Human immunodeficiency virus encephalitis in SCID mice

American Journal of Pathology

Volumn 149, Issue 3, 1996, Pages 1027-1053

  Persidsky, Yuri ^a   Limoges, Jenae ^a   McComb, Rodney ^a   Bock, Paul ^a   Baldwin, Tonia ^a   Tyor, William ^b   Patil, Angelo ^a   Nottet, Hans S L M ^a   Epstein, Leon ^c   Gelbard, Harris ^c   Flanagan, Ellen ^d   Reinhard, John ^d   Pirruccello, Samuel J ^a   Gendelman, Howard E ^a,e  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d GLAXOSMITHKLINE   (United States)

^e UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN P24; CYTOKINE; GLIAL FIBRILLARY ACIDIC PROTEIN; HLA DR ANTIGEN; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; ASTROCYTOSIS; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; MICROGLIA; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PUTAMEN; VIRUS ENCEPHALITIS; XENOGRAFT;

AIDS DEMENTIA COMPLEX; ANIMALS; ASTROCYTES; BRAIN; DISEASE MODELS, ANIMAL; ENCEPHALITIS, VIRAL; ENDOTHELIUM, VASCULAR; HIV INFECTIONS; HIV-1; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MICE, SCID; MICROGLIA; MONOCYTES; NEURONS;

