565-567.
28. Ye, S. Q., Simon, B. A., Maloney, J. P., Zambelli-Weiner, A., Gao, L., Grant, A., Easley, R. B., McVerry, B. J., Tuder, R. M., Standiford, T., Brower, R. G., Barnes, K. C., Garcia, J. G. (2005) Pre-B-cell colony-enhancing factor as a potential novel biomarker in acute lung injury. Am. J. Respir. Crit. Care Med. 171, 361-370.
29. Otero, M., Lago, R., Gomez, R., Lago, F., Dieguez, C., Gómez-Reino, J. J., Gualillo, O. (2006) Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann. Rheum. Dis. 65, 1198-1201.
30. Ismail, S. A., Mohamed, S. A. (2012) Serum levels of visfatin and omentin-1 in patients with psoriasis and their relation to disease severity. Br. J. Dermatol. 167, 436-439.
31. Gosset, M., Berenbaum, F., Salvat, C., Sautet, A., Pigenet, A., Tahiri, K., Jacques, C. (2008) Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: possible influence on osteoarthritis. Arthritis Rheum. 58, 1399-1409.
32. De Sanctis, J. B., Zabaleta, M., Bianco, N. E., Garmendia, J. V., Rivas, L. (2009) Serum adipokine levels in patients with systemic lupus erythematosus. Autoimmunity 42, 272-274.
33. Jia, S. H., Li, Y., Parodo, J., Kapus, A., Fan, L., Rotstein, O. D., Marshall, J. C. (2004) Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. J. Clin. Invest. 113, 1318-1327.
34. Moschen, A. R., Kaser, A., Enrich, B., Mosheimer, B., Theurl, M., Niederegger, H., Tilg, H. (2007) Visfatin, an adipocytokine with proinflammatory and immunomodulating properties. J. Immunol. 178, 1748-1758.
35. Busso, N., Karababa, M., Nobile, M., Rolaz, A., Van Gool, F., Galli, M., Leo, O., So, A., De Smedt, T. (2008) Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD. PloS One 3, e2267.
36. Van Gool, F., Gallí, M., Gueydan, C., Kruys, V., Prevot, P.-P., Bedalov, A., Mostoslavsky, R., Alt, F. W., De Smedt, T., Leo, O. (2009) Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. Nat. Med. 15, 206-210.
37. Bruzzone, S., Fruscione, F., Morando, S., Ferrando, T., Poggi, A., Garuti, A., D'Urso, A., Selmo, M., Benvenuto, F., Cea, M., Zoppoli, G., Moran, E., Soncini, D., Ballestrero, A., Sordat, B., Patrone, F., Mostoslavsky, R., Uccelli, A., Nencioni, A. (2009) Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE. PloS One 4, e7897.
38. Esposito, E., Impellizzeri, D., Mazzon, E., Fakhfouri, G., Rahimian, R., Travelli, C., Tron, G. C., Genazzani, A. A., Cuzzocrea, S. (2012) The NAMPT inhibitor FK866 reverts the damage in spinal cord injury. J. Neuroinflammation. 9, 66.
39. Gao, W., Mao, Q., Feng, A-W., Sun, H-M., Sun, W-K., Lu, X., Su, X., Shi, Y. (2011) Inhibition of pre-B cell colony-enhancing factor attenuates inflammation and apoptosis induced by pandemic H1N1 2009 in lung endothelium. Respir. Physiol. Neurobiol. 178, 235-241.
40. Orecchia, A., Scarponi, C., Di Felice, F., Cesarini, E., Avitabile, S., Mai, A., Mauro, M. L., Sirri, V., Zambruno, G., Albanesi, C., Camilloni, G., Failla, C. M. (2011) Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells. PloS One 6, e24307.
41. Chalkiadaki, A., Guarente, L. (2012) High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. Cell. Metab. 16, 180-188.
42. Yoshino, J., Mills, K. F., Yoon, M. J., Imai, S. (2011) Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet-and age-induced diabetes in mice. Cell. Metab. 14, 528-536.
43. Yang, H., Yang, T., Baur, J. A., Perez, E., Matsui, T., Carmona, J. J., Lamming, D. W., Souza-Pinto, N. C., Bohr, V. A., Rosenzweig, A., de Cabo, R., Sauve, A. A., Sinclair, D. A. (2007) Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell 130, 1095-1107.
