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Volumn 6, Issue 3, 2013, Pages 451-463

The role of pattern recognition receptors in intestinal inflammation

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CRX 526; CRYOPYRIN; GLIBENCLAMIDE; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PATTERN RECOGNITION RECEPTOR; PROTEIN NLRP12; PROTEIN NLRP6; RECEPTOR BLOCKING AGENT; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 2 AGONIST; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

EID: 84876348441     PISSN: 19330219     EISSN: 19353456     Source Type: Journal    
DOI: 10.1038/mi.2013.13     Document Type: Review
Times cited : (183)

References (144)
  • 1
    • 79959634861 scopus 로고    scopus 로고
    • Pattern recognition receptors and the innate immune response to viral infection
    • Thompson, M.R., Kaminski, J.J., Kurt-Jones, E.A. & Fitzgerald, K.A. Pattern recognition receptors and the innate immune response to viral infection. Viruses 3, 920-940 (2011).
    • (2011) Viruses , vol.3 , pp. 920-940
    • Thompson, M.R.1    Kaminski, J.J.2    Kurt-Jones, E.A.3    Fitzgerald, K.A.4
  • 2
    • 77249145443 scopus 로고    scopus 로고
    • TLR signalling regulated antigen presentation in dendritic cells
    • Watts, C., West, M.A. & Zaru, R. TLR signalling regulated antigen presentation in dendritic cells. Curr. Opin. Immunol. 22, 124-130 (2010).
    • (2010) Curr. Opin. Immunol. , vol.22 , pp. 124-130
    • Watts, C.1    West, M.A.2    Zaru, R.3
  • 3
    • 70349583503 scopus 로고    scopus 로고
    • The contribution of direct TLR signaling to Tcell responses
    • Rahman, A.H., Taylor, D.K. & Turka, L.A. The contribution of direct TLR signaling to Tcell responses. Immunol. Res. 45, 25-36 (2009).
    • (2009) Immunol. Res. , vol.45 , pp. 25-36
    • Rahman, A.H.1    Taylor, D.K.2    Turka, L.A.3
  • 4
    • 84859712235 scopus 로고    scopus 로고
    • Contribution of Toll-like receptor signaling to germinal center antibody responses
    • DeFranco, A.L., Rookhuizen, D.C. & Hou, B. Contribution of Toll-like receptor signaling to germinal center antibody responses. Immunol. Rev. 247, 64-72 (2012).
    • (2012) Immunol. Rev. , vol.247 , pp. 64-72
    • Defranco, A.L.1    Rookhuizen, D.C.2    Hou, B.3
  • 5
    • 1842583729 scopus 로고    scopus 로고
    • Mechanisms of cross hyporespon-siveness to Toll-like receptor bacterial ligands in intestinal epithelial cells
    • Otte, J.M., Cario, E. & Podolsky, D.K. Mechanisms of cross hyporespon-siveness to Toll-like receptor bacterial ligands in intestinal epithelial cells. Gastroenterology 126, 1054-1070 (2004).
    • (2004) Gastroenterology , vol.126 , pp. 1054-1070
    • Otte, J.M.1    Cario, E.2    Podolsky, D.K.3
  • 6
    • 0037307854 scopus 로고    scopus 로고
    • Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: Implications for host-microbial interactions in the gut
    • Melmed, G. et al. Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut. J. Immunol. 170, 1406-1415 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 1406-1415
    • Melmed, G.1
  • 7
    • 13744256812 scopus 로고    scopus 로고
    • Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity
    • Smythies, L.E. et al. Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J. Clin. Invest. 115, 66-75 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 66-75
    • Smythies, L.E.1
  • 8
    • 77954314592 scopus 로고    scopus 로고
    • Epithelial-specific blockade of MyD88-dependent pathway causes spontaneous small intestinal inflammation
    • Gong, J. et al. Epithelial-specific blockade of MyD88-dependent pathway causes spontaneous small intestinal inflammation. Clin. Immunol. 136, 245-256 (2010).
    • (2010) Clin. Immunol. , vol.136 , pp. 245-256
    • Gong, J.1
  • 9
    • 34047173496 scopus 로고    scopus 로고
    • Epithelial NEMO links innate immunity to chronic intestinal inflammation
    • Nenci, A. et al. Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 446, 557-561 (2007).
    • (2007) Nature , vol.446 , pp. 557-561
    • Nenci, A.1
  • 10
    • 49049095991 scopus 로고    scopus 로고
    • Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis
    • Kajino-Sakamoto, R. et al. Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis. J. Immunol. 181, 1143-1152 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 1143-1152
    • Kajino-Sakamoto, R.1
  • 11
    • 33751551466 scopus 로고    scopus 로고
    • Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells
    • Lee, J. et al. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat. Cell Biol. 8, 1327-1336 (2006).
    • (2006) Nat. Cell Biol. , vol.8 , pp. 1327-1336
    • Lee, J.1
  • 12
    • 58549111588 scopus 로고    scopus 로고
    • Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
    • Vaishnava, S., Behrendt, C.L, Ismail, A.S., Eckmann, L. & Hooper, L.V Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc. Natl. Acad. Sci. USA 105, 20858-20863 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 20858-20863
    • Vaishnava, S.1    Behrendt, C.L.2    Ismail, A.S.3    Eckmann, L.4    Hooper, L.V.5
  • 13
    • 84865464872 scopus 로고    scopus 로고
    • Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice
    • e701-705
    • Sodhi, C.P. et al. Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice. Gastroenterology 143, 708-718. e701-705 (2012).
    • (2012) Gastroenterology , vol.143 , pp. 708-718
    • Sodhi, C.P.1
  • 14
    • 33947667036 scopus 로고    scopus 로고
    • Activation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion
    • Palazzo, M. et al. Activation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion. J. Immunol. 178, 4296-4303 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 4296-4303
    • Palazzo, M.1
  • 15
    • 13244292161 scopus 로고    scopus 로고
    • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    • Kobayashi, K.S. et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307, 731-734 (2005).
    • (2005) Science , vol.307 , pp. 731-734
    • Kobayashi, K.S.1
  • 16
    • 7244257312 scopus 로고    scopus 로고
    • NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression
    • Wehkamp, J. et al. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression. Gut 53, 1658-1664 (2004).
