Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues

Journal of Biological Chemistry

Volumn 287, Issue 34, 2012, Pages 28362-28377

  Hoffmann, Frauke ^a   Müller, Wiebke ^a   Schütz, Dagmar ^a   Penfold, Mark E ^b   Wong, Yung H ^c   Schulz, Stefan ^a   Stumm, Ralf ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b ChemoCentryx Inc   (United States)

^c HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

C TERMINUS; C-TERMINAL DOMAINS; CARBOXYL-TERMINAL; CELL MIGRATION; DEGRADATION PRODUCTS; DISEASE STATE; G PROTEIN; HEK-293; HUMAN EMBRYONIC KIDNEY CELLS; LYSINE RESIDUES; RECEPTOR TRAFFICKING; REGULATORY PATHWAY; SECOND INTRACELLULAR LOOPS; TERMINAL RESIDUES; WILD TYPES;

AMINO ACIDS; CELL MEMBRANES; DEGRADATION; LIGANDS; PHOSPHORYLATION;

PROTEINS;

CHEMOKINE RECEPTOR CXCR7; EPITOPE; G PROTEIN COUPLED RECEPTOR; SERINE; STROMAL CELL DERIVED FACTOR 1; THREONINE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INTERNALIZATION; KIDNEY CELL CULTURE; LIGAND BINDING; MOUSE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; UBIQUITINATION; WILD TYPE;

ANIMALS; CHEMOKINE CXCL12; HEK293 CELLS; HUMANS; MICE; MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PROTEOLYSIS; RECEPTORS, CXCR; RECEPTORS, CXCR4;

EID: 84865266090     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.335679     Document Type: Article

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