The effect of gp120 on morphine's antinociceptive and neurophysiological actions

Brain, Behavior, and Immunity

Volumn 25, Issue 7, 2011, Pages 1434-1443

  Chen, Xiaohong ^a   Kirby, Lynn G ^a   Palma, Jonathan ^a   Benamar, Khalid ^a   Geller, Ellen B ^a   Eisenstein, Toby K ^a   Adler, Martin W ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antinociception; CXCR4; Electrophysiology; Gp120; Morphine; PAG; Rat

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; GLYCOPROTEIN GP 120; MORPHINE; MU OPIATE RECEPTOR; PLERIXAFOR; RANTES;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN NERVE CELL; BRAIN SLICE; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; HOT PLATE TEST; HYPERPOLARIZATION; MALE; NEUROPHYSIOLOGY; NONHUMAN; PATCH CLAMP; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; TAIL FLICK TEST;

ANALGESIA; ANALGESICS, OPIOID; ANIMALS; BEHAVIOR, ANIMAL; COLD TEMPERATURE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HETEROCYCLIC COMPOUNDS; HIV ENVELOPE PROTEIN GP120; HOT TEMPERATURE; MALE; MEMBRANE POTENTIALS; MORPHINE; PAIN MEASUREMENT; PAIN PERCEPTION; PERIAQUEDUCTAL GRAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CXCR4; RECEPTORS, OPIOID, MU;

EID: 80052739099     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2011.04.014     Document Type: Article

References (42)