    • (2004) Gut , vol.53 , pp. 1658-1664
    • Wehkamp, J.1
  • 17
    • 0032692721 scopus 로고    scopus 로고
    • The intestinal mucus layer from patients with inflammatory bowel disease harbors high numbers of bacteria compared with controls
    • Schultsz, C, Van Den Berg, F.M., Ten Kate, F.W., Tytgat, G.N. & Dankert, J. The intestinal mucus layer from patients with inflammatory bowel disease harbors high numbers of bacteria compared with controls. Gastroenterology 117, 1089-1097 (1999).
    • (1999) Gastroenterology , vol.117 , pp. 1089-1097
    • Schultsz, C.1    Van Den Berg, F.M.2    Ten Kate, F.W.3    Tytgat, G.N.4    Dankert, J.5
  • 18
    • 6344225825 scopus 로고    scopus 로고
    • Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells
    • Vora, P. et al. Beta-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells. J. Immunol. 173, 5398-5405 (2004).
    • (2004) J. Immunol. , vol.173 , pp. 5398-5405
    • Vora, P.1
  • 19
    • 34247239745 scopus 로고    scopus 로고
    • Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines
    • Uehara, A., Fujimoto, Y., Fukase, K. & Takada, H. Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines. Mol. Immunol. 44, 3100-3111 (2007).
    • (2007) Mol. Immunol. , vol.44 , pp. 3100-3111
    • Uehara, A.1    Fujimoto, Y.2    Fukase, K.3    Takada, H.4
  • 20
    • 34250205694 scopus 로고    scopus 로고
    • Intestinal bacteriatriggerTcell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL
    • He, B. et al. Intestinal bacteriatriggerTcell-independent immunoglobulin A(2) class switching by inducing epithelial-cell secretion of the cytokine APRIL. Immunity 26, 812-826 (2007).
    • (2007) Immunity , vol.26 , pp. 812-826
    • He, B.1
  • 21
    • 48549103766 scopus 로고    scopus 로고
    • Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria
    • Shang, L. et al. Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria. Gastroenterology 135, 529-538 (2008).
    • (2008) Gastroenterology , vol.135 , pp. 529-538
    • Shang, L.1
  • 22
    • 77952158547 scopus 로고    scopus 로고
    • Regulation of the polymeric immunoglobulin receptor in intestinal epithelial cells by Enterobacteriaceae: Implications for mucosal homeostasis
    • Bruno, M.E. et al. Regulation of the polymeric immunoglobulin receptor in intestinal epithelial cells by Enterobacteriaceae: implications for mucosal homeostasis. Immunol. Invest. 39, 356-382 (2010).
    • (2010) Immunol. Invest. , vol.39 , pp. 356-382
    • Bruno, M.E.1
  • 23
    • 21244462251 scopus 로고    scopus 로고
    • Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: Linking innate and adaptive immune responses
    • Schneeman, TA. et al. Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses. J. Immunol. 175, 376-384 (2005).
    • (2005) J. Immunol. , vol.175 , pp. 376-384
    • Schneeman, T.A.1
  • 24
    • 1542618118 scopus 로고    scopus 로고
    • Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria
    • Macpherson, A.J. & Uhr, T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303, 1662-1665 (2004).
    • (2004) Science , vol.303 , pp. 1662-1665
    • MacPherson, A.J.1    Uhr, T.2
  • 25
    • 36849000520 scopus 로고    scopus 로고
    • Deletion of TLR5 results in spontaneous colitis in mice
    • Vijay-Kumar, M. et al. Deletion of TLR5 results in spontaneous colitis in mice. J. Clin. Invest. 117, 3909-3921 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 3909-3921
    • Vijay-Kumar, M.1
  • 26
    • 35348839535 scopus 로고    scopus 로고
    • Rig-I-/-mice develop colitis associated with downregulation of G alpha i2
    • Wang, Y. et al. Rig-I-/-mice develop colitis associated with downregulation of G alpha i2. Cell Res. 17, 858-868 (2007).
    • (2007) Cell Res. , vol.17 , pp. 858-868
    • Wang, Y.1
  • 27
    • 79957576718 scopus 로고    scopus 로고
    • NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    • Elinav, E. et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145, 745-757 (2011).
    • (2011) Cell , vol.145 , pp. 745-757
    • Elinav, E.1
  • 28
    • 79958840965 scopus 로고    scopus 로고
    • Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis
    • Fukata, M. et al. Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis. Inflamm. Bowel Dis. 17, 1464-1473 (2011).
    • (2011) Inflamm. Bowel Dis. , vol.17 , pp. 1464-1473
    • Fukata, M.1
  • 29
    • 77955346494 scopus 로고    scopus 로고
    • Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease
    • e511-512
    • Asquith, M.J., Boulard, O., Powrie, F. & Maloy, K.J. Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease. Gastroenterology 139, 519-529. e511-512 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 519-529
    • Asquith, M.J.1    Boulard, O.2    Powrie, F.3    Maloy, K.J.4
  • 30
    • 77957364734 scopus 로고    scopus 로고
    • Interleukin-11 reduces TLR4-induced colitis in TLR2-deficient mice and restores intestinal STAT3 signaling
    • Gibson, D.L. et al. Interleukin-11 reduces TLR4-induced colitis in TLR2-deficient mice and restores intestinal STAT3 signaling. Gastro-enterology 139, 1277-1288 (2010).
    • (2010) Gastro-enterology , vol.139 , pp. 1277-1288
    • Gibson, D.L.1
  • 32
    • 38649129512 scopus 로고    scopus 로고
    • Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4
    • Heimesaat, M.M. et al. Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS One 2, e662 (2007).
    • (2007) PLoS One , vol.2
    • Heimesaat, M.M.1
  • 33
    • 84866461477 scopus 로고    scopus 로고
    • Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice
    • Ubeda, C. et al. Familial transmission rather than defective innate immunity shapes the distinct intestinal microbiota of TLR-deficient mice. J. Exp. Med. 209, 1445-1456 (2012).
    • (2012) J. Exp. Med. , vol.209 , pp. 1445-1456
    • Ubeda, C.1
  • 34
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn, R., Lohler, J., Rennick, D., Rajewsky, K. & Muller, W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75, 263-274 (1993).
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Muller, W.5
  • 35
    • 17144383927 scopus 로고    scopus 로고
    • Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria
    • Kim, S.C. et al. Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria. Gastroenterology 128, 891-906 (2005).
    • (2005) Gastroenterology , vol.128 , pp. 891-906
    • Kim, S.C.1
  • 36
    • 33747114270 scopus 로고    scopus 로고
    • Role of toll-like receptors in spontaneous commensal-dependent colitis
    • Rakoff-Nahoum, S., Hao, L. & Medzhitov, R. Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity 25, 319-329 (2006).
