-
1
-
-
34247628356
-
Endothelium as a therapeutic target in sepsis
-
Aird WC. Endothelium as a therapeutic target in sepsis. Curr Drug Targets. 2007;8:501-507.
-
(2007)
Curr Drug Targets
, vol.8
, pp. 501-507
-
-
Aird, W.C.1
-
2
-
-
0032484956
-
Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome
-
Amato MB, Barbas CS, Medeiros DM, et al. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med. 1998;338:347-354.
-
(1998)
N Engl J Med
, vol.338
, pp. 347-354
-
-
Amato, M.B.1
Barbas, C.S.2
Medeiros, D.M.3
-
3
-
-
0034924156
-
Epidemiology of sepsis: An update
-
Angus DC, Wax RS. Epidemiology of sepsis: An update. Crit Care Med. 2001;29(Suppl. 1):S109-S116.
-
(2001)
Crit Care Med
, vol.29
, Issue.SUPPL. 1
-
-
Angus, D.C.1
Wax, R.S.2
-
4
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
-
Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29:1303-1310.
-
(2001)
Crit Care Med
, vol.29
, pp. 1303-1310
-
-
Angus, D.C.1
Linde-Zwirble, W.T.2
Lidicker, J.3
Clermont, G.4
Carcillo, J.5
Pinsky, M.R.6
-
5
-
-
0037151571
-
Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
-
Annane D, Sebille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA. 2002;288:862-871.
-
(2002)
JAMA
, vol.288
, pp. 862-871
-
-
Annane, D.1
Sebille, V.2
Charpentier, C.3
-
6
-
-
0023239471
-
Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. The Veterans Administration Systemic Sepsis Cooperative Study Group
-
Anon
-
Anon. Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. The Veterans Administration Systemic Sepsis Cooperative Study Group. N Engl J Med. 1987;317:659-665.
-
(1987)
N Engl J Med
, vol.317
, pp. 659-665
-
-
-
7
-
-
0343893748
-
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network
-
Anon
-
Anon. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000;342:1301-1308.
-
(2000)
N Engl J Med
, vol.342
, pp. 1301-1308
-
-
-
8
-
-
38649102112
-
Eritoran [E 5564] reduces 28-day mortality in patients with severe sepsis
-
Anon
-
Anon. Eritoran [E 5564] reduces 28-day mortality in patients with severe sepsis. Inpharma Weekly. 2005;1:8.
-
(2005)
Inpharma Weekly
, vol.1
, pp. 8
-
-
-
9
-
-
33846456617
-
A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass
-
Bennett-Guerrero E, Grocott HP, Levy JH, et al. A phase II, double-blind, placebo-controlled, ascending-dose study of Eritoran (E5564), a lipid A antagonist, in patients undergoing cardiac surgery with cardiopulmonary bypass. Anesth Analg. 2007;104:378-383.
-
(2007)
Anesth Analg
, vol.104
, pp. 378-383
-
-
Bennett-Guerrero, E.1
Grocott, H.P.2
Levy, J.H.3
-
10
-
-
0035826096
-
Efficacy and safety of recombinant human activated protein C for severe sepsis
-
Bernard GR, Vincent J, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med. 2001;344:699-709.
-
(2001)
N Engl J Med
, vol.344
, pp. 699-709
-
-
Bernard, G.R.1
Vincent, J.2
Laterre, P.F.3
-
11
-
-
0031942028
-
Reversal of late septic shock with supraphysiologic doses of hydrocortisone
-
Bollaert PE, Charpentier C, Levy B, et al. Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med. 1998;26:645-650.
-
(1998)
Crit Care Med
, vol.26
, pp. 645-650
-
-
Bollaert, P.E.1
Charpentier, C.2
Levy, B.3
-
12
-
-
0023252009
-
A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock
-
Bone RC, Fisher CJ Jr, Clemmer TP, Slotman GJ, Metz CA, Balk RA. A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med. 1987;317:653-658.
-
(1987)
N Engl J Med
, vol.317
, pp. 653-658
-
-
Bone, R.C.1
Fisher Jr, C.J.2
Clemmer, T.P.3
Slotman, G.J.4
Metz, C.A.5
Balk, R.A.6
-
13
-
-
0032946372
-
Stress doses of hydrocortisone reverse hyperdynamic septic shock: A prospective, randomized, double-blind, single-center study
-
Briegel J, Forst H, Haller M, et al. Stress doses of hydrocortisone reverse hyperdynamic septic shock: A prospective, randomized, double-blind, single-center study. Crit Care Med. 1999;27:723-732.