44. Hayashida, S., Arimoto, A., Kuramoto, Y., Kozako, T., Honda, S-I., Shimeno, H., Soeda, S. (2010) Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice. Mol. Cell. Biochem. 339, 285-292.
45. Fulco, M., Cen, Y., Zhao, P., Hoffman, E. P., McBurney, M. W., Sauve, A. A., Sartorelli, V. (2008) Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev. Cell 14, 661-673.
46. Matsuzaki, J., Kuwamura, M., Yamaji, R., Inui, H., Nakano, Y. (2001) Nutritional immunology inflammatory responses to lipopolysaccharide are suppressed in 40% energy-restricted mice. J. Nutr. 131, 2139-2144.
47. Hayden, M. S., Ghosh, S. (2008) Shared principles in NF-κB signaling. Cell 132, 344-362.
48. Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., Mayo, M. W. (2004) Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 23, 2369-2380.
49. Kwon, H-S., Brent, M. M., Getachew, R., Jayakumar, P., Chen, L-F., Schnolzer, M., McBurney, M. W., Marmorstein, R., Greene, W. C., Ott, M. (2008) Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe 3, 158-167.
50. Shen, Z., Ajmo, J. M., Rogers, C. Q., Liang, X., Le, L., Murr, M. M., Peng, Y., You, M. (2009) Role of SIRT1 in regulation of LPS-or two ethanol metabolites-induced TNF-α production in cultured macrophage cell lines. Am. J. Physiol. Gastrointest. Liver Physiol. 296, G1047-G1053.
51. Rajendrasozhan, S., Yang, S-R., Kinnula, V. L., Rahman, I. (2008) SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 177, 861-870.
52. Yang, S., Wright, J., Bauter, M., Seweryniak, K., Kode, A., Rahman, I. (2007) Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-κB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. Am. J. Physiol. Lung Cell. Mol. Physiol. 292, L567-L576.
53. Nakamaru, Y., Vuppusetty, C., Wada, H., Milne, J. C., Ito, M., Rossios, C., Elliot, M., Hogg, J., Kharitonov, S., Goto, H., Bemis, J. E., Elliott, P., Barnes, P. J., Ito, K. (2009) A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J. 23, 2810-2819.
54. Schug, T. T., Xu, Q., Gao, H., Peres-da-Silva, A., Draper, D. W., Fessler, M. B., Purushotham, A., Li, X. (2010) Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress. Mol. Cell. Biol. 30, 4712-4721.
55. Pfluger, P. T., Herranz, D., Velasco-Miguel, S., Serrano, M., Tschöp, M. H. (2008) Sirt1 protects against high-fat diet-induced metabolic damage. Proc. Natl. Acad. Sci. USA 105, 9793-9798.
56. Escande, C., Chini, C. C. S., Nin, V., Dykhouse, K. M., Novak, C. M., Levine, J., Van Deursen, J., Gores, G. J., Chen, J., Lou, Z., Chini, E. N. (2010) Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J. Clin. Invest. 120, 545-558.
57. Rajamohan, S. B., Pillai, V. B., Gupta, M., Sundaresan, N. R., Birukov, K. G., Samant, S., Hottiger, M. O., Gupta, M. P. (2009) SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Mol. Cell. Biol. 29, 4116-4129.
58. Rothgiesser, K. M., Erener, S., Waibel, S., Lüscher, B., Hottiger, M. O. (2010) SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310. J. Cell Sci. 123, 4251-4258.
59. Yao, H., Chung, S., Hwang, J., Rajendrasozhan, S., Sundar, I. K., Dean, D. A., McBurney, M. W., Guarente, L., Gu, W., Rönty, M., Kinnula, V. L., Rahman, I. (2012) SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J. Clin. Invest. 122, 2032-2045.
60. Zhang, R., Chen, H-Z., Liu, J-J., Jia, Y-Y., Zhang, Z-Q., Yang, R-F., Zhang, Y., Xu, J., Wei, Y-S., Liu, D-P., Liang, C. C. (2010) SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages. J. Biol. Chem. 285, 7097-7110.
61. Sequeira, J., Boily, G., Bazinet, S., Saliba, S., He, X., Jardine, K., Kennedy, C., Staines, W., Rousseaux, C., Mueller, R., McBurney, M. W. (2008) Sirt1-null mice develop an autoimmune-like condition. Exp. Cell. Res. 314, 3069-3074.