    • (2006) Immunity , vol.25 , pp. 319-329
    • Rakoff-Nahoum, S.1    Hao, L.2    Medzhitov, R.3
  • 37
    • 75649147911 scopus 로고    scopus 로고
    • TLR4 signaling in effector CD4 + T cells regulates TCR activation and experimental colitis in mice
    • Gonzalez-Navajas, J.M. et al. TLR4 signaling in effector CD4 + T cells regulates TCR activation and experimental colitis in mice. J. Clin. Invest. 120, 570-581 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 570-581
    • Gonzalez-Navajas, J.M.1
  • 38
    • 78650404485 scopus 로고    scopus 로고
    • Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine
    • Biswas, A. et al. Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine. Eur. J. Immunol. 41, 182-194 (2011).
    • (2011) Eur. J. Immunol. , vol.41 , pp. 182-194
    • Biswas, A.1
  • 39
    • 70349427086 scopus 로고    scopus 로고
    • Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice
    • e1381-1383
    • Matharu, K.S. et al. Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice. Gastroenterology 137, 1380-1390. e1381-1383 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 1380-1390
    • Matharu, K.S.1
  • 40
    • 70349972786 scopus 로고    scopus 로고
    • Loss of Toll-like receptor 2 and 4 leads to differential induction of endoplasmic reticulum stress and proapoptotic responses in the intestinal epithelium under conditions of chronic inflammation
    • Messlik, A. et al. Loss of Toll-like receptor 2 and 4 leads to differential induction of endoplasmic reticulum stress and proapoptotic responses in the intestinal epithelium under conditions of chronic inflammation. J. Proteome Res. 8, 4406-4417 (2009).
    • (2009) J. Proteome Res. , vol.8 , pp. 4406-4417
    • Messlik, A.1
  • 41
    • 69249232549 scopus 로고    scopus 로고
    • Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells
    • Garrett, W.S. et al. Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells. Cancer Cell 16, 208-219 (2009).
    • (2009) Cancer Cell , vol.16 , pp. 208-219
    • Garrett, W.S.1
  • 42
    • 84867856710 scopus 로고    scopus 로고
    • The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor + innate lymphoid cells
    • Powell, N. et al. The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor + innate lymphoid cells. Immunity 37, 674-684 (2012).
    • (2012) Immunity , vol.37 , pp. 674-684
    • Powell, N.1
  • 43
    • 84857049212 scopus 로고    scopus 로고
    • Interleukin-1beta (IL-1beta) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis
    • Carvalho, F.A. et al. Interleukin-1beta (IL-1beta) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis. Gut 61, 373-384 (2012).
    • (2012) Gut , vol.61 , pp. 373-384
    • Carvalho, F.A.1
  • 44
    • 78650319438 scopus 로고    scopus 로고
    • Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production
    • Gonzalez-Navajas, J.M. et al. Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production. J. Exp. Med. 207, 2799-2807 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 2799-2807
    • Gonzalez-Navajas, J.M.1
  • 45
    • 70649109981 scopus 로고    scopus 로고
    • Regulation of colonic epithelial repair in mice by Toll-like receptors and hyaluronic acid
    • Zheng, L., Riehl, T.E. & Stenson, W.F. Regulation of colonic epithelial repair in mice by Toll-like receptors and hyaluronic acid. Gastroenterology 137, 2041-2051 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 2041-2051
    • Zheng, L.1    Riehl, T.E.2    Stenson, W.F.3
  • 46
    • 79959827677 scopus 로고    scopus 로고
    • Toll-like receptor 3 signaling enables human esophageal epithelial cells to sense endogenous danger signals released by necrotic cells
    • Lim, D.M. & Wang, M.L. Toll-like receptor 3 signaling enables human esophageal epithelial cells to sense endogenous danger signals released by necrotic cells. Am. J. Physiol. Gastrointest. Liver Physiol. 301, G91-G99 (2011).
    • (2011) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.301
    • Lim, D.M.1    Wang, M.L.2
  • 47
    • 0028006855 scopus 로고
    • Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice
    • Dieleman, L.A. et al. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology 107, 1643-1652 (1994).
    • (1994) Gastroenterology , vol.107 , pp. 1643-1652
    • Dieleman, L.A.1
  • 48
    • 0035489567 scopus 로고    scopus 로고
    • Dextran sodium sulfate-induced colitis in germ-free IQI/Jic mice
    • Kitajima, S., Morimoto, M., Sagara, E., Shimizu, C. & Ikeda, Y. Dextran sodium sulfate-induced colitis in germ-free IQI/Jic mice. Exp. Anim. 50, 387-395 (2001).
    • (2001) Exp. Anim. , vol.50 , pp. 387-395
    • Kitajima, S.1    Morimoto, M.2    Sagara, E.3    Shimizu, C.4    Ikeda, Y.5
  • 49
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S. & Medzhitov, R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118, 229-241 (2004).
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 50
    • 20244372724 scopus 로고    scopus 로고
    • Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis
    • Fukata, M. et al. Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 288, G1055-G1065 (2005).
    • (2005) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.288
    • Fukata, M.1
  • 51
    • 78549284013 scopus 로고    scopus 로고
    • TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells
    • Choi, Y.J., Im, E., Chung, H.K., Pothoulakis, C. & Rhee, S.H. TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells. J. Biol. Chem. 285, 37570-37578 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 37570-37578
    • Choi, Y.J.1    Im, E.2    Chung, H.K.3    Pothoulakis, C.4    Rhee, S.H.5
  • 52
    • 34247235029 scopus 로고    scopus 로고
    • Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function
    • Cario, E., Gerken, G. & Podolsky, D.K. Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology 132, 1359-1374 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 1359-1374
    • Cario, E.1    Gerken, G.2    Podolsky, D.K.3
  • 53
    • 3242692641 scopus 로고    scopus 로고
    • Toll-like receptor2 enhancesZO-1-associated intestinal epithelial barrier integrity via protein kinase C
    • Cario, E., Gerken, G. & Podolsky, D.K. Toll-like receptor2 enhancesZO-1-associated intestinal epithelial barrier integrity via protein kinase C. Gastroenterology 127, 224-238 (2004).