-
(1999)
Crit Care Med
, vol.27
, pp. 723-732
-
-
Briegel, J.1
Forst, H.2
Haller, M.3
-
14
-
-
33745932547
-
Compartmentalization of the inflammatory response in sepsis and SIRS
-
Cavaillon JM, Annane D. Compartmentalization of the inflammatory response in sepsis and SIRS. J Endotoxin Res. 2006;12:151-170
-
(2006)
J Endotoxin Res
, vol.12
, pp. 151-170
-
-
Cavaillon, J.M.1
Annane, D.2
-
16
-
-
0037180768
-
The immunopathogenesis of sepsis
-
Cohen J. The immunopathogenesis of sepsis. Nature. 2002;420:885-891.
-
(2002)
Nature
, vol.420
, pp. 885-891
-
-
Cohen, J.1
-
17
-
-
34249650685
-
E5564 (Eritoran) inhibits lipopolysaccharide-induced cytokine production in human blood monocytes
-
Czeslick E, Struppert A, Simm A, Sablotzki A. E5564 (Eritoran) inhibits lipopolysaccharide-induced cytokine production in human blood monocytes. Inflamm Res. 2006;55:511-515.
-
(2006)
Inflamm Res
, vol.55
, pp. 511-515
-
-
Czeslick, E.1
Struppert, A.2
Simm, A.3
Sablotzki, A.4
-
18
-
-
3242775982
-
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
-
Dellinger RP, Carlet JM, Masur H, et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med. 2004;32:858-873.
-
(2004)
Crit Care Med
, vol.32
, pp. 858-873
-
-
Dellinger, R.P.1
Carlet, J.M.2
Masur, H.3
-
19
-
-
3042671649
-
Incidence and definition of sepsis and associated organ dysfunction
-
Dremsizov TT, Kellum JA, Angus DC. Incidence and definition of sepsis and associated organ dysfunction. Int J Artif Organs. 2004;27:352-359.
-
(2004)
Int J Artif Organs
, vol.27
, pp. 352-359
-
-
Dremsizov, T.T.1
Kellum, J.A.2
Angus, D.C.3
-
20
-
-
0032848001
-
The patient-related costs of care for sepsis patients in a United Kingdom adult general intensive care unit
-
Edbrooke DL, Hibbert CL, Kingsley JM, Smith S, Bright NM, Quinn JM. The patient-related costs of care for sepsis patients in a United Kingdom adult general intensive care unit. Crit Care Med. 1999;27:1760-1767.
-
(1999)
Crit Care Med
, vol.27
, pp. 1760-1767
-
-
Edbrooke, D.L.1
Hibbert, C.L.2
Kingsley, J.M.3
Smith, S.4
Bright, N.M.5
Quinn, J.M.6
-
22
-
-
0034925134
-
Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and inflammation
-
Esmon CT. Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and inflammation. Crit Care Med. 2001;29(Suppl.):S48-S51.
-
(2001)
Crit Care Med
, vol.29
, Issue.SUPPL.
-
-
Esmon, C.T.1
-
23
-
-
1942500844
-
Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units
-
Finfer S, Bellomo R, Lipman J, French C, Dobb G, Myburgh J. Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units. Intensive Care Med. 2004;30:589-596.
-
(2004)
Intensive Care Med
, vol.30
, pp. 589-596
-
-
Finfer, S.1
Bellomo, R.2
Lipman, J.3
French, C.4
Dobb, G.5
Myburgh, J.6
-
24
-
-
0026534242
-
Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies
-
Fourrier F, Chopin C, Goudemand J, et al. Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies. Chest. 1992;101:816-823.
-
(1992)
Chest
, vol.101
, pp. 816-823
-
-
Fourrier, F.1
Chopin, C.2
Goudemand, J.3
-
25
-
-
0028872009
-
A trial of goal-oriented hemodynamic therapy in critically ill patients. SvO2 Collaborative Group
-
Gattinoni L, Brazzi L, Pelosi P, et al. A trial of goal-oriented hemodynamic therapy in critically ill patients. SvO2 Collaborative Group. N Engl J Med. 1995;333:1025-1032.
-
(1995)
N Engl J Med
, vol.333
, pp. 1025-1032
-
-
Gattinoni, L.1
Brazzi, L.2
Pelosi, P.3
-
26
-
-
0028275095
-
Elevation of systemic oxygen delivery in the treatment of critically ill patients
-
Hayes MA, Timmins AC, Yau EH, Palazzo M, Hinds CJ, Watson D. Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med. 1994;330:1717-1722.
