Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man

British Journal of Clinical Pharmacology

Volumn 75, Issue 1, 2013, Pages 186-196

  Hoffmann, Ethan ^a   Wald, Jeff ^a   Lavu, Siva ^a   Roberts, John ^a   Beaumont, Claire ^b   Haddad, Jon ^a   Elliott, Peter ^a   Westphal, Christoph ^a   Jacobson, Eric ^a  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Activator; Microtracer; Pharmacokinetics; SIRT1; Sirtuin; SRT2104

Indexed keywords

SIRTUIN 1; SMALL MOLECULE TRANSPORT AGENT; SRT 2104; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DIARRHEA; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; DRUG METABOLISM; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; FLATULENCE; HEADACHE; HUMAN; HUMAN EXPERIMENT; INJECTION SITE PAIN; MALE; NAUSEA; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RHINOPHARYNGITIS; SEX DIFFERENCE;

BIOLOGICAL AVAILABILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ENZYME ACTIVATION; FEMALE; HUMANS; IMIDAZOLES; MALE; SIRTUIN 1; THIAZOLES;

EID: 84871118476     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2012.04340.x     Document Type: Article

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