Discovery, optimization, and pharmacological characterization of novel heteroaroylphenylureas antagonists of C-C chemokine ligand 2 function

Journal of Medicinal Chemistry

Volumn 54, Issue 6, 2011, Pages 1667-1681

  Laborde, Edgardo ^a   MacSata, Robert W ^a   Meng, Finying ^a   Peterson, Brian T ^a   Robinson, Louise ^a   Schow, Steve R ^a   Simon, Reyna J ^a   Xu, Hua ^a   Baba, Kunihisa ^b   Inagaki, Hideaki ^b   Ishiwata, Yoshiro ^b   Jomori, Takahito ^b   Matsumoto, Yukiharu ^b   Miyachi, Atsushi ^b   Nakamura, Takashi ^b   Okamoto, Masayuki ^b   Handel, Tracy M ^c   Bernard, Claude C A ^d  

^a Telik Inc   (United States)

^b SANWA KAGAKU KENKYUSHO CO LTD   (Japan)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

1 (1,3 DIMETHYL 1H PYRAZOLO[3,4B]PYRIDINE 5 CARBONYL) 3 [4 FLUORO 3 (TRIFLUOROMETHYL)PHENYL]UREA; 1 (BENZO[D][1,3]DIOXOL 5 YL) 3 (3 CHLOROBENZOYL)UREA; 1 (BENZO[D][1,3]DIOXOLE 6 CARBONYL) 3 (3 CHLORO 4 HYDROXYPHENYL)UREA; 1 (BENZO[D][1,3]DIOXOLE 6 CARBONYL) 3 (3 CHLOROPHENYL) 1 METHYLUREA; 1 (BENZO[D][1,3]DIOXOLE 6 CARBONYL) 3 (3 CHLOROPHENYL) 1,3 DIMETHYLUREA; 1 (BENZO[D][1,3]DIOXOLE 6 CARBONYL) 3 (3 CHLOROPHENYL)GUANIDINE; 1 (BENZO[D][1,3]DIOXOLE 6 CARBONYL) 3 (3 CHLOROPHENYL)UREA; 1 (BENZO[D][1,3]DIOXOLE 6 CARBONYL) 3 (3 ISOPROPOXYPHENYL)UREA; 1 (BENZO[D][1,3]DIOXOLE 6 CARBONYL) 3 (3 PHENYLPHENYL)UREA; 1 (BENZO[D][1,3]DIOXOLE 6 CARBONYL) 3 (3,4 DICHLOROPHENYL)UREA; 1 (BENZO[D][1,3]DIOXOLE 6 CARBONYL) 3 (4 PHENYLPHENYL)UREA; 1 (BENZO[D][1,3]DIOXOLE 6 CARBONYL) 3 [3 (TRIFLUOROMETHYL)PHENYL]UREA; 1 [6 [[2 (DIMETHYLAMINO)ETHYL]METHYL]AMINO] 1,3 DIMETHYL 1H PYRAZOLO[3,4B]PYRIDINE 5 CARBONYL 3 (3 ISOPROPOXYPHENYL)UREA; 5 (BENZO[D][1,3]DIOXOL 5 YL) N (3,4 DICHLOROPHENYL) 1,2,4 OXADIAZOL 3 AMINE; CHEMOKINE RECEPTOR CCR2; METHOTREXATE; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 1 INHIBITOR; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CALCIUM MOBILIZATION; CHEMOTAXIS; CONTROLLED STUDY; DISTRIBUTION VOLUME; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; JOINT DESTRUCTION; JOINT SWELLING; LEUKEMIA CELL LINE; MACROPHAGE; MALE; MAXIMUM PLASMA CONCENTRATION; MONOCYTE; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PERITONITIS; RAT; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; TIME TO MAXIMUM PLASMA CONCENTRATION; TOXICITY TESTING;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; BICYCLO COMPOUNDS, HETEROCYCLIC; BIOLOGICAL AVAILABILITY; CELL LINE, TUMOR; CHEMOKINE CCL2; CHEMOTAXIS; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; JOINTS; MACROPHAGES; MICE; MICE, INBRED ICR; MONOCYTES; MULTIPLE SCLEROSIS; PHENYLUREA COMPOUNDS; RADIOLIGAND ASSAY; RATS; RECEPTORS, CCR2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79952794175     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1012903     Document Type: Article

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