Current status of chemokines in the adult CNS

Progress in Neurobiology

Volumn 104, Issue , 2013, Pages 67-92

  Réaux Le Goazigo, Annabelle ^a   Van Steenwinckel, Juliette ^a,b   Rostène, William ^a   Mélik Parsadaniantz, Stéphane ^a  

^a INSTITUT DE LA VISION   (France)

^b HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

Central nervous system; Chemokines; CNS disorders; Neuromodulation; Opioid receptors

Indexed keywords

4 AMINOBUTYRIC ACID; CHEMOKINE; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CX3CR1; CHEMOKINE RECEPTOR CXCR4; CXCL3 CHEMOKINE; CXCL3C1 CHEMOKINE; DOPAMINE; G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; MELANIN CONCENTRATING HORMONE; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUROTRANSMITTER; OPIATE RECEPTOR; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ASTROCYTE; BLOOD BRAIN BARRIER; CELL MIGRATION; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; CEREBROVASCULAR ACCIDENT; DOPAMINE RELEASE; HIV ASSOCIATED DEMENTIA; HUMAN; MEMBRANE PERMEABILITY; MICROGLIA; MULTIPLE SCLEROSIS; NERVE CELL; NERVE SPROUTING; NEURAL STEM CELL; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CENTRAL NERVOUS SYSTEM; CHEMOKINES; HUMANS; RECEPTORS, CHEMOKINE; SIGNAL TRANSDUCTION;

EID: 84876799802     PISSN: 03010082     EISSN: 18735118     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2013.02.001     Document Type: Review

References (360)

1. Allen N.J., Attwell D. A chemokine-glutamate connection. Nature Neuroscience 2001, 4:676-678.
2. Andjelkovic A.V., Song L., Dzenko K.A., Cong H., Pachter J.S. Functional expression of CCR2 by human fetal astrocytes. Journal of Neuroscience Research 2002, 70:219-231.
3. Andjelkovic A.V., Spencer D.D., Pachter J.S. Visualization of chemokine binding sites on human brain microvessels. Journal of Cell Biology 1999, 145:403-412.
4. Arakawa Y., Bito H., Furuyashiki T., Tsuji T., Takemoto-Kimura S., Kimura K., Nozaki K., Hashimoto N., Narumiya S. Control of axon elongation via an SDF-1alpha/Rho/mDia pathway in cultured cerebellar granule neurons. Journal of Cell Biology 2003, 161:381-391.
5. Armstrong B.D., Abad C., Chhith S., Cheung-Lau G., Hajji O.E., Nobuta H., Waschek J.A. Impaired nerve regeneration and enhanced neuroinflammatory response in mice lacking pituitary adenylyl cyclase activating peptide. Neuroscience 2008, 151:63-73.
6. Arvidsson A., Collin T., Kirik D., Kokaia Z., Lindvall O. Neuronal replacement from endogenous precursors in the adult brain after stroke. Nature Medicine 2002, 8:963-970.
7. Baamonde A., Hidalgo A., Menendez L. Involvement of glutamate NMDA and AMPA receptors, glial cells and IL-1beta in the spinal hyperalgesia evoked by the chemokine CCL2 in mice. Neuroscience Letters 2011, 502:178-181.
8. Bachis A., Mocchetti I. The chemokine receptor CXCR4 and not the N-methyl-D-aspartate receptor mediates gp120 neurotoxicity in cerebellar granule cells. Journal of Neuroscience Research 2004, 75:75-82.
9. Baggiolini M., Loetscher P. Chemokines in inflammation and immunity. Immunology Today 2000, 21:418-420.
10. Bagri A., Gurney T., He X., Zou Y.R., Littman D.R., Tessier-Lavigne M., Pleasure S.J. The chemokine SDF1 regulates migration of dentate granule cells. Development 2002, 129:4249-4260.
11. Bajetto A., Barbero S., Bonavia R., Piccioli P., Pirani P., Florio T., Schettini G. Stromal cell-derived factor-1alpha induces astrocyte proliferation through the activation of extracellular signal-regulated kinases 1/2 pathway. Journal of Neurochemistry 2001, 77:1226-1236.
12. Bajetto A., Bonavia R., Barbero S., Piccioli P., Costa A., Florio T., Schettini G. Glial and neuronal cells express functional chemokine receptor CXCR4 and its natural ligand stromal cell-derived factor 1. Journal of Neurochemistry 1999, 73:2348-2357.
13. Banisadr G., Dicou E., Berbar T., Rostene W., Lombet A., Haour F. Characterization and visualization of [125I] stromal cell-derived factor-1alpha binding to CXCR4 receptors in rat brain and human neuroblastoma cells. Journal of Neuroimmunology 2000, 110:151-160.
14. Banisadr G., Fontanges P., Haour F., Kitabgi P., Rostene W., Melik Parsadaniantz S. Neuroanatomical distribution of CXCR4 in adult rat brain and its localization in cholinergic and dopaminergic neurons. European Journal of Neuroscience 2002, 16:1661-1671.
15. Banisadr G., Frederick T.J., Freitag C., Ren D., Jung H., Miller S.D., Miller R.J. The role of CXCR4 signaling in the migration of transplanted oligodendrocyte progenitors into the cerebral white matter. Neurobiology of Disease 2011, 44:19-27.
16. Banisadr G., Gosselin R., Mechighel P., Kitabgi P., Rostene W., Mélik Parsadaniantz S. Highly regionalized neuronal expression of MCP-1/CCL2 in rat brain. Evidence for its colocalization with neurotransmitters and neuropeptides. Journal of Comparative Neurology 2005, 489:275-292.
17. Banisadr G., Queraud-Lesaux F., Boutterin M.C., Pelaprat D., Zalc B., Rostene W., Haour F., Parsadaniantz S.M. Distribution, cellular localization and functional role of CCR2 chemokine receptors in adult rat brain. Journal of Neurochemistry 2002, 81:257-269.
18. Banisadr G., Rostene W., Kitabgi P., Parsadaniantz S.M. Chemokines and brain functions. Current Drug Targets-Inflammation & Allergy 2005, 4:387-399.
19. Banisadr G., Skrzydelski D., Kitabgi P., Rostene W., Parsadaniantz S.M. Highly regionalized distribution of stromal cell-derived factor-1/CXCL12 in adult rat brain: constitutive expression in cholinergic, dopaminergic and vasopressinergic neurons. European Journal of Neuroscience 2003, 18:1593-1606.
20. Barna B.P., Pettay J., Barnett G.H., Zhou P., Iwasaki K., Estes M.L. Regulation of monocyte chemoattractant protein-1 expression in adult human non-neoplastic astrocytes is sensitive to tumor necrosis factor (TNF) or antibody to the 55-kDa TNF receptor. Journal of Neuroimmunology 1994, 50:101-107.
21. Baron P., Bussini S., Cardin V., Corbo M., Conti G., Galimberti D., Scarpini E., Bresolin N., Wharton S.B., Shaw P.J., Silani V. Production of monocyte chemoattractant protein-1 in amyotrophic lateral sclerosis. Muscle & Nerve 2005, 32:541-544.
22. Bazan J.F., Bacon K.B., Hardiman G., Wang W., Soo K., Rossi D., Greaves D.R., Zlotnik A., Schall T.J. A new class of membrane-bound chemokine with a CX3C motif. Nature 1997, 385:640-644.
23. Belkouch M., Dansereau M.A., Reaux-Le Goazigo A., Van Steenwinckel J., Beaudet N., Chraibi A., Melik-Parsadaniantz S., Sarret P. The chemokine CCL2 increases Nav1.8 sodium channel activity in primary sensory neurons through a Gbetagamma-dependent mechanism. Journal of Neuroscience 2011, 31:18381-18390.
24. Belmadani A., Tran P.B., Ren D., Miller R.J. Chemokines regulate the migration of neural progenitors to sites of neuroinflammation. Journal of Neuroscience 2006, 26:3182-3191.
25. Berger O., Li G., Han S.M., Paredes M., Pleasure S.J. Expression of SDF-1 and CXCR4 during reorganization of the postnatal dentate gyrus. Developmental Neuroscience 2007, 29:48-58.
26. Berman J.W., Guida M.P., Warren J., Amat J., Brosnan C.F. Localization of monocyte chemoattractant peptide-1 expression in the central nervous system in experimental autoimmune encephalomyelitis and trauma in the rat. Journal of Immunology 1996, 156:3017-3023.
27. Bezzi P., Domercq M., Brambilla L., Galli R., Schols D., De Clercq E., Vescovi A., Bagetta G., Kollias G., Meldolesi J., Volterra A. CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity. Nature Neuroscience 2001, 4:702-710.
28. Bhattacharyya B.J., Banisadr G., Jung H., Ren D., Cronshaw D.G., Zou Y., Miller R.J. The chemokine stromal cell-derived factor-1 regulates GABAergic inputs to neural progenitors in the postnatal dentate gyrus. Journal of Neuroscience 2008, 28:6720-6730.
29. Biber K., Vinet J., Boddeke H.W. Neuron-microglia signaling: chemokines as versatile messengers. Journal of Neuroimmunology 2008, 198:69-74.
30. Bleul C.C., Farzan M., Choe H., Parolin C., Clark-Lewis I., Sodroski J., Springer T.A. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 1996, 382:829-833.
31. Boehme S.A., Lio F.M., Maciejewski-Lenoir D., Bacon K.B., Conlon P.J. The chemokine fractalkine inhibits Fas-mediated cell death of brain microglia. Journal of Immunology 2000, 165:397-403.
32. Boillee S., Vande Velde C., Cleveland D.W. ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron 2006, 52:39-59.
33. Bonavia R., Bajetto A., Barbero S., Pirani P., Florio T., Schettini G. Chemokines and their receptors in the CNS: expression of CXCL12/SDF-1 and CXCR4 and their role in astrocyte proliferation. Toxicology Letters 2003, 139:181-189.
34. Boven L.A., Middel J., Breij E.C., Schotte D., Verhoef J., Soderland C., Nottet H.S. Interactions between HIV-infected monocyte-derived macrophages and human brain microvascular endothelial cells result in increased expression of CC chemokines. Journal for Neurovirology 2000, 6:382-389.
35. Brosnan C.F., Raine C.S. Mechanisms of immune injury in multiple sclerosis. Brain Pathology 1996, 6:243-257.
36. Bruno V., Copani A., Besong G., Scoto G., Nicoletti F. Neuroprotective activity of chemokines against N-methyl-D-aspartate or beta-amyloid-induced toxicity in culture. European Journal of Pharmacology 2000, 399:117-121.
37. Burbassi S., Sengupta R., Meucci O. Alterations of CXCR4 function in mu-opioid receptor-deficient glia. European Journal of Neuroscience 2010, 32:1278-1288.
38. Burns J.M., Summers B.C., Wang Y., Melikian A., Berahovich R., Miao Z., Penfold M.E., Sunshine M.J., Littman D.R., Kuo C.J., Wei K., McMaster B.E., Wright K., Howard M.C., Schall T.J. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. Journal of Experimental Medicine 2006, 203:2201-2213.