62. Zhang, J., Lee, S., Shannon, S., Gao, B., Chen, W., Chen, A., Divekar, R., McBurney, M. W., Braley-Mullen, H., Zaghouani, H., Fang, D. (2009) The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice. J. Clin. Invest. 119, 3048-3058.
63. Van Loosdregt, J., Vercoulen, Y., Guichelaar, T., Gent, Y. Y. J., Beekman, J. M., Van Beekum, O., Brenkman, A. B., Hijnen, D., Mutis, T., Kalkhoven, E., Prakken, B. J., Coffer, P. J. (2010) Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization. Blood 115, 965-974.
64. Kume, S., Haneda, M., Kanasaki, K., Sugimoto, T., Araki, S., Isshiki, K., Isono, M., Uzu, T., Guarente, L., Kashiwagi, A., Koya, D. (2007) SIRT1 inhibits transforming growth factor γ-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation. J. Biol. Chem. 282, 151-158.
65. Legutko, A., Marichal, T., Fiévez, L., Bedoret, D., Mayer, A., De Vries, H., Klotz, L., Drion, P-V., Heirman, C., Cataldo, D., Louis, R., Thielemans, K., Andris, F., Leo, O., Lekeux, P., Desmet, C. J., Bureau, F. (2011) Sirtuin 1 promotes Th2 responses and airway allergy by repressing peroxisome proliferator-activated receptor-γ activity in dendritic cells. J. Immunol. 187, 4517-4529.
66. Niederer, F., Ospelt, C., Brentano, F., Hottiger, M. O., Gay, R. E., Gay, S., Detmar, M., Kyburz, D. (2011) SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance. Ann. Rheum. Dis. 70, 1866-1873.
67. Lee, S-I., Park, K-H., Kim, S-J., Kang, Y-G., Lee, Y-M., Kim, E-C. (2012) Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells. Clin. Exp. Immunol. 168, 113-124.
68. Andersson, U., Tracey, K. J. (2011) HMGB1 is a therapeutic target for sterile inflammation and infection. Annu. Rev. Immunol. 29, 139-162.
69. Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M. M., Mills, K. D., Patel, P., Hsu, J. T., Hong, A. L., Ford, E., Cheng, H. L., Kennedy, C., Nunez, N., Bronson, R., Frendewey, D., Auerbach, W., Valenzuela, D., Karow, M., Hottiger, M. O., Hursting, S., Barrett, J.C., Guarente, L., Mulligan, R., Demple, B., Yancopoulos, G. D., Alt, F. W. (2006) Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 124, 315-329.
70. Kawahara, T. L. Michishita, E., Adler, A. S., Damian, M., Berber, E., Lin, M., McCord, R. A., Ongaigui, K. C. L., Boxer, L. D., Chang, H. Y., Chua, K. F. (2009) SIRT6 links histone H3 lysine 9 deacetylation to NF-κB-dependent gene expression and organismal life span. Cell 136, 62-74.
71. Xiao, C., Wang, R-H., Lahusen, T. J., Park, O., Bertola, A., Maruyama, T., Reynolds, D., Chen, Q., Xu, X., Young, H. A., Chen, W. J., Gao, B., Deng, C. X. (2012) Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice. J. Biol. Chem. 287, 41903-41913.
72. Montecucco, F., Bauer, I., Braunersreuther, V., Bruzzone, S., Akhmedov, A., Lüscher, T. F., Speer, T., Poggi, A., Mannino, E., Pelli, G., Galan, K., Bertolotto, M., Lenglet, S., Garuti, A., Montessuit, C., Lerch, R., Pellieux, C., Vuilleumier, N., Dallegri, F., Mage, J., Sebastian, C., Mostoslavsky, R., Gayet-Ageron, A., Patrone, F., Mach, F., Nencioni, A. (2012) Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in Myocardial infarction. Antioxid. Redox Signal. doi: 10.1089/ars.2011.4487 [Epub ahead of print].
73. Bauer, I., Grozio, A., Lasiglie, D., Basile, G., Sturla, L., Magnone, M., Sociali, G., Soncini, D., Caffa, I., Poggi, A., Zoppoli, G., Cea, M., Feldmann, G., Mostoslavsky, R., Ballestrero, A., Patrone, F., Bruzzone, S., Nencioni, A. (2012) The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses. J. Biol. Chem. 287, 40924-40937.