EID: 2442751427     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Janssen RS, Cornblath DR, Epstein LG, Foa RP, McArthur JC, Price RW, Asbury AKK, Beckett A, Benson DF, Bridge TP, Leventhal CM, Satz P, Saykin AJ, Sidtis JJ, Tross S: Nomenclature and research case definitions for neurological manifestations of human immunodeficiency virus type 1 (HIV-1) infection. Neurology 1991, 41:778-785
2. Navia BA, Jordan BD, Price RW: The AIDS dementia complex. I. Clinical features, Ann Neurol 1986, 19:517-524
3. Kieburtz K, Schiffer RB: Neurologic manifestations of human immunodeficiency virus infections. Neurol Clin 1988, 7:447-468
4. Wiley CA, Achim C: Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome. Ann Neurol 1994, 36:673-676
5. Price RW, Brew B, Sidtis J, Rosenblum M, Scheck AC, Clearly P: The brain and AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science 1988, 239:586-592
6. Wiley CA, Schrier RD, Nelson JA, Lampert PW, Oldstone MBA: Cellular localization of human immunodeficiency virus infection within brains of acquired immune deficiency syndrome patients, Proc Natl Acad Sci USA 1986, 83:7089-7093
7. Everall I, Luthbert P, Lantos P: Neuronal loss in the frontal cortex in HIV infection. Lancet 1991, 337:1119-1121
8. Petito KC, Roberts B: Evidence of apoptotic cell death in HIV encephalitis. Am J Pathol 1995, 146:1121-1130
9. Gendelman HE, Lipton SA, Tardieu M, Bukrinsky MI, Nottet HSLM: The neuropathogenesis of HIV-1 infection. J Leukocyte Biol 1994, 56:389-398
10. Koenig S, Gendelman HE, Orenstein JM, Dal Canto MC, Pezeshkpour GH, Yungbluth M, Janotta F, Aksamit A, Martin MA, Fauci AS: Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 1986, 233:1089-1093
11. Lipton SA, Gendelman HE: Dementia associated with the acquired immunodeficiency syndrome. N Engl J Med 1995, 332:934-940
12. Heyes MP, Brew BB, Martin A, Price RW, Salazar A, Sidtis JJ, Yergey JA, Mouradian MM, Sadler AE, Keilp J, Rubinow R, Markey SP: Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status. Ann Neurol 1991, 29: 202-209
13. Genis P, Jett M, Bernton EW, Boyle T, Gelbard HA, Dzenko K, Keane RW, Resnick L, Mizrachi Y, Volsky DJ, Epstein LG, Gendelman HE: Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophage-astroglia interactions: implications for the neuropathogenesis of HIV disease. J Exp Med 1992, 176:1703-1718
14. Tyor WR, Glass JD, Griffin JW, Becker PS, McArthur JC, Bezman L, Griffin DE: Cytokine expression in the brain during the acquired immunodeficiency syndrome. Ann Neurol 1992, 31:349-360
15. Lipton SA, Choi Y-B, Pan Z-H, Lei SZ, Chen H-SV, Sucher NJ, Loscalzo J, Singel DJ, Stamler JS: A redoxbased mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitrosocompounds. Nature 1993, 364:626-631
16. Wesselingh SL, Power C, Glass JD, Tyor WR, McArthur JC, Farber JM, Griffin JW, Griffin DE: Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia. Ann Neurol 1993, 33:576-582
17. Gelbard HA, Nottet HSLM, Swindells S, Jett M, Dzenko KA, Genis P, White R, Wang L, Choi Y-B, Zhang D, Lipton SA, Tourtellotte WW, Epstein LG, Gendelman HE: Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin. J Virol 1994, 68:4628-4635
18. Griffin DE, Wesselingh SL, McArthur JC: Elevated central nervous system prostaglandins in human immunodeficiency virus-associated dementia. Ann Neurol 1994, 35:592-597
19. Bukrinsky M, Nottet HSLM, Schmidtmayerova H, Dubrovsky L, Flanagan CR, Mullins ME, Lipton SA, Gendelman HE: Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease. J Exp Med 1995, 181:735-745
20. Nottet HSLM, Jett M, Flanagan CR, Zhai Q-H, Persidsky Y, Rizzino A, Bernton EW, Genis P, Baldwin T, Schwartz J, LaBenz CJ, Gendelman HE: A regulatory role for astrocytes in HIV-1 encephalitis: an overexpression of eicosanoids, platelet-activating factor, and tumor necrosis factor-α by activated HIV-1-infected monocytes is attenuated by primary human astrocytes. J Immunol 1995, 154:3567-3581
21. Nottet HSLM, Persidsky Y, Sasseville VG, Zhai Q-H, Bock P, Sharer LR, McComb RD, Swindells S, Soderland C, Gendelman HE: Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain. J Immunol 1996, 156:1284-1295
22. Schmidtamerova H, Nottet HSLM, Nuovo G, Raabe T, Flanagan CR, Dubrovsky L, Gendelman HE, Cerami A, Bukrinsky M, Sherry B: HIV-1 infection alters chemokine β peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes. Proc Natl Acad Sci USA 1996, 93: 700-704
23. Lackner AA, Smith MO, Munn RJ, Martfeld DJ, Gardner MB, Marx PA, Dandekar S: Localization of simian immunodeficiency virus in the central nervous system of rhesus monkeys. Am J Pathol 1991, 139:609-621
24. Hurtrel M, Ganiere JP, Guelfi JF, Chakrabarti L, Maire MA, Gray F, Montagnier L, Hurtrel B: Comparison of early and late feline immunodeficiency virus encephalopathies. AIDS 1992, 6:399-406
25. Persidsky Y, Nottet HSLM, Sasseville VG, Epstein LG, Gendelman HE: The development of animal model systems for HIV-1 encephalitis and associated dementia. J NeuroVirol 1995, 1:229-243