39. Cali C., Bezzi P. CXCR4-mediated glutamate exocytosis from astrocytes. Journal of Neuroimmunology 2010, 224:13-21.
40. Cali C., Marchaland J., Regazzi R., Bezzi P. SDF 1-alpha (CXCL12) triggers glutamate exocytosis from astrocytes on a millisecond time scale: imaging analysis at the single-vesicle level with TIRF microscopy. Journal of Neuroimmunology 2008, 198:82-91.
41. Callewaere C., Banisadr G., Desarmenien M.G., Mechighel P., Kitabgi P., Rostene W.H., Melik Parsadaniantz S. The chemokine SDF-1/CXCL12 modulates the firing pattern of vasopressin neurons and counteracts induced vasopressin release through CXCR4. Proceedings of the National Academy of Sciences U S A 2006, 103:8221-8226.
42. Callewaere C., Fernette B., Raison D., Mechighel P., Burlet A., Calas A., Kitabgi P., Parsadaniantz S.M., Rostene W. Cellular and subcellular evidence for neuronal interaction between the chemokine stromal cell-derived factor-1/CXCL 12 and vasopressin: regulation in the hypothalamo-neurohypophysial system of the Brattleboro rats. Endocrinology 2008, 149:310-319.
43. Carbajal K.S., Schaumburg C., Strieter R., Kane J., Lane T.E. Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis. Proceedings of the National Academy of Sciences U S A 2010, 107:11068-11073.
44. Cardona A.E., Pioro E.P., Sasse M.E., Kostenko V., Cardona S.M., Dijkstra I.M., Huang D., Kidd G., Dombrowski S., Dutta R., Lee J.C., Cook D.N., Jung S., Lira S.A., Littman D.R., Ransohoff R.M. Control of microglial neurotoxicity by the fractalkine receptor. Nature Neuroscience 2006, 9:917-924.
45. Cartier L., Hartley O., Dubois-Dauphin M., Krause K.H. Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases. Brain Research Brain Research Reviews 2005, 48:16-42.
46. Casas A.T., Hubsch A.P., Doran J.E. Effects of reconstituted high-density lipoprotein in persistent gram-negative bacteremia. The American Surgeon 1996, 62:350-355.
47. Chalasani S.H., Sabelko K.A., Sunshine M.J., Littman D.R., Raper J.A. A chemokine, SDF-1, reduces the effectiveness of multiple axonal repellents and is required for normal axon pathfinding. Journal of Neuroscience 2003, 23:1360-1371.
48. Che X., Ye W., Panga L., Wu D.C., Yang G.Y. Monocyte chemoattractant protein-1 expressed in neurons and astrocytes during focal ischemia in mice. Brain Research 2001, 902:171-177.
49. Chen L., Liu J., Xu C., Keblesh J., Zang W., Xiong H. HIV-1gp120 induces neuronal apoptosis through enhancement of 4-aminopyridine-senstive outward K+ currents. PLoS One 2011, 6:e25994.
50. Chen X., Geller E.B., Rogers T.J., Adler M.W. The chemokine CX3CL1/fractalkine interferes with the antinociceptive effect induced by opioid agonists in the periaqueductal grey of rats. Brain Research 2007, 1153:52-57.
51. Chen X., Geller E.B., Rogers T.J., Adler M.W. Rapid heterologous desensitization of antinociceptive activity between mu or delta opioid receptors and chemokine receptors in rats. Drug and Alcohol Dependence 2007, 88:36-41.
52. Chen X., Kirby L.G., Palma J., Benamar K., Geller E.B., Eisenstein T.K., Adler M.W. The effect of gp120 on morphine's antinociceptive and neurophysiological actions. Brain Behavior and Immunity 2011, 25:1434-1443.
53. Chen Y., Hallenbeck J.M., Ruetzler C., Bol D., Thomas K., Berman N.E., Vogel S.N. Overexpression of monocyte chemoattractant protein 1 in the brain exacerbates ischemic brain injury and is associated with recruitment of inflammatory cells. Journal of Cerebral Blood Flow & Metabolism 2003, 23:748-755.
54. Cho S.H., Sun B., Zhou Y., Kauppinen T.M., Halabisky B., Wes P., Ransohoff R.M., Gan L. CX3CR1 protein signaling modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer disease. Journal of Biological Chemistry 2011, 286:32713-32722.
55. Cinque P., Vago L., Mengozzi M., Torri V., Ceresa D., Vicenzi E., Transidico P., Vagani A., Sozzani S., Mantovani A., Lazzarin A., Poli G. Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HIV-1 encephalitis and local viral replication. AIDS 1998, 12:1327-1332.
56. Cipriani R., Villa P., Chece G., Lauro C., Paladini A., Micotti E., Perego C., De Simoni M.G., Fredholm B.B., Eusebi F., Limatola C. CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents. Journal of Neuroscience 2011, 31:16327-16335.
57. Clark A.K., Malcangio M. Microglial signalling mechanisms: Cathepsin S and Fractalkine. Experimental Neurology 2012, 234:283-292.
58. Clark A.K., Wodarski R., Guida F., Sasso O., Malcangio M. Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor. Glia 2010, 58:1710-1726.
59. Clark A.K., Yip P.K., Grist J., Gentry C., Staniland A.A., Marchand F., Dehvari M., Wotherspoon G., Winter J., Ullah J., Bevan S., Malcangio M. Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Proceedings of the National Academy of Sciences U S A 2007, 104:10655-10660.
60. Clark A.K., Yip P.K., Malcangio M. The liberation of fractalkine in the dorsal horn requires microglial cathepsin S. Journal of Neuroscience 2009, 29:6945-6954.
61. Clark-Lewis I., Kim K.S., Rajarathnam K., Gong J.H., Dewald B., Moser B., Baggiolini M., Sykes B.D. Structure-activity relationships of chemokines. Journal of Leukocyte Biology 1995, 57:703-711.
62. Clore G.M., Gronenborn A.M. Three-dimensional structures of alpha and beta chemokines. FASEB Journal 1995, 9:57-62.
63. Cocchi F., DeVico A.L., Garzino-Demo A., Arya S.K., Gallo R.C., Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 1995, 270:1811-1815.
64. Compston A., Coles A. Multiple sclerosis. Lancet 2008, 372:1502-1517.
65. Conant K., Garzino-Demo A., Nath A., McArthur J.C., Halliday W., Power C., Gallo R.C., Major E.O. Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia. Proceedings of the National Academy of Sciences U S A 1998, 95:3117-3121.
66. Conductier G., Blondeau N., Guyon A., Nahon J.L., Rovere C. The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases. Journal of Neuroimmunology 2010, 224:93-100.
67. Corcione A., Arduino N., Ferretti E., Raffaghello L., Roncella S., Rossi D., Fedeli F., Ottonello L., Trentin L., Dallegri F., Semenzato G., Pistoia V. CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells. Clinical Cancer Research 2004, 10:964-971.
68. Correa J.D., Starling D., Teixeira A.L., Caramelli P., Silva T.A. Chemokines in CSF of Alzheimer's disease patients. Arquivos de neuro-psiquiatria 2011, 69:455-459.
69. Corti S., Locatelli F., Papadimitriou D., Del Bo R., Nizzardo M., Nardini M., Donadoni C., Salani S., Fortunato F., Strazzer S., Bresolin N., Comi G.P. Neural stem cells LewisX+ CXCR4+ modify disease progression in an amyotrophic lateral sclerosis model. Brain 2007, 130:1289-1305.
70. Cotter R., Williams C., Ryan L., Erichsen D., Lopez A., Peng H., Zheng J. Fractalkine (CX3CL1) and brain inflammation: implications for HIV-1-associated dementia. Journal for Neurovirology 2002, 8:585-598.
71. Coughlan C.M., McManus C.M., Sharron M., Gao Z., Murphy D., Jaffer S., Choe W., Chen W., Hesselgesser J., Gaylord H., Kalyuzhny A., Lee V.M., Wolf B., Doms R.W., Kolson D.L. Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons. Neuroscience 2000, 97:591-600.
72. Croitoru-Lamoury J., Guillemin G.J., Boussin F.D., Mognetti B., Gigout L.I., Cheret A., Vaslin B., Le Grand R., Brew B.J., Dormont D. Expression of chemokines and their receptors in human and simian astrocytes: evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation. Glia 2003, 41:354-370.
73. Cui X., Chen J., Zacharek A., Roberts C., Yang Y., Chopp M. Nitric oxide donor up-regulation of SDF1/CXCR4 and Ang1/Tie2 promotes neuroblast cell migration after stroke. Journal of Neuroscience Research 2009, 87:86-95.
74. D'Aversa T.G., Yu K.O., Berman J.W. Expression of chemokines by human fetal microglia after treatment with the human immunodeficiency virus type 1 protein Tat. Journal for Neurovirology 2004, 10:86-97.
75. Dansereau M.A., Gosselin R.D., Pohl M., Pommier B., Mechighel P., Mauborgne A., Rostene W., Kitabgi P., Beaudet N., Sarret P., Melik-Parsadaniantz S. Spinal CCL2 pronociceptive action is no longer effective in CCR2 receptor antagonist-treated rats. Journal of Neurochemistry 2008, 106:757-769.
76. de Haas A.H., van Weering H.R., de Jong E.K., Boddeke H.W., Biber K.P. Neuronal chemokines: versatile messengers in central nervous system cell interaction. Molecular Neurobiology 2007, 36:137-151.
77. Deiva K., Geeraerts T., Salim H., Leclerc P., Hery C., Hugel B., Freyssinet J.M., Tardieu M. Fractalkine reduces N-methyl-d-aspartate-induced calcium flux and apoptosis in human neurons through extracellular signal-regulated kinase activation. European Journal of Neuroscience 2004, 20:3222-3232.
78. Dimitrijevic O.B., Stamatovic S.M., Keep R.F., Andjelkovic A.V. Effects of the chemokine CCL2 on blood-brain barrier permeability during ischemia-reperfusion injury. Journal of Cerebral Blood Flow & Metabolism 2006, 26:797-810.
79. Dimitrijevic O.B., Stamatovic S.M., Keep R.F., Andjelkovic A.V. Absence of the chemokine receptor CCR2 protects against cerebral ischemia/reperfusion injury in mice. Stroke 2007, 38:1345-1353.
80. Dogan R.N., Elhofy A., Karpus W.J. Production of CCL2 by central nervous system cells regulates development of murine experimental autoimmune encephalomyelitis through the recruitment of TNF- and iNOS-expressing macrophages and myeloid dendritic cells. Journal of Immunology 2008, 180:7376-7384.
81. Duan R.S., Yang X., Chen Z.G., Lu M.O., Morris C., Winblad B., Zhu J. Decreased fractalkine and increased IP-10 expression in aged brain of APP(swe) transgenic mice. Neurochemical Research 2008, 33:1085-1089.
82. Dzenko K.A., Andjelkovic A.V., Kuziel W.A., Pachter J.S. The chemokine receptor CCR2 mediates the binding and internalization of monocyte chemoattractant protein-1 along brain microvessels. Journal of Neuroscience 2001, 21:9214-9223.
