Anti-inflammatory effects of a novel, potent inhibitor of poly(ADP-ribose) polymerase

Inflammation Research

Volumn 50, Issue 11, 2001, Pages 561-569

  Mabley, J G ^a   Jagtap, P ^a   Perretti, M ^b   Getting, S J ^b   Salzman, A L ^a   Virag L ^a   Szabo E ^a   Soriano, F G ^c   Liaudet, L ^c   Abdelkarim, G E ^a   Hasko G ^a   Marton, A ^a   Southan, G J ^a   Szabo C ^a  

^a INOTEK CORPORATION   (United States)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Arthritis; Colitis; Nitric oxide; Pleurisy; Uveitis

Indexed keywords

ANTIINFLAMMATORY AGENT; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PHENANTHRIDINE DERIVATIVE; POLY(ADP RIBOSE) POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; COLITIS; CONTROLLED STUDY; DNA STRAND BREAKAGE; DRUG EFFECT; INFLAMMATION; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PERITONITIS; UVEITIS;

EID: 0035205574     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00000234     Document Type: Article

References (37)

1. Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity
2. Role of poly-ADP ribosyl-transferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitite
3. Inhibition of poly(ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects
4. Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes
5. Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia
6. Blockade of Poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis
7. Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly(ADP-ribose) polymerase-1 deficient mice
8. Inhibition of poly(ADP-ribose) polymerase attenuates inflammation in a model of chronic colitis
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10. Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase in vitro and in vivo models of stroke
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12. Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: Evidence for an inhibitory loop involving endogenous IL-10
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14. Adenosine kinase inhibitor GP515 improves experimental colitis in mice
15. Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose) polymerase
16. Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes
17. Inhibition of poly(ADP-ribose) synthetase either by gene disruption or by enzyme inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes and islets of Langerhans from cytokine-mediated dysfunction
18. Development of autoimmune diabetes in NOD mice is associated with the formation of peroxynitrite in pancreatic islet beta-cells
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20. Nicotinamide prevents the development of diabetes in the cyclophosphamide-induced NOD mouse model by reducing beta-cell apoptosis
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22. Synergistic effects of thalidomide and poly(ADP-ribose) polymerase inhibition on type II collagen-induced arthritis in mice
23. T cell traffic and the inflammatory response in experimental autoimmune uveoretinitis
24. Role of free radicals and poly(ADP-ribose) synthetase in intestinal tight junction permeability
25. Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin
26. Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes
27. The role of poly(ADP-ribose) synthase in endotoxin-induced uveitis in the rat
28. Poly(ADP-ribose) polymerase is a mediator of necrotic cell death by ATP depletion
29. Peroxynitrite-induced thymocyte apoptosis: The role of caspases and poly(ADP-ribose) synthetase (PARS) activation
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32. 2 and tumor necrosis factor-alpha activate intercellular adhesion molecule 1 (ICAM-1) gene transcription through distinct cis-regulatory elements within the ICAM-1 promoter
33. Genetic disruption of poly(ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule- 1 in myocardial ischemia/reperfusion injury
34. Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase
35. Immunosuppressive activities of 6(5H)-phenanthridinone, a new poly(ADP-ribose) polymerase inhibitor