74. Michalek, R. D., Gerriets, V. A., Jacobs, S. R., Macintyre, A. N., MacIver, N. J., Mason, E. F., Sullivan, S. A., Nichols, A. G., Rathmell, J. C. (2011) Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J. Immunol. 186, 3299-3303.
75. Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., Green, D. R. (2011) The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 35, 871-882.
76. Shi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., Chi, H. (2011) HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J. Exp. Med. 208, 1367-1376.
77. Vander Heiden, M. G., Cantley, L. C., Thompson, C. B. (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033.
78. Lunt, S. Y., Vander Heiden, M. G. (2011) Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu. Rev. Cell Dev. Biol. 27, 441-464.
79. Pearce, E. L. (2010) Metabolism in T cell activation and differentiation. Curr. Opin. Immunol. 22, 314-320.
80. Liu, T. F., Vachharajani, V. T., Yoza, B. K., McCall, C. E. (2012) NAD+-dependent sirtuins 1 and 6 coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response. J. Biol. Chem. 287, 25758-25769.
81. Zhong, L., D'Urso, A., Toiber, D., Sebastian, C., Henry, R. E., Vadysirisack, D. D., Guimaraes, A., Marinelli, B., Wikstrom, J. D., Nir, T., Clish, C. B., Vaitheesvaran, B., Iliopoulos, O., Kurland, I., Dor, Y., Weissleder, R., Shirihai, O. S., Ellisen, L. W., Espinosa, J. M., Mostoslavsky, R. (2010) The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1α. Cell 140, 280-293.
82. Kim, H-S., Xiao, C., Wang, R-H., Lahusen, T., Xu, X., Vassilopoulos, A., Vazquez-Ortiz, G., Jeong, W-I., Park, O., Ki, S. H., Gao, B., Deng C. X. (2010) Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab. 12, 224-236.
83. Fang, H-Y., Hughes, R., Murdoch, C., Coffelt, S. B., Biswas, S. K., Harris, A. L., Johnson, R. S., Imityaz, H. Z., Simon, M. C., Fredlund, E., Greten, F. R., Rius, J., Lewis, C. E. (2009) Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood 114, 844-859.
84. Zhang, W., Petrovic, J-M., Callaghan, D., Jones, A., Cui, H., Howlett, C., Stanimirovic, D. (2006) Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1β (IL-1β) in astrocyte cultures. J. Neuroimmunol. 174, 63-73.
85. Köhler, T., Reizis, B., Johnson, R. S., Weighardt, H., Förster, I. (2012) Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration. Eur. J. Immunol. 42, 1226-1236.
86. Greer, S. N., Metcalf, J. L., Wang, Y., Ohh, M. (2012) The updated biology of hypoxia-inducible factor. EMBO J. 31, 2448-2460.
87. Vega, R. B., Huss, J. M., Kelly, D. P. (2000) The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol. Cell. Biol. 20, 1868-1876.
88. Kelly, T. J., Lerin, C., Haas, W., Gygi, S. P., Puigserver, P. (2009) GCN5-mediated transcriptional control of the metabolic coactivator PGC-1β through lysine acetylation. J. Biol. Chem. 284, 19945-19952.
89. Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., Geny, B., Laakso, M., Puigserver, P., Auwerx, J. (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1β. Cell 127, 1109-1122.
90. Handschin, C., Chin, S., Li, P., Liu, F., Maratos-Flier, E., Lebrasseur, N. K., Yan, Z., Spiegelman, B. M. (2007) Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1β muscle-specific knock-out animals. J. Biol. Chem. 282, 30014-30021.
91. Wang, R., Green, D. R. (2012) Metabolic checkpoints in activated T cells. Nat. Immunol. 13, 907-915.
92. Liu, T. F., Brown, C. M., El Gazzar, M., McPhail, L., Millet, P., Rao, A., Vachharajani, V. T., Yoza, B. K., McCall, C. E. (2012) Fueling the flame: bioenergy couples metabolism and inflammation. J. Leukoc. Biol. 92, 499-507.
93. Liu, T. F., Yoza, B. K., El Gazzar, M., Vachharajani, V. T., McCall, C. E. (2011) NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. J. Biol. Chem. 286, 9856-9864.
94. Schwer, B., North, B. J., Frye, R. A., Ott, M., Verdin, E. (2002) The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J. Cell Biol. 158, 647-657.