83. El Khoury J., Toft M., Hickman S.E., Means T.K., Terada K., Geula C., Luster A.D. Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nature Medicine 2007, 13:432-438.
84. El-Hage N., Bruce-Keller A.J., Knapp P.E., Hauser K.F. CCL5/RANTES gene deletion attenuates opioid-induced increases in glial CCL2/MCP-1 immunoreactivity and activation in HIV-1 Tat-exposed mice. Journal of Neuroimmune Pharmacology 2008, 3:275-285.
85. El-Hage N., Gurwell J.A., Singh I.N., Knapp P.E., Nath A., Hauser K.F. Synergistic increases in intracellular Ca2+, and the release of MCP-1, RANTES, and IL-6 by astrocytes treated with opiates and HIV-1 Tat. Glia 2005, 50:91-106.
86. El-Hage N., Wu G., Ambati J., Bruce-Keller A.J., Knapp P.E., Hauser K.F. CCR2 mediates increases in glial activation caused by exposure to HIV-1 Tat and opiates. Journal of Neuroimmunology 2006, 178:9-16.
87. El-Hage N., Wu G., Wang J., Ambati J., Knapp P.E., Reed J.L., Bruce-Keller A.J., Hauser K.F. HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines. Glia 2006, 53:132-146.
88. Eltayeb S., Berg A.L., Lassmann H., Wallstrom E., Nilsson M., Olsson T., Ericsson-Dahlstrand A., Sunnemark D. Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE. Journal of Neuroinflammation 2007, 4:14.
89. Ensoli B., Buonaguro L., Barillari G., Fiorelli V., Gendelman R., Morgan R.A., Wingfield P., Gallo R.C. Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation. Journal of Virology 1993, 67:277-287.
90. Eugenin E.A., D'Aversa T.G., Lopez L., Calderon T.M., Berman J.W. MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis. Journal of Neurochemistry 2003, 85:1299-1311.
91. Eugenin E.A., Dyer G., Calderon T.M., Berman J.W. HIV-1 tat protein induces a migratory phenotype in human fetal microglia by a CCL2 (MCP-1)-dependent mechanism: possible role in NeuroAIDS. Glia 2005, 49:501-510.
92. Eugenin E.A., Osiecki K., Lopez L., Goldstein H., Calderon T.M., Berman J.W. CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS. Journal of Neuroscience 2006, 26:1098-1106.
93. Everall I., Luthert P., Lantos P. A review of neuronal damage in human immunodeficiency virus infection: its assessment, possible mechanism and relationship to dementia. Journal of Neuropathology & Experimental Neurology 1993, 52:561-566.
94. Everall I.P., Luthert P.J., Lantos P.L. Neuronal loss in the frontal cortex in HIV infection. Lancet 1991, 337:1119-1121.
95. Everall I.P., Luthert P.J., Lantos P.L. Neuronal number and volume alterations in the neocortex of HIV infected individuals. Journal of Neurology, Neurosurgery & Psychiatry 1993, 56:481-486.
96. Felszeghy K., Banisadr G., Rostene W., Nyakas C., Haour F. Dexamethasone downregulates chemokine receptor CXCR4 and exerts neuroprotection against hypoxia/ischemia-induced brain injury in neonatal rats. Neuroimmunomodulation 2004, 11:404-413.
97. Feng Y., Broder C.C., Kennedy P.E., Berger E.A. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 1996, 272:872-877.
98. Ferguson K.L., Vanderluit J.L., Hebert J.M., McIntosh W.C., Tibbo E., MacLaurin J.G., Park D.S., Wallace V.A., Vooijs M., McConnell S.K., Slack R.S. Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development. EMBO Journal 2002, 21:3337-3346.
99. Finley M.J., Chen X., Bardi G., Davey P., Geller E.B., Zhang L., Adler M.W., Rogers T.J. Bi-directional heterologous desensitization between the major HIV-1 co-receptor CXCR4 and the kappa-opioid receptor. Journal of Neuroimmunology 2008, 197:114-123.
100. Floridi F., Trettel F., Di Bartolomeo S., Ciotti M.T., Limatola C. Signalling pathways involved in the chemotactic activity of CXCL12 in cultured rat cerebellar neurons and CHP100 neuroepithelioma cells. Journal of Neuroimmunology 2003, 135:38-46.
101. Fraticelli P., Sironi M., Bianchi G., D'Ambrosio D., Albanesi C., Stoppacciaro A., Chieppa M., Allavena P., Ruco L., Girolomoni G., Sinigaglia F., Vecchi A., Mantovani A. Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses. Journal of Clinical Investigation 2001, 107:1173-1181.
102. Fuentes M.E., Durham S.K., Swerdel M.R., Lewin A.C., Barton D.S., Megill J.R., Bravo R., Lira S.A. Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1. Journal of Immunology 1995, 155:5769-5776.
103. Galimberti D., Fenoglio C., Lovati C., Venturelli E., Guidi I., Corra B., Scalabrini D., Clerici F., Mariani C., Bresolin N., Scarpini E. Serum MCP-1 levels are increased in mild cognitive impairment and mild Alzheimer's disease. Neurobiology of Aging 2006, 27:1763-1768.
104. Galimberti D., Schoonenboom N., Scheltens P., Fenoglio C., Venturelli E., Pijnenburg Y.A., Bresolin N., Scarpini E. Intrathecal chemokine levels in Alzheimer disease and frontotemporal lobar degeneration. Neurology 2006, 66:146-147.
105. Ganju R.K., Brubaker S.A., Meyer J., Dutt P., Yang Y., Qin S., Newman W., Groopman J.E. The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. Journal of Biological Chemistry 1998, 273:23169-23175.
106. Ganju R.K., Dutt P., Wu L., Newman W., Avraham H., Avraham S., Groopman J.E. Beta-chemokine receptor CCR5 signals via the novel tyrosine kinase RAFTK. Blood 1998, 91:791-797.
107. Gao Y.J., Zhang L., Samad O.A., Suter M.R., Yasuhiko K., Xu Z.Z., Park J.Y., Lind A.L., Ma Q., Ji R.R. JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. Journal of Neuroscience 2009, 29:4096-4108.
108. Gaupp S., Arezzo J., Dutta D.J., John G.R., Raine C.S. On the occurrence of hypomyelination in a transgenic mouse model: a consequence of the myelin basic protein promoter?. Journal of Neuropathology & Experimental Neurology 2003, 70:1138-1150.
109. Gendelman H.E., Lipton S.A., Tardieu M., Bukrinsky M.I., Nottet H.S. The neuropathogenesis of HIV-1 infection. Journal of Leukocyte Biology 1994, 56:389-398.
110. Glabinski A.R., Balasingam V., Tani M., Kunkel S.L., Strieter R.M., Yong V.W., Ransohoff R.M. Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain. Journal of Immunology 1996, 156:4363-4368.
111. Glass J.D., Wesselingh S.L., Selnes O.A., McArthur J.C. Clinical-neuropathologic correlation in HIV-associated dementia. Neurology 1993, 43:2230-2237.
112. Gleichmann M., Gillen C., Czardybon M., Bosse F., Greiner-Petter R., Auer J., Muller H.W. Cloning and characterization of SDF-1gamma, a novel SDF-1 chemokine transcript with developmentally regulated expression in the nervous system. European Journal of Neuroscience 2000, 12:1857-1866.
113. Gonzalez-Scarano F., Martin-Garcia J. The neuropathogenesis of AIDS. Nature Review Immunology 2005, 5:69-81.
114. Gosselin R.D., Dansereau M.A., Pohl M., Kitabgi P., Beaudet N., Sarret P., Melik Parsadaniantz S. Chemokine network in the nervous system: a new target for pain relief. Current Medicinal Chemistry 2008, 15:2866-2875.
115. Gourmala N.G., Buttini M., Limonta S., Sauter A., Boddeke H.W. Differential and time-dependent expression of monocyte chemoattractant protein-1 mRNA by astrocytes and macrophages in rat brain: effects of ischemia and peripheral lipopolysaccharide administration. Journal of Neuroimmunology 1997, 74:35-44.
116. Grammas P., Ovase R. Inflammatory factors are elevated in brain microvessels in Alzheimer's disease. Neurobiology of Aging 2001, 22:837-842.
117. Graus F., Ribalta T., Abos J., Alom J., Cruz-Sanchez F., Mallolas J., Miro J.M., Cardesa A., Tolosa E. Subacute cerebellar syndrome as the first manifestation of AIDS dementia complex. Acta Neurologica Scandinavica 1990, 81:118-120.
118. Gunther K., Leier J., Henning G., Dimmler A., Weissbach R., Hohenberger W., Forster R. Prediction of lymph node metastasis in colorectal carcinoma by expressionof chemokine receptor CCR7. International Journal of Cancer 2005, 116:726-733.
119. Gupta P.K., Prabhakar S., Sharma S., Anand A. Vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) in amyotrophic lateral sclerosis (ALS) patients. Journal of Neuroinflammation 2011, 8:47.
120. Guyon A., Banisadr G., Rovere C., Cervantes A., Kitabgi P., Melik-Parsadaniantz S., Nahon J.L. Complex effects of stromal cell-derived factor-1alpha on melanin-concentrating hormone neuron excitability. European Journal of Neuroscience 2005, 21:701-710.
121. Guyon A., Conductier G., Rovere C., Enfissi A., Nahon J.L. Melanin-concentrating hormone producing neurons: activities and modulations. Peptides 2009, 30:2031-2039.
122. Guyon A., Nahon J.L. Multiple actions of the chemokine stromal cell-derived factor-1alpha on neuronal activity. Journal of Molecular Endocrinology 2007, 38:365-376.
123. Guyon A., Rovere C., Cervantes A., Allaeys I., Nahon J.L. Stromal cell-derived factor-1alpha directly modulates voltage-dependent currents of the action potential in mammalian neuronal cells. Journal of Neurochemistry 2005, 93:963-973.
124. Guyon A., Skrzydelski D., De Giry I., Rovere C., Conductier G., Trocello J.M., Dauge V., Kitabgi P., Rostene W., Nahon J.L., Melik Parsadaniantz S. Long term exposure to the chemokine CCL2 activates the nigrostriatal dopamine system: a novel mechanism for the control of dopamine release. Neuroscience 2009, 162:1072-1080.
125. Guyon A., Skrzydelski D., Rovere C., Apartis E., Rostene W., Kitabgi P., Melik Parsadaniantz S., Nahon J.L. Stromal-cell-derived factor 1alpha/CXCL12 modulates high-threshold calcium currents in rat substantia nigra. European Journal of Neuroscience 2008, 28:862-870.
126. Guyon A., Skrzydelski D., Rovere C., Rostene W., Parsadaniantz S.M., Nahon J.L. Stromal cell-derived factor-1alpha modulation of the excitability of rat substantia nigra dopaminergic neurones: presynaptic mechanisms. Journal of Neurochemistry 2006, 96:1540-1550.
127. Hagman S., Raunio M., Rossi M., Dastidar P., Elovaara I. Disease-associated inflammatory biomarker profiles in blood in different subtypes of multiple sclerosis: prospective clinical and MRI follow-up study. Journal of Neuroimmunology 2011, 234:141-147.
