The chemokine fractalkine inhibits Fas-mediated cell death of brain microglia

Journal of Immunology

Volumn 165, Issue 1, 2000, Pages 397-403

  Boehme, Stefen A ^a   Lio, Francisco M ^a   Maciejewski Lenoir, Dominique ^a   Bacon, Kevin B ^a,b   Conlon, Paul J ^a  

^a NEUROCRINE BIOSCIENCES INC   (United States)

^b BAYER YAKUHIN LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; FRACTALKINE;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT;

EID: 0034235306     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.1.397     Document Type: Article

References (38)

1. Baggiolini, M., B. Dewald, and B. Moser. 1997. Human chemokines: an update. Annu. Rev. Immunol. 15:675.
2. Rollins, B. J. 1997. Chemokines. Blood 90:909.
3. Bazan, J. F., K. B. Bacon, G. Hardiman, W. Wang, K. Soo, D. Rossi, D. R. Greaves, A. Zlotnick, and T. J. Schall. 1997. A new class of membrane-bound chemokine with a CX3C motif. Nature 385:640.
4. Pan, Y., C. Lloyd, H. Zhou, S. Dolich, J. Deeds, J. A. Gonzalo, J. Vath, M. Gosselin, J. Ma, B. Dussault, et al. 1997. Neurotactin, a membrane-anchored chemokine up-regulated in brain inflammation. Nature 387:611.
5. Harrison, J. K., Y. Jiang, S. Chen, Y. Xia, D. Maciejewski, R. K. McNamara, W. J. Streit, M. N. Salafranca, S. Adhikari, D. A. Thompson, et al. 1998. Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR-1-expressing microglia. Proc. Natl. Acad. Sci. USA 95:10896.
6. Maciejewski-Lenoir, D., S. Chen, L. Feng, R. Maki, and K. B. Bacon, 1999. Characterization of fractalkine in rat brain cells: migratory and activation signals for CX3CR-1-expressing microglia. J. Immunol 163:1628.
7. Imai, T., K. Hieshima, C. Haskell, M. Baba, M. Nagira, M. Kakizaki, S. Takagi, H. Nomiyama, T. J. Schall, and O. Yoshie. 1997. Identification and molecular characterization of fractalkine receptor CX3CR-1, which mediates both leukocyte migration and adhesion. Cell 91:521.
8. Harrison, J. K., C. M. Barber, and K. R. Lynch. 1994. cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors. Neurosci. Lett. 169:85.
9. Combadiere, C., S. K. Ahuja, and P. M. Murphy. 1995. Cloning, chromosomal localization, and RNA expression of a human β chemokine receptor-like gene. DNA Cell Biol. 14:673.
10. Vogt, M., M. K. A. Bauer, D. Ferrari, and K. Schulze-Osthoff. 1998. Oxidative stress and hypoxia/reoxygenation trigger CD95 ligand expression in microglial cells. FEBS Lett. 429:67.
11. Matsuyama, T., R. Hata, M. Tagaya, Y. Yamamoto, T. Nakajima, J. Furuyama, A. Wanaka, and M. Sugita. 1994. Fas antigen mRNA induction in postischemic murine brain. Brain Res. 657:342.
12. Dowling, P., G. Shang, S. Raval, J. Menonna, S. Cook, and W. Husar. 1996. Involvement of the CD95 receptor/ligand system in multiple sclerosis brain. J. Exp. Med. 184:1513.
13. Bonetti, B., and C. S. Raine. 1997. Multiple sclerosis: oligodendrocytes display cell-death-related molecules in situ but do not undergo apoptosis. Ann. Neurol. 42:74.
14. D'Souza, S. D., B. Bonetti, V. Balasingam, N. R. Cashman, P. A. Barker, A. B. Troutt, C. S. Raine and J. P. Antel. 1996. Multiple sclerosis: Fas signaling in oligodendrocyte cell death. J. Exp. Med. 184:2361.
15. Bonetti, B., J. Pohl, Y. L. Gao, and C. S. Raine. 1997. Cell death during autoimmune demyelination: effector but not target cells are eliminated by apoptosis. J. Immunol. 159:5733.