95. Haigis, M. C., Mostoslavsky, R., Haigis, K. M., Fahie, K., Christodoulou, D. C., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Karow, M., Blander, G., Wolberger, C., Prolla, T. A., Weindruch, R., Alt, F. W., Guarente, L. (2006) SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic β cells. Cell 126, 941-954.
96. Nakagawa, T., Lomb, D. J., Haigis, M. C., Guarente, L. (2009) SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell 137, 560-570.
97. Ahn, B-H., Kim, H-S., Song, S., Lee, I. H., Liu, J., Vassilopoulos, A., Deng, C-X., Finkel, T. (2008) A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc. Natl. Acad. Sci. USA 105, 14447-14452.
98. Finley, L. W. S., Carracedo, A., Lee, J., Souza, A., Egia, A., Zhang, J., Teruya-Feldstein, J., Moreira, P. I., Cardoso, S. M., Clish, C. B., Pandolfi, P. P., Haigis M. C. (2011) SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization. Cancer Cell 19, 416-428.
99. Schwer, B., Bunkenborg, J., Verdin, R. O., Andersen, J. S., Verdin, E. (2006) Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc. Natl. Acad. Sci. USA 103, 10224-10229.
100. Nogueiras, R., Habegger, K. M., Chaudhary, N., Finan, B., Banks, A. S., Dietrich, M. O., Horvath, T. L., Sinclair, D. A., Pfluger, P. T., Tschöp, M. H. (2012) Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol. Rev. 92, 1479-1514.
101. Hirschey, M. D., Shimazu, T., Goetzman, E., Jing, E., Schwer, B., Lombard, D. B., Grueter, C. A., Harris, C., Biddinger, S., Ilkayeva, O. R., Stevens, R. D., Li, Y., Saha A. K., Ruderman N. B., Bain J. R., Newgard, C. B., Farese R. V., Jr., Alt F. W., Kahn, C. R., Verdin, E. (2010) SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature 464, 121-125.
102. Purushotham, A., Schug, T. T., Xu, Q., Surapureddi, S., Guo, X., Li, X. (2009) Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell. Metab. 9, 327-338.
103. Mootha, V. K., Lindgren, C. M., Eriksson, K-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstrale, M., Laurila, E., Houstis, N., Daly, M. J., Patterson, N., Mesirov, J. P., Golub, T. R., Tamayo, P., Spiegelman, B., Lander, E. S., Hirschhorn, J. N., Altshuler, D., Groop, L. C. (2003) PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 34, 267-273.
104. De Kreutzenberg, S. V., Ceolotto, G., Papparella, I., Bortoluzzi, A., Semplicini, A., Dalla Man, C., Cobelli, C., Fadini, G. P., Avogaro, A. (2010) Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms. Diabetes 59, 1006-1015.
105. Fernandes, C. A., Fievez, L., Neyrinck, A. M., Delzenne, N. M., Bureau, F., Vanbever, R. (2012) Sirtuin inhibition attenuates the production of inflammatory cytokines in lipopolysaccharide-stimulated macrophages. Biochem. Biophys. Res. Commun. 420, 857-861.
106. Fukuzawa, M., Satoh, J., Muto, G., Muto, Y., Nishimura, S., Miyaguchi, S., Qiang, X. L., Toyota, T. (1997) Inhibitory effect of nicotinamide on in vitro and in vivo production of tumor necrosis factor-α. Immunol. Lett. 59, 7-11.
107. Ungerstedt, J. S., Blömback, M., Söderström, T. (2003) Nicotinamide is a potent inhibitor of proinflammatory cytokines. Clin. Exp. Immunol. 131, 48-52.
108. Yuan, H., Wan, J., Li, L., Ge, P., Li, H., Zhang, L. (2012) Therapeutic benefits of the group B3 vitamin nicotinamide in mice with lethal endotoxemia and polymicrobial sepsis. Pharmacol. Res. 65, 328-337.
109. Soop, A., Albert, J., Weitzberg, E., Bengtsson, A., Nilsson, C., Sollevi, A. (2004) Nicotinamide does not influence cytokines or exhaled NO in human experimental endotoxaemia. Clin. Exp. Immunol. 135, 114-118.