128. Hanisch U.K. Microglia as a source and target of cytokines. Glia 2002, 40:140-155.
129. Harrison J.K., Fong A.M., Swain P.A., Chen S., Yu Y.R., Salafranca M.N., Greenleaf W.B., Imai T., Patel D.D. Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion. Journal of Biological Chemistry 2001, 276:21632-21641.
130. Harrison J.K., Jiang Y., Chen S., Xia Y., Maciejewski D., McNamara R.K., Streit W.J., Salafranca M.N., Adhikari S., Thompson D.A., Botti P., Bacon K.B., Feng L. Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proceedings of the National Academy of Sciences U S A 1998, 95:10896-10901.
131. Heinisch S., Kirby L.G. Fractalkine/CX3CL1 enhances GABA synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Neuroscience 2009, 164:1210-1223.
132. Heinisch S., Kirby L.G. SDF-1alpha/CXCL12 enhances GABA and glutamate synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Neuropharmacology 2009, 58:501-514.
133. Heinisch S., Kirby L.G. SDF-1alpha/CXCL12 enhances GABA and glutamate synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Neuropharmacology 2010, 58:501-514.
134. Heinisch S., Palma J., Kirby L.G. Interactions between chemokine and mu-opioid receptors: anatomical findings and electrophysiological studies in the rat periaqueductal grey. Brain Behavior and Immunity 2011, 25:360-372.
135. Henkel J.S., Engelhardt J.I., Siklos L., Simpson E.P., Kim S.H., Pan T., Goodman J.C., Siddique T., Beers D.R., Appel S.H. Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue. Annals of Neurology 2004, 55:221-235.
136. Hesselgesser J., Taub D., Baskar P., Greenberg M., Hoxie J., Kolson D.L., Horuk R. Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1 alpha is mediated by the chemokine receptor CXCR4. Current Biology 1998, 8:595-598.
137. Hidalgo-Estevez A.M., Punzon C., Sanchez-Duffhues G., Munoz E., Fresno M. HIV-1-Tat potentiates CXCL12/stromal cell-derived factor 1-induced downregulation of membrane CXCR4 in T lymphocytes through protein kinase C zeta. Molecular Immunology 2008, 46:106-115.
138. Hill W.D., Hess D.C., Martin-Studdard A., Carothers J.J., Zheng J., Hale D., Maeda M., Fagan S.C., Carroll J.E., Conway S.J. SDF-1 (CXCL12) is upregulated in the ischemic penumbra following stroke: association with bone marrow cell homing to injury. Journal of Neuropathology & Experimental Neurology 2004, 63:84-96.
139. Hoffmann F., Muller W., Schutz D., Penfold M.E., Wong Y.H., Schulz S., Stumm R. Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues. Journal of Biological Chemistry 2012, 287:28362-28377.
140. Holman D.W., Klein R.S., Ransohoff R.M. The blood-brain barrier, chemokines and multiple sclerosis. Biochimica et Biophysica Acta 2011, 1812:220-230.
141. Howard O.M., Ben-Baruch A., Oppenheim J.J. Chemokines: progress toward identifying molecular targets for therapeutic agents. Trends in Biotechnology 1996, 14:46-51.
142. Huang D., Shi F.D., Jung S., Pien G.C., Wang J., Salazar-Mather T.P., He T.T., Weaver J.T., Ljunggren H.G., Biron C.A., Littman D.R., Ransohoff R.M. The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. FASEB Journal 2006, 20:896-905.
143. Huang D.R., Wang J., Kivisakk P., Rollins B.J., Ransohoff R.M. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. Journal of Experimental Medicine 2001, 193:713-726.
144. Huerta C., Alvarez V., Mata I.F., Coto E., Ribacoba R., Martinez C., Blazquez M., Guisasola L.M., Salvador C., Lahoz C.H., Pena J. Chemokines (RANTES and MCP-1) and chemokine-receptors (CCR2 and CCR5) gene polymorphisms in Alzheimer's and Parkinson's disease. Neuroscience Letters 2004, 370:151-154.
145. Hughes P.M., Botham M.S., Frentzel S., Mir A., Perry V.H. Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS. Glia 2002, 37:314-327.
146. Huising M.O., Stet R.J., Kruiswijk C.P., Savelkoul H.F., Lidy Verburg-van Kemenade B.M. Molecular evolution of CXC chemokines: extant CXC chemokines originate from the CNS. Trends in Immunology 2003, 24:307-313.
147. Hulkower K., Brosnan C.F., Aquino D.A., Cammer W., Kulshrestha S., Guida M.P., Rapoport D.A., Berman J.W. Expression of CSF-1, c-fms, and MCP-1 in the central nervous system of rats with experimental allergic encephalomyelitis. Journal of Immunology 1993, 150:2525-2533.
148. Hundhausen C., Misztela D., Berkhout T.A., Broadway N., Saftig P., Reiss K., Hartmann D., Fahrenholz F., Postina R., Matthews V., Kallen K.J., Rose-John S., Ludwig A. The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood 2003, 102:1186-1195.
149. Imai T., Hieshima K., Haskell C., Baba M., Nagira M., Nishimura M., Kakizaki M., Takagi S., Nomiyama H., Schall T.J., Yoshie O. Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 1997, 91:521-530.
150. Imitola J., Raddassi K., Park K.I., Mueller F.J., Nieto M., Teng Y.D., Frenkel D., Li J., Sidman R.L., Walsh C.A., Snyder E.Y., Khoury S.J. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway. Proceedings of the National Academy of Sciences U S A 2004, 101:18117-18122.
151. Ishizuka K., Kimura T., Igata-yi R., Katsuragi S., Takamatsu J., Miyakawa T. Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease. Psychiatry & Clinical Neurosciences 1997, 51:135-138.
152. Izikson L., Klein R.S., Charo I.F., Weiner H.L., Luster A.D. Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. Journal of Experimental Medicine 2000, 192:1075-1080.
153. Jiang Y., Salafranca M.N., Adhikari S., Xia Y., Feng L., Sonntag M.K., deFiebre C.M., Pennell N.A., Streit W.J., Harrison J.K. Chemokine receptor expression in cultured glia and rat experimental allergic encephalomyelitis. Journal of Neuroimmunology 1998, 86:1-12.
154. Jin K., Minami M., Lan J.Q., Mao X.O., Batteur S., Simon R.P., Greenberg D.A. Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proceedings of the National Academy of Sciences U S A 2001, 98:4710-4715.
155. Johnston I.N., Milligan E.D., Wieseler-Frank J., Frank M.G., Zapata V., Campisi J., Langer S., Martin D., Green P., Fleshner M., Leinwand L., Maier S.F., Watkins L.R. A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. Journal of Neuroscience 2004, 24:7353-7365.
156. Johnstone M., Gearing A.J., Miller K.M. A central role for astrocytes in the inflammatory response to beta-amyloid; chemokines, cytokines and reactive oxygen species are produced. Journal of Neuroimmunology 1999, 93:182-193.
157. Kalkonde Y.V., Morgan W.W., Sigala J., Maffi S.K., Condello C., Kuziel W., Ahuja S.S., Ahuja S.K. Chemokines in the MPTP model of Parkinson's disease: absence of CCL2 and its receptor CCR2 does not protect against striatal neurodegeneration. Brain Research 2007, 1128:1-11.
158. Karpus W.J., Kennedy K.J. MIP-1alpha and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelitis as well as Th1/Th2 lymphocyte differentiation. Journal of Leukocyte Biology 1997, 62:681-687.
159. Kastenbauer S., Koedel U., Wick M., Kieseier B.C., Hartung H.P., Pfister H.W. CSF and serum levels of soluble fractalkine (CX3CL1) in inflammatory diseases of the nervous system. Journal of Neuroimmunology 2003, 137:210-217.
160. Kaul M., Lipton S.A. Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis. Proceedings of the National Academy of Sciences U S A 1999, 96:8212-8216.
161. Kelder W., McArthur J.C., Nance-Sproson T., McClernon D., Griffin D.E. Beta-chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia. Annals of Neurology 1998, 44:831-835.
162. Kennedy K.J., Strieter R.M., Kunkel S.L., Lukacs N.W., Karpus W.J. Acute and relapsing experimental autoimmune encephalomyelitis are regulated by differential expression of the CC chemokines macrophage inflammatory protein-1alpha and monocyte chemotactic protein-1. Journal of Neuroimmunology 1998, 92:98-108.
163. Ketzler S., Weis S., Haug H., Budka H. Loss of neurons in the frontal cortex in AIDS brains. Acta Neuropathologica 1990, 80:92-94.
164. Khan M.Z., Brandimarti R., Shimizu S., Nicolai J., Crowe E., Meucci O. The chemokine CXCL12 promotes survival of postmitotic neurons by regulating Rb protein. Cell Death & Differentiation 2008, 15:1663-1672.
165. Kim T.S., Lim H.K., Lee J.Y., Kim D.J., Park S., Lee C., Lee C.U. Changes in the levels of plasma soluble fractalkine in patients with mild cognitive impairment and Alzheimer's disease. Neuroscience Letters 2008, 436:196-200.
166. Kiyota T., Yamamoto M., Schroder B., Jacobsen M.T., Swan R.J., Lambert M.P., Klein W.L., Gendelman H.E., Ransohoff R.M., Ikezu T. AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice. Molecular Therapy 2009, 17:803-809.
167. Kiyota T., Yamamoto M., Xiong H., Lambert M.P., Klein W.L., Gendelman H.E., Ransohoff R.M., Ikezu T. CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction. PLoS One 2009, 4:e6197.
168. Knall C., Young S., Nick J.A., Buhl A.M., Worthen G.S., Johnson G.L. Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils. Journal of Biological Chemistry 1996, 271:2832-2838.
169. Kolodziej A., Schulz S., Guyon A., Wu D.F., Pfeiffer M., Odemis V., Hollt V., Stumm R. Tonic activation of CXC chemokine receptor 4 in immature granule cells supports neurogenesis in the adult dentate gyrus. Journal of Neuroscience 2008, 28:4488-4500.
170. Krumbholz M., Theil D., Cepok S., Hemmer B., Kivisakk P., Ransohoff R.M., Hofbauer M., Farina C., Derfuss T., Hartle C., Newcombe J., Hohlfeld R., Meinl E. Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment. Brain 2006, 129:200-211.
171. Kuhle J., Lindberg R.L., Regeniter A., Mehling M., Steck A.J., Kappos L., Czaplinski A. Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis. European Journal of Neurology 2009, 16:771-774.
172. Kumar A., Manna S.K., Dhawan S., Aggarwal B.B. HIV-Tat protein activates c-Jun N-terminal kinase and activator protein-1. Journal of Immunology 1998, 161:776-781.
173. Laborde E., Macsata R.W., Meng F., Peterson B.T., Robinson L., Schow S.R., Simon R.J., Xu H., Baba K., Inagaki H., Ishiwata Y., Jomori T., Matsumoto Y., Miyachi A., Nakamura T., Okamoto M., Handel T.M., Bernard C.C. Discovery, optimization, and pharmacological characterization of novel heteroaroylphenylureas antagonists of C-C chemokine ligand 2 function. Journal of Medicinal Chemistry 2011, 54:1667-1681.
