7-Substituted-pyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as antagonists of the transient receptor potential ankyrin 1 (TRPA1) channel: A promising approach for treating pain and inflammation

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 5, 2012, Pages 1690-1698

  Baraldi, Pier Giovanni ^a   Romagnoli, Romeo ^a   Saponaro, Giulia ^a   Aghazadeh Tabrizi, Mojgan ^a   Baraldi, Stefania ^a   Pedretti, Pamela ^b   Fusi, Camilla ^b   Nassini, Romina ^b   Materazzi, Serena ^b   Geppetti, Pierangelo ^b   Preti, Delia ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Asthma; Inflammation; Pain; TRPA1 antagonists; TRPA1 channel

Indexed keywords

(1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL)ACETIC ACID; (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL)ACETIC ACID ETHYL ESTER; 1,3 DIMETHYL 1,5 DIHYDRO PYRROLO[3,2 D]PYRIMIDINE 2,4 DIONE DERIVATIVE; 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL) N (3 IODOPHENYL)ACETAMIDE; 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL) N (4 FLUOROPHENYL) N METHYL ACETAMIDE; 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL) N (4 FLUOROPHENYL)ACETAMIDE; 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL) N (4 HEXYLPHENYL)ACETAMIDE; 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL) N (4 IODOPHENYL)ACETAMIDE; 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL) N (4 ISOPROPYLPHENYL)ACETAMIDE; 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL) N (4 METHOXYPHENYL)ACETAMIDE; 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL) N (4 METHYLBENZYL)ACETAMIDE; 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL) N (4 MORPHOLIN 4 YL PHENYL)ACETAMIDE; 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL) N (4 TRIFLUOROMETHOXYPHENYL)ACETAMIDE; 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL) N (4 TRIFLUOROMETHYLPHENYL)ACETAMIDE; 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL) N (4 TRIFLUOROMETHYLSULFANYLPHENYL)ACETAMIDE; 2 (1,3 DIMETHYL 2,6 DIOXO 1,2,3,6 TETRAHYDRO PURIN 7 YL) N (4 ISOPROPYLPHENYL)ACETAMIDE; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; HC 030031; N (2,4 DIFLUOROPHENYL) 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL)ACETAMIDE; N (3,4 DIFLUOROPHENYL) 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL)ACETAMIDE; N (4 BENZYLSULFAMOYLPHENYL) 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL)ACETAMIDE; N (4 BUTYLPHENYL) 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL)ACETAMIDE; N (4 CHLOROPHENYL) 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL)ACETAMIDE; N (4 CYCLOHEXYLPHENYL) 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL)ACETAMIDE; N (4 DIETHYLSULFAMOYLPHENYL) 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL)ACETAMIDE; N (4 TERT BUTYLPHENYL) 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL)ACETAMIDE; N ADAMANTAN 1 YL 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL)ACETAMIDE; N BENZYL 2 (1,3 DIMETHYL 2,4 DIOXO 1,2,3,4 TETRAHYDRO PYRROLO[3,2 D]PYRIMIDIN 5 YL)ACETAMIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CRYSTALLIZATION; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FLUORINATION; HUMAN; HUMAN CELL; HYDROLYSIS; INFLAMMATION; MALE; NONHUMAN; PAIN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CALCIUM CHANNELS; HUMANS; INFLAMMATION; MALE; NERVE TISSUE PROTEINS; PAIN; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; TRANSIENT RECEPTOR POTENTIAL CHANNELS; TRPC CATION CHANNELS;

ANIMALIA; RATTUS; RODENTIA;

EID: 84857367292     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.01.020     Document Type: Article

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