110. Cantó, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y., Oosterveer, M. H., Cen, Y., Fernandez-Marcos, P. J., Yamamoto, H., Andreux, P. A., Cettour-Rose, P., Gademann, K., Rinsch, C., Schoonjans, K., Sauve, A. A., Auwerx, J. (2012) The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell. Metab. 15, 838-847.
111. Pillai, J. B., Isbatan, A., Imai, S., Gupta, M. P. (2005) Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2α deacetylase activity. J. Biol. Chem. 280, 43121-43130.
112. Bai, P., Cantó, C., Oudart, H., Brunyánszki, A., Cen, Y., Thomas, C., Yamamoto, H., Huber, A., Kiss, B., Houtkooper, R. H., Schoonjans, K., Schreiber, V., Sauve A. A., Menissier-de Murcia, J., Auwerx, J. (2011) PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation. Cell Metab. 13, 461-468.
113. Aksoy, P., Escande, C., White, T. A., Thompson, M., Soares, S., Benech, J. C., Chini, E. N. (2006) Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38. Biochem. Biophys. Res. Commun. 349, 353-359.
114. Hwang, J., Chung, S., Sundar, I. K., Yao, H., Arunachalam, G., McBurney, M. W., Rahman, I. (2010) Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. Arch. Biochem. Biophys. 500, 203-209.
115. Caito, S., Hwang, J-W., Chung, S., Yao, H., Sundar, I. K., Rahman, I. (2010) PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity. Biochem. Biophys. Res. Commun. 392, 264-2670.
116. Welsby, I., Hutin, D., Leo, O. (2012) Complex roles of members of the ADP-ribosyl transferase super family in immune defences: looking beyond PARP1. Biochem. Pharmacol. 84, 11-20.
117. Mabley, J. G., Jagtap, P., Perretti, M., Getting, S. J., Salzman, A. L., Virág, L., Szabó, E., Soriano, F. G., Liaudet, L., Abdelkarim, G. E., Haskó, G., Marton, A., Southan, G. J., Szabó, C. (2001) Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. Inflamm. Res. 50, 561-569.
118. Boulares, A. H., Zoltoski, A. J., Yakovlev, A., Xu, M., Smulson, M. E. (2001) Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase in an amplification phase of tumor necrosis factor-induced apoptosis. J. Biol. Chem. 276, 38185-38192.
119. Hamby, A. M., Suh, S. W., Kauppinen, T. M., Swanson, R. A. (2007) Use of a poly(ADP-ribose) polymerase inhibitor to suppress inflammation and neuronal death after cerebral ischemia-reperfusion. Stroke 38, 632-636.
120. Langcake, P., Pryce, R. J. (1976) The production of resveratrol by Vitis vinifera and other members of the Vitaceae as a response to infection or injury. Physiol. Plant Pathol. 9, 77-86.
121. Shigematsu, S., Ishida, S., Hara, M., Takahashi, N., Yoshimatsu, H., Sakata, T., Korthuis, R. J. (2003) Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-activating factor, or oxidants. Free Radic. Biol. Med. 34, 810-817.
122. Wirleitner, B., Schroecksnadel, K., Winkler, C., Schennach, H., Fuchs, D. (2005) Resveratrol suppresses interferon-γ-induced biochemical pathways in human peripheral blood mononuclear cells in vitro. Immunol. Lett. 100, 159-163.
123. Martín, A. R., Villegas, I., Sánchez-Hidalgo, M., De la Lastra, C. A. (2006) The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model. Br. J. Pharmacol. 147, 873-885.
124. Pearson, K. J., Baur, J. A., Lewis, K. N., Peshkin, L., Price, N. L., Labinskyy, N., Swindell, W. R., Kamara, D., Minor, R. K., Perez, E., Jamieson, H. A., Zhang, Y., Dunn, S. R., Sharma, K., Pleshko, N., Woollett, L. A., Csiszar, A., Ikeno, Y., Le Couteur, D., Elliott, P. J., Becker, K. G., Navas, P., Ingram, D. K., Wolf, N. S., Ungvari, Z., Sinclair, D. A., de Cabo, R. (2008) Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab. 8, 157-168.
125. Wong, Y. T., Gruber, J., Jenner, A. M., Tay, F. E. H., Ruan, R. (2011) Chronic resveratrol intake reverses pro-inflammatory cytokine profile and oxidative DNA damage in ageing hybrid mice. Age 33, 229-246.