174. Langford D., Sanders V.J., Mallory M., Kaul M., Masliah E. Expression of stromal cell-derived factor 1alpha protein in HIV encephalitis. Journal of Neuroimmunology 2002, 127:115-126.
175. Laske C., Stellos K., Stransky E., Seizer P., Akcay O., Eschweiler G.W., Leyhe T., Gawaz M. Decreased plasma and cerebrospinal fluid levels of stem cell factor in patients with early Alzheimer's disease. Journal of Alzheimers Disease 2008, 15:451-460.
176. Lauro C., Cipriani R., Catalano M., Trettel F., Chece G., Brusadin V., Antonilli L., van Rooijen N., Eusebi F., Fredholm B.B., Limatola C. Adenosine A1 receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death. Neuropsychopharmacology 2010, 35:1550-1559.
177. Lauro C., Di Angelantonio S., Cipriani R., Sobrero F., Antonilli L., Brusadin V., Ragozzino D., Limatola C. Activity of adenosine receptors type 1 Is required for CX3CL1-mediated neuroprotection and neuromodulation in hippocampal neurons. Journal of Immunology 2008, 180:7590-7596.
178. Lee E.O., Kim S.E., Park H.K., Kang J.L., Chong Y.H. Extracellular HIV-1 Tat upregulates TNF-alpha dependent MCP-1/CCL2 production via activation of ERK1/2 pathway in rat hippocampal slice cultures: inhibition by resveratrol, a polyphenolic phytostilbene. Experimental Neurology 2011, 229:399-408.
179. Lee E.O., Park H.J., Kang J.L., Kim H.S., Chong Y.H. Resveratrol reduces glutamate-mediated monocyte chemotactic protein-1 expression via inhibition of extracellular signal-regulated kinase 1/2 pathway in rat hippocampal slice cultures. Journal of Neurochemistry 2010, 112:1477-1487.
180. Lee E.Y., Chang C.Y., Hu N., Wang Y.C., Lai C.C., Herrup K., Lee W.H., Bradley A. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 1992, 359:288-294.
181. Lee S., Varvel N.H., Konerth M.E., Xu G., Cardona A.E., Ransohoff R.M., Lamb B.T. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. American Journal of Pathology 2010, 177:2549-2562.
182. Lee Y.B., Nagai A., Kim S.U. Cytokines, chemokines, and cytokine receptors in human microglia. Journal of Neuroscience Research 2002, 69:94-103.
183. Levoye A., Balabanian K., Baleux F., Bachelerie F., Lagane B. CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling. Blood 2009, 113:6085-6093.
184. Lewis C.A., Solomon J.N., Rossi F.M., Krieger C. Bone marrow-derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX(3)CR1. Glia 2009, 57:1410-1419.
185. Li M., Hale J.S., Rich J.N., Ransohoff R.M., Lathia J.D. Chemokine CXCL12 in neurodegenerative diseases: an SOS signal for stem cell-based repair. Trends in Neuroscience 2012, 35:619-628.
186. Li M., Ransohoff R.M. Multiple roles of chemokine CXCL12 in the central nervous system: a migration from immunology to neurobiology. Progress in Neurobiology 2008, 84:116-131.
187. Li R., Luo C., Mines M., Zhang J., Fan G.H. Chemokine CXCL12 induces binding of ferritin heavy chain to the chemokine receptor CXCR4, alters CXCR4 signaling, and induces phosphorylation and nuclear translocation of ferritin heavy chain. Journal of Biological Chemistry 2006, 281:37616-37627.
188. Lim S.P., Garzino-Demo A. The human immunodeficiency virus type 1 Tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell line U-87 MG: role of SP-1, AP-1, and NF-kappaB consensus sites. Journal of Virology 2000, 74:1632-1640.
189. Limatola C., Giovannelli A., Maggi L., Ragozzino D., Castellani L., Ciotti M.T., Vacca F., Mercanti D., Santoni A., Eusebi F. SDF-1alpha-mediated modulation of synaptic transmission in rat cerebellum. European Journal of Neuroscience 2000, 12:2497-2504.
190. Limatola C., Lauro C., Catalano M., Ciotti M.T., Bertollini C., Di Angelantonio S., Ragozzino D., Eusebi F. Chemokine CX3CL1 protects rat hippocampal neurons against glutamate-mediated excitotoxicity. Journal of Neuroimmunology 2005, 166:19-28.
191. Lindia J.A., McGowan E., Jochnowitz N., Abbadie C. Induction of CX3CL1 expression in astrocytes and CX3CR1 in microglia in the spinal cord of a rat model of neuropathic pain. Journal of Pain 2005, 6:434-438.
192. Liu X.S., Zhang Z.G., Zhang R.L., Gregg S.R., Wang L., Yier T., Chopp M. Chemokine ligand 2 (CCL2) induces migration and differentiation of subventricular zone cells after stroke. Journal of Neuroscience Research 2007, 85:2120-2125.
193. Losy J., Zaremba J. Monocyte chemoattractant protein-1 is increased in the cerebrospinal fluid of patients with ischemic stroke. Stroke 2001, 32:2695-2696.
194. Lu M., Grove E.A., Miller R.J. Abnormal development of the hippocampal dentate gyrus in mice lacking the CXCR4 chemokine receptor. Proceedings of the National Academy of Sciences U S A 2002, 99:7090-7095.
195. Luker K.E., Gupta M., Luker G.D. Imaging chemokine receptor dimerization with firefly luciferase complementation. FASEB Journal 2009, 23:823-834.
196. Luo Y., Xue H., Pardo A.C., Mattson M.P., Rao M.S., Maragakis N.J. Impaired SDF1/CXCR4 signaling in glial progenitors derived from SOD1(G93A) mice. Journal of Neuroscience Research 2007, 85:2422-2432.
197. Lysko D.E., Putt M., Golden J.A. SDF1 regulates leading process branching and speed of migrating interneurons. Journal of Neuroscience 2011, 31:1739-1745.
198. Ma Q., Jones D., Borghesani P.R., Segal R.A., Nagasawa T., Kishimoto T., Bronson R.T., Springer T.A. Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proceedings of the National Academy of Sciences U S A 1998, 95:9448-9453.
199. Madrigal J.L., Leza J.C., Polak P., Kalinin S., Feinstein D.L. Astrocyte-derived MCP-1 mediates neuroprotective effects of noradrenaline. Journal of Neuroscience 2009, 29:263-267.
200. Mahad D.J., Ransohoff R.M. The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Seminars in Immunology 2003, 15:23-32.
201. Mahajan S.D., Schwartz S.A., Aalinkeel R., Chawda R.P., Sykes D.E., Nair M.P. Morphine modulates chemokine gene regulation in normal human astrocytes. Clinical Immunology 2005, 115:323-332.
202. Marchionni I., Beaumont M., Maccaferri G. The chemokine CXCL12 and the HIV-1 envelope protein gp120 regulate spontaneous activity of Cajal-Retzius cells in opposite directions. Journal of Physiology 2010, 590:3185-3202.
203. Masliah E., Ge N., Mucke L. Pathogenesis of HIV-1 associated neurodegeneration. Critical Review in Neurobiology 1996, 10:57-67.
204. McArthur J.C., Haughey N., Gartner S., Conant K., Pardo C., Nath A., Sacktor N. Human immunodeficiency virus-associated dementia: an evolving disease. Journal for Neurovirology 2003, 9:205-221.
205. McCandless E.E., Budde M., Lees J.R., Dorsey D., Lyng E., Klein R.S. IL-1R signaling within the central nervous system regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune encephalomyelitis. Journal of Immunology 2009, 183:613-620.
206. McCandless E.E., Piccio L., Woerner B.M., Schmidt R.E., Rubin J.B., Cross A.H., Klein R.S. Pathological expression of CXCL12 at the blood-brain barrier correlates with severity of multiple sclerosis. American Journal of Pathology 2008, 172:799-808.
207. McClellan K.A., Slack R.S. Specific in vivo roles for E2Fs in differentiation and development. Cell Cycle 2007, 6:2917-2927.
208. McGeer P.L., McGeer E.G. Inflammation and the degenerative diseases of aging. Annals of the New York Academy of Sciences 2004, 1035:104-116.
209. Mellado M., Rodriguez-Frade J.M., Aragay A., del Real G., Martin A.M., Vila-Coro A.J., Serrano A., Mayor F., Martinez A.C. The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor. Journal of Immunology 1998, 161:805-813.
210. Mellado M., Rodriguez-Frade J.M., Vila-Coro A.J., Fernandez S., Martin de Ana A., Jones D.R., Toran J.L., Martinez A.C. Chemokine receptor homo- or heterodimerization activates distinct signaling pathways. EMBO Journal 2001, 20:2497-2507.
211. Meng S.Z., Oka A., Takashima S. Developmental expression of monocyte chemoattractant protein-1 in the human cerebellum and brainstem. Brain & Development 1999, 21:30-35.
212. Mengozzi M., De Filippi C., Transidico P., Biswas P., Cota M., Ghezzi S., Vicenzi E., Mantovani A., Sozzani S., Poli G. Human immunodeficiency virus replication induces monocyte chemotactic protein-1 in human macrophages and U937 promonocytic cells. Blood 1999, 93:1851-1857.
213. Mercer A., Ronnholm H., Holmberg J., Lundh H., Heidrich J., Zachrisson O., Ossoinak A., Frisen J., Patrone C. PACAP promotes neural stem cell proliferation in adult mouse brain. Journal of Neuroscience Research 2004, 76:205-215.
214. Merino J.J., Montes M.L., Blanco A., Bustos M.J., Oreja-Guevara C., Bayon C., Cuadrado A., Lubrini G., Cambron I., Munoz A., Cebolla S., Gutierrez-Fernandez M., Bernardino J.I., Arribas J.R., Fiala M. HIV-1 neuropathogenesis: therapeutic strategies against neuronal loss induced by gp120/Tat glycoprotein in the central nervous system. Revista de Neurología 2011, 52:101-111.
215. Meucci O., Fatatis A., Simen A.A., Bushell T.J., Gray P.W., Miller R.J. Chemokines regulate hippocampal neuronal signaling and gp120 neurotoxicity. Proceedings of the National Academy of Sciences U S A 1998, 95:14500-14505.
216. Meucci O., Fatatis A., Simen A.A., Miller R.J. Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Proceedings of the National Academy of Sciences U S A 2000, 97:8075-8080.
217. Miljkovic D., Stanojevic Z., Momcilovic M., Odoardi F., Flugel A., Mostarica-Stojkovic M. CXCL12 expression within the CNS contributes to the resistance against experimental autoimmune encephalomyelitis in Albino Oxford rats. Immunobiology 2011, 216:979-987.
218. Miller R.J., Rostene W., Apartis E., Banisadr G., Biber K., Milligan E.D., White F.A., Zhang J. Chemokine action in the nervous system. Journal of Neuroscience 2008, 28:11792-11795.
219. Mizuno T., Kawanokuchi J., Numata K., Suzumura A. Production and neuroprotective functions of fractalkine in the central nervous system. Brain Research 2003, 979:65-70.