    • (2004) Gastroenterology , vol.127 , pp. 224-238
    • Cario, E.1    Gerken, G.2    Podolsky, D.K.3
  • 54
    • 67649231565 scopus 로고    scopus 로고
    • Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency
    • Podolsky, D.K., Gerken, G., Eyking, A. & Cario, E. Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency. Gastroenterology 137, 209-220 (2009).
    • (2009) Gastroenterology , vol.137 , pp. 209-220
    • Podolsky, D.K.1    Gerken, G.2    Eyking, A.3    Cario, E.4
  • 55
    • 33748271299 scopus 로고    scopus 로고
    • Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine
    • Fukata, M. et al. Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine. Gastroenterology 131, 862-877 (2006).
    • (2006) Gastroenterology , vol.131 , pp. 862-877
    • Fukata, M.1
  • 56
    • 77954559878 scopus 로고    scopus 로고
    • The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia
    • Hernandez, Y. et al. The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia. BMC Gastroenterol. 10, 82 (2010).
    • (2010) BMC Gastroenterol. , vol.10 , pp. 82
    • Hernandez, Y.1
  • 57
    • 11844279745 scopus 로고    scopus 로고
    • Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury
    • Pull, S.L., Doherty, J.M., Mills, J.C., Gordon, J.I. & Stappenbeck, TS. Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury. Proc. Natl. Acad. Sci. USA 102, 99-104 (2005).
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 99-104
    • Pull, S.L.1    Doherty, J.M.2    Mills, J.C.3    Gordon, J.I.4    Stappenbeck, T.S.5
  • 58
    • 33846017279 scopus 로고    scopus 로고
    • Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury
    • Brown, S.L. et al. Myd88-dependent positioning of Ptgs2-expressing stromal cells maintains colonic epithelial proliferation during injury. J. Clin. Invest. 117, 258-269 (2007).
    • (2007) J. Clin. Invest. , vol.117 , pp. 258-269
    • Brown, S.L.1
  • 59
    • 36549082403 scopus 로고    scopus 로고
    • Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors
    • Fukata, M. et al. Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology 133, 1869-1881 (2007).
    • (2007) Gastroenterology , vol.133 , pp. 1869-1881
    • Fukata, M.1
  • 60
    • 24144461193 scopus 로고    scopus 로고
    • CpG motifs of bacterial DNA essentially contribute to the perpetuation of chronic intestinal inflammation
    • Obermeier, F. et al. CpG motifs of bacterial DNA essentially contribute to the perpetuation of chronic intestinal inflammation. Gastroenterology 129, 913-927 (2005).
    • (2005) Gastroenterology , vol.129 , pp. 913-927
    • Obermeier, F.1
  • 61
    • 79959540809 scopus 로고    scopus 로고
    • Afunctional role for Nlrp6 in intestinal inflammation and tumorigenesis
    • Chen, G.Y., Liu, M., Wang, F., Bertin, J. & Nunez, G. Afunctional role for Nlrp6 in intestinal inflammation and tumorigenesis. J. Immunol. 186, 7187-7194 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 7187-7194
    • Chen, G.Y.1    Liu, M.2    Wang, F.3    Bertin, J.4    Nunez, G.5
  • 62
    • 79959369355 scopus 로고    scopus 로고
    • Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury
    • Normand, S. et al. Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc. Natl. Acad. Sci. USA 108, 9601-9606 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 9601-9606
    • Normand, S.1
  • 63
    • 79251558406 scopus 로고    scopus 로고
    • Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine
    • Kempster, S.L. et al. Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 300, G253-G263 (2011).
    • (2011) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.300
    • Kempster, S.L.1
  • 64
    • 33645844823 scopus 로고    scopus 로고
    • Attenuation of colonic inflammation by PPARgamma in intestinal epithelial cells: Effect on Toll-like receptor pathway
    • Eun, C.S. et al. Attenuation of colonic inflammation by PPARgamma in intestinal epithelial cells: effect on Toll-like receptor pathway. Dig. Dis. Sci. 51, 693-697 (2006).
    • (2006) Dig. Dis. Sci. , vol.51 , pp. 693-697
    • Eun, C.S.1
  • 65
    • 0037847511 scopus 로고    scopus 로고
    • Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis
    • Dubuquoy, L. et al. Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis. Gastroenterology 124, 1265-1276 (2003).
    • (2003) Gastroenterology , vol.124 , pp. 1265-1276
    • Dubuquoy, L.1
  • 66
    • 84864270714 scopus 로고    scopus 로고
    • ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation
    • Hashimoto, T. et al. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature 487, 477-481 (2012).
    • (2012) Nature , vol.487 , pp. 477-481
    • Hashimoto, T.1
  • 67
    • 34848889673 scopus 로고    scopus 로고
    • Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system
    • Garrett, W.S. et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell 131, 33-45 (2007).
    • (2007) Cell , vol.131 , pp. 33-45
    • Garrett, W.S.1
  • 68
    • 70350451119 scopus 로고    scopus 로고
    • NOD2 regulates hematopoietic cell function during graft-versus-host disease
    • Penack, O. et al. NOD2 regulates hematopoietic cell function during graft-versus-host disease. J. Exp. Med. 206, 2101-2110 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 2101-2110
    • Penack, O.1
  • 69
    • 70349468054 scopus 로고    scopus 로고
    • Nod2 is required for the regulation of commensal microbiota in the intestine
    • Petnicki-Ocwieja, T. et al. Nod2 is required for the regulation of commensal microbiota in the intestine. Proc. Natl. Acad. Sci. USA 106, 15813-15818 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 15813-15818
    • Petnicki-Ocwieja, T.1
  • 70
    • 35648995482 scopus 로고    scopus 로고
    • NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis induction
    • Yang, Z. et al. NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis induction. Gastroenterology 133, 1510-1521 (2007).
    • (2007) Gastroenterology , vol.133 , pp. 1510-1521
    • Yang, Z.1
  • 71
    • 13244277880 scopus 로고    scopus 로고
    • Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
    • Maeda, S. et al. Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science 307, 734-738 (2005).
    • (2005) Science , vol.307 , pp. 734-738
    • Maeda, S.1
  • 72
    • 57749094105 scopus 로고    scopus 로고
    • The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis
    • Chen, G.Y, Shaw, M.H., Redondo, G. & Nunez, G. The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis. Cancer Res. 68, 10060-10067 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 10060-10067
    • Chen, G.Y.1    Shaw, M.H.2    Redondo, G.3    Nunez, G.4
  • 73
    • 84863987697 scopus 로고    scopus 로고
    • Commensal and probiotic bacteria influence intestinal barrier function and susceptibility to colitis in Nod1 (-/-);Nod2(-/-) Mice
    • Natividad, J.M. et al. Commensal and probiotic bacteria influence intestinal barrier function and susceptibility to colitis in Nod1 (-/-);Nod2(-/-) Mice. Inflamm. Bowel Dis. 18, 1434-1446 (2011).