126. Capiralla, H., Vingtdeux, V., Zhao, H., Sankowski, R., Al-Abed, Y., Davies, P., Marambaud, P. (2012) Resveratrol mitigates lipopolysaccharide-and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade. J. Neurochem. 120, 461-472.
127. Shindler, K. S., Ventura, E., Dutt, M., Elliott, P., Fitzgerald, D. C., Rostami, A. (2010) Oral resveratrol reduces neuronal damage in a model of multiple sclerosis. J. Neuroophthalmol. 30, 328-339.
128. Singh, N. P., Hegde, V. L., Hofseth, L. J., Nagarkatti, M., Carolina, S. (2007) Experimental allergic encephalomyelitis, primarily via induction of apoptosis in T cells involving activation of aryl hydrocarbon receptor and estrogen receptor. Mol. Pharmacol. 72, 1508-1521.
129. Meng, Y., Ma, Q-Y., Kou, X-P., Xu, J. (2005) Effect of resveratrol on activation of nuclear factor κ-B and inflammatory factors in rat model of acute pancreatitis. World J. Gastroenterol. 11, 525-528.
130. Kubota, S., Kurihara, T., Mochimaru, H., Satofuka, S., Noda, K., Ozawa, Y., Oike, Y., Ishida, S., Tsubota, K. (2009) Prevention of ocular inflammation in endotoxin-induced uveitis with resveratrol by inhibiting oxidative damage and nuclear factor-κB activation. Invest. Ophthalmol. Vis. Sci. 50, 3512-3519.
131. Elmali, N., Esenkaya, I., Harma, A., Ertem, K., Turkoz, Y., Mizrak, B. (2005) Effect of resveratrol in experimental osteoarthritis in rabbits. Inflamm. Res. 54, 158-162.
132. Busch, F., Mobasheri, A., Shayan, P., Lueders, C., Stahlmann, R., Shakibaei, M. (2012) Resveratrol modulates IL-1β-induced PI3K and NF-κB signaling pathways in human tenocytes. J. Biol. Chem. 16, 144-144.
133. Hoffmann, E., Wald, J., Lavu, S., Roberts, J., Beaumont, C., Haddad, J., Elliott, P., Westphal, C., Jacobson, E. (2013) Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man. Br. J. Clin. Pharmacol. 75, 186-196.
134. Yoshizaki, T., Milne, J. C., Imamura, T., Schenk, S., Sonoda, N., Babendure, J. L., Lu, J-C., Smith, J. J., Jirousek, M. R., Olefsky, J. M. (2009) SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Mol. Cell. Biol. 29, 1363-1374.
135. Milne, J. C., Lambert, P. D., Schenk, S., Carney, D. P., Smith, J. J., Gagne, D. J., Jin, L., Boss, O., Perni, R. B., Vu, C. B., Bemis, J. E., Xie, R., Disch, J. S., Ng, P. Y., Nunes, J. J., Lynch, A. V., Yang, H., Galonek, H., Israelian, K., Choy, W., Iffland, A., Lavu, S., Medvedik, O., Sinclair, D. A., Olefsky, J. M., Jirousek, M. R., Elliott, P. J., Westphal, C. H. (2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450, 712-716.
136. Bemis, J. E., Vu, C. B., Xie, R., Nunes, J. J., Ng, P. Y., Disch, J. S., Milne, J. C., Carney, D. P., Lynch, A. V., Jin, L., Smith, J. J., Lavu, S., Iffland, A., Jirousek, M. R., Perni, R. B. (2009) Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators. Bioorg. Med. Chem. Lett. 19, 2350-2353.
137. Vu, C. B., Bemis, J. E., Disch, J. S., Ng, P. Y., Nunes, J. J., Milne, J. C., Carney, D. P., Lynch, A. V., Smith, J. J., Lavu, S., Lambert, P. D., Gagne, D. J., Jirousek, M. R., Schenk, S., Olefsky, J. M., Perni, R. B. (2009) Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators. J. Med. Chem. 52, 1275-1283.
138. Mai, A., Valente, S., Meade, S., Carafa, V., Tardugno, M., Nebbioso, A., Galmozzi, A., Mitro, N., De Fabiani, E., Altucci, L., Kazantsev, A. (2009) Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors. J. Med. Chem. 52, 5496-5504.
