CCL2 accelerates microglia-mediated Aβ oligomer formation and progression of neurocognitive dysfunction

PLoS ONE

Volumn 4, Issue 7, 2009, Pages

  Kiyota, Tomomi ^a,b   Yamamoto, Masaru ^a,b   Xiong, Huangui ^a,b   Lambert, Mary P ^c   Klein, William L ^c   Gendelman, Howard E ^a,b   Ransohoff, Richard M ^d   Ikezu, Tsuneya ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; AMYLOID BETA PROTEIN; BIOPOLYMER; CCL2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; INTRACELLULAR TRANSPORT; MALE; MICROGLIA; MOUSE; NEUROPATHOLOGY; NONHUMAN; OLIGOMERIZATION; ONSET AGE; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN TRANSPORT; SPATIAL MEMORY; SYNAPTIC TRANSMISSION; WORKING MEMORY; ANIMAL; BIOSYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; IMMUNOHISTOCHEMISTRY; MEMORY DISORDER; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE; WESTERN BLOTTING;

MUS; RODENTIA;

AMYLOID BETA-PEPTIDES; ANIMALS; BIOPOLYMERS; BLOTTING, WESTERN; CHEMOKINE CCL2; COGNITION DISORDERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; MICROGLIA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 67650539049     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006197     Document Type: Article

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