-
(1994)
N Engl J Med
, vol.330
, pp. 1717-1722
-
-
Hayes, M.A.1
Timmins, A.C.2
Yau, E.H.3
Palazzo, M.4
Hinds, C.J.5
Watson, D.6
-
27
-
-
0033710233
-
Long-term health-related quality of life in survivors of sepsis. Short Form 36: A valid and reliable measure of health-related quality of life
-
Heyland DK, Hopman W, Coo H, Tranmer J, McColl MA. Long-term health-related quality of life in survivors of sepsis. Short Form 36: A valid and reliable measure of health-related quality of life. Crit Care Med. 2000;28:3599-3605.
-
(2000)
Crit Care Med
, vol.28
, pp. 3599-3605
-
-
Heyland, D.K.1
Hopman, W.2
Coo, H.3
Tranmer, J.4
McColl, M.A.5
-
28
-
-
65849526022
-
Surviving Sepsis Campaign
-
IHI Institute for Healthcare Improvements, Available at:, accessed June 28, 2007
-
IHI (Institute for Healthcare Improvements). Surviving Sepsis Campaign. Sepsis. Available at: http://www.ihi.org/IHI/Topics/ CriticalCare/Sepsis/Changes/ (accessed June 28, 2007).
-
Sepsis
-
-
-
29
-
-
34047258169
-
Cellular mechanisms in sepsis
-
Jean-Baptiste E. Cellular mechanisms in sepsis. J Intensive Care Med. 2007;22:63-72.
-
(2007)
J Intensive Care Med
, vol.22
, pp. 63-72
-
-
Jean-Baptiste, E.1
-
30
-
-
33845683916
-
Incidence, pathogenesis, and management of sepsis: An overview
-
Kleinpell RM, Graves BT, Ackerman MH. Incidence, pathogenesis, and management of sepsis: An overview. AACN Adv Crit Care. 2006;17:385-393.
-
(2006)
AACN Adv Crit Care
, vol.17
, pp. 385-393
-
-
Kleinpell, R.M.1
Graves, B.T.2
Ackerman, M.H.3
-
31
-
-
34447619710
-
Long-term outcome and quality of life of patients treated in surgical intensive care: A comparison between sepsis and trauma
-
Korosec Jagodic H, Jagodic K, Podbregar M. Long-term outcome and quality of life of patients treated in surgical intensive care: A comparison between sepsis and trauma. Crit Care. 2006;10:R134.
-
(2006)
Crit Care
, vol.10
-
-
Korosec Jagodic, H.1
Jagodic, K.2
Podbregar, M.3
-
32
-
-
33744527833
-
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
-
Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006;34:1589-1596.
-
(2006)
Crit Care Med
, vol.34
, pp. 1589-1596
-
-
Kumar, A.1
Roberts, D.2
Wood, K.E.3
-
33
-
-
0242721762
-
Pharmacokinetics of E5564, a lipopolysaccharide antagonist, in patients with impaired hepatic function
-
Liang E, Wong YN, Allen I, Kao R, Marino M, DiLea C. Pharmacokinetics of E5564, a lipopolysaccharide antagonist, in patients with impaired hepatic function. J Clin Pharmacol. 2003;43:1361-1369.
-
(2003)
J Clin Pharmacol
, vol.43
, pp. 1361-1369
-
-
Liang, E.1
Wong, Y.N.2
Allen, I.3
Kao, R.4
Marino, M.5
DiLea, C.6
-
34
-
-
4344711662
-
Severe sepsis epidemiology: Sampling, selection, and society
-
Linde-Zwirble WT, Angus DC. Severe sepsis epidemiology: Sampling, selection, and society. Crit Care. 2004;8:222-226.
-
(2004)
Crit Care
, vol.8
, pp. 222-226
-
-
Linde-Zwirble, W.T.1
Angus, D.C.2
-
35
-
-
0037442501
-
Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia
-
Lynn M, Rossignol DP, Wheeler JL, et al. Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia. J Infect Dis. 2003;187:631-639.
-
(2003)
J Infect Dis
, vol.187
, pp. 631-639
-
-
Lynn, M.1
Rossignol, D.P.2
Wheeler, J.L.3
-
36
-
-
0037451929
-
The epidemiology of sepsis in the United States from 1979 through 2000
-
Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348:1546-1554.
-
(2003)
N Engl J Med
, vol.348
, pp. 1546-1554
-
-
Martin, G.S.1
Mannino, D.M.2
Eaton, S.3
Moss, M.4
-
37
-
-
0037372661
-
Inhibition of endotoxin response by E5564, a novel toll-like receptor 4-directed endotoxin antagonist
-
Mullarkey M, Rose JR, Bristol J, et al. Inhibition of endotoxin response by E5564, a novel toll-like receptor 4-directed endotoxin antagonist. J Pharmacol Exp Ther. 2003;304:1093-1102.