139. Zhang, Q., Zeng, S. X., Zhang, Y., Zhang, Y., Ding, D., Ye, Q., Meroueh, S. O., Lu, H. (2012) A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53. EMBO Mol. Med. 4, 298-312.
140. Halperin-Sheinfeld, M., Gertler, A., Okun, E., Sredni, B., Cohen, H. Y. (2012) The Tellurium compound, AS101, increases SIRT1 level and activity and prevents type 2 diabetes. Aging 4, 436-447.
141. Yoshizaki, T., Schenk, S., Imamura, T., Babendure, J. L., Sonoda, N., Bae, E. J., Oh, D. Y., Lu, M., Milne, J. C., Westphal, C., Bandyopadhyay, G., Olefsky, J. M. (2010) SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. Am. J. Physiol. Endocrinol. Metab. 298, E419-E428.
142. Yamazaki, Y., Usui, I., Kanatani, Y., Matsuya, Y., Tsuneyama, K., Fujisaka, S., Bukhari, A., Suzuki, H., Senda, S., Imanishi, S., Hirata, K., Ishiki, M., Hayashi, R., Urakaze, M., Nemoto, H., Kobayashi, M., Tobe, K. (2009) Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice. Am. J. Physiol. Endocrinol. Metab. 297, E1179-E1186.
143. Huber, J. L., McBurney, M. W., Distefano, P. S., McDonagh, T. (2010) SIRT1-independent mechanisms of the putative sirtuin enzyme activators SRT1720 and SRT2183. Future Med. Chem. 2, 1751-1759.
144. Pacholec, M., Bleasdale, J. E., Chrunyk, B., Cunningham, D., Flynn, D., Garofalo, R. S., Griffith, D., Griffor, M., Loulakis, P., Pabst, B., Qiu, X., Stockman, B., Thanabal, V., Varghese, A., Ward, J., Withka, J., Ahn, K. (2010) SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J. Biol. Chem. 285, 8340-8351.
145. Chen, C-L., Wang, Y-M., Liu, C-F., Wang, J-Y. (2008) The effect of water-soluble chitosan on macrophage activation and the attenuation of mite allergen-induced airway inflammation. Biomaterials 29, 2173-2182.
146. Qiao, Y., Bai, X., Du, Y. (2011) Chitosan oligosaccharides protect mice from LPS challenge by attenuation of inflammation and oxidative stress. Int. Immunopharmacol. 11, 121-127.
147. Jeong, H. W., Cho, S. Y., Kim, S., Shin, E. S., Kim, J. M., Song, M. J., Park, P. J., Sohn, J. H., Park, H., Seo, D-B., Kim, W. G., Lee, S. J. (2012) Chitooligosaccharide induces mitochondrial biogenesis and increases exercise endurance through the activation of Sirt1 and AMPK in rats. PloS One 7, e40073.
148. Samuel, S. M., Thirunavukkarasu, M., Penumathsa, S. V., Paul, D., Maulik, N. (2008) Akt/FOXO3a/SIRT1-mediated cardioprotection by n-tyrosol against ischemic stress in rat in vivo model of myocardial infarction: switching gears toward survival and longevity. J. Agric. Food Chem. 56, 9692-9698.
149. Heltweg, B., Gatbonton, T., Schuler, A. D., Posakony, J., Li, H., Goehle, S., Kollipara, R., Depinho, R. A., Gu, Y., Simon, J. A., Bedalov, A. (2006) Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 66, 4368-4377.
150. Biswas, S. K., Lopez-Collazo, E. (2009) Endotoxin tolerance: new mechanisms, molecules and clinical significance. Trends Immunol. 30, 475-487.
151. Michishita, E., McCord, R. A., Berber, E., Kioi, M., Padilla-Nash, H., Damian, M., Cheung, P., Kusumoto, R., Kawahara, T. L. A., Barrett, J. C., Chang, H. Y., Bohr, V. A., Ried, T., Gozani, O., Chua, K. F. (2008) SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 452, 492-496.
152. Yang, B., Zwaans, B. M. M., Eckersdorff, M., Lombard, D. B. (2009) The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability. Cell Cycle 8, 2662-2663.
153. Das, C., Lucia, M. S., Hansen, K. C., Tyler, J. K. (2009) CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature 459, 113-117.
154. North, B. J., Marshall, B. L., Borra, M. T., Denu, J. M., Verdin, E. (2003) The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol. Cell 11, 437-444.