    • (2011) Inflamm. Bowel Dis. , vol.18 , pp. 1434-1446
    • Natividad, J.M.1
  • 74
    • 79955846705 scopus 로고    scopus 로고
    • NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
    • Hirota, S.A. et al. NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm. Bowel Dis. 17, 1359-1372 (2011).
    • (2011) Inflamm. Bowel Dis. , vol.17 , pp. 1359-1372
    • Hirota, S.A.1
  • 75
    • 77950002937 scopus 로고    scopus 로고
    • The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
    • Zaki, M.H. et al. The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 32, 379-391 (2010).
    • (2010) Immunity , vol.32 , pp. 379-391
    • Zaki, M.H.1
  • 76
    • 77952303410 scopus 로고    scopus 로고
    • The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
    • Allen, I.C. et al. The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J. Exp. Med. 207, 1045-1056 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1045-1056
    • Allen, I.C.1
  • 77
    • 77949965210 scopus 로고    scopus 로고
    • Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases
    • Dupaul-Chicoine, J. et al. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity 32, 367-378 (2010).
    • (2010) Immunity , vol.32 , pp. 367-378
    • Dupaul-Chicoine, J.1
  • 78
    • 0034795561 scopus 로고    scopus 로고
    • Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production
    • Siegmund, B. et al. Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281, R1264-R1273 (2001).
    • (2001) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.281
    • Siegmund, B.1
  • 79
    • 0036103112 scopus 로고    scopus 로고
    • Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: Blocking interleukin 18 attenuates intestinal damage
    • Sivakumar, P.V. et al. Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage. Gut 50, 812-820 (2002).
    • (2002) Gut , vol.50 , pp. 812-820
    • Sivakumar, P.V.1
  • 80
    • 0042855191 scopus 로고    scopus 로고
    • Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice
    • Ishikura, T. et al. Interleukin-18 overproduction exacerbates the development of colitis with markedly infiltrated macrophages in interleukin-18 transgenic mice. J. Gastroenterol. Hepatol. 18, 960-969 (2003).
    • (2003) J. Gastroenterol. Hepatol. , vol.18 , pp. 960-969
    • Ishikura, T.1
  • 81
    • 77956128040 scopus 로고    scopus 로고
    • Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome
    • Bauer, C. et al. Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut 59, 1192-1199 (2010).
    • (2010) Gut , vol.59 , pp. 1192-1199
    • Bauer, C.1
  • 82
    • 79953084107 scopus 로고    scopus 로고
    • The Nlrp3 inflammasome: Contributions to intestinal homeostasis
    • Zaki, M.H., Lamkanfi, M. & Kanneganti, T.D. The Nlrp3 inflammasome: contributions to intestinal homeostasis. Trends Immunol. 32, 171-179 (2011).
    • (2011) Trends Immunol. , vol.32 , pp. 171-179
    • Zaki, M.H.1    Lamkanfi, M.2    Kanneganti, T.D.3
  • 83
    • 77949937466 scopus 로고    scopus 로고
    • Interferon-gamma regulates intestinal epithelial home-ostasis through converging beta-catenin signaling pathways
    • Nava, P. et al. Interferon-gamma regulates intestinal epithelial home-ostasis through converging beta-catenin signaling pathways. Immunity 32, 392-402 (2010).
    • (2010) Immunity , vol.32 , pp. 392-402
    • Nava, P.1
  • 84
    • 0032521457 scopus 로고    scopus 로고
    • Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice
    • Fantuzzi, G., Puren, A.J., Harding, M.W., Livingston, D.J. & Dinarello, C.A. Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice. Blood 91, 2118-2125 (1998).
    • (1998) Blood , vol.91 , pp. 2118-2125
    • Fantuzzi, G.1    Puren, A.J.2    Harding, M.W.3    Livingston, D.J.4    Dinarello, C.A.5
  • 85
    • 78049488908 scopus 로고    scopus 로고
    • IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation
    • Zaki, M.H., Vogel, P., Body-Malapel, M., Lamkanfi, M. & Kanneganti, T.D. IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. J. Immunol. 185, 4912-4920 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 4912-4920
    • Zaki, M.H.1    Vogel, P.2    Body-Malapel, M.3    Lamkanfi, M.4    Kanneganti, T.D.5
  • 87
    • 77957367977 scopus 로고    scopus 로고
    • Potential role of the intestinal microbiota of the mother in neonatal immune education
    • Donnet-Hughes, A. et al. Potential role of the intestinal microbiota of the mother in neonatal immune education. Proc. Nutr. Soc. 69, 407-415 (2010).
    • (2010) Proc. Nutr. Soc. , vol.69 , pp. 407-415
    • Donnet-Hughes, A.1
  • 88
    • 4444355606 scopus 로고    scopus 로고
    • Maternal adaptive immunity influences the intestinal microflora of suckling mice
    • Diaz, R.L. et al. Maternal adaptive immunity influences the intestinal microflora of suckling mice. J. Nutr. 134, 2359-2364 (2004).
    • (2004) J. Nutr. , vol.134 , pp. 2359-2364
    • Diaz, R.L.1
  • 89
    • 53649100675 scopus 로고    scopus 로고
    • ATP drives lamina propria T(H)17 cell differentiation
    • Atarashi, K. et al. ATP drives lamina propria T(H)17 cell differentiation. Nature 455, 808-812 (2008).
    • (2008) Nature , vol.455 , pp. 808-812
    • Atarashi, K.1
  • 90
    • 80053297888 scopus 로고    scopus 로고
    • The role of TLR4 activation in photoreceptor mitochondrial oxidative stress
    • Ko, M.K., Saraswathy, S., Parikh, J.G. & Rao, N.A. The role of TLR4 activation in photoreceptor mitochondrial oxidative stress. Invest. Ophthalmol. Vis. Sci. 52, 5824-5835 (2011).
    • (2011) Invest. Ophthalmol. Vis. Sci. , vol.52 , pp. 5824-5835
    • Ko, M.K.1    Saraswathy, S.2    Parikh, J.G.3    Rao, N.A.4
  • 91
    • 24644490059 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli
    • Suliman, H.B. et al. Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli. FASEB J. 19, 1531-1533 (2005).