26. Tyor WR, Power C, Gendelman HE, Markham RB: A model of human immunodeficiency virus encephalitis in SCID mice. Proc Natl Acad Sci USA 1993, 90:8658-8662
27. Gendelman HE, Orenstein JM, Martin MA, Ferruca C, Mitra R, Phipps T, Wahl LA, Lane HC, Fauci SD, Burke DS, Skillman DR, Meltzer MS: Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes. J Exp Med 1988, 167:1498-1506
28. Katler DC, Nakamura M, Turpin JA, Baca LM, Dieffenbach C, Ralph P, Gendelman HE, Meltzer MS: Enhanced HIV replication in MCSF-treated monocytes. J Immunol 1991, 146:298-307
29. Cunningham MG, McKay RDG: A hypothermic miniaturized stereotaxic instrument for surgery in newborn rats. J Neurosci Methods 1993, 47:105-114
30. Sidman RL, Agnevine JB, Pierce ET: Atlas of Mouse Brain and Spinal Cord. Harvard University Press, Cambridge, MA, 1971
31. O'Callaghan JP: Quantification of glial fibrillary acidic protein: comparison of slot-immunoblotting assays with novel sandwich ELISA. Neurotox Teratol 1991, 33:257-281
32. Perry VH, Lawson LJ, Reid DM: Biology of mononuclear phagocyte system of the central nervous system and HIV infection. J Leukocyte Biol 1994, 56:399-406
33. Kure K, Weidenheim KM, Lyman WD, Dickson DW: Morphology and distribution of HIV gp41-positive microglia in subacute AIDS encephalitis: pattern resembling multisystem degeneration. Acta Neuropathol 1990, 80:393-400
34. Dixon DW: Apoptosis in the brain: physiology and pathology. Am J Pathol 1995, 146:1040-1044
35. Teyler TJ, DiScenna P: The role of hippocampus in memory: a hypothesis. Neurosci Behavioral Rev 1985, 9:377-389
36. Nottet HSLM, Gendelman HE: Unraveling the neuroimmune mechanisms for the HIV-1-associated cognitive/ motor complex. Immunol Today 1995, 16:441-448
37. Pulliam L, Herndier BG, Tang NM, McGrath MS: Human immunodeficiency virus-infected macrophages produce soluble factors that cause histological and neurochemical alterations in cultured human brains. J Clin Invest 1991, 87:503-512
38. Giulian D, Vaca K, Noonan CA: Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science 1991, 250:1593-1596
39. Dickson DW, Mattiace LA, Kure K, Hutchins K, Lyman WD, Brosnan CF: Biology of disease: microglia in human disease, with an emphasis on acquired immune deficiency syndrome. Lab Invest 1991, 64:135-156
40. Johnson RT: Neurovirology: evolution of a new discipline, J Neurovirol 1995, 1:2-4
41. Narayan O, Kenndey-Stoskopf S, Zink CM: Lentivirus-host interactions: lessons from visna and caprine arthritis-encephalitis viruses. Ann Neurol 1988, 23:S95-S100
42. Kennedy PGE, Narayan O, Ghotbi Z, Hopkins J, Gendelman HE, Clements JE: Persistent expression of la antigen and viral genome in visna-Maedi virus-induced inflammatory cells: possible role of lentivirus induced interferon. J Exp Med 1985, 162:1970-1982
43. Zink MC, Yager JA, Myers JD: Pathogenesis of caprine arthritis encephalitis virus: cellular localization of viral transcripts in tissues of infected goats. Am J Pathol 1990, 136:843-854
44. Letvin NL, Daniel MD, Sehgal PK, Desrosiers RC, Hunt RD, Waldron LM, McKey JJ, Schmidt DK, Chalifoux LV, King NW: Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III. Science 1985, 230:71-73
45. Baskin GB, Murphey-Corb M, Roberts ED, Didier PJ: Correlates of SIV encephalitis in rhesus monkeys. J Med Primatol 1992, 21:59-63
46. Lackner AA, Vogel P, Ramos RA, Kluge JD, Marthas M: Early events in tissues during infection with pathogenic (SIVmac239) and non-pathogenic (SIVmac1A11) molecular clones of simian immunodeficiency virus. Am J Pathol 1994, 145:428-439
47. Murray EA, Rausch DM, Lendvay J, Sharer LR, Eiden LE: Cognitive and motor impairments associated with SIV infection in rhesus monkeys. Science 1992, 255: 1246-1249
48. Sasseville VG, Newman WA, Lackner AA, Smith MO, Lausen NCG, Beall D, Ringler DJ: Elevated vascular cell adhesion molecule-1 in AIDS encephalitis induced by simian immunodeficiency virus. Am J Pathol 1992, 141:1021-1030
49. Rausch DM, Heyes MP, Murray EA, Lendvay J, Sharer LR, Ward JM, Rehm S, Nohr D, Weihe E, Eiden LE: Cytopathologic and neurochemical correlates of progression to motor/cognitive impairment in SIV-infected rhesus monkeys. J Neuropathol Exp Neurol 1994, 53: 165-175
50. Sasseville VG, Newman W, Brodie SJ, Hesterberg P, Pauley D, Ringler DJ: Monocyte adhesion to endothelium in simian immunodeficiency virus-induced AIDS encephalitis is mediated by vascular cell adhesion molecule-1/α4β1 integrin interactions. Am J Pathol 1994, 144:27-40
51. Toggas SM, Masliah E, Rockenstein EM, Rail GF, Abraham CR, Mucke L: Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature 1994, 367:188-193
52. Epstein LG, Cvetkovich TA, Lazar ES, Dehlinger K, Dzenko K, del Cerro C, del Cerro M: Successful xenografts of second trimester human fetal brain and retinal tissue in the anterior chamber of the eye of adult immunosuppressed rats. J Neural Transplant Plasticity 1992, 3:151-158
53. Glass JD, Fedor H, Wesselingh SL, McArthur JC: Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlations with dementia. Ann Neurol 1995, 38:755-762