-
(2003)
J Pharmacol Exp Ther
, vol.304
, pp. 1093-1102
-
-
Mullarkey, M.1
Rose, J.R.2
Bristol, J.3
-
38
-
-
34249290789
-
-
Nguyen HB, Smith D. Sepsis in the 21st century: Recent definitions and therapeutic advances. Am J Emerg Med. 2007;25:564-571.
-
Nguyen HB, Smith D. Sepsis in the 21st century: Recent definitions and therapeutic advances. Am J Emerg Med. 2007;25:564-571.
-
-
-
-
40
-
-
0041329604
-
Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland
-
Padkin A, Goldfrad C, Brady AR, Young D, Black N, Rowan K. Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland. Crit Care Med. 2003;31:2332-2338.
-
(2003)
Crit Care Med
, vol.31
, pp. 2332-2338
-
-
Padkin, A.1
Goldfrad, C.2
Brady, A.R.3
Young, D.4
Black, N.5
Rowan, K.6
-
41
-
-
31344448078
-
Advances in the management of sepsis: The randomized controlled trials behind the Surviving Sepsis Campaign recommendations
-
Poulton B. Advances in the management of sepsis: The randomized controlled trials behind the Surviving Sepsis Campaign recommendations. Int J Antimicrob Agents. 2006;27:97-101.
-
(2006)
Int J Antimicrob Agents
, vol.27
, pp. 97-101
-
-
Poulton, B.1
-
42
-
-
34250890817
-
Pathophysiology of sepsis
-
Remick DG. Pathophysiology of sepsis. Am J Pathol. 2007;170:1435-1444.
-
(2007)
Am J Pathol
, vol.170
, pp. 1435-1444
-
-
Remick, D.G.1
-
43
-
-
0035829842
-
Early goal-directed therapy in the treatment of severe sepsis and septic shock
-
Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345:1368-1377.
-
(2001)
N Engl J Med
, vol.345
, pp. 1368-1377
-
-
Rivers, E.1
Nguyen, B.2
Havstad, S.3
-
45
-
-
3142742677
-
Safety, pharmacokinetics, pharmacodynamics, and plasma lipoprotein distribution of eritoran (E5564) during continuous intravenous infusion into healthy volunteers
-
Rossignol DP, Wasan KM, Choo E, et al. Safety, pharmacokinetics, pharmacodynamics, and plasma lipoprotein distribution of eritoran (E5564) during continuous intravenous infusion into healthy volunteers. Antimicrob Agents Chemother. 2004;48:3233-3240.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 3233-3240
-
-
Rossignol, D.P.1
Wasan, K.M.2
Choo, E.3
-
46
-
-
0037878075
-
Steroids for septic shock: Back from the dead? (Con)
-
Sessler CN. Steroids for septic shock: Back from the dead? (Con). Chest. 2003;123(Suppl.):482S-489S.
-
(2003)
Chest
, vol.123
, Issue.SUPPL.
-
-
Sessler, C.N.1
-
47
-
-
33847183077
-
Cooperation of toll-like receptor signals in innate immune defence
-
Trinchieri G, Sher A. Cooperation of toll-like receptor signals in innate immune defence. Nat Rev Immunol. 2007;7:179-190.
-
(2007)
Nat Rev Immunol
, vol.7
, pp. 179-190
-
-
Trinchieri, G.1
Sher, A.2
-
49
-
-
33748308787
-
Toll-like receptors and innate immunity
-
Uematsu S, Akira S. Toll-like receptors and innate immunity. J Mol Med. 2006;84:712-725.
-
(2006)
J Mol Med
, vol.84
, pp. 712-725
-
-
Uematsu, S.1
Akira, S.2
-
50
-
-
0035829852
-
Intensive insulin therapy in the critically ill patients
-
van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001;345:1359-1367.
-
(2001)
N Engl J Med
, vol.345
, pp. 1359-1367
-
-
van den Berghe, G.1
Wouters, P.2
Weekers, F.3
-
51
-
-
33847651871
-
Toll-like receptor signalling and the clinical benefits that lie within
-
Verstak B, Hertzog P, Mansell A. Toll-like receptor signalling and the clinical benefits that lie within. Inflamm Res. 2007;56:1-10
-
(2007)
Inflamm Res
, vol.56
, pp. 1-10
-
-
Verstak, B.1
Hertzog, P.2
Mansell, A.3
|