    • (2005) FASEB J. , vol.19 , pp. 1531-1533
    • Suliman, H.B.1
  • 92
    • 84862777872 scopus 로고    scopus 로고
    • Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
    • Shimada, K. et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 36, 401-414 (2012).
    • (2012) Immunity , vol.36 , pp. 401-414
    • Shimada, K.1
  • 93
    • 0034066905 scopus 로고    scopus 로고
    • Microsatellite instability in colitis associated colorectal cancer
    • Itzkowitz, S.H. Microsatellite instability in colitis associated colorectal cancer. Gut 46, 304-305 (2000).
    • (2000) Gut , vol.46 , pp. 304-305
    • Itzkowitz, S.H.1
  • 94
    • 3042599473 scopus 로고    scopus 로고
    • Inflammation and cancer. IV. Colorectal cancer in inflammatory bowel disease: The role of inflammation
    • Itzkowitz, S.H. & Yio, X. Inflammation and cancer. IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am. J. Physiol. Gastrointest. Liver Physiol. 287, G7-17 (2004).
    • (2004) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.287
    • Itzkowitz, S.H.1    Yio, X.2
  • 95
    • 79955564023 scopus 로고    scopus 로고
    • Intestinal inflammation and cancer
    • Ullman, T.A. & Itzkowitz, S.H. Intestinal inflammation and cancer. Gastroenterology 140, 1807-1816 (2011).
    • (2011) Gastroenterology , vol.140 , pp. 1807-1816
    • Ullman, T.A.1    Itzkowitz, S.H.2
  • 96
    • 47849098044 scopus 로고    scopus 로고
    • Inflammation: Gearing the journey to cancer
    • Kundu, J.K. & Surh, Y.J. Inflammation: gearing the journey to cancer. Mutat. Res. 659, 15-30 (2008).
    • (2008) Mutat. Res. , vol.659 , pp. 15-30
    • Kundu, J.K.1    Surh, Y.J.2
  • 97
    • 49749124618 scopus 로고    scopus 로고
    • Molecular links between tumor angiogenesis and inflammation: Inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy
    • Ono, M. Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy. Cancer Sci. 99, 1501-1506 (2008).
    • (2008) Cancer Sci. , vol.99 , pp. 1501-1506
    • Ono, M.1
  • 98
    • 77955622574 scopus 로고    scopus 로고
    • Microbiota matures colonic epithelium through a coordinated induction of cell cycle-related proteins in gnotobiotic rat
    • Cherbuy, C. et al. Microbiota matures colonic epithelium through a coordinated induction of cell cycle-related proteins in gnotobiotic rat. Am. J. Physiol. Gastrointest. Liver Physiol. 299, G348-G357 (2010).
    • (2010) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.299
    • Cherbuy, C.1
  • 99
    • 77956245973 scopus 로고    scopus 로고
    • Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury
    • Hsu, D. et al. Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury. Lab. Invest. 90, 1295-1305 (2010).
    • (2010) Lab. Invest. , vol.90 , pp. 1295-1305
    • Hsu, D.1
  • 100
    • 78650548872 scopus 로고    scopus 로고
    • MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands
    • Brandl, K. et al. MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands. Proc. Natl. Acad. Sci. USA 107, 19967-19972 (2010).
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 19967-19972
    • Brandl, K.1
  • 101
    • 0034637439 scopus 로고    scopus 로고
    • The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes
    • Lin, Y. et al. The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J. Biol. Chem. 275, 24255-24263 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 24255-24263
    • Lin, Y.1
  • 102
    • 0034737660 scopus 로고    scopus 로고
    • PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene
    • Rehli, M. et al. PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene. J. Biol. Chem. 275, 9773-9781 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 9773-9781
    • Rehli, M.1
  • 103
    • 16344394046 scopus 로고    scopus 로고
    • Dose-dependent promoting effect of dextran sodium sulfate on mouse colon carcinogenesis initiated with azoxymethane
    • Suzuki, R., Kohno, H., Sugie, S. & Tanaka, T. Dose-dependent promoting effect of dextran sodium sulfate on mouse colon carcinogenesis initiated with azoxymethane. Histol. Histopathol. 20, 483-492 (2005).
    • (2005) Histol. Histopathol. , vol.20 , pp. 483-492
    • Suzuki, R.1    Kohno, H.2    Sugie, S.3    Tanaka, T.4
  • 104
    • 69449102284 scopus 로고    scopus 로고
    • Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors
    • Fukata, M. et al. Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors. Inflamm. Bowel Dis. 15, 997-1006 (2009).
    • (2009) Inflamm. Bowel Dis. , vol.15 , pp. 997-1006
    • Fukata, M.1
  • 105
    • 77958610178 scopus 로고    scopus 로고
    • Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer
    • Lowe, E.L. et al. Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. PLoS One 5, e13027 (2010).
    • (2010) PLoS One , vol.5
    • Lowe, E.L.1
  • 106
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • Grivennikov, S. et al. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15, 103-113 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 103-113
    • Grivennikov, S.1
  • 107
    • 69949120571 scopus 로고    scopus 로고
    • A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
    • Wu, S. et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat. Med. 15, 1016-1022 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 1016-1022
    • Wu, S.1
  • 108
    • 78650815222 scopus 로고    scopus 로고
    • Differential effect of TLR2 and TLR4 on the immune response after immunization with avaccine against Neisseriameningitidis or Bordetella pertussis
    • Fransen, F. et al. Differential effect of TLR2 and TLR4 on the immune response after immunization with avaccine against Neisseriameningitidis or Bordetella pertussis. PLoS One 5, e15692 (2010).
    • (2010) PLoS One , vol.5
    • Fransen, F.1
  • 109
    • 77955350419 scopus 로고    scopus 로고
    • MyD88-mediated signaling prevents development of adenocarcinomas of the colon: Role of interleukin 18
    • Salcedo, R. et al. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J. Exp. Med. 207, 1625-1636 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1625-1636
    • Salcedo, R.1
  • 110
    • 67650299380 scopus 로고    scopus 로고
    • Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility
    • Uronis, J.M. et al. Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility. PLoS One 4, e6026 (2009).
    • (2009) PLoS One , vol.4
    • Uronis, J.M.1
  • 111
    • 79955504743 scopus 로고    scopus 로고
    • Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+ CD11b(high)Gr1(low) macrophages
    • Schiechl, G. et al. Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+ CD11b(high)Gr1(low) macrophages. J. Clin. Invest. 121, 1692-1708 (2011).