1. Adler M.W., Geller E.B., Chen X., Rogers T.J. Viewing chemokines as a third major system of communication in the brain. AAPS J. 2006, 7:E865-70.
2. Adler M.W., Rogers T.J. Are chemokines the third major system in the brain?. J. Leukoc. Biol. 2005, 78:1204-1209.
3. Banisadr G., Skrzydelski D., Kitabgi P., Rostene W., Parsadaniantz S.M. Highly regionalized distribution of stromal cell-derived factor-1/CXCL12 in adult rat brain: constitutive expression in cholinergic, dopaminergic and vasopressinergic neurons. Eur. J. NeuroSci. 2003, 18:1593-1606.
4. Basbaum A.I., Fields H.L. Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu. Rev. Neurosci. 1984, 7:309-338.
5. Behbehani M.M., Fields H.L. Evidence that an excitatory connection between the periaqueductal gray and nucleus raphe magnus mediates stimulation produced analgesia. Brain Res. 1979, 170:85-93.
6. Benamar K., Rawls S.M., Geller E.B., Adler M.W. Intrahypothalamic injection of deltorphin-II alters body temperature in rats. Brain Res. 2004, 1019:22-27.
7. Berger E.A., Murphy P.M., Farber J.M. Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Annu. Rev. Immunol. 1999, 17:657-700.
8. Cadet P., Weeks B.S., Bilfinger T.V., Mantione K.J., Casares F., Stefano G.B. HIV gp120 and morphine alter mu opiate receptor expression in human vascular endothelium. Int. J. Mol. Med. 2001, 8:165-169.
9. Chen X., Geller E.B., Rogers T.J., Adler M.W. Rapid heterologous desensitization of antinociceptive activity between mu or delta opioid receptors and chemokine receptors in rats. Drug Alcohol Depend. 2007, 88:36-41.
10. Chen Y., Mestek A., Liu J., Hurley J.A., Yu L. Molecular cloning and functional expression of a μ-opioid receptor from rat brain. Mol. Pharmacol. 1993, 44:8-12.
11. De Clercq E. How to overcome resistance of HIV-1 to HIV-1-specific reverse transcriptase inhibitors. AIDS 1994, 8:1020-1021.
12. De Vreese K., Reymen D., Griffin P., Steinkasserer A., Werner G., Bridger G.J., Este J., James W., Henson G.W., Desmyter J., Anne J., De Clercq I. The bicyclams, a new class of potent human immunodeficiency virus inhibitors, block viral entry after binding. Antiviral Res. 1996, 29:209-219.
13. Dewey W.L., Harris L.S., Howes J.F., Nuite J.A. The effect of various neurohumoral modulators on the activity of morphine and the narcotic antagonists in the tail-flick and phenylquinone tests. J. Pharmacol. Exp. Ther. 1970, 175:435-442.
14. Dimitrov D.S. Cell biology of virus entry. Cell 2000, 101:697-702.
15. Donzella G.A., Schols D., Lin S.W., Esté J.A., Nagashima K.A., Maddon P.J., Allaway G.P., Sakmar T.P., Henson G., De Clercq E., Moore J.P. AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor. Nat. Med. 1998, 4(1):72-77.
16. Evans C.J., Keith D.E.J., Morrison H., Magendzo K., Edwards R.H. Cloning of a delta opioid receptor by functional expression. Science 1992, 258:1952-1955.
17. Hartmann T.N., Grabovsky V., Pasvolsky R., Shulman Z., Buss E.C., Spiegel A., Nagler A., Lapidot T., Thelen M., Alon R. A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells. J. Leukoc. Biol. 2008, 84:1130-1140.
18. He J., Chen Y., Farzan M., Choe H., Ohagen A., Gartner S., Busciglio J., Yang X., Hofmann W., Newman W., Mackay C.R., Sodroski J., Gabuzda D. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature 1997, 385:645-649.
19. Heinisch S., Palma J., Kirby L.G. Interactions between chemokine and mu-opioid receptors: Anatomical findings and electrophysiological studies in the rat periaqueductal grey. Brain Behav. Immun. 2011, 25:360-372.
20. Hu S., Sheng W.S., Lokensgard J.R., Peterson P.K. Morphine potentiates HIV-1 gp120-induced neuronal apoptosis. J. Infect. Dis. 2005, 191:886-889.
21. Lavi E., Strizki J.M., Ulrich A.M., Zhang W., Fu L., Wang Q., O'Connor M.A., Hoxie A., Gonźalez-Scarano F. CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types including microglia and neurons. Am. J. Pathol. 1997, 151:1035-1042.
22. Mahajan S.D., Schwartz S.A., Aalinkeel R., Chawda R.P., Sykes D.E., Nair M.P. Morphine modulates chemokine gene regulation in normal human astrocytes. Clin. Immunol. 2005, 115:323-332.
23. Milligan E.D., Mehmert K.K., Hinde J.L., Harvey L.O., Martin D., Tracey K.J., Maier S.F., Watkins L.R. Thermal hyperalgesia and mechanical allodynia produced by intrathecal administration of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein, gp120. Brain Res. 2000, 861:105-116.
24. Milligan E.D., O'Connor K.A., Armstrong C.B., Hansen M.K., Martin D., Tracey K.J., Maier S.F., Watkins L.R. Systemic administration of CNI-1493, a p38 mitogen-activated protein kinase inhibitor, blocks intrathecal human immunodeficiency virus-1 gp120-induced enhanced pain states in rats. J. Pain. 2001, 2:326-333.
25. Murphy P.M., Baggiolini M., Charo I.F., Hebert C.A., Horuk R., Matsushima K., Miller L.H., Oppenheim J.J., Power C.A. International Union of Pharmacology XXII. Nomenclature for chemokine receptors. Pharmacol. Rev. 2000, 52:145-176.
26. Oh S.B., Tran P.B., Gillard S.E., Hurley R.W., Hammond D.L., Miller R.J. Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. J. Neurosci. 2001, 21:5027-5035.
27. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1998, Academic Press, San Diego.
28. Pizziketti R.J., Pressman N.S., Geller E.B., Cowan A., Adler M.W. Rat cold water tail-flick: a novel analgesic test that distinguishes opioid agonists from mixed agonist-antagonists. Eur. J. Pharmacol. 1985, 119:23-29.
29. Schols D., Este J.A., Henson G., De Clercq E. Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4. Antiviral Res. 1997, 35:147-156.
30. Schols D., Struyf S., Van Damme J., Este J.A., Henson G., De Clercq E. Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4. J. Exp. Med. 1997, 186:1383-1388.
31. Shieh J.T., Albright A.V., Sharron M., Gartner S., Strizki J., Doms R.W., Gonzalez-Scarano F. Chemokine receptor utilization by human immunodeficiency virus type 1 isolates that replicate in microglia. J. Virol. 1998, 72:4243-4249.
32. Shimizu N., Soda Y., Kanbe K., Liu H., Mukai R., Kitamura T., Hoshino H. A putative G protein-coupled receptor, RDC1, is a novel coreceptor for human and simian immunodeficiency viruses. J. Virol. 2000, 74:619-626.
33. Singhal P.C., Sagar S., Reddy K., Sharma P., Ranjan R., Franki N. HIV-1 gp120 envelope protein and morphine-tubular cell interaction products modulate kidney fibroblast proliferation. J. Investig. Med. 1998, 46:243-248.
34. Stefano G.B., Salzet M., Bilfinger T.V. Long-term exposure of human blood vessels to HIV gp120, morphine, and anandamide increases endothelial adhesion of monocytes: uncoupling of nitric oxide release. J. Cardiovasc. Pharmacol. 1998, 31:862-868.
35. Szabo I., Chen X.H., Xin L., Adler M.W., Howard O.M.Z., Oppenheim J.J., Rogers T.J. Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:10276-10281.
36. Tanabe S., Heesen M., Yoshizawa I., Berman M.A., Luo Y., Bleul C.C., Springer T.A., Okuda K., Gerard N., Dorf M.E. Functional expression of the CXC-chemokine receptor-4/fusin on mouse microglial cells and astrocytes. J. Immunol. 1997, 159:905-911.
37. Thelen M., Thelen S. CXCR7, CXCR4 and CXCL12: an eccentric trio?. J. Neuroimmunol. 2008, 198:9-13.
38. Van der Meer P., Ulrich A.M., González-Scarano F., Lavi E. Immunohistochemical analysis of CCR2, CCR3, CCR5, and CXCR4 in the human brain: potential mechanisms for HIV dementia. Exp. Mol. Pathol. 2000, 69:192-201. 13.
39. Vaughan C.W., Bagley E.E., Drew G.M., Schuller A., Pintar J.E., Hack S.P., Christie M.J. Cellular actions of opioids on periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR-1. Br. J. Pharmacol. 2003, 139(2):362-367.
40. Xin L., Geller E.B., Liu-Chen L.-Y., Chen C., Adler M.W. Substance P release in the rat periaqueductal gray and preoptic anterior hypothalamus after noxious cold stimulation: effect of selective mu and kappa opioid agonists. J. Pharmacol. Exp. Ther. 1997, 282:1055-1063.
41. Zhang N., Oppenheim J.J. Crosstalk between chemokines and neuronal receptors bridges immune and nervous systems. J. Leukoc. Biol. 2005, 78:1210-1214.
42. Zhang N., Rogers T.J., Caterina M., Oppenheim J.J. Proinflammatory chemokines, such as C-C chemokine ligand 3, desensitize μ-opioid receptors on dorsal root ganglia neurons. J. Immunol. 2004, 173:594-599.