JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain

Journal of Neuroscience

Volumn 29, Issue 13, 2009, Pages 4096-4108

  Gao, Yong Jing ^a   Zhang, Ling ^a   Samad, Omar Abdel ^b   Suter, Marc R ^a   Yasuhiko, Kawasaki ^a   Xu, Zhen Zhong ^a   Park, Jong Yeon ^a   Lind, Anne Li ^a   Ma, Qiufu ^b   Ji, Ru Rong ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; N METHYL DEXTRO ASPARTIC ACID; NEUTRALIZING ANTIBODY; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; 4',6 DIAMIDINO 2 PHENYLINDOLE; AMINO ACID RECEPTOR STIMULATING AGENT; CCL2 PROTEIN, MOUSE; CCR2 PROTEIN, MOUSE; CHEMOKINE RECEPTOR CCR2; CYTOKINE; ENZYME INHIBITOR; GLIAL FIBRILLARY ACIDIC PROTEIN; GREEN FLUORESCENT PROTEIN; INDOLE DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE 1; TNFRSF1A PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL CULTURE; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEAT SENSITIVITY; HYPERALGESIA; MALE; MOUSE; NERVE CONDUCTION; NERVE LIGATION; NEUROPATHIC PAIN; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; SENSITIZATION; SPINAL CORD; SPINAL CORD DORSAL HORN; SPINAL NERVE; SYNAPTIC TRANSMISSION; TISSUE SECTION; UPREGULATION; ANALYSIS OF VARIANCE; ANIMAL; C57BL MOUSE; DOSE RESPONSE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; METABOLISM; METHODOLOGY; MOUSE MUTANT; NEURALGIA; PAIN THRESHOLD; PATHOLOGY; PHYSIOLOGY; REACTION TIME; TIME;

ANALYSIS OF VARIANCE; ANIMALS; ASTROCYTES; CELLS, CULTURED; CHEMOKINE CCL2; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXCITATORY AMINO ACID AGONISTS; GLIAL FIBRILLARY ACIDIC PROTEIN; GREEN FLUORESCENT PROTEINS; INDOLES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 8; NEURALGIA; PAIN THRESHOLD; PATCH-CLAMP TECHNIQUES; REACTION TIME; RECEPTORS, CCR2; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SPINAL CORD; SYNAPTIC TRANSMISSION; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 65249114367     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3623-08.2009     Document Type: Article

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