    • (2011) J. Clin. Invest. , vol.121 , pp. 1692-1708
    • Schiechl, G.1
  • 112
    • 34447296425 scopus 로고    scopus 로고
    • Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88
    • Rakoff-Nahoum, S. & Medzhitov, R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317, 124-127 (2007).
    • (2007) Science , vol.317 , pp. 124-127
    • Rakoff-Nahoum, S.1    Medzhitov, R.2
  • 113
    • 34548459895 scopus 로고    scopus 로고
    • Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins
    • Watters, T.M., Kenny, E.F. & O'Neill, L.A. Structure, function and regulation of the Toll/IL-1 receptor adaptor proteins. Immunol. Cell Biol. 85, 411-419 (2007).
    • (2007) Immunol. Cell Biol. , vol.85 , pp. 411-419
    • Watters, T.M.1    Kenny, E.F.2    O'Neill, L.A.3
  • 114
    • 78650735879 scopus 로고    scopus 로고
    • Inflammation-induced tumorigenesis in the colon isregulated by caspase-1 and NLRC4.Proc
    • Hu, B. et al. Inflammation-induced tumorigenesis in the colon isregulated by caspase-1 and NLRC4.Proc. Natl. Acad. Sci. USA107, 21635-21640 (2010).
    • (2010) Natl. Acad. Sci. USA , vol.107 , pp. 21635-21640
    • Hu, B.1
  • 115
    • 84861460062 scopus 로고    scopus 로고
    • NLRP12 suppresses colon inflammation and tumorigen-esis through the negative regulation of noncanonical NF-kappaB signaling
    • Allen, I.C. et al. NLRP12 suppresses colon inflammation and tumorigen-esis through the negative regulation of noncanonical NF-kappaB signaling. Immunity 36, 742-754 (2012).
    • (2012) Immunity , vol.36 , pp. 742-754
    • Allen, I.C.1
  • 116
    • 81255189478 scopus 로고    scopus 로고
    • The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis
    • Zaki, M.H. et al. The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell 20, 649-660 (2011).
    • (2011) Cancer Cell , vol.20 , pp. 649-660
    • Zaki, M.H.1
  • 117
    • 84873372079 scopus 로고    scopus 로고
    • NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer
    • in press
    • Couturier-Maillard, A. et al. NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer. J. Clin. Invest. in press (2013).
    • (2013) J. Clin. Invest
    • Couturier-Maillard, A.1
  • 118
    • 57649225523 scopus 로고    scopus 로고
    • Dendritic cell activation by combined exposure to anti-CD40 plus interleukin (IL)-12 and IL-18 efficiently stimulates anti-tumor immunity
    • Balkow, S. et al. Dendritic cell activation by combined exposure to anti-CD40 plus interleukin (IL)-12 and IL-18 efficiently stimulates anti-tumor immunity. Exp. Dermatol. 18, 78-87 (2009).
    • (2009) Exp. Dermatol. , vol.18 , pp. 78-87
    • Balkow, S.1
  • 119
    • 69249109191 scopus 로고    scopus 로고
    • TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury
    • Ey, B., Eyking, A., Gerken, G., Podolsky, D.K. & Cario, E. TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury. J. Biol. Chem. 284, 22332-22343 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 22332-22343
    • Ey, B.1    Eyking, A.2    Gerken, G.3    Podolsky, D.K.4    Cario, E.5
  • 120
    • 20844463064 scopus 로고    scopus 로고
    • A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease
    • Fort, M.M. et al. A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease. J. Immunol. 174, 6416-6423 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 6416-6423
    • Fort, M.M.1
  • 121
    • 67049095880 scopus 로고    scopus 로고
    • A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis
    • Ungaro, R. et al. A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 296, G1167-G1179 (2009).
    • (2009) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.296
    • Ungaro, R.1
  • 122
    • 65849141281 scopus 로고    scopus 로고
    • Eritoran: The evidence of its therapeutic potential in sepsis
    • Raja, S.G. & Dreyfus, G.D. Eritoran: the evidence of its therapeutic potential in sepsis. Core Evid. 2, 199-207 (2008).
    • (2008) Core Evid. , vol.2 , pp. 199-207
    • Raja, S.G.1    Dreyfus, G.D.2
  • 123
    • 38849163741 scopus 로고    scopus 로고
    • Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis
    • Watanabe, T. et al. Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J. Clin. Invest. 118, 545-559 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 545-559
    • Watanabe, T.1
  • 124
    • 70449727077 scopus 로고    scopus 로고
    • Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
    • Lamkanfi, M. et al. Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. J. Cell Biol. 187, 61-70 (2009).
    • (2009) J. Cell Biol. , vol.187 , pp. 61-70
    • Lamkanfi, M.1
  • 125
    • 84860738670 scopus 로고    scopus 로고
    • Ventilator-induced lung injury is mediated by the NLRP3 inflammasome
    • Kuipers, M.T. et al. Ventilator-induced lung injury is mediated by the NLRP3 inflammasome. Anesthesiology 116, 1104-1115 (2012).
    • (2012) Anesthesiology , vol.116 , pp. 1104-1115
    • Kuipers, M.T.1
  • 126
    • 17044385039 scopus 로고    scopus 로고
    • TLR signaling in the gut in health and disease
    • Abreu, M.T., Fukata, M. & Arditi, M. TLR signaling in the gut in health and disease. J. Immunol. 174, 4453-4460 (2005).
    • (2005) J. Immunol. , vol.174 , pp. 4453-4460
    • Abreu, M.T.1    Fukata, M.2    Arditi, M.3
  • 127
    • 84862990205 scopus 로고    scopus 로고
    • Age-dependent TLR3 expression of the intestinal epithelium contributes to rotavirus susceptibility
    • Pott, J. et al. Age-dependent TLR3 expression of the intestinal epithelium contributes to rotavirus susceptibility. PLoS Pathog. 8, e1002670 (2012).
    • (2012) PLoS Pathog. , vol.8
    • Pott, J.1
  • 128
    • 71649107595 scopus 로고    scopus 로고
    • The role of innate signaling in the homeostasis of tolerance and immunity in the intestine
    • Wells, J.M., Loonen, L.M. & Karczewski, J.M. The role of innate signaling in the homeostasis of tolerance and immunity in the intestine. Int. J. Med. Microbiol. 300, 41-48 (2010).