220. Murphy P.M. International Union of Pharmacology. XXX. Update on chemokine receptor nomenclature. Pharmacological Reviews 2002, 54:227-229.
221. Naert G., Rivest S. CC chemokine receptor 2 deficiency aggravates cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease. Journal of Neuroscience 2011, 31:6208-6220.
222. Nath A., Anderson C., Jones M., Maragos W., Booze R., Mactutus C., Bell J., Hauser K.F., Mattson M. Neurotoxicity and dysfunction of dopaminergic systems associated with AIDS dementia. Journal of Psychopharmacology 2000, 14:222-227.
223. Nath A., Conant K., Chen P., Scott C., Major E.O. Transient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes. A hit and run phenomenon. Journal of Biological Chemistry 1999, 274:17098-17102.
224. Nicolai J., Burbassi S., Rubin J., Meucci O. CXCL12 inhibits expression of the NMDA receptor's NR2B subunit through a histone deacetylase-dependent pathway contributing to neuronal survival. Cell Death & Disease 2010, 1:e33.
225. Nishiyori A., Minami M., Ohtani Y., Takami S., Yamamoto J., Kawaguchi N., Kume T., Akaike A., Satoh M. Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia?. FEBS Letters 1998, 429:167-172.
226. Oberlin E., Amara A., Bachelerie F., Bessia C., Virelizier J.L., Arenzana-Seisdedos F., Schwartz O., Heard J.M., Clark-Lewis I., Legler D.F., Loetscher M., Baggiolini M., Moser B. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 1996, 382:833-835.
227. Oh S.B., Cho C., Miller R.J. Electrophysiological analysis of neuronal chemokine receptors. Methods 2003, 29:335-344.
228. Oh S.B., Endoh T., Simen A.A., Ren D., Miller R.J. Regulation of calcium currents by chemokines and their receptors. Journal of Neuroimmunology 2002, 123:66-75.
229. Oh S.B., Tran P.B., Gillard S.E., Hurley R.W., Hammond D.L., Miller R.J. Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. Journal of Neuroscience 2001, 21:5027-5035.
230. Ohab J.J., Fleming S., Blesch A., Carmichael S.T. A neurovascular niche for neurogenesis after stroke. Journal of Neuroscience 2006, 26:13007-13016.
231. Ohshima Y., Kubo T., Koyama R., Ueno M., Nakagawa M., Yamashita T. Regulation of axonal elongation and pathfinding from the entorhinal cortex to the dentate gyrus in the hippocampus by the chemokine stromal cell-derived factor 1 alpha. Journal of Neuroscience 2008, 28:8344-8353.
232. Ohta S., Gregg C., Weiss S. Pituitary adenylate cyclase-activating polypeptide regulates forebrain neural stem cells and neurogenesis in vitro and in vivo. Journal of Neuroscience Research 2006, 84:1177-1186.
233. Ohtani Y., Minami M., Kawaguchi N., Nishiyori A., Yamamoto J., Takami S., Satoh M. Expression of stromal cell-derived factor-1 and CXCR4 chemokine receptor mRNAs in cultured rat glial and neuronal cells. Neuroscience Letters 1998, 249:163-166.
234. Okamoto M., Wang X., Baba M. HIV-1-infected macrophages induce astrogliosis by SDF-1alpha and matrix metalloproteinases. Biochemical and Biophysical Research Communications 2005, 336:1214-1220.
235. Pabon M.M., Bachstetter A.D., Hudson C.E., Gemma C., Bickford P.C. CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease. Journal of Neuroinflammation 2011, 8:9.
236. Pan Y., Lloyd C., Zhou H., Dolich S., Deeds J., Gonzalo J.A., Vath J., Gosselin M., Ma J., Dussault B., Woolf E., Alperin G., Culpepper J., Gutierrez-Ramos J.C., Gearing D. Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature 1997, 387:611-617.
237. Parachikova A., Cotman C.W. Reduced CXCL12/CXCR4 results in impaired learning and is downregulated in a mouse model of Alzheimer disease. Neurobiology of Disease 2007, 28:143-153.
238. Parachikova A., Nichol K.E., Cotman C.W. Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition. Neurobiology of Disease 2008, 30:121-129.
239. Parent J.M., Vexler Z.S., Gong C., Derugin N., Ferriero D.M. Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Annals of Neurology 2002, 52:802-813.
240. Park I.W., Wang J.F., Groopman J.E. HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes. Blood 2001, 97:352-358.
241. Pashenkov M., Soderstrom M., Link H. Secondary lymphoid organ chemokines are elevated in the cerebrospinal fluid during central nervous system inflammation. Journal of Neuroimmunology 2003, 135:154-160.
242. Patel J.P., Sengupta R., Bardi G., Khan M.Z., Mullen-Przeworski A., Meucci O. Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO. Journal for Neurovirology 2006, 12:492-500.
243. Patel J.R., McCandless E.E., Dorsey D., Klein R.S. CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination. Proceedings of the National Academy of Sciences U S A 2010, 107:11062-11067.
244. Pattarini R., Smeyne R.J., Morgan J.I. Temporal mRNA profiles of inflammatory mediators in the murine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrimidine model of Parkinson's disease. Neuroscience 2007, 145:654-668.
245. Peng H., Wu Y., Duan Z., Ciborowski P., Zheng J.C. Proteolytic processing of SDF-1alpha by matrix metalloproteinase-2 impairs CXCR4 signaling and reduces neural progenitor cell migration. Protein Cell 2012, 3:875-882.
246. Pereira C.F., Middel J., Jansen G., Verhoef J., Nottet H.S. Enhanced expression of fractalkine in HIV-1 associated dementia. Journal of Neuroimmunology 2001, 115:168-175.
247. Persidsky Y., Limoges J., McComb R., Bock P., Baldwin T., Tyor W., Patil A., Nottet H.S., Epstein L., Gelbard H., Flanagan E., Reinhard J., Pirruccello S.J., Gendelman H.E. Human immunodeficiency virus encephalitis in SCID mice. American Journal of Pathology 1996, 149:1027-1053.
248. Petito C.K., Roberts B., Cantando J.D., Rabinstein A., Duncan R. Hippocampal injury and alterations in neuronal chemokine co-receptor expression in patients with AIDS. Journal of Neuropathology & Experimental Neurology 2001, 60:377-385.
249. Piros E.T., Prather P.L., Loh H.H., Law P.Y., Evans C.J., Hales T.G. Ca2+ channel and adenylyl cyclase modulation by cloned mu-opioid receptors in GH3 cells. Molecular Pharmacology 1995, 47:1041-1049.
250. Pitcher J., Shimizu S., Burbassi S., Meucci O. Disruption of neuronal CXCR4 function by opioids: preliminary evidence of ferritin heavy chain as a potential etiological agent in neuroAIDS. Journal of Neuroimmunology 2010, 224:66-71.
251. Pujol F., Kitabgi P., Boudin H. The chemokine SDF-1 differentially regulates axonal elongation and branching in hippocampal neurons. Journal of Cell Science 2005, 118:1071-1080.
252. Qin X., Wan Y., Wang X. CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons. Journal of Neuroscience Research 2005, 82:51-62.
253. Qiu Z., Ghosh A. A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression. Neuron 2008, 60:775-787.
254. Querfurth H.W., LaFerla F.M. Alzheimer's disease. New England Journal of Medicine 2010, 362:329-344.
255. Quinones M.P., Kalkonde Y., Estrada C.A., Jimenez F., Ramirez R., Mahimainathan L., Mummidi S., Choudhury G.G., Martinez H., Adams L., Mack M., Reddick R.L., Maffi S., Haralambous S., Probert L., Ahuja S.K., Ahuja S.S. Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt. Molecular and Cellular Neuroscience 2008, 37:96-109.
256. Ragozzino D. CXC chemokine receptors in the central nervous system: Role in cerebellar neuromodulation and development. Journal for Neurovirology 2002, 8:559-572.
257. Ragozzino D., Di Angelantonio S., Trettel F., Bertollini C., Maggi L., Gross C., Charo I.F., Limatola C., Eusebi F. Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons. Journal of Neuroscience 2006, 26:10488-10498.
258. Ragozzino D., Giovannelli A., Mileo A.M., Limatola C., Santoni A., Eusebi F. Modulation of the neurotransmitter release in rat cerebellar neurons by GRO beta. Neuroreport 1998, 9:3601-3606.
259. Rajagopal S., Kim J., Ahn S., Craig S., Lam C.M., Gerard N.P., Gerard C., Lefkowitz R.J. Beta-arrestin-but not G protein-mediated signaling by the decoy" receptor CXCR7. Proceedings of the National Academy of Sciences U S A 2010, 107:628-632.
260. Raman D., Milatovic S.Z., Milatovic D., Splittgerber R., Fan G.H., Richmond A. Chemokines, macrophage inflammatory protein-2 and stromal cell-derived factor-1alpha, suppress amyloid beta-induced neurotoxicity. Toxicology and Applied Pharmacology 2011, 256:300-313.
261. Ransohoff R.M. Chemokines in neurological trauma models. Annals of the New York Academy of Sciences 2002, 961:346-349.
262. Ransohoff R.M. Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology. Immunity 2009, 31:711-721.
263. Ransohoff R.M., Hamilton T.A., Tani M., Stoler M.H., Shick H.E., Major J.A., Estes M.L., Thomas D.M., Tuohy V.K. Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis. FASEB Journal 1993, 7:592-600.
264. Rappaport J., Joseph J., Croul S., Alexander G., Del Valle L., Amini S., Khalili K. Molecular pathway involved in HIV-1-induced CNS pathology: role of viral regulatory protein, Tat. Journal of Leukocyte Biology 1999, 65:458-465.
265. Reaux-Le Goazigo A., Rivat C., Kitabgi P., Pohl M., Melik Parsadaniantz S. Cellular and subcellular localization of CXCL12 and CXCR4 in rat nociceptive structures: physiological relevance. European Journal of Neuroscience 2012, 36:2619-2631.
266. Reyes M.G., Faraldi F., Senseng C.S., Flowers C., Fariello R. Nigral degeneration in acquired immune deficiency syndrome (AIDS). Acta Neuropathologica 1991, 82:39-44.
267. Riek-Burchardt M., Kolodziej A., Henrich-Noack P., Reymann K.G., Hollt V., Stumm R. Differential regulation of CXCL12 and PACAP mRNA expression after focal and global ischemia. Neuropharmacology 2010, 58:199-207.
268. Rock R.B., Hu S., Sheng W.S., Peterson P.K. Morphine stimulates CCL2 production by human neurons. Journal of Neuroinflammation 2006, 3:32.
269. Rodriguez-Frade J.M., Vila-Coro A.J., de Ana A.M., Albar J.P., Martinez A.C., Mellado M. The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2. Proceedings of the National Academy of Sciences U S A 1999, 96:3628-3633.
270. Rostasy K., Egles C., Chauhan A., Kneissl M., Bahrani P., Yiannoutsos C., Hunter D.D., Nath A., Hedreen J.C., Navia B.A. SDF-1alpha is expressed in astrocytes and neurons in the AIDS dementia complex: an in vivo and in vitro study. Journal of Neuropathology & Experimental Neurology 2003, 62:617-626.