16. Sabelko, K. A., K. A. Kelly, M. H. Nahm, A. H. Cross, and J. H. Russell. 1997. Fas and Fas ligand enhance the pathogenesis of experimental allergic encephalomyelitis, but are not essential for immune privilege in the central nervous system. J. Immunol. 159:3096.
17. Waldner, H., R. A. Sobel, E. Howard, and V. K. Kuchroo. 1997. Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis. J. Immunol. 159:3100.
18. Lenardo, M. J. 1996. Fas and the art of lymphocyte maintenance. J. Exp. Med. 183:721.
19. Peter, M. E., and P. H. Krammer. 1998. Mechanisms of CD95-mediated apoptosis. Curr. Opin. Immunol. 10:545.
20. Lenardo, M. J., F. K.-M. Chan, F. Hornung, H. McFarland, R. Siegel, J. Wang, and L. Zheng. 1999. Mature T lymphocyte apoptosis-immune regulation in a dynamic and unpredictable antigenic environment. Annu. Rev. Immunol. 17:221.
21. L and Bcl-2, displaces Bax and promotes cell death. Cell 80:285.
22. Kauffmann-Zeh, A., P. Rodriguez-Viciana, E. Ulrich, C. Gilbert, P. Coffer, J. Downward, and G. Evan. 1997. Suppression of c-Myc-induced apoptosis by Ras signalling through Pl(3)K and PKB. Nature 385:544.
23. Datta, S. R., H. R. Dudek, X. Tao, S. Masters, H. Fu, Y. Gotoh, and M. E. Greenberg. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231.
24. L. Cell 87:619.
25. Del Peso, L., M. González-García, C. Page, R. Herrera, and G. Nuñez. 1997. Interleukin-3-induced phosphorylation of BAD through protein kinase Akt. Science 278:687.
26. Ozes, O. N., L. D. Mayo, J. A. Gustin, S. R. Pfeffer, L. M. Pfeffer, and D. B. Donner. 1999. NF-κB activation by tumor necrosis factor requires the AKT serine-threonine kinase. Nature 401:82.
27. Romashkova, J. A., and S. S. Makarov. 1999. NF-κB is a target of AKT in anti-apoptotic PDGF signalling. Nature 401:86.
28. Luo, X., I. Budihardo, H. Zou, C. Slaughter, and X. Wang. 1998. Bid, a Bcl-2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94:481.
29. Boehme, S. A., S. K. Sullivan, P. D. Crowe, M. Santos, P. J. Conlon, P. Sriramarao, and K. B. Bacon. 1999. Activation of mitogen-activated protein kinase regulates eotaxin-induced eosinophil migration. J. Immunol. 163:1611.
30. He, J., Y. Chen, M. Farzan, H. Choe, A. Ohagen, S. Gartner, J. Busciglio, X. Yang, W. Hofmann, W. Newman, et al. 1997. CCR3 and CCR5 are coreceptors for HIV-1 infection of microglia. Nature 385:645.
31. Vlahos, C. J., W. F. Matter, K. Y. Hui, and R. F. Brown. 1994. A specific inhibitor of phosphatidylinositol 3-kinase LY294002. J. Biol. Chem. 269:5241.
32. Oltvai, Z. N., and S. J. Korsmeyer. 1994. Checkpoints of dueling dimers foil death wishes. Cell 79:189.
33. Yin, X.-M., K. Wang, A. Gross, Y. Zhao, S. Zinkel, B. Klocke, K. A. Roth, and S. J. Korsmeyer. 1999. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400:886.
34. Gehrmann, J., Y. Matsumoto, and G. W. Kreutzberg. 1995. Microglia: intrinsic immuneffector cell of the brain. Brain Res. Rev. 20:269.
35. Zheng, L., G. Fisher, R. E. Miller, J. Peschon, D. H. Lynch, and M. J. Lenardo. 1995. Induction of apoptosis in mature T cells by tumor necrosis factor. Nature 377:348.
36. Boehme, S. A., and M. J. Lenardo. 1993. Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle. Eur. J. Immunol. 23:1552.
37. Boehme, S. A., and M. J. Lenardo. 1993. Ligand-induced apoptosis of mature T lymphocytes occurs at distinct stages of the cell cycle. Leukemia 7:545.
38. Nishimura, T., H. Akiyama, S. Yonehara, H. Kondo, K. Ikeda, M. Kato, E. Iseki, and K. Kosaka. 1995. Fas antigen expression in brains of patients with Alzheimer-type dementia. Brain Res. 695:137.