    • (2010) Int. J. Med. Microbiol. , vol.300 , pp. 41-48
    • Wells, J.M.1    Loonen, L.M.2    Karczewski, J.M.3
  • 129
    • 1342344961 scopus 로고    scopus 로고
    • Nod1 is anessential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors
    • Kim, J.G., Lee, S.J. & Kagnoff, M.F. Nod1 is anessential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors. Infect. Immun. 72, 1487-1495 (2004).
    • (2004) Infect. Immun. , vol.72 , pp. 1487-1495
    • Kim, J.G.1    Lee, S.J.2    Kagnoff, M.F.3
  • 130
    • 17644366913 scopus 로고    scopus 로고
    • NOD-LRR proteins: Role in host-microbial interactions and inflammatory disease
    • Inohara, Chamaillard, McDonald, C. & Nunez, G. NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu. Rev. Biochem. 74, 355-383 (2005).
    • (2005) Annu. Rev. Biochem. , vol.74 , pp. 355-383
    • Chamaillard, I.1    McDonald, C.2    Nunez, G.3
  • 131
    • 38449111819 scopus 로고    scopus 로고
    • Activation of innate immune defense mechanisms by signaling through RIG-I/IPS-1 in intestinal epithelial cells
    • Hirata, Y., Broquet, A.H., Menchen, L. & Kagnoff, M.F. Activation of innate immune defense mechanisms by signaling through RIG-I/IPS-1 in intestinal epithelial cells. J. Immunol. 179, 5425-5432 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 5425-5432
    • Hirata, Y.1    Broquet, A.H.2    Menchen, L.3    Kagnoff, M.F.4
  • 133
    • 22444433175 scopus 로고    scopus 로고
    • NLRs join TLRs as innate sensors of pathogens
    • Martinon, F. & Tschopp, J. NLRs join TLRs as innate sensors of pathogens. Trends Immunol. 26, 447-454 (2005).
    • (2005) Trends Immunol. , vol.26 , pp. 447-454
    • Martinon, F.1    Tschopp, J.2
  • 134
    • 0035941356 scopus 로고    scopus 로고
    • The membrane-type collectin CL-P1 is a scavenger receptor on vascular endothelial cells
    • Ohtani, K. et al. The membrane-type collectin CL-P1 is a scavenger receptor on vascular endothelial cells. J. Biol. Chem. 276, 44222-44228 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 44222-44228
    • Ohtani, K.1
  • 135
    • 0037331514 scopus 로고    scopus 로고
    • Involvement of macrophage mannose receptor in the binding and transmission of HIV by macrophages
    • Nguyen, D.G. & Hildreth, J.E. Involvement of macrophage mannose receptor in the binding and transmission of HIV by macrophages. Eur. J. Immunol. 33, 483-493 (2003).
    • (2003) Eur. J. Immunol. , vol.33 , pp. 483-493
    • Nguyen, D.G.1    Hildreth, J.E.2
  • 136
    • 58249119896 scopus 로고    scopus 로고
    • Mannose binding lectin plays a crucial role in innate immunity against yeast by enhanced complement activation and enhanced uptake of polymorphonuclear cells
    • van Asbeck, E.C., Hoepelman, A.I., Scharringa, J., Herpers, B.L. & Verhoef, J. Mannose binding lectin plays a crucial role in innate immunity against yeast by enhanced complement activation and enhanced uptake of polymorphonuclear cells. BMC Microbiol. 8, 229 (2008).
    • (2008) BMC Microbiol. , vol.8 , pp. 229
    • Van Asbeck, E.C.1    Hoepelman, A.I.2    Scharringa, J.3    Herpers, B.L.4    Verhoef, J.5
  • 137
    • 0033781775 scopus 로고    scopus 로고
    • M-ficolin is expressed on monocytes and is a lectin binding to N-acetyl-D-glucosamine and mediates monocyte adhesion and phagocytosis of Escherichia coli
    • Teh, C., Le, Y., Lee, S.H. & Lu, J. M-ficolin is expressed on monocytes and is a lectin binding to N-acetyl-D-glucosamine and mediates monocyte adhesion and phagocytosis of Escherichia coli. Immunology 101, 225-232 (2000).
    • (2000) Immunology , vol.101 , pp. 225-232
    • Teh Le C, Y.1    Lee, S.H.2    Lu, J.3
  • 138
  • 139
    • 0038558248 scopus 로고    scopus 로고
    • Dectin-1 mediates the biological effects of beta-glucans
    • Brown, G.D. et al. Dectin-1 mediates the biological effects of beta-glucans. J. Exp. Med. 197, 1119-1124 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 1119-1124
    • Brown, G.D.1
  • 140
    • 10744233159 scopus 로고    scopus 로고
    • Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis
    • Rachmilewitz, D. et al. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology 126, 520-528 (2004).
    • (2004) Gastroenterology , vol.126 , pp. 520-528
    • Rachmilewitz, D.1
  • 141
    • 34547638394 scopus 로고    scopus 로고
    • Activation of toll-like receptor 3 protects against DSS-induced acute colitis
    • Vijay-Kumar, M. et al. Activation of toll-like receptor 3 protects against DSS-induced acute colitis. Inflamm. Bowel Dis. 13, 856-864 (2007).
    • (2007) Inflamm. Bowel Dis. , vol.13 , pp. 856-864
    • Vijay-Kumar, M.1
  • 142
    • 48549085489 scopus 로고    scopus 로고
    • Flagellin treatment protects against chemicals, bacteria, viruses, and radiation
    • Vijay-Kumar, M. et al. Flagellin treatment protects against chemicals, bacteria, viruses, and radiation. J. Immunol. 180, 8280-8285 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 8280-8285
    • Vijay-Kumar, M.1
  • 143
    • 0036241068 scopus 로고    scopus 로고
    • Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis
    • Rachmilewitz, D.et al. Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis. Gastroenterology 122, 1428-1441 (2002).
    • (2002) Gastroenterology , vol.122 , pp. 1428-1441
    • Rachmilewitz, D.1
  • 144
    • 0242606051 scopus 로고    scopus 로고
    • Contrasting activity of cytosin-guanosin dinucleotide oligonucleotides in mice with experimental colitis
    • Obermeier, F. et al. Contrasting activity of cytosin-guanosin dinucleotide oligonucleotides in mice with experimental colitis. Clin. Exp. Immunol. 134, 217-224 (2003).
    • (2003) Clin. Exp. Immunol. , vol.134 , pp. 217-224
    • Obermeier, F.1


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