271. Rostene W., Guyon A., Kular L., Godefroy D., Barbieri F., Bajetto A., Banisadr G., Callewaere C., Conductier G., Rovere C., Melik-Parsadaniantz S., Florio T. Chemokines and chemokine receptors: new actors in neuroendocrine regulations. Frontiers in Neuroendocrinology 2011, 32:10-24.
272. Rostene W., Kitabgi P., Parsadaniantz S.M. Chemokines: a new class of neuromodulator?. Nature Review Neuroscience 2007, 8:895-903.
273. Rudick R.A., Cohen J.A., Weinstock-Guttman B., Kinkel R.P., Ransohoff R.M. Management of multiple sclerosis. New England Journal of Medicine 1997, 337:1604-1611.
274. Sanchez-Alcaniz J.A., Haege S., Mueller W., Pla R., Mackay F., Schulz S., Lopez-Bendito G., Stumm R., Marin O. Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron 2011, 69:77-90.
275. Sargsyan S.A., Blackburn D.J., Barber S.C., Monk P.N., Shaw P.J. Mutant SOD1 G93A microglia have an inflammatory phenotype and elevated production of MCP-1. Neuroreport 2009, 20:1450-1455.
276. Schilling M., Strecker J.K., Schabitz W.R., Ringelstein E.B., Kiefer R. Effects of monocyte chemoattractant protein 1 on blood-borne cell recruitment after transient focal cerebral ischemia in mice. Neuroscience 2009, 161:806-812.
277. Schonemeier B., Kolodziej A., Schulz S., Jacobs S., Hoellt V., Stumm R. Regional and cellular localization of the CXCl12/SDF-1 chemokine receptor CXCR7 in the developing and adult rat brain. Journal of Comparative Neurology 2008, 510:207-220.
278. Schonemeier B., Schulz S., Hoellt V., Stumm R. Enhanced expression of the CXCl12/SDF-1 chemokine receptor CXCR7 after cerebral ischemia in the rat brain. Journal of Neuroimmunology 2008, 198:39-45.
279. Schwaeble W.J., Stover C.M., Schall T.J., Dairaghi D.J., Trinder P.K., Linington C., Iglesias A., Schubart A., Lynch N.J., Weihe E., Schafer M.K. Neuronal expression of fractalkine in the presence and absence of inflammation. FEBS Letters 1998, 439:203-207.
280. Sengupta R., Burbassi S., Shimizu S., Cappello S., Vallee R.B., Rubin J.B., Meucci O. Morphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons. Journal of Neuroscience 2009, 29:2534-2544.
281. Shan S., Hong-Min T., Yi F., Jun-Peng G., Yue F., Yan-Hong T., Yun-Ke Y., Wen-Wei L., Xiang-Yu W., Jun M., Guo-Hua W., Ya-Ling H., Hua-Wei L., Ding-Fang C. New evidences for fractalkine/CX3CL1 involved in substantia nigral microglial activation and behavioral changes in a rat model of Parkinson's disease. Neurobiology of Aging 2011, 32:443-458.
282. Sheng W.S., Hu S., Lokensgard J.R., Peterson P.K. U50,488 inhibits HIV-1 Tat-induced monocyte chemoattractant protein-1 (CCL2) production by human astrocytes. Biochemical Pharmacology 2003, 65:9-14.
283. Shimizu S., Brown M., Sengupta R., Penfold M.E., Meucci O. CXCR7 protein expression in human adult brain and differentiated neurons. PLoS One 2011, 6:e20680.
284. Shimizu S., Khan M.Z., Hippensteel R.L., Parkar A., Raghupathi R., Meucci O. Role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology. Neurobiology of Disease 2007, 25:17-26.
285. Shimoji M., Pagan F., Healton E.B., Mocchetti I. CXCR4 and CXCL12 expression is increased in the nigro-striatal system of Parkinson's disease. Neurotoxicity Research 2009, 16:318-328.
286. Shin J.W., Lee J.K., Lee J.E., Min W.K., Schuchman E.H., Jin H.K., Bae J.S. Combined effects of hematopoietic progenitor cell mobilization from bone marrow by granulocyte colony stimulating factor and AMD3100 and chemotaxis into the brain using stromal cell-derived factor-1alpha in an Alzheimer's disease mouse model. Stem Cells 2011, 29:1075-1089.
287. Shirozu M., Nakano T., Inazawa J., Tashiro K., Tada H., Shinohara T., Honjo T. Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. Genomics 1995, 28:495-500.
288. Shyu W.C., Lin S.Z., Yang H.I., Tzeng Y.S., Pang C.Y., Yen P.S., Li H. Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells. Circulation 2004, 110:1847-1854.
289. Shyu W.C., Lin S.Z., Yen P.S., Su C.Y., Chen D.C., Wang H.J., Li H. Stromal cell-derived factor-1 alpha promotes neuroprotection, angiogenesis, and mobilization/homing of bone marrow-derived cells in stroke rats. Journal of Pharmacology and Experimental Therapeutics 2008, 324:834-849.
290. Skrzydelski D., Guyon A., Dauge V., Rovere C., Apartis E., Kitabgi P., Nahon J.L., Rostene W., Parsadaniantz S.M. The chemokine stromal cell-derived factor-1/CXCL12 activates the nigrostriatal dopamine system. Journal of Neurochemistry 2007, 102:1175-1183.
291. Smits H.A., Rijsmus A., van Loon J.H., Wat J.W., Verhoef J., Boven L.A., Nottet H.S. Amyloid-beta-induced chemokine production in primary human macrophages and astrocytes. Journal of Neuroimmunology 2002, 127:160-168.
292. Sokolova A., Hill M.D., Rahimi F., Warden L.A., Halliday G.M., Shepherd C.E. Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease. Brain Pathology 2009, 19:392-398.
293. Song L., Pachter J.S. Monocyte chemoattractant protein-1 alters expression of tight junction-associated proteins in brain microvascular endothelial cells. Microvascular Research 2004, 67:78-89.
294. Sorce S., Myburgh R., Krause K.H. The chemokine receptor CCR5 in the central nervous system. Progress in Neurobiology 2011, 93:297-311.
295. Sporer B., Kastenbauer S., Koedel U., Arendt G., Pfister H.W. Increased intrathecal release of soluble fractalkine in HIV-infected patients. AIDS Research Human Retroviruses 2003, 19:111-116.
296. Sriram K., Miller D.B., O'Callaghan J.P. Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor-alpha. Journal of Neurochemistry 2006, 96:706-718.
297. Stamatovic S.M., Keep R.F., Kunkel S.L., Andjelkovic A.V. Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase. Journal of Cell Science 2003, 116:4615-4628.
298. Stamatovic S.M., Shakui P., Keep R.F., Moore B.B., Kunkel S.L., Van Rooijen N., Andjelkovic A.V. Monocyte chemoattractant protein-1 regulation of blood-brain barrier permeability. Journal of Cerebral Blood Flow & Metabolism 2005, 25:593-606.
299. Stellos K., Panagiota V., Sachsenmaier S., Trunk T., Straten G., Leyhe T., Seizer P., Geisler T., Gawaz M., Laske C. Increased circulating progenitor cells in Alzheimer's disease patients with moderate to severe dementia: evidence for vascular repair and tissue regeneration?. Journal of Alzheimers Disease 2010, 19:591-600.
300. Streit W.J., Conde J.R., Harrison J.K. Chemokines and Alzheimer's disease. Neurobiology of Aging 2001, 22:909-913.
301. Stumm R., Hollt V. CXC chemokine receptor 4 regulates neuronal migration and axonal pathfinding in the developing nervous system: implications for neuronal regeneration in the adult brain. Journal of Molecular Endocrinology 2007, 38:377-382.
302. Stumm R., Kolodziej A., Schulz S., Kohtz J.D., Hollt V. Patterns of SDF-1alpha and SDF-1gamma mRNAs, migration pathways, and phenotypes of CXCR4-expressing neurons in the developing rat telencephalon. Journal of Comparative Neurology 2007, 502:382-399.
303. Stumm R.K., Rummel J., Junker V., Culmsee C., Pfeiffer M., Krieglstein J., Hollt V., Schulz S. A dual role for the SDF-1/CXCR4 chemokine receptor system in adult brain: isoform-selective regulation of SDF-1 expression modulates CXCR4-dependent neuronal plasticity and cerebral leukocyte recruitment after focal ischemia. Journal of Neuroscience 2002, 22:5865-5878.
304. Stumm R.K., Zhou C., Ara T., Lazarini F., Dubois-Dalcq M., Nagasawa T., Hollt V., Schulz S. CXCR4 regulates interneuron migration in the developing neocortex. Journal of Neuroscience 2003, 23:5123-5130.
305. Su B., Pan S., He X., Li P., Liang Y. Sprouting of nervous fibers and upregulation of C-X-C chemokine receptor type 4 expression in hippocampal formation of rats with enhanced spatial learning and memory. Anatomical Record (Hoboken) 2012, 295:121-126.
306. Sui Y., Stehno-Bittel L., Li S., Loganathan R., Dhillon N.K., Pinson D., Nath A., Kolson D., Narayan O., Buch S. CXCL10-induced cell death in neurons: role of calcium dysregulation. European Journal of Neuroscience 2006, 23:957-964.
307. Sunnemark D., Eltayeb S., Nilsson M., Wallstrom E., Lassmann H., Olsson T., Berg A.L., Ericsson-Dahlstrand A. CX3CL1 (fractalkine) and CX3CR1 expression in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis: kinetics and cellular origin. Journal of Neuroinflammation 2005, 2:17.
308. Surprenant A., Shen K.Z., North R.A., Tatsumi H. Inhibition of calcium currents by noradrenaline, somatostatin and opioids in guinea-pig submucosal neurones. Journal of Physiology 1990, 431:585-608.
309. Szabo I., Chen X.H., Xin L., Adler M.W., Howard O.M., Oppenheim J.J., Rogers T.J. Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain. Proceedings of the National Academy of Sciences U S A 2002, 99:10276-10281.
310. Szczucinski A., Losy J. Chemokines and chemokine receptors in multiple sclerosis. Potential targets for new therapies. Acta Neurologica Scandinavica 2007, 115:137-146.
311. Szmydynger-Chodobska J., Fox L.M., Lynch K.M., Zink B.J., Chodobski A. Vasopressin amplifies the production of proinflammatory mediators in traumatic brain injury. Journal of Neurotrauma 2010, 27:1449-1461.
312. Takeuchi H., Natsume A., Wakabayashi T., Aoshima C., Shimato S., Ito M., Ishii J., Maeda Y., Hara M., Kim S.U., Yoshida J. Intravenously transplanted human neural stem cells migrate to the injured spinal cord in adult mice in an SDF-1- and HGF-dependent manner. Neuroscience Letters 2007, 426:69-74.
313. Tanabe S., Heesen M., Berman M.A., Fischer M.B., Yoshizawa I., Luo Y., Dorf M.E. Murine astrocytes express a functional chemokine receptor. Journal of Neuroscience 1997, 17:6522-6528.
