Roles of TRPA1 in pain pathophysiology and implications for the development of a new class of analgesic drugs

Open Pain Journal

Volumn 6, Issue SPEC.ISSUE.1, 2013, Pages 137-153

  Radresa, Olivier ^a   Dahllöf, Henrik ^b   Nyman, Eva ^b   Nolting, Andreas ^b   Albert, Jeffrey S ^a   Raboisson, Patrick ^b  

^a ASTRAZENECA   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

AITC; Analgesic; Asthma; Cinnamaldehyde; COPD; Drug discovery; Pain; TRP; TRPA1

Indexed keywords

4 HYDROXYNONENAL; A 967079; ANALGESIC AGENT; AP 18; BRADYKININ; CB 189 625; FLUFENAMIC ACID; GRC 17536; N (4 ISOPROPYLPHENYL) 2 (1,2,3,6 TETRAHYDRO 1,3 DIMETHYL 2,6 DIOXO 7H PURIN 7 YL)ACETAMIDE; NEUROTROPHIN; NITRIC OXIDE; PLACEBO; RUTHENIUM; TETRAMER; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; TRYPSIN; TRYPTASE; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; CALCIUM HOMEOSTASIS; CELLULAR DISTRIBUTION; CHANNEL GATING; COLD NOCICEPTIVE PAIN; COLD SENSITIVITY; DISEASE MODEL; DRUG EFFICACY; DRUG SAFETY; DRUG SENSITIZATION; DRUG TARGETING; DRUG TOLERANCE; GENE FUNCTION; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; IN VITRO STUDY; INFLAMMATION; INFLAMMATORY PAIN; MECHANOTRANSDUCTION; NEUROPATHIC PAIN; NOCICEPTIVE PAIN; NOCICEPTIVE STIMULATION; NONHUMAN; OOCYTE; PAIN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PRURITUS; RESPIRATORY TRACT DISEASE; REVIEW; SENSORY SYSTEM ELECTROPHYSIOLOGY; SEQUENCE HOMOLOGY; STIMULUS RESPONSE; TEMPERATURE SENSITIVITY; TRPA1 GENE; XENOPUS LAEVIS;

EID: 84876070713     PISSN: None     EISSN: 18763863     Source Type: Journal    
DOI: 10.2174/1876386301306010137     Document Type: Review

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