Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion

Journal of Biological Chemistry

Volumn 276, Issue 24, 2001, Pages 21632-21641

  Harrison, Jeffrey K ^a   Fong, Alan M ^b   Swain, Peter A W ^a   Chen, Shuzhen ^a   Yu, Yen Rei A ^b   Salafranca, Mina N ^a   Greenleaf, William B ^a   Imai, Toshio ^c   Patel, Dhavalkumar D ^b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c KAN Research Institute ^*  (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION; BIOCHEMISTRY; BIOLOGICAL MEMBRANES; CYTOLOGY; PHYSIOLOGY;

CHEMOKINE DOMAIN (CD); MUTANTS;

GENES;

AMINO ACID; ARGININE; BASIC AMINO ACID; CHEMOKINE; CHEMOKINE RECEPTOR CXC3R1; CHEMOKINE RECEPTOR CXCR1; FRACTALKINE; FRACTALKINE K7A; FRACTALKINE R47A; LYSINE; MUTANT PROTEIN; PARTIAL AGONIST; UNCLASSIFIED DRUG; CALCIUM; CHEMOKINE (C X3 C MOTIF) LIGAND 1; CHEMOKINE (C-X3-C MOTIF) LIGAND 1; CX3C CHEMOKINE; CYTOKINE RECEPTOR; DIAMINO ACID; MEMBRANE PROTEIN; RECOMBINANT PROTEIN; V28 RECEPTOR; VIRUS RECEPTOR;

ARTICLE; BINDING AFFINITY; CELL ADHESION; CHEMOTAXIS; HUMAN; HUMAN CELL; LEUKOCYTE; MULTIGENE FAMILY; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RECEPTOR BINDING; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; STEADY STATE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL; BINDING SITE; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; GENETIC TRANSFECTION; KINETICS; METABOLISM; MOLECULAR GENETICS; MOUSE; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PROTEIN SECONDARY STRUCTURE; RAT; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO ACIDS, DIAMINO; ANIMALS; BINDING SITES; CALCIUM; CELL ADHESION; CELL LINE; CHEMOKINES, CX3C; CHEMOTAXIS; HUMANS; KINETICS; MEMBRANE PROTEINS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POLYMERASE CHAIN REACTION; PROTEIN STRUCTURE, SECONDARY; RATS; RECEPTORS, CYTOKINE; RECEPTORS, HIV; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0035877647     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M010261200     Document Type: Article

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