Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development

EMBO Journal

Volumn 21, Issue 13, 2002, Pages 3337-3346

  Ferguson, Kerry L ^a   Vanderluit, Jacqueline L ^a   Hébert, Jean M ^a   McIntosh, W C ^a   Tibbo, Emma ^a   MacLaurin, Jason G ^a   Park, David S ^a   Wallace, Valerie A ^a   Vooijs, Marc ^a   McConnell, Susan K ^a   Slack, Ruth S ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Apoptosis; Cell cycle; Central nervous system; Differentiation; Retinoblastoma

Indexed keywords

RETINOBLASTOMA PROTEIN;

ALLELE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN DEVELOPMENT; CELL CYCLE; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; EMBRYO; EMBRYO DEVELOPMENT; FOXG1 GENE; GENE DELETION; GENE LOCUS; GENE MUTATION; GERM LINE; HEMATOPOIESIS; KNOCKOUT MOUSE; MITOSIS; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROCESSING; SURVIVAL; TELENCEPHALON;

ALLELES; ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; CELL CYCLE; CELL DIFFERENTIATION; CELL DIVISION; CEREBRAL CORTEX; CROSSES, GENETIC; DNA-BINDING PROTEINS; FETAL DEATH; FORKHEAD TRANSCRIPTION FACTORS; GENES, LETHAL; GENES, RETINOBLASTOMA; MICE; MICE, KNOCKOUT; MUTAGENESIS, INSERTIONAL; NERVE TISSUE PROTEINS; NEURONS; ORGAN SPECIFICITY; RETINOBLASTOMA PROTEIN; TELENCEPHALON; TUBULIN;

ANIMALIA;

EID: 18444389748     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf338     Document Type: Article

References (45)

1. Regulation and deregulation of E2F1 in postmitotic neurons differentiated from embryonal carcinoma P19 cells
2. Mechanisms underlying hypoxia-induced neuronal apoptosis
3. Hypoxia-induced apoptosis: Effect of hypoxic severity and role of p53 in neuronal cell death
4. Neural precursor cells differentiating in the absence of Rb exhibit delayed terminal mitosis and deregulated E2F1 and 3 activity
5. Glial cell lineage in the cerebral cortex: A review and synthesis
6. Requirement for a functional Rb-1 gene in murine development
7. Pontine respiratory neurons in anesthetized cats
8. The regulation of E2F by pRb-family proteins
9. The Rb pathway in neurogenesis
10. E2F1 mediates death of B-amyloid-treated cortical neurons in a manner
11. Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro
12. Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures
13. The transcription factor E2F1 modulates apoptosis of neurons
14. Effects of an Rb mutation in the mouse
15. A 'pneumatic centre' in rats
16. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
17. Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation
18. The fates of cells generated at the end of neurogenesis in developing mouse cortex
19. The retinoblastoma gene family in differentiation and development
20. Cell-autonomous and non-cell-autonomous functions of Rb tumor suppressor in developing central nervous system
21. Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice
22. Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system
23. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum
24. Constructing the cerebral cortex: Neurogenesis and fate determination
25. Cell cycle dependence of laminar determination in developing neocortex
26. Retinoblastoma protein partners
27. Pontine lesions produce apneusis in the rat
28. E2Fs regulate the expression of genes involved in differentiation, development, proliferation and apoptosis
29. The retinoblastoma gene family: Cousins with overlapping interests
30. Toward an understanding of the functional complexity of the E2F and retinoblastoma families
31. Markers for neuronal degeneration in organotypic slice cultures
32. Induction and modulation of cerebellar granule neuron death by E2F-1
33. Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors
34. Induction of DNA synthesis and apoptosis are separable functions of E2F-1
35. Specification of cerebral cortical areas
36. Histopathologic clues to the pathways of neuronal death following ischemia/hypoxia
37. Fluoro-Jade: A novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration
38. Inductive interactions direct early regionalization of the mouse forebrain
39. A critical temporal requirement for the pRb family during neuronal determination
40. Generalized lacZ expression with the ROSA26 Cre reporter strain
41. Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain
42. Mutation of E2F-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
43. Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse
44. The retinoblastoma protein and cell cycle control
45. E2F3 contributes both to the inappropriate proliferation and to the apoptosis arising in Rb mutant embryos