314. Tanaka M., Kikuchi H., Ishizu T., Minohara M., Osoegawa M., Motomura K., Tateishi T., Ohyagi Y., Kira J. Intrathecal upregulation of granulocyte colony stimulating factor and its neuroprotective actions on motor neurons in amyotrophic lateral sclerosis. Journal of Neuropathology & Experimental Neurology 2006, 65:816-825.
315. Tansey M.G., Goldberg M.S. Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention. Neurobiology of Disease 2010, 37:510-518.
316. Tarozzo G., Campanella M., Ghiani M., Bulfone A., Beltramo M. Expression of fractalkine and its receptor, CX3CR1, in response to ischaemia-reperfusion brain injury in the rat. European Journal of Neuroscience 2002, 15:1663-1668.
317. Tateishi T., Yamasaki R., Tanaka M., Matsushita T., Kikuchi H., Isobe N., Ohyagi Y., Kira J. CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis. Journal of Neuroimmunology 2010, 222:76-81.
318. Thompson K.A., McArthur J.C., Wesselingh S.L. Correlation between neurological progression and astrocyte apoptosis in HIV-associated dementia. Annals of Neurology 2001, 49:745-752.
319. Thored P., Arvidsson A., Cacci E., Ahlenius H., Kallur T., Darsalia V., Ekdahl C.T., Kokaia Z., Lindvall O. Persistent production of neurons from adult brain stem cells during recovery after stroke. Stem Cells 2006, 24:739-747.
320. Tiveron M.C., Boutin C., Daou P., Moepps B., Cremer H. Expression and function of CXCR7 in the mouse forebrain. Journal of Neuroimmunology 2010, 224:72-79.
321. Toborek M., Lee Y.W., Pu H., Malecki A., Flora G., Garrido R., Hennig B., Bauer H.C., Nath A. HIV-Tat protein induces oxidative and inflammatory pathways in brain endothelium. Journal of Neurochemistry 2003, 84:169-179.
322. Tong N., Perry S.W., Zhang Q., James H.J., Guo H., Brooks A., Bal H., Kinnear S.A., Fine S., Epstein L.G., Dairaghi D., Schall T.J., Gendelman H.E., Dewhurst S., Sharer L.R., Gelbard H.A. Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system. Journal of Immunology 2000, 164:1333-1339.
323. Tran P.B., Banisadr G., Ren D., Chenn A., Miller R.J. Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain. Journal of Comparative Neurology 2007, 500:1007-1033.
324. Tysseling V.M., Mithal D., Sahni V., Birch D., Jung H., Belmadani A., Miller R.J., Kessler J.A. SDF1 in the dorsal corticospinal tract promotes CXCR4+ cell migration after spinal cord injury. Journal of Neuroinflammation 2011, 8:16.
325. van der Meer P., Ulrich A.M., Gonzalez-Scarano F., Lavi E. Immunohistochemical analysis of CCR2, CCR3, CCR5, and CXCR4 in the human brain: potential mechanisms for HIV dementia. Experimental and Molecular Pathology 2000, 69:192-201.
326. Van Steenwinckel J., Reaux-Le Goazigo A., Pommier B., Mauborgne A., Dansereau M.A., Kitabgi P., Sarret P., Pohl M., Melik Parsadaniantz S. CCL2 released from neuronal synaptic vesicles in the spinal cord is a major mediator of local inflammation and pain after peripheral nerve injury. Journal of Neuroscience 2011, 31:5865-5875.
327. Verge G.M., Milligan E.D., Maier S.F., Watkins L.R., Naeve G.S., Foster A.C. Fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) distribution in spinal cord and dorsal root ganglia under basal and neuropathic pain conditions. European Journal of Neuroscience 2004, 20:1150-1160.
328. Vila M., Jackson-Lewis V., Guegan C., Wu D.C., Teismann P., Choi D.K., Tieu K., Przedborski S. The role of glial cells in Parkinson's disease. Current Opinion in Neurology 2001, 14:483-489.
329. Vila-Coro A.J., Mellado M., Martin de Ana A., Lucas P., del Real G., Martinez A.C., Rodriguez-Frade J.M. HIV-1 infection through the CCR5 receptor is blocked by receptor dimerization. Proceedings of the National Academy of Sciences U S A 2000, 97:3388-3393.
330. Vila-Coro A.J., Rodriguez-Frade J.M., Martin De Ana A., Moreno-Ortiz M.C., Martinez A.C., Mellado M. The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway. FASEB Journal 1999, 13:1699-1710.
331. Walsh D.M., Selkoe D.J. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron 2004, 44:181-193.
332. Wang J.F., Park I.W., Groopman J.E. Stromal cell-derived factor-1alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C. Blood 2000, 95:2505-2513.
333. Wang X., Yue T.L., Barone F.C., Feuerstein G.Z. Monocyte chemoattractant protein-1 messenger RNA expression in rat ischemic cortex. Stroke 1995, 26:661-665. (discussion 665-666).
334. Wang Y., Deng Y., Zhou G.Q. SDF-1alpha/CXCR4-mediated migration of systemically transplanted bone marrow stromal cells towards ischemic brain lesion in a rat model. Brain Research 2008, 1195:104-112.
335. Weeraratna A.T., Kalehua A., Deleon I., Bertak D., Maher G., Wade M.S., Lustig A., Becker K.G., Wood W., Walker D.G., Beach T.G., Taub D.D. Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues. Experimental Cell Research 2007, 313:450-461.
336. Wei F., Qiu C.S., Liauw J., Robinson D.A., Ho N., Chatila T., Zhuo M. Calcium calmodulin-dependent protein kinase IV is required for fear memory. Nature Neuroscience 2002, 5:573-579.
337. Wei S.G., Zhang Z.H., Yu Y., Weiss R.M., Felder R.B. Central actions of the chemokine stromal cell-derived factor 1 contribute to neurohumoral excitation in heart failure rats. Hypertension 2012, 59:991-998.
338. Weiss J.M., Downie S.A., Lyman W.D., Berman J.W. Astrocyte-derived monocyte-chemoattractant protein-1 directs the transmigration of leukocytes across a model of the human blood-brain barrier. Journal of Immunology 1998, 161:6896-6903.
339. Wells T.N., Power C.A., Proudfoot A.E. Definition, function and pathophysiological significance of chemokine receptors. Trends in Pharmacological Sciences 1998, 19:376-380.
340. Westin K., Buchhave P., Nielsen H., Minthon L., Janciauskiene S., Hansson O. CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease. PLoS One 2012, 7:e30525.
341. Wilms H., Sievers J., Dengler R., Bufler J., Deuschl G., Lucius R. Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: further evidence for microglial activation in neurodegeneration. Journal of Neuroimmunology 2003, 144:139-142.
342. Wittendorp M.C., Boddeke H.W., Biber K. Adenosine A3 receptor-induced CCL2 synthesis in cultured mouse astrocytes. Glia 2004, 46:410-418.
343. Wong M., Fish E.N. RANTES and MIP-1alpha activate stats in T cells. Journal of Biological Chemistry 1998, 273:309-314.
344. Wong Y.H., Demoliou-Mason C.D., Barnard E.A. Opioid receptors in magnesium-digitonin-solubilized rat brain membranes are tightly coupled to a pertussis toxin-sensitive guanine nucleotide-binding protein. Journal of Neurochemistry 1989, 52:999-1009.
345. Xiang Y., Li Y., Zhang Z., Cui K., Wang S., Yuan X.B., Wu C.P., Poo M.M., Duan S. Nerve growth cone guidance mediated by G protein-coupled receptors. Nature Neuroscience 2002, 5:843-848.
346. Xiao H., Neuveut C., Tiffany H.L., Benkirane M., Rich E.A., Murphy P.M., Jeang K.T. Selective CXCR4 antagonism by Tat: implications for in vivo expansion of coreceptor use by HIV-1. Proceedings of the National Academy of Sciences U S A 2000, 97:11466-11471.
347. Yamagami S., Tamura M., Hayashi M., Endo N., Tanabe H., Katsuura Y., Komoriya K. Differential production of MCP-1 and cytokine-induced neutrophil chemoattractant in the ischemic brain after transient focal ischemia in rats. Journal of Leukocyte Biology 1999, 65:744-749.
348. Yamamoto M., Horiba M., Buescher J.L., Huang D., Gendelman H.E., Ransohoff R.M., Ikezu T. Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition. American Journal of Pathology 2005, 166:1475-1485.
349. Yamamoto M., Kiyota T., Walsh S.M., Ikezu T. Kinetic analysis of aggregated amyloid-beta peptide clearance in adult bone-marrow-derived macrophages from APP and CCL2 transgenic mice. Journal of Neuroimmune Pharmacology 2007, 2:213-221.
350. Yan Y.P., Sailor K.A., Lang B.T., Park S.W., Vemuganti R., Dempsey R.J. Monocyte chemoattractant protein-1 plays a critical role in neuroblast migration after focal cerebral ischemia. Journal of Cerebral Blood Flow & Metabolism 2007, 27:1213-1224.
351. Yao H., Peng F., Dhillon N., Callen S., Bokhari S., Stehno-Bittel L., Ahmad S.O., Wang J.Q., Buch S. Involvement of TRPC channels in CCL2-mediated neuroprotection against tat toxicity. Journal of Neuroscience 2009, 29:1657-1669.
352. Yoshimura T., Matsushima K., Tanaka S., Robinson E.A., Appella E., Oppenheim J.J., Leonard E.J. Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proceedings of the National Academy of Sciences U S A 1987, 84:9233-9237.
353. Yu L., Cecil J., Peng S.B., Schrementi J., Kovacevic S., Paul D., Su E.W., Wang J. Identification and expression of novel isoforms of human stromal cell-derived factor 1. Gene 2006, 374:174-179.
354. Zamvil S.S., Steinman L. The T lymphocyte in experimental allergic encephalomyelitis. Annual Review of Immunology 1990, 8:579-621.
355. Zhang R., Zhang Z., Tsang W., Wang L., Chopp M. Down-regulation of p27kip1 increases proliferation of progenitor cells in adult rats. Neuroreport 2004, 15:1797-1800.
356. Zheng J., Thylin M.R., Ghorpade A., Xiong H., Persidsky Y., Cotter R., Niemann D., Che M., Zeng Y.C., Gelbard H.A., Shepard R.B., Swartz J.M., Gendelman H.E. Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia. Journal of Neuroimmunology 1999, 98:185-200.
357. Zhu J., Zhou Z., Liu Y., Zheng J. Fractalkine and CX3CR1 are involved in the migration of intravenously grafted human bone marrow stromal cells toward ischemic brain lesion in rats. Brain Research 2009, 1287:173-183.
358. Zhu Y., Murakami F. Chemokine CXCL12 and its receptors in the developing central nervous system: emerging themes and future perspectives. Developmental Neurobiology 2012.
359. Zou Y.R., Kottmann A.H., Kuroda M., Taniuchi I., Littman D.R. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 1998, 393:595-599.
360. Zujovic V., Benavides J., Vige X., Carter C., Taupin V. Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation. Glia 2000, 29:305-315.